Peter Loewen

Affiliations: 
Microbiology University of Manitoba, Winnipeg, Manitoba, Canada 
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Machuqueiro M, Victor B, Switala J, et al. (2017) Catalase activity of catalase-peroxidases is modulated by changes in pKa of the distal histidine. Biochemistry
Miner KD, Pfister TD, Hosseinzadeh P, et al. (2014) Identifying the elusive sites of tyrosyl radicals in cytochrome c peroxidase: implications for oxidation of substrates bound at a site remote from the heme. Biochemistry. 53: 3781-9
Vidossich P, Loewen PC, Carpena X, et al. (2014) Binding of the antitubercular pro-drug isoniazid in the heme access channel of catalase-peroxidase (KatG). A combined structural and metadynamics investigation. The Journal of Physical Chemistry. B. 118: 2924-31
Loewen PC, Didychuk AL, Switala J, et al. (2013) Structure of Pisum sativum Rubisco with bound ribulose 1,5-bisphosphate. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 69: 10-4
Zámocký M, García-Fernández Q, Gasselhuber B, et al. (2012) High conformational stability of secreted eukaryotic catalase-peroxidases: answers from first crystal structure and unfolding studies. The Journal of Biological Chemistry. 287: 32254-62
Jha V, Chelikani P, Carpena X, et al. (2012) Influence of main channel structure on H(2)O(2) access to the heme cavity of catalase KatE of Escherichia coli. Archives of Biochemistry and Biophysics. 526: 54-9
Jha V, Louis S, Chelikani P, et al. (2011) Modulation of heme orientation and binding by a single residue in catalase HPII of Escherichia coli. Biochemistry. 50: 2101-10
Colin J, Wiseman B, Switala J, et al. (2009) Distinct role of specific tryptophans in facilitating electron transfer or as [Fe(IV)=O Trp•] intermediates in the peroxidase reaction of Bulkholderia pseudomallei catalase-peroxidase: A multifrequency EPR spectroscopy investigation Journal of the American Chemical Society. 131: 8557-8563
Singh R, Switala J, Loewen PC, et al. (2007) Two [Fe(IV)=O Trp*] intermediates in M. tuberculosis catalase-peroxidase discriminated by multifrequency (9-285 GHz) EPR spectroscopy: reactivity toward isoniazid. Journal of the American Chemical Society. 129: 15954-63
Deemagarn T, Wiseman B, Carpena X, et al. (2007) Two alternative substrate paths for compound I formation and reduction in catalase-peroxidase KatG from Burkholderia pseudomallei Proteins: Structure, Function and Genetics. 66: 219-228
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