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Ralph E. Kleiner, Ph.D. - Publications

Affiliations: 
2011 Harvard University, Cambridge, MA, United States 
Area:
The Chemistry of Molecular Evolution
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13/45 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Wang D, Zhang Y, Kleiner RE. Cell- and Polymerase-Selective Metabolic Labeling of Cellular RNA with 2'-Azidocytidine. Journal of the American Chemical Society. 142: 14417-14421. PMID 32786764 DOI: 10.1021/Jacs.0C04566  0.31
2019 Seo KW, Kleiner RE. YTHDF2 recognition of N1-methyladenosine (m1A)-modified RNA is associated with transcript destabilization. Acs Chemical Biology. PMID 31815430 DOI: 10.1021/Acschembio.9B00655  0.333
2019 Arguello AE, Leach RW, Kleiner RE. Selection with a Site-Specifically Modified RNA Library Reveals the Binding Preferences of N-Methyladenosine Reader Proteins. Biochemistry. PMID 31287290 DOI: 10.1021/Acs.Biochem.9B00485  0.34
2019 Zhang Y, Kleiner RE. A Metabolic Engineering Approach to Incorporate Modified Pyrimidine Nucleosides into Cellular RNA. Journal of the American Chemical Society. PMID 30735369 DOI: 10.1021/Jacs.8B11449  0.303
2016 Aleem SU, Georghiou G, Kleiner RE, Guja KE, Craddock BP, Lyczek A, Chan AI, Garcia-Diaz M, Miller WT, Liu DR, Seeliger MA. Structural and Biochemical Basis for Intracellular Kinase Inhibition by Src-specific Peptidic Macrocycles. Cell Chemical Biology. PMID 27593110 DOI: 10.1016/J.Chembiol.2016.07.017  0.475
2015 Kleiner RE, Verma P, Molloy KR, Chait BT, Kapoor TM. Chemical proteomics reveals a γH2AX-53BP1 interaction in the DNA damage response. Nature Chemical Biology. 11: 807-14. PMID 26344695 DOI: 10.1038/Nchembio.1908  0.329
2014 Maianti JP, McFedries A, Foda ZH, Kleiner RE, Du XQ, Leissring MA, Tang WJ, Charron MJ, Seeliger MA, Saghatelian A, Liu DR. Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones. Nature. 511: 94-8. PMID 24847884 DOI: 10.1038/Nature13297  0.453
2013 Kleiner RE, Ti SC, Kapoor TM. Site-specific chemistry on the microtubule polymer. Journal of the American Chemical Society. 135: 12520-3. PMID 23930594 DOI: 10.1021/Ja405199H  0.337
2012 Georghiou G, Kleiner RE, Pulkoski-Gross M, Liu DR, Seeliger MA. Highly specific, bisubstrate-competitive Src inhibitors from DNA-templated macrocycles. Nature Chemical Biology. 8: 366-74. PMID 22344177 DOI: 10.1038/Nchembio.792  0.503
2011 Kleiner RE, Dumelin CE, Liu DR. Small-molecule discovery from DNA-encoded chemical libraries. Chemical Society Reviews. 40: 5707-17. PMID 21674077 DOI: 10.1039/C1Cs15076F  0.486
2010 Kleiner RE, Dumelin CE, Tiu GC, Sakurai K, Liu DR. In vitro selection of a DNA-templated small-molecule library reveals a class of macrocyclic kinase inhibitors. Journal of the American Chemical Society. 132: 11779-91. PMID 20681606 DOI: 10.1021/Ja104903X  0.522
2010 Brudno Y, Birnbaum ME, Kleiner RE, Liu DR. An in vitro translation, selection and amplification system for peptide nucleic acids. Nature Chemical Biology. 6: 148-55. PMID 20081830 DOI: 10.1038/Nchembio.280  0.664
2008 Kleiner RE, Brudno Y, Birnbaum ME, Liu DR. DNA-templated polymerization of side-chain-functionalized peptide nucleic acid aldehydes. Journal of the American Chemical Society. 130: 4646-59. PMID 18341334 DOI: 10.1021/Ja0753997  0.661
Low-probability matches (unlikely to be authored by this person)
