Gjumrakch Aliev, MD

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Bio:

Education: M.D., Baku Medical Institute, Baku, Azerbaijan (former USSR);
Ph.D., Cardiovascular Biology and Pathology, Moscow State University and Ivanovo Medical Institute, Ivanovo, Russia (former USSR); Institute of Human Morphology, Russian Academy of Medical Sciences, and Russian Cardiology Center, Moscow, Russia (former USSR); Research Fellow, Department of Anatomy and Developmental Biology, University College London, London, United Kingdom; Research Fellow, The Cleveland Clinic Foundation, Cleveland, Ohio, USA

Dr. Aliev joined the UTSA faculty in 2006 from Case Western Reserve University as Assistant Professor of Pathology and co-Director of the Microscopy Research Center. He is a member of several editorial boards including Microscopy Research and Techniques, Journal of Cellular and Molecular Medicine, Neurotoxicity Research, Histology & Histopathology, American Journal of Alzheimer’s Disease and Other Dementia. He also serves as Editor for Central European Journal of Biology (Neuroscience Section).

Research Interests

Our research focuses on the cellular and subcellular mechanisms of pyramidal neuronal and vascular wall cell damage during the development of Alzheimer’s diseases (AD) and the future new wave of treatments for this devastating disease. We have shown the ultrastructural and molecular mechanisms of the features in the changes on mitochondria (DNA deletion, Cytochrome C Oxidase activity, and redox activity (Fe)), protein modification and oxidation (HNE) and RNA (8OHG) oxidation during normal aging (in a dog model of aging), stroke (cardiac arrest and resuscitation), and in transgenic mouse models of AD and human AD by using in situ hybridization and immunocytochemistry techniques at the light and electron microscopic levels. Selective mitochondrial antioxidant (e.g., lipoic acid and l-carnitine) will also be tested in different experimental models for future application in future clinical trials of these compounds as an alternative prophylactic and treatment strategy for neurodegeneration, cardio- and cerebrovascular diseases. The biochemical properties of these protein activities are also of interest in our ongoing research.
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Cross-listing: Alzheimer's Tree