Wilfred D. Stein - Publications

Affiliations: 
1963-1969 University of Manchester, Manchester, England, United Kingdom 
 1969-2001 Biological Chemistry Hebrew University, Jerusalem, Jerusalem, Israel 
Area:
Biological Chemistry
Website:
http://www.huji.ac.il/dataj/controller/ihoker/MOP-STAFF_LINK?sno=9837809&Save_t=

71/248 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2017 Bakouh N, Bellanca S, Nyboer B, Moliner Cubel S, Karim Z, Sanchez CP, Stein WD, Planelles G, Lanzer M. Iron is a substrate of the Plasmodium falciparum chloroquine resistance transporter PfCRT in Xenopus oocytes. The Journal of Biological Chemistry. PMID 28768767 DOI: 10.1074/jbc.M117.805200  0.322
2014 Bellanca S, Summers RL, Meyrath M, Dave A, Nash MN, Dittmer M, Sanchez CP, Stein WD, Martin RE, Lanzer M. Multiple drugs compete for transport via the Plasmodium falciparum chloroquine resistance transporter at distinct but interdependent sites. The Journal of Biological Chemistry. 289: 36336-51. PMID 25378409 DOI: 10.1074/jbc.M114.614206  0.355
2014 Summers RL, Dave A, Dolstra TJ, Bellanca S, Marchetti RV, Nash MN, Richards SN, Goh V, Schenk RL, Stein WD, Kirk K, Sanchez CP, Lanzer M, Martin RE. Diverse mutational pathways converge on saturable chloroquine transport via the malaria parasite's chloroquine resistance transporter. Proceedings of the National Academy of Sciences of the United States of America. 111: E1759-67. PMID 24728833 DOI: 10.1073/pnas.1322965111  0.322
2011 Sanchez CP, Mayer S, Nurhasanah A, Stein WD, Lanzer M. Genetic linkage analyses redefine the roles of PfCRT and PfMDR1 in drug accumulation and susceptibility in Plasmodium falciparum. Molecular Microbiology. 82: 865-78. PMID 21999470 DOI: 10.1111/j.1365-2958.2011.07855.x  0.308
2010 Sanchez CP, Dave A, Stein WD, Lanzer M. Transporters as mediators of drug resistance in Plasmodium falciparum. International Journal For Parasitology. 40: 1109-18. PMID 20399785 DOI: 10.1016/j.ijpara.2010.04.001  0.338
2008 Sanchez CP, Rotmann A, Stein WD, Lanzer M. Polymorphisms within PfMDR1 alter the substrate specificity for anti-malarial drugs in Plasmodium falciparum. Molecular Microbiology. 70: 786-98. PMID 18713316 DOI: 10.1111/j.1365-2958.2008.06413.x  0.334
2008 Steadman K, Stein WD, Litman T, Yang SX, Abu-Asab M, Dutcher SK, Bates S. PolyHEMA spheroids are an inadequate model for the drug resistance of the intractable solid tumors. Cell Cycle (Georgetown, Tex.). 7: 818-29. PMID 18239467 DOI: 10.4161/Cc.7.6.5597  0.32
2008 Sanchez CP, Stein WD, Lanzer M. Dissecting the components of quinine accumulation in Plasmodium falciparum. Molecular Microbiology. 67: 1081-93. PMID 18194156 DOI: 10.1111/j.1365-2958.2008.06108.x  0.33
2007 Sanchez CP, Stein WD, Lanzer M. Is PfCRT a channel or a carrier? Two competing models explaining chloroquine resistance in Plasmodium falciparum. Trends in Parasitology. 23: 332-9. PMID 17493873 DOI: 10.1016/j.pt.2007.04.013  0.322
2007 Sanchez CP, Rohrbach P, McLean JE, Fidock DA, Stein WD, Lanzer M. Differences in trans-stimulated chloroquine efflux kinetics are linked to PfCRT in Plasmodium falciparum. Molecular Microbiology. 64: 407-20. PMID 17493125 DOI: 10.1111/J.1365-2958.2007.05664.X  0.33
2006 Wang Y, Hao D, Stein WD, Yang L. A kinetic study of Rhodamine123 pumping by P-glycoprotein. Biochimica Et Biophysica Acta. 1758: 1671-6. PMID 16854369 DOI: 10.1016/j.bbamem.2006.06.004  0.34
2005 Sanchez CP, McLean JE, Rohrbach P, Fidock DA, Stein WD, Lanzer M. Evidence for a pfcrt-associated chloroquine efflux system in the human malarial parasite Plasmodium falciparum. Biochemistry. 44: 9862-70. PMID 16026158 DOI: 10.1021/Bi050061F  0.34
2005 Stein WD, Litman T, Fojo T, Bates SE. Differential expression of cell adhesion genes: implications for drug resistance. International Journal of Cancer. Journal International Du Cancer. 113: 861-5. PMID 15514970 DOI: 10.1002/Ijc.20671  0.33
2004 Sanchez CP, McLean JE, Stein W, Lanzer M. Evidence for a substrate specific and inhibitable drug efflux system in chloroquine resistant Plasmodium falciparum strains. Biochemistry. 43: 16365-73. PMID 15610031 DOI: 10.1021/Bi048241X  0.338
2004 Bates SE, Bakke S, Kang M, Robey RW, Zhai S, Thambi P, Chen CC, Patil S, Smith T, Steinberg SM, Merino M, Goldspiel B, Meadows B, Stein WD, Choyke P, et al. A phase I/II study of infusional vinblastine with the P-glycoprotein antagonist valspodar (PSC 833) in renal cell carcinoma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 10: 4724-33. PMID 15269145 DOI: 10.1158/1078-0432.Ccr-0829-03  0.313
2004 Stein WD, Bates SE, Fojo T. Intractable cancers: the many faces of multidrug resistance and the many targets it presents for therapeutic attack. Current Drug Targets. 5: 333-46. PMID 15134216 DOI: 10.2174/1389450043345489  0.322
2004 Stein WD, Litman T, Fojo T, Bates SE. A Serial Analysis of Gene Expression (SAGE) database analysis of chemosensitivity: comparing solid tumors with cell lines and comparing solid tumors from different tissue origins. Cancer Research. 64: 2805-16. PMID 15087397 DOI: 10.1158/0008-5472.Can-03-3383  0.308
2003 Litman T, Skovsgaard T, Stein WD. Pumping of drugs by P-glycoprotein: a two-step process? The Journal of Pharmacology and Experimental Therapeutics. 307: 846-53. PMID 14534356 DOI: 10.1124/jpet.103.056960  0.34
2003 Sanchez CP, Stein W, Lanzer M. Trans stimulation provides evidence for a drug efflux carrier as the mechanism of chloroquine resistance in Plasmodium falciparum. Biochemistry. 42: 9383-94. PMID 12899625 DOI: 10.1021/bi034269h  0.334
2003 Stein WD, Robey R, Cardarelli C, Gottesman MM, Bates SE. Low and high concentrations of the topo II inhibitor daunorubicin in NIH3T3 cells: reversible G2/M versus irreversible G1 and S arrest. Cell Cycle (Georgetown, Tex.). 2: 134-42. PMID 12695665 DOI: 10.4161/Cc.2.2.294  0.305
2002 Stein WD. Cell volume homeostasis: ionic and nonionic mechanisms. The sodium pump in the emergence of animal cells. International Review of Cytology. 215: 231-58. PMID 11952230 DOI: 10.1016/S0074-7696(02)15011-X  0.336
2001 Hoshen MB, Stein WD, Ginsburg HD. Pharmacokinetic-pharmacodynamic modelling of the antimalarial activity of mefloquine. Parasitology. 123: 337-46. PMID 11676365 DOI: 10.1017/S003118200100854X  0.301
2001 Litman T, Druley TE, Stein WD, Bates SE. From MDR to MXR: new understanding of multidrug resistance systems, their properties and clinical significance. Cellular and Molecular Life Sciences : Cmls. 58: 931-59. PMID 11497241 DOI: 10.1007/Pl00000912  0.366
2001 Ruth A, Stein WD, Rose E, Roninson IB. Coordinate changes in drug resistance and drug-induced conformational transitions in altered-function mutants of the multidrug transporter P-glycoprotein. Biochemistry. 40: 4332-9. PMID 11284689 DOI: 10.1021/bi001373f  0.319