2018 Arguello AE, Srikumar T, Kleiner RE. A Photocrosslinking-Based RNA Chemical Proteomics Approach to Profile m A-Regulated Protein-RNA Interactions. Current Protocols in Nucleic Acid Chemistry. e69. PMID 30408339 DOI: 10.1002/Cpnc.69  0.296
2017 Arguello AE, DeLiberto AN, Kleiner RE. RNA Chemical Proteomics Reveals the N(6)-Methyladenosine (m(6)A)-Regulated Protein-RNA Interactome. Journal of the American Chemical Society. PMID 29140688 DOI: 10.1021/Jacs.7B09213  0.294
2019 Nechay M, Kleiner RE. High-throughput approaches to profile RNA-protein interactions. Current Opinion in Chemical Biology. 54: 37-44. PMID 31812895 DOI: 10.1016/J.Cbpa.2019.11.002  0.293
2013 Kleiner RE, Kapoor TM. Bumping up kinase activity with an ATP-derived neo-substrate. Cell. 154: 716-8. PMID 23953104 DOI: 10.1016/J.Cell.2013.07.043  0.279
2017 Kleiner RE, Hang LE, Molloy KR, Chait BT, Kapoor TM. A Chemical Proteomics Approach to Reveal Direct Protein-Protein Interactions in Living Cells. Cell Chemical Biology. PMID 29104064 DOI: 10.1016/J.Chembiol.2017.10.001  0.262
2023 Ji J, Yu NJ, Kleiner RE. A minimal sequence motif drives selective tRNA dihydrouridylation by hDUS2. Biorxiv : the Preprint Server For Biology. PMID 37961591 DOI: 10.1101/2023.11.04.565616  0.237
2016 Ti SC, Pamula MC, Howes SC, Duellberg C, Cade NI, Kleiner RE, Forth S, Surrey T, Nogales E, Kapoor TM. Mutations in Human Tubulin Proximal to the Kinesin-Binding Site Alter Dynamic Instability at Microtubule Plus- and Minus-Ends. Developmental Cell. 37: 72-84. PMID 27046833 DOI: 10.1016/J.Devcel.2016.03.003  0.235
2005 Bradley LH, Kleiner RE, Wang AF, Hecht MH, Wood DW. An intein-based genetic selection allows the construction of a high-quality library of binary patterned de novo protein sequences. Protein Engineering, Design & Selection : Peds. 18: 201-7. PMID 15849217 DOI: 10.1093/Protein/Gzi020  0.234
2017 Kleiner RE. Reading the RNA Code. Biochemistry. PMID 28937209 DOI: 10.1021/Acs.Biochem.7B00866  0.227
2022 Arguello AE, Li A, Sun X, Eggert TW, Mairhofer E, Kleiner RE. Reactivity-dependent profiling of RNA 5-methylcytidine dioxygenases. Nature Communications. 13: 4176. PMID 35853884 DOI: 10.1038/s41467-022-31876-2  0.212
2022 Li A, Sun X, Arguello AE, Kleiner RE. Chemical Method to Sequence 5-Formylcytosine on RNA. Acs Chemical Biology. PMID 35212224 DOI: 10.1021/acschembio.1c00707  0.209
2023 Nechay M, Kleiner RE. Oxaliplatin Inhibits RNA Polymerase I via DNA Damage Signaling Targeted to the Nucleolus. Biorxiv : the Preprint Server For Biology. PMID 37066425 DOI: 10.1101/2023.04.02.535301  0.203
2023 Nechay M, Wang D, Kleiner RE. Inhibition of nucleolar transcription by oxaliplatin involves ATM/ATR kinase signaling. Cell Chemical Biology. PMID 37433295 DOI: 10.1016/j.chembiol.2023.06.010  0.194
2023 Dai W, Yu NJ, Kleiner RE. Chemoproteomic Approaches to Studying RNA Modification-Associated Proteins. Accounts of Chemical Research. 56: 2726-2739. PMID 37733063 DOI: 10.1021/acs.accounts.3c00450  0.182
2021 Dai W, Li A, Yu NJ, Nguyen T, Leach RW, Wühr M, Kleiner RE. Activity-based RNA-modifying enzyme probing reveals DUS3L-mediated dihydrouridylation. Nature Chemical Biology. PMID 34556860 DOI: 10.1038/s41589-021-00874-8  0.177
2023 Yu NJ, Dai W, Li A, He M, Kleiner RE. Cell type-specific translational regulation by human DUS enzymes. Biorxiv : the Preprint Server For Biology. PMID 37965204 DOI: 10.1101/2023.11.03.565399  0.175
