Frédéric Saudou, PhD

Affiliations: 
1999-2013 Inserm U1005 Institut Curie, Bures-sur-Yvette, Île-de-France, France 
 2013- Grenoble Institute of Neurosciences Université Grenoble Alpes, INSERM 
Area:
Huntington's disease, intracellular dynamics, axonal transport
Website:
https://neurosciences.ujf-grenoble.fr/search/team-saudou-intracellular-dynamics-neurodegeneration?language=en
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"Frédéric Saudou"
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Publications

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Lenoir S, Lahaye RA, Vitet H, et al. (2022) Pridopidine rescues BDNF/TrkB trafficking dynamics and synapse homeostasis in a Huntington disease brain-on-a-chip model. Neurobiology of Disease. 105857
Virlogeux A, Scaramuzzino C, Lenoir S, et al. (2021) Increasing brain palmitoylation rescues behavior and neuropathology in Huntington disease mice. Science Advances. 7
Agasse F, Mendez-David I, Christaller W, et al. (2020) Chronic Corticosterone Elevation Suppresses Adult Hippocampal Neurogenesis by Hyperphosphorylating Huntingtin. Cell Reports. 32: 107865
Bruyère J, Abada YS, Vitet HM, et al. (2020) Presynaptic APP levels and synaptic homeostasis are regulated by Akt phosphorylation of Huntingtin. Elife. 9
Asselin L, Rivera Alvarez J, Heide S, et al. (2020) Mutations in the KIF21B kinesin gene cause neurodevelopmental disorders through imbalanced canonical motor activity. Nature Communications. 11: 2441
Vitet H, Brandt V, Saudou F. (2020) Traffic signaling: new functions of huntingtin and axonal transport in neurological disease. Current Opinion in Neurobiology. 63: 122-130
Ehinger Y, Bruyère J, Panayotis N, et al. (2020) Huntingtin phosphorylation governs BDNF homeostasis and improves the phenotype of Mecp2 knockout mice. Embo Molecular Medicine. e10889
Kacher R, Lamazière A, Heck N, et al. (2019) CYP46A1 gene therapy deciphers the role of brain cholesterol metabolism in Huntington's disease. Brain : a Journal of Neurology
Zhang H, Zhang C, Vincent J, et al. (2018) Modulation of AMPA receptor surface diffusion restores hippocampal plasticity and memory in Huntington's disease models. Nature Communications. 9: 4272
Galvan L, Francelle L, Gaillard MC, et al. (2018) The striatal kinase DCLK3 produces neuroprotection against mutant huntingtin. Brain : a Journal of Neurology
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