2001 Druley TE, Stein WD, Ruth A, Roninson IB. P-glycoprotein-mediated colchicine resistance in different cell lines correlates with the effects of colchicine on P-glycoprotein conformation. Biochemistry. 40: 4323-31. PMID 11284688 DOI: 10.1021/bi001372n  0.342
2001 Druley TE, Stein WD, Roninson IB. Analysis of MDR1 P-glycoprotein conformational changes in permeabilized cells using differential immunoreactivity. Biochemistry. 40: 4312-22. PMID 11284687 DOI: 10.1021/bi001371v  0.324
1998 Stein WD. Kinetics of the P-glycoprotein, the multidrug transporter. Experimental Physiology. 83: 221-32. PMID 9568482 DOI: 10.1113/Expphysiol.1998.Sp004106  0.314
1997 Mechetner EB, Schott B, Morse BS, Stein WD, Druley T, Davis KA, Tsuruo T, Roninson IB. P-glycoprotein function involves conformational transitions detectable by differential immunoreactivity. Proceedings of the National Academy of Sciences of the United States of America. 94: 12908-13. PMID 9371774 DOI: 10.1073/pnas.94.24.12908  0.339
1997 Litman T, Zeuthen T, Skovsgaard T, Stein WD. Competitive, non-competitive and cooperative interactions between substrates of P-glycoprotein as measured by its ATPase activity. Biochimica Et Biophysica Acta. 1361: 169-76. PMID 9300798 DOI: 10.1016/S0925-4439(97)00027-6  0.31
1997 Litman T, Zeuthen T, Skovsgaard T, Stein WD. Structure-activity relationships of P-glycoprotein interacting drugs: kinetic characterization of their effects on ATPase activity. Biochimica Et Biophysica Acta. 1361: 159-68. PMID 9300797 DOI: 10.1016/S0925-4439(97)00026-4  0.321
1997 Litman T, Nielsen D, Skovsgaard T, Zeuthen T, Stein WD. ATPase activity of P-glycoprotein related to emergence of drug resistance in Ehrlich ascites tumor cell lines. Biochimica Et Biophysica Acta. 1361: 147-58. PMID 9300796 DOI: 10.1016/S0925-4439(97)00025-2  0.334
1997 Ambudkar SV, Cardarelli CO, Pashinsky I, Stein WD. Relation between the turnover number for vinblastine transport and for vinblastine-stimulated ATP hydrolysis by human P-glycoprotein. The Journal of Biological Chemistry. 272: 21160-6. PMID 9261121 DOI: 10.1074/jbc.272.34.21160  0.347
1996 Lan LB, Ayesh S, Lyubimov E, Pashinsky I, Stein WD. Kinetic parameters for reversal of the multidrug pump as measured for drug accumulation and cell killing. Cancer Chemotherapy and Pharmacology. 38: 181-90. PMID 8616910 DOI: 10.1007/s002800050468  0.339
1996 Stein WD, Hoshen MB. The role of ligand-binding proteins in increasing the transcellular flux of metabolites, in particular that of calcium, bilirubin, and fatty acids Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology. 115: 307-312. DOI: 10.1016/S0305-0491(96)00177-0  0.314
1995 Lyubimov E, Lan LB, Pashinsky I, Ayesh S, Stein WD. Saturation reversal of the multidrug pump using many reversers in low-dose combinations. Anti-Cancer Drugs. 6: 727-35. PMID 8845484 DOI: 10.1097/00001813-199512000-00003  0.35
1995 Stein WD. The sodium pump in the evolution of animal cells. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 349: 263-9. PMID 8577837 DOI: 10.1098/rstb.1995.0112  0.333
1994 Gottesman MM, Currier S, Bruggemann E, Lelong I, Stein W, Pastan I. Chapter 1 The Multidrug Transporter: Mechanistic Considerations Current Topics in Membranes. 41: 3-17. DOI: 10.1016/S0070-2161(08)60451-7  0.394
1991 Ginsburg H, Stein WD. Kinetic modelling of chloroquine uptake by malaria-infected erythrocytes. Assessment of the factors that may determine drug resistance. Biochemical Pharmacology. 41: 1463-70. PMID 1826839 DOI: 10.1016/0006-2952(91)90562-J  0.318
1987 Ginsburg H, Stein WD. New permeability pathways induced by the malarial parasite in the membrane of its host erythrocyte: potential routes for targeting of drugs into infected cells. Bioscience Reports. 7: 455-63. PMID 3322419 DOI: 10.1007/BF01116501  0.339
1987 Ginsburg H, Stein WD. Biophysical analysis of novel transport pathways induced in red blood cell membranes. The Journal of Membrane Biology. 96: 1-10. PMID 3295251 DOI: 10.1007/BF01869329  0.334
1983 Weiser MB, Razin M, Stein WD. Kinetic tests of models for sugar transport in human erythrocytes and a comparison of fresh and cold-stored cells Bba - Biomembranes. 727: 379-388. PMID 6838879 DOI: 10.1016/0005-2736(83)90423-6  0.363
1983 Stein WD, Klein A. Multiple controls on the intracellular trapping of uridine Bba - Molecular Cell Research. 762: 94-101. PMID 6830868 DOI: 10.1016/0167-4889(83)90121-0  0.341
1982 Karlish SJD, Lieb WR, Stein WD. Combined effects of ATP and phosphate on rubidium exchange mediated by Na-K-ATPase reconstituted into phospholipid vesicles Journal of Physiology. 333-350. PMID 6290648 DOI: 10.1113/jphysiol.1982.sp014267  0.309
1982 Karlish SJD, Stein WD. Passive rubidium fluxes mediated by Na-K-ATPase reconstituted into phospholipid vesicles when ATP- and phosphate-free Journal of Physiology. 295-316. PMID 6290646 DOI: 10.1113/jphysiol.1982.sp014265  0.309
1979 Foster DM, Jacquez JA, Lieb WR, Stein WD. A high affinity site for sugar transport at the inner face of the human erythrocyte membrane? Biochimica Et Biophysica Acta. 555: 349-51. PMID 476109 DOI: 10.1016/0005-2736(79)90173-1  0.334
1979 Heichal O, Ish-Shalom D, Koren R, Stein WD. The kinetic dissection of transport from metabolic trapping during substrate uptake by intact cells. Uridine uptake by quiescent and serum-activated nil 8 hamster cells and their murine sarcoma virus-transformed counterparts Bba - Biomembranes. 551: 169-186. PMID 218628 DOI: 10.1016/0005-2736(79)90363-8  0.328
1978 Goldenberg GJ, Stein WD. Increase in the affinity of the uridine phosphorylation system for ATP after serum or insulin activation of 3T3 fibroblasts Journal of Supramolecular and Cellular Biochemistry. 9: 489-496. PMID 750762 DOI: 10.1002/Jss.400090404  0.301
1978 Honig B, Stein WD. Design principles for active transport systems Journal of Theoretical Biology. 75: 299-305. PMID 745445 DOI: 10.1016/0022-5193(78)90336-3  0.338
1978 Goldenberg GJ, Stein WD. Stimulation of uridine uptake in 3T3 cells is associated with increased ATP affinity of uridine-phosphorylating system Nature. 274: 475-477. PMID 672973 DOI: 10.1038/274475A0  0.321
1977 Rozengurt E, Stein WD, Wigglesworth NM. Uptake of nucleosides in density-inhibited cultures of 3T3 cells [25] Nature. 267: 442-444. PMID 876360 DOI: 10.1038/267442A0  0.329
1977 Stein WD, Honig B. Models for the active transport of cations ⋯ The steady-state analysis Molecular and Cellular Biochemistry. 15: 27-44. PMID 865483 DOI: 10.1007/Bf01731287  0.344
1977 Lieb WR, Stein WD. Is there a high affinity site for sugar transport at the inner face of the human red cell membrane? Journal of Theoretical Biology. 69: 311-319. PMID 592880 DOI: 10.1016/0022-5193(77)90140-0  0.332
