William Rudolf Kobertz, PhD

Affiliations: 
1997 Chemistry University of Massachusetts Medical School, Worcester, MA, United States 
Area:
Ion Channels
Website:
https://profiles.umassmed.edu/display/133220
Google:
"William Kobertz"
Bio:

Kobertz, William Rudolf, Total synthesis of a Furan-side psoralen-thymidine monoadduct and its biochemical applications Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1998.
Our laboratory investigates the glycosylation, assembly, structure, trafficking and function of ion channel complexes. We rely on traditional electrophysiological, biochemical, and imaging modalities, but we also design, develop, and utilize novel chemical tools to interrogate a wide variety of ion channels and membrane transport proteins responsible for cardiac and neuronal function. Thus, we have synthetic organic chemists, glycobiologists, membrane protein biochemists, and electrophysiologists working together to elucidate the molecular underpinnings of these membrane transport proteins in both healthy and diseased tissues.

Mean distance: (not calculated yet)
 

Parents

Sign in to add mentor
John M. Essigmann grad student 1998 MIT (Chemistry Tree)
 (Total synthesis of a Furan-side psoralen-thymidine monoadduct and its biochemical applications.)
Gerald Norman Wogan grad student 1998 MIT (Chemistry Tree)
 (co-advisor)
Christopher Miller post-doc Brandeis (Chemistry Tree)
BETA: Related publications

Publications

You can help our author matching system! If you notice any publications incorrectly attributed to this author, please sign in and mark matches as correct or incorrect.

Bandara HMD, Hua Z, Zhang M, et al. (2017) Palladium-mediated Synthesis of a Near-IR Fluorescent K(+) Sensor. The Journal of Organic Chemistry
Öktem EK, Mruk K, Chang J, et al. (2016) Erratum to: Mutant SOD1 protein increases Nav1.3 channel excitability. Journal of Biological Physics
Kubat Öktem E, Mruk K, Chang J, et al. (2016) Mutant SOD1 protein increases Nav1.3 channel excitability. Journal of Biological Physics
Mruk K, Kobertz WR. (2015) Bioreactive Tethers. Advances in Experimental Medicine and Biology. 869: 77-100
Aromolaran AS, Subramanyam P, Chang DD, et al. (2014) LQT1 mutations in KCNQ1 C-terminus assembly domain suppress IKs using different mechanisms. Cardiovascular Research. 104: 501-11
Mruk K, Farley BM, Ritacco AW, et al. (2014) Calmodulation meta-analysis: predicting calmodulin binding via canonical motif clustering. The Journal of General Physiology. 144: 105-14
Hua Z, Kobertz WR. (2013) Chemical derivatization and purification of peptide-toxins for probing ion channel complexes. Methods in Molecular Biology (Clifton, N.J.). 995: 19-30
Mruk K, Shandilya SM, Blaustein RO, et al. (2012) Structural insights into neuronal K+ channel-calmodulin complexes. Proceedings of the National Academy of Sciences of the United States of America. 109: 13579-83
Gabriel L, Lvov A, Orthodoxou D, et al. (2012) The acid-sensitive, anesthetic-activated potassium leak channel, KCNK3, is regulated by 14-3-3β-dependent, protein kinase C (PKC)-mediated endocytic trafficking. The Journal of Biological Chemistry. 287: 32354-66
O'Connell D, Mruk K, Rocheleau JM, et al. (2011) Xenopus laevis oocytes infected with multi-drug-resistant bacteria: implications for electrical recordings. The Journal of General Physiology. 138: 271-7
See more...