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Robert A. Britton, Ph.D. - Publications

Affiliations: 
University of British Columbia, Vancouver, Vancouver, BC, Canada 
Area:
Natural Product Isolation, Elucidation, and Synthesis
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40 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Wilson DM, Driedger DJ, Liu DY, Keerthisinghe S, Hermann A, Bieniossek C, Linington RG, Britton RA. Targeted sampling of natural product space to identify bioactive natural product-like polyketide macrolides. Nature Communications. 15: 2534. PMID 38514617 DOI: 10.1038/s41467-024-46721-x  0.554
2024 Wilson DM, Britton R. Enantioselective Total Synthesis of the Marine Macrolides Salarins A and C. Journal of the American Chemical Society. PMID 38479352 DOI: 10.1021/jacs.3c14553  0.353
2023 Yuan Z, Britton R. Development and application of decatungstate catalyzed C-H F- and F-fluorination, fluoroalkylation and beyond. Chemical Science. 14: 12883-12897. PMID 38023504 DOI: 10.1039/d3sc04027e  0.337
2023 Kaghad A, Panagopoulos D, Caballero-García G, Zhai H, Britton R. An α-chloroaldehyde-based formal synthesis of eribulin. Nature Communications. 14: 1904. PMID 37019928 DOI: 10.1038/s41467-023-37346-7  0.364
2022 Davison EK, Petrone DA, Meanwell M, Nodwell MB, Silverman SM, Campeau LC, Britton R. Practical and concise synthesis of nucleoside analogs. Nature Protocols. PMID 35788720 DOI: 10.1038/s41596-022-00705-7  0.76
2021 Meanwell M, Fehr G, Ren W, Adluri B, Rose V, Lehmann J, Silverman SM, Rowshanpour R, Adamson C, Bergeron-Brlek M, Foy H, Challa VR, Campeau LC, Dudding T, Britton R. Diversity-oriented synthesis of glycomimetics. Communications Chemistry. 4: 96. PMID 36697548 DOI: 10.1038/s42004-021-00520-3  0.756
2021 Ye Z, Lei Z, Ye X, Zhou L, Wang Y, Yuan Z, Gao F, Britton R. Decatungstate Catalyzed Synthesis of Trifluoromethylthioesters from Aldehydes via a Radical Process. The Journal of Organic Chemistry. PMID 34882428 DOI: 10.1021/acs.joc.1c02244  0.307
2021 Challa VR, Kwon D, Taron M, Fan H, Kang B, Wilson D, Haeckl FPJ, Keerthisinghe S, Linington RG, Britton R. Total synthesis of biselide A. Chemical Science. 12: 5534-5543. PMID 34168790 DOI: 10.1039/d0sc06223e  0.63
2021 Meanwell M, Fehr G, Ren W, Adluri B, Rose V, Lehmann J, Silverman SM, Rowshanpour R, Adamson C, Bergeron-Brlek M, Foy H, Challa VR, Campeau L, Dudding T, Britton R. Diversity-oriented synthesis of glycomimetics Communications Chemistry. 4. DOI: 10.1038/s42004-021-00520-3  0.368
2020 Meanwell M, Silverman SM, Lehmann J, Adluri B, Wang Y, Cohen R, Campeau LC, Britton R. A short de novo synthesis of nucleoside analogs. Science (New York, N.Y.). 369: 725-730. PMID 32764073 DOI: 10.1126/Science.Abb3231  0.771
2020 Newton JJ, Jelier BJ, Meanwell M, Martin RE, Britton R, Friesen CM. Quaternary Ammonium Trifluoromethoxide Salts as Stable Sources of Nucleophilic OCF. Organic Letters. PMID 32053386 DOI: 10.1021/Acs.Orglett.0C00099  0.734
2019 Newton J, Driedger D, Nodwell MB, Schaffer P, Martin RE, Britton R, Friesen CM. A Convenient Synthesis of Difluoroalkyl Ethers from Thionoesters using Silver(I) Fluoride. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 31538366 DOI: 10.1002/Chem.201904132  0.306
2019 Ren W, Gries R, Kurita KL, McCaughey CS, Alamsetti SK, Linington RG, Gries G, Britton R. Isolation, Structure Elucidation, and Total Synthesis of Dolichovespulide, a Sesquiterpene from Dolichovespula Yellowjackets. Journal of Natural Products. PMID 31244148 DOI: 10.1021/Acs.Jnatprod.9B00238  0.553