1976 Stein WD, Rosengurt E. Temperature dependence of uridine transport in quiescent and serum-stimulated 3T3 cells Bba - Biomembranes. 419: 112-118. PMID 1244857 DOI: 10.1016/0005-2736(76)90376-X  0.321
1976 Lieb WR, Stein WD. Testing the simple carrier using irreversible inhibitors Bba - Biomembranes. 455: 913-927. PMID 999944 DOI: 10.1016/0005-2736(76)90060-2  0.35
1974 Lieb WR, Stein WD. Simultaneity, occlusion and the sodium pump Nature. 252: 730-732. PMID 4437628 DOI: 10.1038/252730A0  0.345
1974 Stein WD, Eilam Y, Lieb WR. Active transport of cations across biological membranes Annals of the New York Academy of Sciences. 227: 328-336. PMID 4275122 DOI: 10.1111/J.1749-6632.1974.Tb14397.X  0.326
1973 Stein WD, Lieb WR, Karlish SJ, Eilam Y. A modle for active transport of sodium and potassium ions as mediated by a tetrameric enzyme Proceedings of the National Academy of Sciences of the United States of America. 70: 275-278. PMID 4265117 DOI: 10.1073/pnas.70.1.275  0.352
1972 Karlish SJD, Lieb WR, Ram D, Stein WD. Kinetic parameters of glucose efflux from human red blood cells under zero-trans conditions Bba - Biomembranes. 255: 126-132. PMID 5010989 DOI: 10.1016/0005-2736(72)90014-4  0.317
1972 Hankin BL, Lieb WR, Stein WD. Rejection criteria for the asymmetric carrier and their application to glucose transport in the human red blood cell. Biochimica Et Biophysica Acta. 288: 114-26. PMID 4640379 DOI: 10.1016/0005-2736(72)90229-5  0.357
1972 Lieb WR, Stein WD. Carrier and non-carrier models for sugar transport in the human red blood cell Bba - Reviews On Biomembranes. 265: 187-207. PMID 4555470 DOI: 10.1016/0304-4157(72)90002-0  0.311
1971 Lieb WR, Stein WD. New theory for glucose transport across membranes. Nature. 230: 108-109. PMID 5279338 DOI: 10.1038/Newbio230108A0  0.332
1971 Nir S, Stein WD. Two Modes of Diffusion in Liquids Journal of Chemical Physics. 55: 1598-1603. DOI: 10.1063/1.1676285  0.426
1971 Stein WD, Nir S. On the mass dependence of diffusion within biological membranes and polymers The Journal of Membrane Biology. 5: 246-249. DOI: 10.1007/Bf01870552  0.507
1969 Stein WD. Intra-protein interactions across a fluid membrane as a model for biological transport. The Journal of General Physiology. 54: 81-90. PMID 19873658 DOI: 10.1085/Jgp.54.1.81  0.321
1968 Stein WD. Turnover Numbers of Membrane Carriers and the Action of the Polypeptide Antibiotics Nature. 218: 570-571. PMID 5650965 DOI: 10.1038/218570A0  0.303
1967 Kolber AR, Stein WD. Isolation of a Protein Coded for by the Permease Gene of the Lac Operon of Escherichia coli Protoplasma. 63: 309-314. DOI: 10.1007/978-3-7091-5577-6_62  0.351
1960 Barnard EA, Stein WD. Some relations between enzyme activity, chemical reactivity and urea-induced disorientations in ribonuclease Bba - Biochimica Et Biophysica Acta. 37: 371-372. PMID 13796852  0.377
1959 Stein W, Barnard E. The histidine residue in the active centre of ribonuclease Journal of Molecular Biology. 1: 350-IN9. DOI: 10.1016/S0022-2836(59)80017-6  0.452
1959 Barnard E, Stein W. The histidine residue in the active centre of ribonuclease Journal of Molecular Biology. 1: 339-349. DOI: 10.1016/S0022-2836(59)80016-4  0.451
1958 BARNARD EA, STEIN WD. The roles of imidazole in biological systems Advances in Enzymology and Related Subjects of Biochemistry. 20: 51-110. PMID 13605980  0.347
1956 Stein WD, Danielli JF. Structure and function in red cell permeability Discussions of the Faraday Society. 21: 238-251. DOI: 10.1039/DF9562100238  0.5
Low-probability matches (unlikely to be authored by this person)
1973 Eilam Y, Stein WD. The efflux of sodium from human red blood cells Bba - Biomembranes. 323: 606-618. PMID 4761094 DOI: 10.1016/0005-2736(73)90169-7  0.3
1996 Lyubimov E, Lan LB, Pashinsky I, Stein WD. Effect of modulators of the multidrug resistance pump on the distribution of vinblastine in tissues of the mouse. Anti-Cancer Drugs. 7: 60-9. PMID 8742100 DOI: 10.1097/00001813-199601000-00007  0.3
1982 Karlish SJD, Stein WD. Effects of ATP or phosphate on passive rubidium fluxes mediated by Na-K-ATPase reconstituted into phospholipid vesicles Journal of Physiology. 317-331. PMID 6290647 DOI: 10.1113/jphysiol.1982.sp014266  0.299
1972 Eilam Y, Stein WD. A simple resolution of the kinetic anomaly in the exchange of different sugars across the membrane of the human red blood cell Bba - Biomembranes. 266: 161-173. PMID 5041086 DOI: 10.1016/0005-2736(72)90132-0  0.299
2005 Ginsburg H, Stein WD. How many functional transport pathways does Plasmodium falciparum induce in the membrane of its host erythrocyte? Trends in Parasitology. 21: 118-21. PMID 15734658 DOI: 10.1016/j.pt.2005.01.004  0.298
1986 Lieb WR, Stein WD. Non-Stokesian nature of transverse diffusion within human red cell membranes. The Journal of Membrane Biology. 92: 111-9. PMID 3761357 DOI: 10.1007/BF01870701  0.297
1985 Karlish SJ, Stein WD. Cation activation of the pig kidney sodium pump: transmembrane allosteric effects of sodium The Journal of Physiology. 359: 119-149. PMID 2582111 DOI: 10.1113/jphysiol.1985.sp015578  0.296
1999 Robey R, Bakke S, Stein W, Meadows B, Litman T, Patil S, Smith T, Fojo T, Bates S. Efflux of Rhodamine From CD56+ Cells as a Surrogate Marker for Reversal of P-Glycoprotein–Mediated Drug Efflux by PSC 833 Blood. 93: 306-314. DOI: 10.1182/Blood.V93.1.306.401K42_306_314  0.296
1974 Lieb WR, Stein WD. Testing and characterizing the simple carrier Bba - Biomembranes. 373: 178-196. PMID 4429733 DOI: 10.1016/0005-2736(74)90144-8  0.295
2014 Luchenko VL, Litman T, Chakraborty AR, Heffner A, Devor C, Wilkerson J, Stein W, Robey RW, Bangiolo L, Levens D, Bates SE. Histone deacetylase inhibitor-mediated cell death is distinct from its global effect on chromatin. Molecular Oncology. 8: 1379-92. PMID 24954856 DOI: 10.1016/j.molonc.2014.05.001  0.295
2005 Huberman M, Zehavi U, Stein WD, Etxeberria E, Goren R. In vitro sugar uptake by grapefruit (Citrus paradisi) juice-sac cells. Functional Plant Biology : Fpb. 32: 357-366. PMID 32689137 DOI: 10.1071/FP04125  0.294
1998 Hoshen MB, Stein WD, Ginsburg H. Modelling the chloroquine chemotherapy of falciparum malaria: the value of spacing a split dose. Parasitology. 116: 407-16. PMID 9614323 DOI: 10.1017/S0031182098002480  0.294
1967 Levine M, Stein WD. The kinetic parameters of the monosaccharide transfer system of the human erythrocyte. Biochimica Et Biophysica Acta. 127: 179-93. PMID 5970872 DOI: 10.1016/0304-4165(66)90488-0  0.291
1967 Levine M, Stein WD. Techniques for analysis of glucose binding by human erythrocyte membranes. Biochimica Et Biophysica Acta. 135: 710-6. PMID 4292718 DOI: 10.1016/0005-2736(67)90101-0  0.291