2023 Villers J, McCann Smith E, DeLiberto AN, Arguello AE, Nyaanga J, Kleiner RE. Chemoproteomic Profiling of 8-Oxoguanosine-Sensitive RNA-Protein Interactions. Biochemistry. 62: 3411-3419. PMID 38010074 DOI: 10.1021/acs.biochem.3c00461  0.175
2006 Kleiner RE, Hutchins AM, Johnston CS, Swan PD. Effects of an 8-week high-protein or high-carbohydrate diet in adults with hyperinsulinemia. Medgenmed : Medscape General Medicine. 8: 39. PMID 17415320  0.174
2023 Kleiner RE. Chemical Approaches To Investigate Post-transcriptional RNA Regulation. Acs Chemical Biology. 18: 1684-1697. PMID 37540831 DOI: 10.1021/acschembio.3c00406  0.174
2023 Ciancone AM, Seo KW, Chen M, Borne AL, Libby AH, Bai DL, Kleiner RE, Hsu KL. Global Discovery of Covalent Modulators of Ribonucleoprotein Granules. Journal of the American Chemical Society. PMID 37159397 DOI: 10.1021/jacs.3c00165  0.161
2023 Riback JA, Eeftens JM, Lee DSW, Quinodoz SA, Donlic A, Orlovsky N, Wiesner L, Beckers L, Becker LA, Strom AR, Rana U, Tolbert M, Purse BW, Kleiner R, Kriwacki R, et al. Viscoelasticity and advective flow of RNA underlies nucleolar form and function. Molecular Cell. 83: 3095-3107.e9. PMID 37683610 DOI: 10.1016/j.molcel.2023.08.006  0.159
2023 Seo KW, Kleiner RE. Profiling dynamic RNA-protein interactions using small-molecule-induced RNA editing. Nature Chemical Biology. PMID 37349582 DOI: 10.1038/s41589-023-01372-9  0.154
2023 Nakano Y, Gamper H, McGuigan H, Maharjan S, Sun Z, Krishnan K, Yigit E, Li NS, Piccirilli JA, Kleiner R, Nichols N, Hou YM. Genome-Wide Profiling of tRNA Using an Unexplored Reverse Transcriptase with High Processivity. Biorxiv : the Preprint Server For Biology. PMID 38106225 DOI: 10.1101/2023.12.09.569604  0.145
2020 Seo KW, Kleiner RE. Mechanisms of epitranscriptomic gene regulation. Biopolymers. e23403. PMID 33001446 DOI: 10.1002/bip.23403  0.142
2021 Kan L, Ott S, Joseph B, Park ES, Dai W, Kleiner RE, Claridge-Chang A, Lai EC. A neural mA/Ythdf pathway is required for learning and memory in Drosophila. Nature Communications. 12: 1458. PMID 33674589 DOI: 10.1038/s41467-021-21537-1  0.141
2023 Seath CP, Burton AJ, Sun X, Lee G, Kleiner RE, MacMillan DWC, Muir TW. Tracking chromatin state changes using nanoscale photo-proximity labelling. Nature. PMID 37020029 DOI: 10.1038/s41586-023-05914-y  0.139
2021 Kleiner RE. Interrogating the transcriptome with metabolically incorporated ribonucleosides. Molecular Omics. 17: 833-841. PMID 34635895 DOI: 10.1039/d1mo00334h  0.138
2024 Berggren KA, Schwartz RE, Kleiner RE, Ploss A. The impact of epitranscriptomic modifications on liver disease. Trends in Endocrinology and Metabolism: Tem. PMID 38212234 DOI: 10.1016/j.tem.2023.12.007  0.122
2024 Kleiner RE, Höbartner C, Jia G. Introduction to 'The Epitranscriptome'. Rsc Chemical Biology. 5: 271-272. PMID 38576727 DOI: 10.1039/d4cb90006e  0.12
2022 Wang D, Shalamberidze A, Arguello AE, Purse BW, Kleiner RE. Live-Cell RNA Imaging with Metabolically Incorporated Fluorescent Nucleosides. Journal of the American Chemical Society. PMID 35930766 DOI: 10.1021/jacs.2c04142  0.117
2021 Kan L, Ott S, Joseph B, Park ES, Dai W, Kleiner RE, Claridge-Chang A, Lai EC. Publisher Correction: A neural mA/Ythdf pathway is required for learning and memory in Drosophila. Nature Communications. 12: 1743. PMID 33723258 DOI: 10.1038/s41467-021-22219-8  0.037
2000 Kleiner RE. The new science of staffing Chemical Innovation. 30: 39-44.  0.033
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