Vincent P. Santarelli, PhD

Affiliations: 
Physiology  Thomas Jefferson University, Philadelphia, PA, United States 
Area:
Ion channels, sodium channels, potassium channels
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"Vincent Santarelli"
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Publications

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Chen YT, Hong MR, Zhang XJ, et al. (2023) Identification, structural, and biophysical characterization of a positive modulator of human Kv3.1 channels. Proceedings of the National Academy of Sciences of the United States of America. 120: e2220029120
Yao J, McHedlishvili D, McIntire WE, et al. (2017) Functional TASK-3-Like Channels in Mitochondria of Aldosterone-Producing Zona Glomerulosa Cells. Hypertension (Dallas, Tex. : 1979)
Roecker AJ, Egbertson M, Jones KL, et al. (2017) Discovery of selective, orally bioavailable, N-linked arylsulfonamide Nav1.7 inhibitors with pain efficacy in mice. Bioorganic & Medicinal Chemistry Letters
Coburn CA, Luo Y, Cui M, et al. (2012) Discovery of a pharmacologically active antagonist of the two-pore-domain potassium channel K2P9.1 (TASK-3). Chemmedchem. 7: 123-33
Uebele VN, Nuss CE, Fox SV, et al. (2009) Positive allosteric interaction of structurally diverse T-type calcium channel antagonists. Cell Biochemistry and Biophysics. 55: 81-93
Uebele VN, Nuss CE, Santarelli VP, et al. (2009) T-type calcium channels regulate cortical plasticity in-vivo. [corrected]. Neuroreport. 20: 257-62
Santarelli VP, Eastwood AL, Dougherty DA, et al. (2007) Calcium block of single sodium channels: role of a pore-lining aromatic residue. Biophysical Journal. 93: 2341-9
Santarelli VP, Eastwood AL, Dougherty DA, et al. (2007) A cation-pi interaction discriminates among sodium channels that are either sensitive or resistant to tetrodotoxin block. The Journal of Biological Chemistry. 282: 8044-51
Xia M, Imredy JP, Santarelli VP, et al. (2003) Generation and characterization of a cell line with inducible expression of Ca(v)3.2 (T-type) channels. Assay and Drug Development Technologies. 1: 637-45
Sheng Z, Skach W, Santarelli V, et al. (1997) Evidence for interaction between transmembrane segments in assembly of Kv1.3. Biochemistry. 36: 15501-13
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