2002 Hoshen MB, Stein WD, Ginsburg H. Mathematical modelling of malaria chemotherapy: combining artesunate and mefloquine. Parasitology. 124: 9-15. PMID 11811806 DOI: 10.1017/S0031182001008952  0.289
1975 Ginsburg H, Stein WD. Zero-trans and infinte-cis uptake of galactose in human Erythrocytes Bba - Biomembranes. 382: 353-368. PMID 1125238 DOI: 10.1016/0005-2736(75)90277-1  0.289
2009 Stein WD, Sanchez CP, Lanzer M. Virulence and drug resistance in malaria parasites. Trends in Parasitology. 25: 441-3. PMID 19734096 DOI: 10.1016/j.pt.2009.07.003  0.285
2013 Wilkerson J, Bates SE, Stein WD, Fojo T. Using a program that computes tumor decay (d) and regrowth (g) rates and the fraction (Φ) of tumor killed to assist in clinical trials and improve patient survival. Journal of Clinical Oncology. 31: e22213-e22213. DOI: 10.1200/Jco.2013.31.15_Suppl.E22213  0.284
1982 Karlish SJD, Stein WD. Protein conformational changes in [Na,K]-ATPase and the role of cation occlusion in active transport Annals of the New York Academy of Sciences. 226-238. PMID 6301332 DOI: 10.1111/j.1749-6632.1982.tb25744.x  0.283
1966 Bobinski H, Stein WD. Isolation of a glucose-binding component from human erythrocyte membranes. Nature. 211: 1366-1368. PMID 5969828 DOI: 10.1038/2111366A0  0.283
1972 Hankin BL, Stein WD. On the temperature dependence of initial velocities of glucose transport in the human red blood cell. Biochimica Et Biophysica Acta. 288: 127-36. PMID 4640380 DOI: 10.1016/0005-2736(72)90230-1  0.282
2011 Blagoev KB, Wilkerson J, Stein WD, Motzer RJ, Bates SE, Fojo AT. Effect of sunitinib (SU) administration on post-treatment survival in patients with metastatic renal cell carcinoma (mRCC) treated on the upfront randomized phase III trial of sunitinib or interferon alfa (IFN). Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 29: 4634. PMID 28023954 DOI: 10.1200/jco.2011.29.15_suppl.4634  0.282
1990 Stein WD. Energetics and the design principles of the Na/K-ATPase. Journal of Theoretical Biology. 147: 145-59. PMID 2177514 DOI: 10.1016/S0022-5193(05)80049-9  0.281
2011 Manasanch EE, Wilkerson J, Xiu L, Zhuang S, Bates S, Stein W, Fojo AT. Assessment of Tumor Growth (g) and Regression (d) Rate Constants in Patients with Multiple Myeloma (MM) Shows That the Superiority of Bortezomib with Liposomal Doxorubicin (PLD+B) Over Bortezomib Alone (B) Is a Result of Reduced Growth of Refractory Tumor Cells and Not of Higher Regression Rates, and Provides An Earlier Efficacy Endpoint That Allows for Comparison Across Trials Blood. 118: 5113-5113. DOI: 10.1182/Blood.V118.21.5113.5113  0.28
1971 Lieb WR, Stein WD. Implications of two different types of diffusion for biological membranes Nature: New Biology. 234: 220-222. PMID 5288811 DOI: 10.1038/Newbio234220A0  0.28
2013 Stein WD, Wilkerson J, Manasanch E, Zhuang SH, Bates SE, Fojo T. Abstract 5152: Estimating the fraction of a tumor that is killed by a drug. Cancer Research. 73: 5152-5152. DOI: 10.1158/1538-7445.Am2013-5152  0.279
1988 Bronner F, Stein WD. CaBPr facilitates intracellular diffusion for Ca pumping in distal convoluted tubule. The American Journal of Physiology. 255: F558-62. PMID 2970802 DOI: 10.1152/Ajprenal.1988.255.3.F558  0.279
1966 Kolber AR, Stein WD. Identification of a component of a transport 'carrier' system: isolation of the permease expression of the LAC operon of Escherichia coli. Nature. 209: 691-694. PMID 5332012 DOI: 10.1038/209691A0  0.279
1996 Ayesh S, Shao YM, Stein WD. Co-operative, competitive and non-competitive interactions between modulators of P-glycoprotein. Biochimica Et Biophysica Acta. 1316: 8-18. PMID 8634345 DOI: 10.1016/0925-4439(96)00008-7  0.278
1996 Ayesh S, Lyubimov E, Algour N, Stein WD. Reversal of P-glycoprotein is greatly reduced by the presence of plasma but can be monitored by an ex vivo clinical assay. Anti-Cancer Drugs. 7: 678-86. PMID 8913437 DOI: 10.1097/00001813-199608000-00009  0.278
2014 Burotto M, Wilkerson J, Stein W, Motzer R, Bates S, Fojo T. Continuing a cancer treatment despite tumor growth may be valuable: sunitinib in renal cell carcinoma as example. Plos One. 9: e96316. PMID 24796484 DOI: 10.1371/Journal.Pone.0096316  0.275
2010 Fojo AT, Stein WD, Wilkerson J, Bates SE. Kinetic analysis of breast tumor decay and growth following ixabepilone plus capecitabine (IXA + CAP) versus capecitabine alone (CAP) to discern whether the superiority of the combination is a result of slower growth, enhanced tumor cell kill, or both. Journal of Clinical Oncology. 28: 1096-1096. DOI: 10.1200/Jco.2010.28.15_Suppl.1096  0.275
2010 Wilkerson J, Stein WD, Kim ST, Huang X, Motzer RJ, Fojo AT, Bates SE. Validation of a kinetic analysis of renal cancer regression and growth following treatment with sunitinib and interferon-alfa (IFN-{alpha}): Analysis of the pivotal randomized trial. Journal of Clinical Oncology. 28: 4597-4597. DOI: 10.1200/Jco.2010.28.15_Suppl.4597  0.274
2004 Ginsburg H, Stein WD. The new permeability pathways induced by the malaria parasite in the membrane of the infected erythrocyte: comparison of results using different experimental techniques. The Journal of Membrane Biology. 197: 113-34. PMID 15014913 DOI: 10.1007/s00232-003-0646-7  0.274
2012 Stein WD, Wilkerson J, Adesunloye B, Madan R, Bates SE, Wells S, Dahut W, Ning Y, Zhuang SH, Motzer RJ, Fojo T. Abstract 765: Growth rates of tumors with numerous histologies remain constant while patients are on therapy Cancer Research. 72: 765-765. DOI: 10.1158/1538-7445.Am2012-765  0.273
2000 Hoshen MB, Na-Bangchang K, Stein WD, Ginsburg H. Mathematical modelling of the chemotherapy of Plasmodium falciparum malaria with artesunate: postulation of 'dormancy', a partial cytostatic effect of the drug, and its implication for treatment regimens. Parasitology. 121: 237-46. PMID 11085244 DOI: 10.1017/S0031182099006332  0.271
2007 Stein WD, Litman T, Fojo T, Bates SE. A database study that identifies genes whose expression correlates, negatively or positively, with 5-year survival of cancer patients. Biochimica Et Biophysica Acta. 1770: 857-71. PMID 17398010 DOI: 10.1016/J.Bbagen.2006.12.013  0.271
1997 Shao YM, Ayesh S, Stein WD. Mutually co-operative interactions between modulators of P-glycoprotein. Biochimica Et Biophysica Acta. 1360: 30-8. PMID 9061037 DOI: 10.1016/S0925-4439(96)00065-8  0.27
2014 Sanchez CP, Liu CH, Mayer S, Nurhasanah A, Cyrklaff M, Mu J, Ferdig MT, Stein WD, Lanzer M. A HECT ubiquitin-protein ligase as a novel candidate gene for altered quinine and quinidine responses in Plasmodium falciparum. Plos Genetics. 10: e1004382. PMID 24830312 DOI: 10.1371/Journal.Pgen.1004382  0.268
