Helen L. Hellmich, Ph. D - Publications

Affiliations: 
Anesthesiology University of Texas Medical Branch, Galveston, TX 
Area:
Traumatic Brain Injury

41 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Weisz HA, Boone DR, Coggins WS, Edwards GA, Willey HE, Widen SG, Siegel D, Nelson AT, Prough DS, Hellmich HL. Mechanistic insights gained from cell and molecular analysis of the neuroprotective potential of bioactive natural compounds in an immortalized hippocampal cell line. Plos One. 17: e0267682. PMID 35657963 DOI: 10.1371/journal.pone.0267682  0.772
2021 Sell SL, Prough DS, Weisz HA, Widen SG, Hellmich HL. Leveraging publicly available coronavirus data to identify new therapeutic targets for COVID-19. Plos One. 16: e0257965. PMID 34587192 DOI: 10.1371/journal.pone.0257965  0.725
2020 Sell SL, Widen SG, Prough DS, Hellmich HL. Principal component analysis of blood microRNA datasets facilitates diagnosis of diverse diseases. Plos One. 15: e0234185. PMID 32502186 DOI: 10.1371/Journal.Pone.0234185  0.317
2020 Weisz HA, Kennedy D, Widen S, Spratt H, Sell SL, Bailey C, Sheffield-Moore M, DeWitt DS, Prough DS, Levin H, Robertson C, Hellmich HL. MicroRNA sequencing of rat hippocampus and human biofluids identifies acute, chronic, focal and diffuse traumatic brain injuries. Scientific Reports. 10: 3341. PMID 32094409 DOI: 10.1038/S41598-020-60133-Z  0.761
2019 Sell SL, Boone DR, Weisz HA, Cardenas C, Willey HE, Bolding IJ, Micci MA, Falduto MT, Torres KEO, DeWitt DS, Prough DS, Hellmich HL. MicroRNA profiling identifies a novel compound with antidepressant properties. Plos One. 14: e0221163. PMID 31442236 DOI: 10.1371/Journal.Pone.0221163  0.77
2019 Boone DR, Weisz HA, Willey HE, Torres KEO, Falduto MT, Sinha M, Spratt H, Bolding IJ, Johnson KM, Parsley MA, DeWitt DS, Prough DS, Hellmich HL. Traumatic brain injury induces long-lasting changes in immune and regenerative signaling. Plos One. 14: e0214741. PMID 30943276 DOI: 10.1371/Journal.Pone.0214741  0.783
2018 Boone DK, Weisz HA, Bi M, Falduto MT, Torres KEO, Willey HE, Volsko CM, Kumar AM, Micci MA, Dewitt DS, Prough DS, Hellmich HL. Publisher Correction: Evidence linking microRNA suppression of essential prosurvival genes with hippocampal cell death after traumatic brain injury. Scientific Reports. 8: 14994. PMID 30297835 DOI: 10.1038/S41598-018-31991-5  0.772
2018 Esenaliev RO, Petrov IY, Petrov Y, Guptarak J, Boone DR, Mocciaro E, Weisz H, Parsley MO, Sell SL, Hellmich HL, Ford JM, Pogue C, DeWitt D, Prough DS, Micci MA. Nano Pulsed Laser Therapy Is Neuroprotective In A Rat Model Of Blast-Induced Neurotrauma. Journal of Neurotrauma. PMID 29562823 DOI: 10.1089/Neu.2017.5249  0.771
2018 Boone DR, Weisz HA, Sell SL, Hellmich HL. Laser Capture Microdissection in Traumatic Brain Injury Research: Obtaining Hippocampal Subregions and Pools of Injured Neurons for Genomic Analyses. Methods in Molecular Biology (Clifton, N.J.). 1723: 235-245. PMID 29344864 DOI: 10.1007/978-1-4939-7558-7_13  0.787
