Anirvan Ghosh

Affiliations: 
University of California, San Diego, La Jolla, CA 
Area:
the specification of connections in the developing cerebral cortex
Website:
http://www-biology.ucsd.edu/labs/ghosh/
Google:
"Anirvan Ghosh"
Bio:

The Ghosh Lab studies the mechanisms that regulate the specification of connections in the developing cerebral cortex. There are two major areas of research in the lab. First, we are investigating the mechanisms that regulate synapse formation and synaptic specificity in the developing cortex.

The goal of these experiments is to identify signals that allow neurons to select appropriate synaptic partners and to understand how synaptic components are recruited to a developing synapse. Second, we are exploring the mechanisms by which synaptic activity influences the assembly and plasticity of neural circuits. These experiments are directed towards understanding how calcium signaling regulates neuronal morphology and the formation of functional connections.

Mean distance: 12.68 (cluster 11)
 
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Publications

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Sriram B, Li L, Cruz-Martín A, et al. (2019) A Sparse Probabilistic Code Underlies the Limits of Behavioral Discrimination. Cerebral Cortex (New York, N.Y. : 1991)
Cheng C, Yang K, Wu X, et al. (2019) Loss of CREST leads to neuroinflammatory responses and ALS-like motor defects in mice. Translational Neurodegeneration. 8: 13
Jason Stachniak T, Lauren Sylwestrak E, Scheiffele P, et al. (2019) Elfn1-induced constitutive activation of mGluR7 determines frequency-dependent recruitment of SOM interneurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience
Savas JN, Wang YZ, DeNardo LA, et al. (2017) Amyloid Accumulation Drives Proteome-wide Alterations in Mouse Models of Alzheimer's Disease-like Pathology. Cell Reports. 21: 2614-2627
Martin EA, Muralidhar S, Wang Z, et al. (2016) Correction: The intellectual disability gene Kirrel3 regulates target-specific mossy fiber synapse development in the hippocampus. Elife. 5
Costa V, Aigner S, Vukcevic M, et al. (2016) mTORC1 Inhibition Corrects Neurodevelopmental and Synaptic Alterations in a Human Stem Cell Model of Tuberous Sclerosis. Cell Reports. 15: 86-95
de Wit J, Ghosh A. (2015) Specification of synaptic connectivity by cell surface interactions. Nature Reviews. Neuroscience
Martin EA, Muralidhar S, Wang Z, et al. (2015) The intellectual disability gene Kirrel3 regulates target-specific mossy fiber synapse development in the hippocampus. Elife. 4
Bourane S, Duan B, Koch SC, et al. (2015) Gate control of mechanical itch by a subpopulation of spinal cord interneurons. Science (New York, N.Y.). 350: 550-4
Savas JN, Ribeiro LF, Wierda KD, et al. (2015) The Sorting Receptor SorCS1 Regulates Trafficking of Neurexin and AMPA Receptors. Neuron. 87: 764-80
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