2012 Wilkerson J, Amiri-Kordestani L, Madan RA, Adesunloye B, Zhuang SH, Wells SA, Fojo AT, Bates SE, Stein WD. A method for assessing tumor response to therapy and more precisely guiding treatment decisions so as to improve survival. Journal of Clinical Oncology. 30. DOI: 10.1200/Jco.2012.30.15_Suppl.E13122  0.267
1972 Caygill CPJ, Stein WD. The kinetics of glucose uptake by isolated fat cells and the influence of insulin Acta Diabetologica Latina. 9: 900-923. PMID 4663573 DOI: 10.1007/BF01564591  0.265
1972 Stein WD. THE MECHANISM OF SUGAR TRANSFER ACROSS ERYTHROCYTE MEMBRANES. Annals of the New York Academy of Sciences. 195: 412-428. PMID 29090779 DOI: 10.1111/j.1749-6632.1972.tb54823.x  0.264
2012 Stein WD, Wilkerson J, Kim ST, Huang X, Motzer RJ, Fojo AT, Bates SE. Analyzing the pivotal trial that compared sunitinib and IFN-α in renal cell carcinoma, using a method that assesses tumor regression and growth. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 18: 2374-81. PMID 22344231 DOI: 10.1158/1078-0432.CCR-11-2275  0.264
1980 Stein WD. The epigenetic address: A model for embryological development Journal of Theoretical Biology. 82: 663-677. PMID 6155566 DOI: 10.1016/0022-5193(80)90185-X  0.264
2006 Stein WD, Litman T. Data on the recurrence of breast tumors fit a model in which dormant cells are subject to slow attrition but can randomly awaken to become malignant. Cell Cycle (Georgetown, Tex.). 5: 2348-53. PMID 17102622 DOI: 10.4161/Cc.5.20.3349  0.263
2013 Burotto Pichun ME, Wilkerson J, Stein WD, Motzer RJ, Bates SE, Fojo T. Continuation of sunitinib following RECIST progression on first-line sunitinib. Journal of Clinical Oncology. 31: 4585-4585. DOI: 10.1200/Jco.2013.31.15_Suppl.4585  0.263
1983 Ponten J, Stein WD, Shall S. A quantitative analysis of the aging of human glial cells in culture Journal of Cellular Physiology. 117: 342-352. PMID 6361044 DOI: 10.1002/Jcp.1041170309  0.263
1976 Stein WD. An algorithm for writing down flux equations for carrier kinetics, and its application to co-transport Journal of Theoretical Biology. 62: 467-478. PMID 994530 DOI: 10.1016/0022-5193(76)90131-4  0.263
2011 Beez D, Sanchez CP, Stein WD, Lanzer M. Genetic predisposition favors the acquisition of stable artemisinin resistance in malaria parasites. Antimicrobial Agents and Chemotherapy. 55: 50-5. PMID 21041511 DOI: 10.1128/AAC.00916-10  0.262
1978 Lam HY, Begleiter A, Stein W, Goldenberg GJ. On the mechanism of uptake of procarbazine by L5178Y lymphoblasts in vitro. Biochemical Pharmacology. 27: 1883-5. PMID 708471 DOI: 10.1016/0006-2952(78)90038-2  0.261
1972 Stein WD. DISCUSSION PAPER: MODELS OF MEMBRANE STRUCTURE. Annals of the New York Academy of Sciences. 195: 37-38. PMID 29090784 DOI: 10.1111/j.1749-6632.1972.tb54783.x  0.261
2006 Chen Y, Dokmanovic M, Stein WD, Ardecky RJ, Roninson IB. Agonist and antagonist of retinoic acid receptors cause similar changes in gene expression and induce senescence-like growth arrest in MCF-7 breast carcinoma cells. Cancer Research. 66: 8749-61. PMID 16951191 DOI: 10.1158/0008-5472.CAN-06-0581  0.258
1991 Stein WD. Rate-limiting steps in carcinogenesis and their bearing on the incidence/age data for cutaneous melanoma and hepatocellular carcinoma. Journal of Theoretical Biology. 153: 519-29. PMID 1666904 DOI: 10.1016/S0022-5193(05)80154-7  0.258
2019 Burotto M, Wilkerson J, Stein WD, Bates SE, Fojo T. Adjuvant and neoadjuvant cancer therapies: A historical review and a rational approach to understand outcomes. Seminars in Oncology. PMID 30738604 DOI: 10.1053/J.Seminoncol.2019.01.002  0.256
1995 Stein WD, Stein AD. Familial and sporadic human renal cell carcinoma: evidence against a double-loss mechanism of carcinogenesis. Journal of Clinical Epidemiology. 48: 767-77. PMID 7769407 DOI: 10.1016/0895-4356(94)00192-S  0.255
1969 Lieb WR, Stein WD. Biological Membranes behave as Non-porous Polymeric Sheets with Respect to the Diffusion of Non-electrolytes Nature. 224: 240-243. PMID 5344600 DOI: 10.1038/224240A0  0.255
2011 Stein WD, Gulley JL, Schlom J, Madan RA, Dahut W, Figg WD, Ning YM, Arlen PM, Price D, Bates SE, Fojo T. Tumor regression and growth rates determined in five intramural NCI prostate cancer trials: the growth rate constant as an indicator of therapeutic efficacy. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 17: 907-17. PMID 21106727 DOI: 10.1200/Jco.2012.30.5_Suppl.133  0.255
1974 Lieb WR, Stein WD. Testing and characterizing the simple pore Bba - Biomembranes. 373: 165-177. PMID 4429732 DOI: 10.1016/0005-2736(74)90143-6  0.253
2008 Huang H, Menefee ME, Edgerly M, Kotz H, Poruchynsky M, Stein WD, Bates SE, Fojo AT. Ixabepilone (BMS-247550) and metastatic renal cell carcinoma (mRCC). Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 26: 5053. PMID 27948880 DOI: 10.1200/jco.2008.26.15_suppl.5053  0.253
2018 Wilkerson J, Blagoev KB, Stein WD, Hecht E, Chabot JA, Dominguez EE, Blanco-Codesido M, Murphy MJ, Fojo AT, Bates SE. The rate of tumor growth during treatment accurately predicts the FDA gold standard of overall survival [OS] in a broad range of malignancies. Journal of Clinical Oncology. 36: 2545-2545. DOI: 10.1200/Jco.2018.36.15_Suppl.2545  0.252
2011 Amiri-Kordestani L, Jawed I, Wilkerson J, Stein WD, Fojo AT, Swain SM, Bates SE. Early assessment of efficacy of ixabepilone (IXA) by analysis of the rate of tumor growth and decay using data from phase II and phase III clinical trials in metastatic breast cancer (MBC) patients (Pts). Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 29: 2527. PMID 28022342 DOI: 10.1200/jco.2011.29.15_suppl.2527  0.25
1992 Stein WD. Facilitated diffusion of calcium across the rat intestinal epithelial cell. The Journal of Nutrition. 122: 651-6. PMID 1542027 DOI: 10.1093/Jn/122.Suppl_3.651  0.25
2011 Amiri-Kordestani L, Jawed I, Wilkerson J, Stein WD, Bates SE, Swain SM, Fojo AT. Determining the rate of tumor growth and decay in patients with metastatic breast cancer as an early efficacy endpoint: A study assessing ixabepilone efficacy. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 29: 246. PMID 27958168 DOI: 10.1200/jco.2011.29.27_suppl.246  0.25
2013 Madan RA, Stein WD, Wilkerson J, Dahut WL, Heery CR, Schlom J, Wilding G, DiPaola RS. Effect of PSA-tricom, a pox-viral vaccine in prostate cancer (PCa), on tumor growth rates within 80 days after initiation in nonmetastatic PCa. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 31: 57. PMID 28137072 DOI: 10.1200/Jco.2013.31.6_Suppl.57  0.25
1994 Zeuthen T, Stein WD. Cotransport of salt and water in membrane proteins: membrane proteins as osmotic engines. The Journal of Membrane Biology. 137: 179-95. PMID 8182729 DOI: 10.1007/BF00232587  0.249
1985 Stein WD. Mathematics and membranes Nature. 314: 564-565. DOI: 10.1038/314564A0  0.248
