Roi Isaac
Affiliations: | 2011-2017 | Molecular Cell biology | Weizmann Institute of Science, Rehovot, Israel |
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"Roi Isaac"
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| Isaac R, Vinik Y, Mikl M, et al. (2022) A seven-transmembrane protein-TM7SF3, resides in nuclear speckles and regulates alternative splicing. Iscience. 25: 105270 |
| Cao M, Isaac R, Yan W, et al. (2022) Cancer-cell-secreted extracellular vesicles suppress insulin secretion through miR-122 to impair systemic glucose homeostasis and contribute to tumour growth. Nature Cell Biology |
| Moon JS, Riopel M, Seo JB, et al. (2022) HIF-2α Preserves Mitochondrial Activity And Glucose Sensing in Compensating Beta Cells in Obesity. Diabetes |
| Shatz-Azoulay H, Vinik Y, Isaac R, et al. (2020) The Animal Lectin Galectin-8 Promotes Cytokine Expression and Metastatic Tumor Growth in Mice. Scientific Reports. 10: 7375 |
| El Ouarrat D, Isaac R, Lee YS, et al. (2019) TAZ Is a Negative Regulator of PPARγ Activity in Adipocytes and TAZ Deletion Improves Insulin Sensitivity and Glucose Tolerance. Cell Metabolism |
| Lackey DE, Reis FCG, Isaac R, et al. (2019) Adipocyte PU.1 knockout promotes insulin sensitivity in HFD-fed obese mice. Scientific Reports. 9: 14779 |
| Ying W, Lee YS, Dong Y, et al. (2018) Expansion of Islet-Resident Macrophages Leads to Inflammation Affecting β Cell Proliferation and Function in Obesity. Cell Metabolism |
| Isaac R, Boura-Halfon S, Gurevitch D, et al. (2018) Selective serotonin reuptake inhibitors (SSRIs) inhibit insulin secretion and action in pancreatic β cells. The Journal of Biological Chemistry. 293: 4577-4578 |
| Isaac R, Vinik Y, Boura-Halfon S, et al. (2017) Prolonged Elimination of Negative Feedback Control Mechanisms Along the Insulin Signalling Pathway Impairs β Cell Function In Vivo. Diabetes |
| Isaac R, Goldstein I, Furth N, et al. (2016) TM7SF3, a novel p53-regulated homeostatic factor, attenuates cellular stress and the subsequent induction of the unfolded protein response. Cell Death and Differentiation |