Gjumrakch Aliev, MD

Affiliations: 
University of Atlanta 
Area:
Alzheimer's disease, atherosclerosis, cancer, antioxidant treatment
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"Gjumrakch Aliev"
Bio:

Education: M.D., Baku Medical Institute, Baku, Azerbaijan (former USSR);
Ph.D., Cardiovascular Biology and Pathology, Moscow State University and Ivanovo Medical Institute, Ivanovo, Russia (former USSR); Institute of Human Morphology, Russian Academy of Medical Sciences, and Russian Cardiology Center, Moscow, Russia (former USSR); Research Fellow, Department of Anatomy and Developmental Biology, University College London, London, United Kingdom; Research Fellow, The Cleveland Clinic Foundation, Cleveland, Ohio, USA

Dr. Aliev joined the UTSA faculty in 2006 from Case Western Reserve University as Assistant Professor of Pathology and co-Director of the Microscopy Research Center. He is a member of several editorial boards including Microscopy Research and Techniques, Journal of Cellular and Molecular Medicine, Neurotoxicity Research, Histology & Histopathology, American Journal of Alzheimer’s Disease and Other Dementia. He also serves as Editor for Central European Journal of Biology (Neuroscience Section).

Research Interests

Our research focuses on the cellular and subcellular mechanisms of pyramidal neuronal and vascular wall cell damage during the development of Alzheimer’s diseases (AD) and the future new wave of treatments for this devastating disease. We have shown the ultrastructural and molecular mechanisms of the features in the changes on mitochondria (DNA deletion, Cytochrome C Oxidase activity, and redox activity (Fe)), protein modification and oxidation (HNE) and RNA (8OHG) oxidation during normal aging (in a dog model of aging), stroke (cardiac arrest and resuscitation), and in transgenic mouse models of AD and human AD by using in situ hybridization and immunocytochemistry techniques at the light and electron microscopic levels. Selective mitochondrial antioxidant (e.g., lipoic acid and l-carnitine) will also be tested in different experimental models for future application in future clinical trials of these compounds as an alternative prophylactic and treatment strategy for neurodegeneration, cardio- and cerebrovascular diseases. The biochemical properties of these protein activities are also of interest in our ongoing research.
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Mean distance: 16.32 (cluster 28)
 
SNBCP
Cross-listing: Alzheimer's Tree

Parents

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Geoffrey Burnstock post-doc 1993-1995 UCL
George Perry post-doc 1998-1999 Case Western
 (Deceased December 2020)

Collaborators

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George Perry collaborator 1998-2008 UT San Antonio
BETA: Related publications

Publications

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Muresanu C, Somasundaram SG, Vissarionov SV, et al. (2020) Updated Understanding of Cancer as a Metabolic and Telomere-Driven Disease, and Proposal for Complex Personalized Treatment, a Hypothesis. International Journal of Molecular Sciences. 21
Leszek J, Mikhaylenko EV, Belousov DM, et al. (2020) The Links between Cardiovascular Diseases and Alzheimer's Disease. Current Neuropharmacology
Chrishtop VV, Tomilova IK, Rumyantseva TA, et al. (2020) The Effect of Short-Term Physical Activity on the Oxidative Stress in Rats with Different Stress Resistance Profiles in Cerebral Hypoperfusion. Molecular Neurobiology
Belousov DM, Mikhaylenko EV, Chubarev VN, et al. (2020) The Dawn of Mitophagy: What Do We Know by Now? Current Neuropharmacology
Mikhaleva LM, Davydov AI, Patsap OI, et al. (2020) Malignant Transformation and Associated Biomarkers of Ovarian Endometriosis: A Narrative Review. Advances in Therapy
Nikolenko VN, Oganesyan MV, Vovkogon AD, et al. (2019) Current Understanding of Central Nervous System Drainage Systems: Implications in the Context of Neurodegenerative Diseases. Current Neuropharmacology
Muresanu C, Somasundaram SG, Neganova ME, et al. (2019) Updated Understanding of the Degenerative Disc Diseases - Causes versus Effects - Treatments, Studies and Hypothesis. Current Topics in Medicinal Chemistry
Bachurin SO, Makhaeva GF, Shevtsova EF, et al. (2019) Conjugates of methylene blue with γ-carboline derivatives as new multifunctional agents for the treatment of neurodegenerative diseases. Scientific Reports. 9: 4873
Putta S, Yarla NS, Peluso I, et al. (2017) Anthocyanins: Possible role as Multitarget therapeutic agents for prevention and therapy of chronic diseases. Current Pharmaceutical Design
Sawikr Y, Yarla NS, Peluso I, et al. (2017) Neuroinflammation in Alzheimer's Disease: The Preventive and Therapeutic Potential of Polyphenolic Nutraceuticals. Advances in Protein Chemistry and Structural Biology. 108: 33-57
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