1994 Stein WD, Cardarelli C, Pastan I, Gottesman MM. Kinetic evidence suggesting that the multidrug transporter differentially handles influx and efflux of its substrates. Molecular Pharmacology. 45: 763-72. PMID 7910372  0.247
2008 Fojo AT, Stein WD, Yang J, Bates SE. Effect of bevacizumab (Bev) on the growth rate constants of renal carcinoma (RCC) tumors Journal of Clinical Oncology. 26: 11044-11044. DOI: 10.1200/Jco.2008.26.15_Suppl.11044  0.247
2008 Ning YM, Arlen PM, Gulley JL, Stein WD, Fojo AT, Latham L, Wright JJ, Parnes H, Figg WD, Dahut WL. Phase II trial of thalidomide (T), bevacizumab (Bv), and docetaxel (Doc) in patients (pts) with metastatic castration-refractory prostate cancer (mCRPC). Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 26: 5000. PMID 27948607 DOI: 10.1200/jco.2008.26.15_suppl.5000  0.242
1990 Stein WD, Stein AD. Testing and characterizing the two-stage model of carcinogenesis for a wide range of human cancers. Journal of Theoretical Biology. 145: 95-122. PMID 2214810 DOI: 10.1016/S0022-5193(05)80537-5  0.24
2003 Köhler S, Stein WD. Optimizing chemotherapy by measuring reversal of P-glycoprotein activity in plasma membrane vesicles. Biotechnology and Bioengineering. 81: 507-17. PMID 12514799 DOI: 10.1002/bit.10488  0.239
1995 Bronner F, Stein WD. Calcium homeostasis--an old problem revisited. The Journal of Nutrition. 125: 1987S-1995S. PMID 7602381 DOI: 10.1093/Jn/125.Suppl_7.1987S  0.237
2006 Braitbard O, Bishara-Shieban J, Glickstein H, Kott-Gutkowski M, Pace U, Rund DG, Stein WD. An ELISA-based procedure for assaying proteins in digests of human leukocytes and cell lines, using specifically selected peptides and appropriate antibodies. Proteome Science. 4: 14. PMID 16790042 DOI: 10.1186/1477-5956-4-14  0.236
1970 Lieb WR, Stein WD. Quantitative predictions of a noncarrier model for glucose transport across the human red cell membrane. Biophysical Journal. 10: 585-609. PMID 5449913 DOI: 10.1016/S0006-3495(70)86322-6  0.236
1992 Bronner F, Stein WD. Modulation of bone calcium-binding sites regulates plasma calcium: an hypothesis. Calcified Tissue International. 50: 483-9. PMID 1525701 DOI: 10.1007/BF00582159  0.235
2000 Hoshen MB, Heinrich R, Stein WD, Ginsburg H. Mathematical modelling of the within-host dynamics of Plasmodium falciparum. Parasitology. 121: 227-35. PMID 11085243 DOI: 10.1017/S0031182099006368  0.234
1978 Wolosin JM, Ginsburg H, Lieb WR, Stein WD. Diffusion within egg lecithin bilayers resembles that within soft polymers Journal of General Physiology. 71: 93-100. PMID 621494 DOI: 10.1085/Jgp.71.1.93  0.233
2010 Gulley JL, Stein WD, Schlom J, Madan RA, Dahut WL, Figg WD, Ning YM, Price D, Bates SE, Fojo AT. A retrospective analysis of intramural NCI prostate cancer trials: Progress made and insights gleaned. Journal of Clinical Oncology. 28: 4657-4657. DOI: 10.1200/JCO.2010.28.15_SUPPL.4657  0.232
1973 West IC, Stein WD. The kinetics of induction of β-galactoside permease Bba Section Nucleic Acids and Protein Synthesis. 308: 161-167. PMID 4579082 DOI: 10.1016/0005-2787(73)90133-0  0.231
1997 Stein WD. Kinetics of the multidrug transporter (P-glycoprotein) and its reversal. Physiological Reviews. 77: 545-90. PMID 9114823  0.229
2018 Stein WD. The ages of the cancer-associated genes. Seminars in Oncology. PMID 30554805 DOI: 10.1053/j.seminoncol.2018.11.001  0.224
1997 Ayesh S, Litman T, Stein WD. Drug accumulation in the presence of the multidrug resistance pump: dissociation between verapamil accumulation and the action of P-glycoprotein. Receptors & Channels. 5: 175-83. PMID 9606721  0.222
1976 Rao ML, Rao GS, Höller M, Breuer H, Schattenberg PJ, Stein WD. Uptake of Cortisol by Isolated Rat Liver Cells: A Phenomenon Indicative of Carrier-Mediation and Simple Diffusion | Aufnahme von Cortisol Durch Isolierte Leberzellen der Ratte. Hinweise auf Die Beteiligung von TräGerproteinen und Freier Diffusion Hoppe-Seyler's Zeitschrift Fur Physiologische Chemie. 357: 573-584. PMID 964917 DOI: 10.1515/bchm2.1976.357.1.573  0.219
1977 Stein WD. How the kinetic parameters of the simple carrier are affected by an applied voltage Bba - Biomembranes. 467: 376-385. PMID 884078 DOI: 10.1016/0005-2736(77)90315-7  0.216
2002 Stein WD. Reversers of the multidrug resistance transporter P-glycoprotein. Current Opinion in Investigational Drugs (London, England : 2000). 3: 812-7. PMID 12090558  0.215
1989 Bronner F, Bosco JJ, Stein WD. Acute plasma calcium regulation in rats: effect of vitamin D deficiency. Bone and Mineral. 6: 141-53. PMID 2765705 DOI: 10.1016/0169-6009(89)90046-9  0.213
2018 Litman T, Stein WD. Obtaining estimates for the ages of all the protein-coding genes and most of the ontology-identified noncoding genes of the human genome, assigned to 19 phylostrata. Seminars in Oncology. PMID 30558821 DOI: 10.1053/j.seminoncol.2018.11.002  0.213
1978 Koren R, Shohami E, Bibi O, Stein WD. Uridine transport properties of mammalian cell membranes are not directly involved with growth control or oncogenesis Febs Letters. 86: 71-75. PMID 620832 DOI: 10.1016/0014-5793(78)80101-X  0.209
2006 Braitbard O, Glickstein H, Bishara-Shieban J, Pace U, Stein WD. Competition between bound and free peptides in an ELISA-based procedure that assays peptides derived from protein digests. Proteome Science. 4: 12. PMID 16737525 DOI: 10.1186/1477-5956-4-12  0.208
1988 Ginsburg H, Stein WD. Biophysical analysis of a novel transport pathway induced in red blood cell membranes by the malaria parasite. Progress in Clinical and Biological Research. 252: 317-22. PMID 3279428  0.203
1966 Levine M, Oxender DL, Stein WD. The substrate-facilitated transport of the glucose carrier across the human erythrocyte membrane. Biochimica Et Biophysica Acta. 109: 151-63. PMID 5864008 DOI: 10.1016/0926-6585(65)90099-3  0.199
2011 Arnaud O, Boumendjel A, Gèze A, Honorat M, Matera EL, Guitton J, Stein WD, Bates SE, Falson P, Dumontet C, Di Pietro A, Payen L. The acridone derivative MBLI-87 sensitizes breast cancer resistance protein-expressing xenografts to irinotecan. European Journal of Cancer (Oxford, England : 1990). 47: 640-8. PMID 21216589 DOI: 10.1016/j.ejca.2010.11.019  0.194
1986 Stein Z, Stein W, Susser M. ATTRITION OF TRISOMIES AS A MATERNAL SCREENING DEVICE: An Explanation of the Association of Trisomy 21 with Maternal Age The Lancet. 327: 944-947. PMID 2871243 DOI: 10.1016/S0140-6736(86)91046-9  0.193
1970 Shimmin E, Stein W. The influence of analogues of i-fluoro-2,4-dinitrobenzene on the kinetics of irreversible inhibition of sugar transport in the human erythrocyte Biochimica Et Biophysica Acta (Bba) - Biomembranes. 211: 308-312. DOI: 10.1016/0005-2736(70)90102-1  0.189