2017 Boone DR, Leek JM, Falduto MT, Torres KEO, Sell SL, Parsley MA, Cowart JC, Uchida T, Micci MA, DeWitt DS, Prough DS, Hellmich HL. Effects of AAV-mediated knockdown of nNOS and GPx-1 gene expression in rat hippocampus after traumatic brain injury. Plos One. 12: e0185943. PMID 29016640 DOI: 10.1371/Journal.Pone.0185943  0.555
2017 Weisz HA, Boone DR, Sell SL, Hellmich HL. Stereotactic Atlas-Guided Laser Capture Microdissection of Brain Regions Affected by Traumatic Injury. Journal of Visualized Experiments : Jove. PMID 28930995 DOI: 10.3791/56134  0.789
2017 Boone DK, Weisz HA, Bi M, Falduto MT, Torres KEO, Willey HE, Volsko CM, Kumar AM, Micci MA, Dewitt DS, Prough DS, Hellmich HL. Evidence linking microRNA suppression of essential prosurvival genes with hippocampal cell death after traumatic brain injury. Scientific Reports. 7: 6645. PMID 28751711 DOI: 10.1038/S41598-017-06341-6  0.796
2015 Micci MA, Boone DR, Parsley MA, Wei J, Patrikeev I, Motamedi M, Hellmich HL. Development of a novel imaging system for cell therapy in the brain. Stem Cell Research & Therapy. 6: 131. PMID 26194790 DOI: 10.1186/S13287-015-0129-7  0.423
2015 Shearer J, Boone D, Weisz H, Jennings K, Uchida T, Parsley M, DeWitt D, Prough D, Hellmich H. Stochastic fluctuations in gene expression in aging hippocampal neurons could be exacerbated by traumatic brain injury. Aging Clinical and Experimental Research. PMID 26140916 DOI: 10.1007/S40520-015-0396-2  0.792
2015 Boone DR, Micci MA, Taglialatela IG, Hellmich JL, Weisz HA, Bi M, Prough DS, DeWitt DS, Hellmich HL. Pathway-focused PCR array profiling of enriched populations of laser capture microdissected hippocampal cells after traumatic brain injury. Plos One. 10: e0127287. PMID 26016641 DOI: 10.1371/Journal.Pone.0127287  0.794
2014 Yu GX, Mueller M, Hawkins BE, Mathew BP, Parsley MA, Vergara LA, Hellmich HL, Prough DS, Dewitt DS. Traumatic brain injury in vivo and in vitro contributes to cerebral vascular dysfunction through impaired gap junction communication between vascular smooth muscle cells Journal of Neurotrauma. 31: 739-748. PMID 24341563 DOI: 10.1089/Neu.2013.3187  0.399
2013 Boone DR, Sell SL, Hellmich HL. Laser capture microdissection of enriched populations of neurons or single neurons for gene expression analysis after traumatic brain injury. Journal of Visualized Experiments : Jove. PMID 23603738 DOI: 10.3791/50308  0.576
2013 Hellmich HL, Rojo DR, Micci MA, Sell SL, Boone DR, Crookshanks JM, DeWitt DS, Masel BE, Prough DS. Pathway analysis reveals common pro-survival mechanisms of metyrapone and carbenoxolone after traumatic brain injury. Plos One. 8: e53230. PMID 23326402 DOI: 10.1371/Journal.Pone.0053230  0.51
2013 Hawkins BE, Cowart JC, Parsley MA, Capra BA, Eidson KA, Hellmich HL, Dewitt DS, Prough DS. Effects of trauma, hemorrhage and resuscitation in aged rats. Brain Research. 1496: 28-35. PMID 23274538 DOI: 10.1016/J.Brainres.2012.12.027  0.411
2012 Boone DR, Sell SL, Micci MA, Crookshanks JM, Parsley M, Uchida T, Prough DS, DeWitt DS, Hellmich HL. Traumatic brain injury-induced dysregulation of the circadian clock. Plos One. 7: e46204. PMID 23056261 DOI: 10.1371/Journal.Pone.0046204  0.471
