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Yih-Shyan Lin - Publications

Affiliations: 
2014 Chemistry McGill University, Montreal, QC, Canada 
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9 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2017 Park J, Rodionov D, De Schutter JW, Lin YS, Tsantrizos YS, Berghuis AM. Crystallographic and thermodynamic characterization of phenylaminopyridine bisphosphonates binding to human farnesyl pyrophosphate synthase. Plos One. 12: e0186447. PMID 29036218 DOI: 10.1371/Journal.Pone.0186447  0.664
2015 Gritzalis D, Park J, Chiu W, Cho H, Lin YS, De Schutter JW, Lacbay CM, Zielinski M, Berghuis AM, Tsantrizos YS. Probing the molecular and structural elements of ligands binding to the active site versus an allosteric pocket of the human farnesyl pyrophosphate synthase. Bioorganic & Medicinal Chemistry Letters. 25: 1117-23. PMID 25630225 DOI: 10.1016/J.Bmcl.2014.12.089  0.641
2014 Lacbay CM, Mancuso J, Lin YS, Bennett N, Götte M, Tsantrizos YS. Modular assembly of purine-like bisphosphonates as inhibitors of HIV-1 reverse transcriptase. Journal of Medicinal Chemistry. 57: 7435-49. PMID 25144111 DOI: 10.1021/Jm501010F  0.626
2014 De Schutter JW, Park J, Leung CY, Gormley P, Lin YS, Hu Z, Berghuis AM, Poirier J, Tsantrizos YS. Multistage screening reveals chameleon ligands of the human farnesyl pyrophosphate synthase: implications to drug discovery for neurodegenerative diseases. Journal of Medicinal Chemistry. 57: 5764-76. PMID 24911527 DOI: 10.1021/Jm500629E  0.604
2014 Park J, Lin YS, Tsantrizos YS, Berghuis AM. Structure of human farnesyl pyrophosphate synthase in complex with an aminopyridine bisphosphonate and two molecules of inorganic phosphate. Acta Crystallographica. Section F, Structural Biology Communications. 70: 299-304. PMID 24598914 DOI: 10.1107/S2053230X14002106  0.651
2014 Park J, Leung C, Lin Y, De Schutter J, Tsantrizos Y, Berghuis A. Crystal structures of hFPPS in complex with novel anticancer drug leads Acta Crystallographica Section a Foundations and Advances. 70: C712-C712. DOI: 10.1107/S2053273314092870  0.668
2012 Park J, Lin YS, De Schutter JW, Tsantrizos YS, Berghuis AM. Ternary complex structures of human farnesyl pyrophosphate synthase bound with a novel inhibitor and secondary ligands provide insights into the molecular details of the enzyme's active site closure. Bmc Structural Biology. 12: 32. PMID 23234314 DOI: 10.1186/1472-6807-12-32  0.662
2012 De Schutter JW, Shaw J, Lin YS, Tsantrizos YS. Design of potent bisphosphonate inhibitors of the human farnesyl pyrophosphate synthase via targeted interactions with the active site 'capping' phenyls. Bioorganic & Medicinal Chemistry. 20: 5583-91. PMID 22884353 DOI: 10.1016/J.Bmc.2012.07.019  0.659
2012 Lin YS, Park J, De Schutter JW, Huang XF, Berghuis AM, Sebag M, Tsantrizos YS. Design and synthesis of active site inhibitors of the human farnesyl pyrophosphate synthase: apoptosis and inhibition of ERK phosphorylation in multiple myeloma cells. Journal of Medicinal Chemistry. 55: 3201-15. PMID 22390415 DOI: 10.1021/Jm201657X  0.638
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