1982 Stein WD. Replicating RNA duplexes and the epigenetic address Journal of Theoretical Biology. 94: 869-883. PMID 6176815 DOI: 10.1016/0022-5193(82)90082-0  0.189
1990 Karlish SJ, Goldshleger R, Stein WD. A 19-kDa C-terminal tryptic fragment of the alpha chain of Na/K-ATPase is essential for occlusion and transport of cations. Proceedings of the National Academy of Sciences of the United States of America. 87: 4566-70. PMID 2162048 DOI: 10.1073/pnas.87.12.4566  0.187
1987 Goldshlegger R, Karlish SJ, Rephaeli A, Stein WD. The effect of membrane potential on the mammalian sodium-potassium pump reconstituted into phospholipid vesicles. The Journal of Physiology. 387: 331-55. PMID 2443682 DOI: 10.1113/jphysiol.1987.sp016576  0.186
2000 Krishan A, Sridhar KS, Mou C, Stein WD, Lyubimov E, Hu YP, Fernandez H. Synergistic effect of prochlorperazine and dipyridamole on the cellular retention and cytotoxicity of doxorubicin. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 6: 1508-17. PMID 10778983  0.185
2014 Blagoev KB, Wilkerson J, Stein WD, Yang J, Bates SE, Fojo T. Therapies with diverse mechanisms of action kill cells by a similar exponential process in advanced cancers. Cancer Research. 74: 4653-62. PMID 25183789 DOI: 10.1158/0008-5472.Can-14-0420  0.184
1973 Stein WD, Lieb WR. A Necessary Simplification of the Kinetics of Carrier Transport Israel Journal of Chemistry. 11: 325-339. DOI: 10.1002/IJCH.197300032  0.182
1997 Scala S, Akhmed N, Rao US, Paull K, Lan LB, Dickstein B, Lee JS, Elgemeie GH, Stein WD, Bates SE. P-glycoprotein substrates and antagonists cluster into two distinct groups. Molecular Pharmacology. 51: 1024-33. PMID 9187269 DOI: 10.1124/mol.51.6.1024  0.178
1973 STEIN WD. Transport Kinetics Nature. 241: 483-483. DOI: 10.1038/241483a0  0.177
2005 Huberman M, Zehavi U, Stein WD, Etxeberria E, Goren R. In vitro sugar uptake by grapefruit (Citrus paradisi) juice-sac cells Functional Plant Biology. 32: 357-366. DOI: 10.1071/FP04125  0.177
2003 Agrawal M, Abraham J, Balis FM, Edgerly M, Stein WD, Bates S, Fojo T, Chen CC. Increased 99mTc-sestamibi accumulation in normal liver and drug-resistant tumors after the administration of the glycoprotein inhibitor, XR9576. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 9: 650-6. PMID 12576431  0.172
2014 Stein WD, Litman T. Channels, Carriers, and Pumps: An Introduction to Membrane Transport Channels, Carriers, and Pumps: An Introduction to Membrane Transport. 1-406.  0.168
1986 Bronner F, Pansu D, Stein WD. An analysis of intestinal calcium transport across the rat intestine. The American Journal of Physiology. 250: G561-9. PMID 2939728  0.167
1981 Giorgi EP, Stein WD. The transport of steroids into animal cells in culture Endocrinology. 108: 688-697. PMID 7449743  0.166
1968 Stein WD. The transport of sugars. British Medical Bulletin. 24: 146-9. PMID 5649934 DOI: 10.1093/OXFORDJOURNALS.BMB.A070617  0.164
1999 Robey R, Bakke S, Stein W, Meadows B, Litman T, Patil S, Smith T, Fojo T, Bates S. Efflux of Rhodamine From CD56+ Cells as a Surrogate Marker for Reversal of P-Glycoprotein–Mediated Drug Efflux by PSC 833 Blood. 93: 306-314. DOI: 10.1182/blood.v93.1.306  0.162
1994 Ayesh S, Lan L, Lyubimova E, Stein WD. A multidrug approach to reversing the multidrug transporter Anti-Cancer Drugs. 5: 26. DOI: 10.1097/00001813-199409001-00058  0.161
1988 Stein WD. Boycott of South Africa Nature. 328: 374. DOI: 10.1038/328374A0  0.16
1981 Stein WD. Chapter 5 Concepts of mediated transport New Comprehensive Biochemistry. 2: 123-157. DOI: 10.1016/S0167-7306(08)60033-2  0.159
1989 Stein WD. Kinetics of transport: analyzing, testing, and characterizing models using kinetic approaches. Methods in Enzymology. 171: 23-62. PMID 2593843 DOI: 10.1016/S0076-6879(89)71006-5  0.157
1998 STEIN WD. Spontaneous and enzyme-induced dimer formation and its role in membrane permeability. III. The mechanism of movement of glucose across the human erythrocyte membrane. Biochimica Et Biophysica Acta. 59: 66-77. PMID 13916653 DOI: 10.1016/0006-3002(62)90698-4  0.15
1993 Altuvia S, Stein WD, Goldenberg S, Kane SE, Pastan I, Gottesman MM. Targeted disruption of the mouse mdr1b gene reveals that steroid hormones enhance mdr gene expression. The Journal of Biological Chemistry. 268: 27127-32. PMID 7903303  0.149
1977 Rozengurt E, Stein WD. Regulation of uridine uptake by serum and insulin in density-inhibited 3T3 cells Bba - Biomembranes. 464: 417-432. PMID 831802 DOI: 10.1016/0005-2736(77)90015-3  0.149
2002 STEIN WD. The permeability of erythrocyte ghosts. Experimental Cell Research. 11: 232-4. PMID 13356850 DOI: 10.1016/0014-4827(56)90213-0  0.145
1998 STEIN WD. Dimer formation and glucose transfer across the membrane of the red blood cell. Nature. 191: 1277-80. PMID 13916650 DOI: 10.1038/1911277A0  0.145
1998 STEIN WD. Spontaneous and enzyme-induced dimer formation and its role in membrane permeability. I. The permeability of non-electrolytes at high concentration. Biochimica Et Biophysica Acta. 59: 35-46. PMID 13916651 DOI: 10.1016/0006-3002(62)90696-0  0.144
2009 Stein WD, Huang H, Menefee M, Edgerly M, Kotz H, Dwyer A, Yang J, Bates SE. Other paradigms: growth rate constants and tumor burden determined using computed tomography data correlate strongly with the overall survival of patients with renal cell carcinoma. Cancer Journal (Sudbury, Mass.). 15: 441-7. PMID 19826366 DOI: 10.1097/PPO.0b013e3181be1b90  0.143
1972 Lieb WR, Stein WD. The influence of unstirred layers on the kinetics of carrier-mediated transport Journal of Theoretical Biology. 36: 641-645. PMID 5080454 DOI: 10.1016/0022-5193(72)90016-1  0.14
1998 STEIN WD. Spontaneous and enzyme-induced dimer formation and its role in membrane permeability. II. The mechanism of movement of glycerol across the human erythrocyte membrane. Biochimica Et Biophysica Acta. 59: 47-65. PMID 13916652 DOI: 10.1016/0006-3002(62)90697-2  0.137
2012 Adesunloye B, Stein WD, Wilkerson J, Huang X, Karzai FH, Madan RA, Apolo AB, Figg WD, Dahut WL, Fojo T. Tumor regression and growth rates determined in two intramural NCI prostate cancer trials: The growth rate constant as an indicator of therapeutic efficacy. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 30: 133. PMID 27968174 DOI: 10.1200/jco.2012.30.5_suppl.133  0.134
1986 Stein WD. Quantitative relationships between the measurable transport resistances of membrane carriers: theory and experiment. Biochimica Et Biophysica Acta. 856: 634-9. PMID 3964700 DOI: 10.1016/0005-2736(86)90158-6  0.132
1992 Goldshleger R, Tal DM, Moorman J, Stein WD, Karlish SJ. Chemical modification of Glu-953 of the alpha chain of Na+,K(+)-ATPase associated with inactivation of cation occlusion. Proceedings of the National Academy of Sciences of the United States of America. 89: 6911-5. PMID 1353883  0.132