2011 Avila MA, Sell SL, Hawkins BE, Hellmich HL, Boone DR, Crookshanks JM, Prough DS, DeWitt DS. Cerebrovascular connexin expression: effects of traumatic brain injury. Journal of Neurotrauma. 28: 1803-11. PMID 21895483 DOI: 10.1089/Neu.2011.1900  0.413
2011 Rojo DR, Prough DS, Falduto MT, Boone DR, Micci MA, Kahrig KM, Crookshanks JM, Jimenez A, Uchida T, Cowart JC, Hawkins BE, Avila M, DeWitt DS, Hellmich HL. Influence of stochastic gene expression on the cell survival rheostat after traumatic brain injury. Plos One. 6: e23111. PMID 21853077 DOI: 10.1371/Journal.Pone.0023111  0.53
2008 Avila MA, Sell SL, Kadoi Y, Prough DS, Hellmich HL, Velasco M, Dewitt DS. L-Arginine decreases fluid-percussion injury-induced neuronal nitrotyrosine immunoreactivity in rats. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 28: 1733-41. PMID 18612319 DOI: 10.1038/Jcbfm.2008.66  0.439
2008 Hellmich HL, Eidson K, Cowart J, Crookshanks J, Boone DK, Shah S, Uchida T, DeWitt DS, Prough DS. Chelation of neurotoxic zinc levels does not improve neurobehavioral outcome after traumatic brain injury. Neuroscience Letters. 440: 155-9. PMID 18556117 DOI: 10.1016/J.Neulet.2008.05.068  0.486
2007 Saban MR, Hellmich HL, Simpson C, Davis CA, Lang ML, Ihnat MA, O'Donnell MA, Wu XR, Saban R. Repeated BCG treatment of mouse bladder selectively stimulates small GTPases and HLA antigens and inhibits single-spanning uroplakins. Bmc Cancer. 7: 204. PMID 17980030 DOI: 10.1186/1471-2407-7-204  0.334
2007 Hoogerwerf WA, Hellmich HL, Cornélissen G, Halberg F, Shahinian VB, Bostwick J, Savidge TC, Cassone VM. Clock gene expression in the murine gastrointestinal tract: endogenous rhythmicity and effects of a feeding regimen. Gastroenterology. 133: 1250-60. PMID 17919497 DOI: 10.1053/J.Gastro.2007.07.009  0.339
2007 Hellmich HL, Eidson KA, Capra BA, Garcia JM, Boone DR, Hawkins BE, Uchida T, Dewitt DS, Prough DS. Injured Fluoro-Jade-positive hippocampal neurons contain high levels of zinc after traumatic brain injury. Brain Research. 1127: 119-26. PMID 17109824 DOI: 10.1016/J.Brainres.2006.09.094  0.489
2006 Shah SA, Prough DS, Garcia JM, DeWitt DS, Hellmich HL. Molecular correlates of age-specific responses to traumatic brain injury in mice. Experimental Gerontology. 41: 1201-5. PMID 16978820 DOI: 10.1016/J.Exger.2006.07.006  0.52
2006 Prough DS, Kramer GC, Uchida T, Stephenson RT, Hellmich HL, Dewitt DS. Effects of hypertonic arginine on cerebral blood flow and intracranial pressure after traumatic brain injury combined with hemorrhagic hypotension. Shock (Augusta, Ga.). 26: 290-5. PMID 16912655 DOI: 10.1097/01.Shk.0000225405.66693.49  0.345
2005 Hellmich HL, Capra B, Eidson K, Garcia J, Kennedy D, Uchida T, Parsley M, Cowart J, DeWitt DS, Prough DS. Dose-dependent neuronal injury after traumatic brain injury. Brain Research. 1044: 144-54. PMID 15885213 DOI: 10.1016/J.Brainres.2005.02.054  0.531
2005 Hellmich HL, Garcia JM, Shimamura M, Shah SA, Avila MA, Uchida T, Parsley MA, Capra BA, Eidson KA, Kennedy DR, Winston JH, DeWitt DS, Prough DS. Traumatic brain injury and hemorrhagic hypotension suppress neuroprotective gene expression in injured hippocampal neurons. Anesthesiology. 102: 806-14. PMID 15791111 DOI: 10.1097/00000542-200504000-00017  0.564
