Daniel Rauh
Affiliations: | 2003-2005 | Cellular and Molecular Pharmacology | University of California, San Francisco, San Francisco, CA |
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Publications
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| Grabe T, Jeyakumar K, Niggenaber J, et al. (2023) Addressing the Osimertinib Resistance Mutation EGFR-L858R/C797S with Reversible Aminopyrimidines. Acs Medicinal Chemistry Letters. 14: 591-598 |
| Goebel L, Kirschner T, Koska S, et al. (2023) Targeting oncogenic KRasG13C with nucleotide-based covalent inhibitors. Elife. 12 |
| Stehle J, Weisner J, Eichhorn L, et al. (2023) Insights into the Conformational Plasticity of the Protein Kinase Akt1 by Multi-Lateral Dipolar Spectroscopy. Chemistry (Weinheim An Der Bergstrasse, Germany). e202203959 |
| Gehrtz P, Marom S, Bührmann M, et al. (2022) Optimization of Covalent MKK7 Inhibitors Crude Nanomole-Scale Libraries. Journal of Medicinal Chemistry |
| Lategahn J, Tumbrink HL, Schultz-Fademrecht C, et al. (2022) Insight into Targeting Exon20 Insertion Mutations of the Epidermal Growth Factor Receptor with Wild Type-Sparing Inhibitors. Journal of Medicinal Chemistry |
| van der Westhuizen L, Weisner J, Taher A, et al. (2022) Covalent allosteric inhibitors of Akt generated using a click fragment approach. Chemmedchem |
| Quambusch L, Depta L, Landel I, et al. (2021) Cellular model system to dissect the isoform-selectivity of Akt inhibitors. Nature Communications. 12: 5297 |
| Niggenaber J, Heyden L, Grabe T, et al. (2020) Complex Crystal Structures of EGFR with Third-Generation Kinase Inhibitors and Simultaneously Bound Allosteric Ligands. Acs Medicinal Chemistry Letters. 11: 2484-2490 |
| Lategahn J, Hardick J, Grabe T, et al. (2020) Targeting Her2-insYVMA with Covalent Inhibitors - A Focused Compound Screening and Structure-Based Design Approach. Journal of Medicinal Chemistry |
| Roser P, Weisner J, Stehle J, et al. (2020) Conformational selection vs. induced fit: insights into the binding mechanisms of p38α MAP Kinase inhibitors. Chemical Communications (Cambridge, England). 56: 8818-8821 |