Robert M. Kotin, PhD

Affiliations: 
National Institutes of Health, Bethesda, MD 
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"Robert Kotin"
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Publications

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Destro F, Joseph J, Srinivasan P, et al. (2023) Mechanistic modeling explains the production dynamics of recombinant adeno-associated virus with the baculovirus expression vector system. Molecular Therapy. Methods & Clinical Development. 30: 122-146
Hildebrandt E, Penzes JJ, Gifford RJ, et al. (2020) Evolution of dependoparvoviruses across geological timescales-implications for design of AAV-based gene therapy vectors. Virus Evolution. 6: veaa043
Kotin RM, Wright JF. (2019) Recombinant Adeno-Associated Virus Quality Control for Non-Clinical and Clinical Vectors: How an Unregulated Commercial Sector Can Compromise Development of New Gene Therapies. Human Gene Therapy. 30: 1447-1448
Kotin RM, Snyder RO. (2017) Manufacturing clinical grade recombinant adeno-associated virus using invertebrate cell lines. Human Gene Therapy
Smith RH, Hallwirth CV, Westerman M, et al. (2016) Germline viral "fossils" guide in silico reconstruction of a mid-Cenozoic era marsupial adeno-associated virus. Scientific Reports. 6: 28965
Choudhury SR, Fitzpatrick Z, Harris AF, et al. (2016) In vivo selection yields AAV-B1 capsid for CNS and muscle gene therapy. Molecular Therapy : the Journal of the American Society of Gene Therapy
Hallwirth CV, Smith RH, Westerman M, et al. (2016) 541. Use of Endogenous Viral Elements to Deduce the Sequence of an Ancient Adeno-Associated Virus That Circulated Amongst Australian Marsupials ~30 Million Years Ago Molecular Therapy. 24: S216
Le Guiner C, Montus M, Servais L, et al. (2014) Forelimb treatment in a large cohort of dystrophic dogs supports delivery of a recombinant AAV for exon skipping in Duchenne patients. Molecular Therapy : the Journal of the American Society of Gene Therapy. 22: 1923-35
Li L, Dimitriadis EK, Yang Y, et al. (2013) Production and characterization of novel recombinant adeno-associated virus replicative-form genomes: a eukaryotic source of DNA for gene transfer. Plos One. 8: e69879
Airenne KJ, Hu YC, Kost TA, et al. (2013) Baculovirus: an insect-derived vector for diverse gene transfer applications. Molecular Therapy : the Journal of the American Society of Gene Therapy. 21: 739-49
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