2005 Shimamura M, Garcia JM, Prough DS, Dewitt DS, Uchida T, Shah SA, Avila MA, Hellmich HL. Analysis of long-term gene expression in neurons of the hippocampal subfields following traumatic brain injury in rats. Neuroscience. 131: 87-97. PMID 15680694 DOI: 10.1016/J.Neuroscience.2004.10.041  0.524
2004 Shimamura M, Garcia JM, Prough DS, Hellmich HL. Laser capture microdissection and analysis of amplified antisense RNA from distinct cell populations of the young and aged rat brain: effect of traumatic brain injury on hippocampal gene expression. Brain Research. Molecular Brain Research. 122: 47-61. PMID 14992815 DOI: 10.1016/J.Molbrainres.2003.11.015  0.508
2004 Hellmich HL, Frederickson CJ, DeWitt DS, Saban R, Parsley MO, Stephenson R, Velasco M, Uchida T, Shimamura M, Prough DS. Protective effects of zinc chelation in traumatic brain injury correlate with upregulation of neuroprotective genes in rat brain. Neuroscience Letters. 355: 221-5. PMID 14732471 DOI: 10.1016/J.Neulet.2003.10.074  0.546
2002 Toma H, Winston JH, Micci MA, Li H, Hellmich HL, Pasricha PJ. Characterization of the neurotrophic response to acute pancreatitis. Pancreas. 25: 31-8. PMID 12131768 DOI: 10.1097/00006676-200207000-00009  0.38
2002 Lee HM, Wang C, Hu Z, Greeley GH, Makalowski W, Hellmich HL, Englander EW. Hypoxia induces mitochondrial DNA damage and stimulates expression of a DNA repair enzyme, the Escherichia coli MutY DNA glycosylase homolog (MYH), in vivo, in the rat brain. Journal of Neurochemistry. 80: 928-37. PMID 11948257 DOI: 10.1046/J.0022-3042.2002.00774.X  0.313
2001 Saban MR, Hellmich H, Nguyen NB, Winston J, Hammond TG, Saban R. Time course of LPS-induced gene expression in a mouse model of genitourinary inflammation. Physiological Genomics. 5: 147-60. PMID 11285368 DOI: 10.1152/Physiolgenomics.2001.5.3.147  0.329
2000 Hoogerwerf WA, Micci M, Shenoy M, Winston JH, Hellmich HL, Pasricha PJ. Protease-activated receptors are expressed by peptidergic nociceptor neurons, are upregulated in pancreatitis and result in neuronal sensitization: Implications for the role of trypsin in the pathogenes is of pain in pancreatitis Gastroenterology. 118. DOI: 10.1016/S0016-5085(00)82744-4  0.322
2000 Toma H, Winston JH, Hellmich HL, Pasricha PJ. Changes in gene expression in sensory neurons in acute pancreatitis Gastroenterology. 118. DOI: 10.1016/S0016-5085(00)80637-X  0.371
2000 Hoogerwerf WA, Hellmich HL, Shenoy M, Winston JH, Micci M, Pasricha PJ. Cholinergic modulation of sensory neuronal function and selective expression of the muscarinic receptor subtypes on nociceptive lumbo-sacral sensory neurons: Implications for the treatment of colonic pain syndromes Gastroenterology. 118. DOI: 10.1016/S0016-5085(00)80529-6  0.314
1996 Hellmich HL, Kos L, Cho ES, Mahon KA, Zimmer A. Embryonic expression of glial cell-line derived neurotrophic factor (GDNF) suggests multiple developmental roles in neural differentiation and epithelial-mesenchymal interactions. Mechanisms of Development. 54: 95-105. PMID 8808409 DOI: 10.1016/0925-4773(95)00464-5  0.348
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