2018 Newton JJ, Britton R, Friesen CM. Base-Catalyzed Transesterification of Thionoesters. The Journal of Organic Chemistry. PMID 30235418 DOI: 10.1021/Acs.Joc.8B02260  0.301
2018 Ren W, Pengelly R, Farren-Dai M, Abadi SSK, Oehler V, Akintola O, Draper J, Meanwell M, Chakladar S, Świderek K, Moliner V, Britton R, Gloster TM, Bennet AJ. Author Correction: Revealing the mechanism for covalent inhibition of glycoside hydrolases by carbasugars at an atomic level. Nature Communications. 9: 3700. PMID 30194298 DOI: 10.1038/S41467-018-06264-4  0.69
2018 Meanwell M, Lehmann J, Eichenberger M, Martin RE, Britton R. Synthesis of acyl fluorides via photocatalytic fluorination of aldehydic C-H bonds. Chemical Communications (Cambridge, England). PMID 30123905 DOI: 10.1039/C8Cc06375C  0.762
2018 Ren W, Pengelly R, Farren-Dai M, Shamsi Kazem Abadi S, Oehler V, Akintola O, Draper J, Meanwell M, Chakladar S, Świderek K, Moliner V, Britton R, Gloster TM, Bennet AJ. Revealing the mechanism for covalent inhibition of glycoside hydrolases by carbasugars at an atomic level. Nature Communications. 9: 3243. PMID 30104598 DOI: 10.1038/S41467-018-05702-7  0.732
2018 Meanwell M, Adluri BS, Yuan Z, Newton J, Prevost P, Nodwell MB, Friesen CM, Schaffer P, Martin RE, Britton R. Direct heterobenzylic fluorination, difluorination and trifluoromethylthiolation with dibenzenesulfonamide derivatives. Chemical Science. 9: 5608-5613. PMID 30061993 DOI: 10.1039/C8Sc01221K  0.756
2018 Ren W, Gries R, McCaughey C, Derstine N, Alamsetti S, Kurita K, Tu L, Linington R, Britton R, Gries GJ. Maculatic acids - sex attractant pheromone components of bald-faced hornets. Angewandte Chemie (International Ed. in English). PMID 29890016 DOI: 10.1002/Anie.201804666  0.506
2016 Chang S, Holmes M, Mowat J, Meanwell M, Britton R. α-Arylation and Ring Expansion of Annulated Cyclobutanones: Stereoselective Synthesis of Functionalized Tetralones. Angewandte Chemie (International Ed. in English). PMID 27976511 DOI: 10.1002/Anie.201608449  0.735
2016 Meanwell M, Nodwell MB, Martin RE, Britton R. A Convenient Late-Stage Fluorination of Pyridylic C-H Bonds with N-Fluorobenzenesulfonimide. Angewandte Chemie (International Ed. in English). PMID 27653634 DOI: 10.1002/Anie.201606323  0.744
2016 Halperin SD, Kwon D, Holmes M, Regalado EL, Campeau L, DiRocco DA, Britton R. ChemInform Abstract: Development of a Direct Photocatalytic C-H Fluorination for the Preparative Synthesis of Odanacatib. Cheminform. 47: no-no. DOI: 10.1002/CHIN.201613062  0.315
2015 Halperin SD, Kwon D, Holmes M, Regalado EL, Campeau LC, DiRocco DA, Britton R. Development of a Direct Photocatalytic C-H Fluorination for the Preparative Synthesis of Odanacatib. Organic Letters. 17: 5200-3. PMID 26484983 DOI: 10.1021/Acs.Orglett.5B02532  0.383
2015 Nodwell MB, Bagai A, Halperin SD, Martin RE, Knust H, Britton R. Direct photocatalytic fluorination of benzylic C-H bonds with N-fluorobenzenesulfonimide. Chemical Communications (Cambridge, England). PMID 26107990 DOI: 10.1039/c5cc04058b  0.314
2015 Bergeron-Brlek M, Meanwell M, Britton R. Direct synthesis of imino-C-nucleoside analogues and other biologically active iminosugars. Nature Communications. 6: 6903. PMID 25903019 DOI: 10.1038/Ncomms7903  0.759
2014 Halperin SD, Fan H, Chang S, Martin RE, Britton R. A convenient photocatalytic fluorination of unactivated C-H bonds. Angewandte Chemie (International Ed. in English). 53: 4690-3. PMID 24668727 DOI: 10.1002/anie.201400420  0.332
2014 Alzieu T, Lehmann J, Naidu AB, Martin RE, Britton R. Converting oxazoles into imidazoles: new opportunities for diversity-oriented synthesis. Chemical Communications (Cambridge, England). 50: 1867-70. PMID 24402236 DOI: 10.1039/C3Cc48467J  0.336
2013 Dhand V, Chang S, Britton R. Total synthesis of the cytotoxic anhydrophytosphingosine pachastrissamine (jaspine B). The Journal of Organic Chemistry. 78: 8208-13. PMID 23919543 DOI: 10.1021/jo4013223  0.307
2013 Bergeron-Brlek M, Teoh T, Britton R. A tandem organocatalytic α-chlorination-aldol reaction that proceeds with dynamic kinetic resolution: a powerful tool for carbohydrate synthesis. Organic Letters. 15: 3554-7. PMID 23819733 DOI: 10.1021/Ol401370B  0.311
2013 Dhand V, Draper JA, Moore J, Britton R. A short, organocatalytic formal synthesis of (-)-swainsonine and related alkaloids. Organic Letters. 15: 1914-7. PMID 23550817 DOI: 10.1021/Ol400566J  0.3
2013 Britton R, Kang B. α-Haloaldehydes: versatile building blocks for natural product synthesis. Natural Product Reports. 30: 227-36. PMID 23258610 DOI: 10.1039/C2Np20108A  0.302
2013 Chang S, Desai S, Leznoff DB, Merbouh N, Britton R. A short, gram-scale synthesis of 2,5-disubstituted furans European Journal of Organic Chemistry. 3219-3222. DOI: 10.1002/Ejoc.201300305  0.327
2011 Cho I, Meimetis L, Belding L, Katz MJ, Dudding T, Britton R. Directed ortho,ortho'-dimetalation of hydrobenzoin: Rapid access to hydrobenzoin derivatives useful for asymmetric synthesis. Beilstein Journal of Organic Chemistry. 7: 1315-22. PMID 22043241 DOI: 10.3762/Bjoc.7.154  0.312
2011 Halperin SD, Kang B, Britton R. Lithium aldol reactions of α-chloroaldehydes provide versatile building blocks for natural product synthesis Synthesis. 1946-1953. DOI: 10.1055/S-0030-1260032  0.36
2010 Kang B, Chang S, Decker S, Britton R. Regioselective and stereoselective cyclizations of chloropolyols in water: rapid synthesis of hydroxytetrahydrofurans. Organic Letters. 12: 1716-9. PMID 20297827 DOI: 10.1021/Ol100260Z  0.303
2010 Paterson I, Britton R, Delgado O, Gardner NM, Meyer A, Naylor GJ, Poullennec KG. Total synthesis of (-)-dictyostatin, a microtubule-stabilising anticancer macrolide of marine sponge origin Tetrahedron. 66: 6534-6545. DOI: 10.1016/J.Tet.2010.01.083  0.324
2004 Jiang X, Zhao B, Britton R, Lim LY, Leong D, Sanghera JS, Zhou BB, Piers E, Andersen RJ, Roberge M. Inhibition of Chk1 by the G2 DNA damage checkpoint inhibitor isogranulatimide. Molecular Cancer Therapeutics. 3: 1221-7. PMID 15486189  0.398
2004 Paterson I, Britton R, Ashton K, Knust H, Stafford J. Synthesis of antimicrofilament marine macrolides: Synthesis and configurational assignment of a C5-C16 degradation fragment of reidispongiolide A Proceedings of the National Academy of Sciences of the United States of America. 101: 11986-11991. PMID 15201432 DOI: 10.1073/Pnas.0401548101  0.32
2003 Britton R, Roberge M, Brown C, van Soest R, Andersen RJ. New okadaic acid analogues from the marine sponge Merriamum oxeato and their effect on mitosis. Journal of Natural Products. 66: 838-43. PMID 12828471 DOI: 10.1021/Np0300129  0.384
1998 Berlmck RGS, Britton R, Piers E, Lim L, Roberge M, Rosana Moreira Da Rocha, Andersen RJ. Granulatimide and isogranulatimide, aromatic alkaloids with G2 checkpoint inhibition activity isolated from the Brazilian ascidian Didemnum granulatum: Structure elucidation and synthesis Journal of Organic Chemistry. 63: 9850-9856. DOI: 10.1021/Jo981607P  0.499
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