2013 Blagoev KB, Wilkerson J, Stein WD, Motzer RJ, Bates SE, Fojo AT. Sunitinib does not accelerate tumor growth in patients with metastatic renal cell carcinoma. Cell Reports. 3: 277-81. PMID 23395639 DOI: 10.1016/j.celrep.2013.01.015  0.132
2008 Stein WD, Yang J, Bates SE, Fojo T. Bevacizumab reduces the growth rate constants of renal carcinomas: a novel algorithm suggests early discontinuation of bevacizumab resulted in a lack of survival advantage. The Oncologist. 13: 1055-62. PMID 18827177 DOI: 10.1634/Theoncologist.2008-0016  0.131
1972 Lieb WR, Stein WD. The Molecular Basis of Simple Diffusion within Biological Membranes Current Topics in Membranes and Transport. 2: 1-39. DOI: 10.1016/S0070-2161(08)60340-8  0.13
1992 Karlish SJ, Goldshleger R, Tal DM, Capasso JM, Hoving S, Stein WD. Identification of the cation binding domain of Na/K-ATPase. Acta Physiologica Scandinavica. Supplementum. 607: 69-76. PMID 1333162  0.13
1984 Karatza C, Stein WD, Shall S. Kinetics of in vitro ageing of mouse embryo fibroblasts Journal of Cell Science. 65: 163-175. PMID 6715422  0.129
1990 Stein WD. Membrane permeability. Editorial overview Current Opinion in Cell Biology. 2: 687-688.  0.126
1989 Stein WD. Membrane permeability Editorial overview Current Opinion in Cell Biology. 1: 719-720.  0.126
1972 Stein WD. The mechanism of sugar transfer across erythrocyte membranes Annals of the New York Academy of Sciences. 195: 412-428. PMID 4504102  0.124
1972 Stein WD. Discussion paper: models of membrane structure Annals of the New York Academy of Sciences. 195: 37-38. PMID 4504101  0.119
1990 Stein WD, Läuger P. Kinetic properties of F0F1-ATPases. Theoretical predictions from alternating-site models. Biophysical Journal. 57: 255-67. PMID 2138501 DOI: 10.1016/S0006-3495(90)82528-5  0.117
1961 STEIN WD. Dimer Formation and the Transfer of Glycerol Across the Erythrocyte Membrane Nature. 191: 352-355. DOI: 10.1038/191352A0  0.117
1990 Bronner F, Isaacson LC, Christakos S, Stein WD. Renal calcium transport: a mechanistic analysis. Progress in Clinical and Biological Research. 332: 127-41. PMID 2139510  0.115
2014 Burotto M, Wilkerson J, Stein W, Motzer R, Bates S. Correction: Continuing a cancer treatment despite tumor growth may be valuable: Sunitinib in renal cell carcinoma as example (PLoS ONE (2014) 9, 5 (e96316) DOI: 10.1371/journal.pone.0096316) Plos One. 9. DOI: 10.1371/journal.pone.0105179  0.109
2016 Wilkerson J, Abdallah K, Hugh-Jones C, Curt G, Rothenberg M, Simantov R, Murphy M, Morrell J, Beetsch J, Sargent DJ, Scher HI, Lebowitz P, Simon R, Stein WD, Bates SE, et al. Estimation of tumour regression and growth rates during treatment in patients with advanced prostate cancer: a retrospective analysis. The Lancet. Oncology. PMID 27979599 DOI: 10.1016/S1470-2045(16)30633-7  0.105
1986 Bronner F, Pansu D, Stein WD. Analysis of calcium transport in rat intestine Advances in Experimental Medicine and Biology. 208: 227-234. PMID 3551534  0.104
1968 Kolber AR, Stein WD. The isolation of a membrane-bound protein associated with the beta-galactoside-permease of Escherichia coli. Currents in Modern Biology. 1: 244-8. PMID 4872414 DOI: 10.1016/0303-2647(67)90002-0  0.099
1988 Stein WD. How the sodium pump uses ATP to render pumping of both Na and K effective. Progress in Clinical and Biological Research. 273: 239-46. PMID 3420131  0.099
1991 Karlish SJ, Goldshleger R, Tal DM, Stein WD. Structure of the cation binding sites of Na/K-ATPase. Society of General Physiologists Series. 46: 129-41. PMID 1653974  0.097
2008 Stein WD, Figg WD, Dahut W, Stein AD, Hoshen MB, Price D, Bates SE, Fojo T. Tumor growth rates derived from data for patients in a clinical trial correlate strongly with patient survival: a novel strategy for evaluation of clinical trial data. The Oncologist. 13: 1046-54. PMID 18838440 DOI: 10.1634/Theoncologist.2008-0075  0.097
1986 Bronner F, Pansu D, Stein W. An analysis of transmural Ca transport in rat intestine Bone. 7: 403. DOI: 10.1016/8756-3282(86)90314-5  0.095
2023 Litman T, Stein WD. Ancient lineages of the keratin-associated protein (KRTAP) genes and their co-option in the evolution of the hair follicle. Bmc Ecology and Evolution. 23: 7. PMID 36941546 DOI: 10.1186/s12862-023-02107-z  0.095
1979 Shall S, Stein WD. A mortalization theory for the control of cell proliferation and for the origin of immortal cell lines Journal of Theoretical Biology. 76: 219-231. PMID 431096 DOI: 10.1016/0022-5193(79)90371-0  0.093
1991 Stein WD. Analysis of cancer incidence data on the basis of multistage and clonal growth models. Advances in Cancer Research. 56: 161-213. PMID 2028841  0.092
1983 Karlish JD, Stein WD. Rubidium Movements in Vesicles Reconstituted with Na,K-ATPase, Measured in the Absence of ATP and Pi, in the Presence of Either Ligand, and in the Presence of Both Ligands: Role of the "Occluded Staté in Allowing for the Control of the Direction of Ion Movements 5 Current Topics in Membranes and Transport. 19: 425-449. DOI: 10.1016/S0070-2161(08)60593-6  0.086
1969 Shaw IS, Stein WD, Wynn CH. Cyanide binding and inhibition of a purified arylsulphatase of Alcaligenes metalcaligenes. The Biochemical Journal. 112: 14P. PMID 5774494 DOI: 10.1042/BJ1120014PA  0.084
1988 Bronner F, Stein WD. CaBP(r) facilitates intracellular diffusion for Ca pumping in distal convoluted tubule American Journal of Physiology - Renal Fluid and Electrolyte Physiology. 255: 24/3.  0.074
1988 Stein WD. How the energy from ATP hydrolysis is used to render ion pumping effective. Progress in Clinical and Biological Research. 268: 575-81. PMID 2843905  0.069
1986 Stein WD. Intrinsic, apparent, and effective affinities of co- and countertransport systems. The American Journal of Physiology. 250: C523-33. PMID 3008563  0.068
2000 STEIN WD. N-terminal histidine at the active centre of a permeability mechanism. Nature. 181: 1662-3. PMID 13566102 DOI: 10.1038/1811662B0  0.068
2009 Lorenz WEA, Kuzian RO, Drechsler SL, Stein WD, Wizent N, Behr G, Mlek J, Nitzsche U, Rosner H, Hiess A, Schmidt W, Klingeler R, Loewenhaupt M, Büchner B. Highly dispersive spin excitations in the chain cuprate Li 2CuO2 Epl. 88. DOI: 10.1209/0295-5075/88/37002  0.064
1969 Caygill CP, Stein WD. Binding of insulin by liposomes incorporating protein. Life Sciences. 8: 809-12. PMID 5803375 DOI: 10.1016/0024-3205(69)90098-8  0.064
1968 Saundry RH, Stein WD. The binding of cupric ions to bovine pancreatic ribonuclease studies with diligand metal-ion buffers. The Biochemical Journal. 105: 107-15. PMID 6070125 DOI: 10.1042/BJ1050107  0.063
1968 Saundry RH, Stein WD. The binding of cupric ions to 1-carboxymethylhistidine-119-ribonuclease. The Biochemical Journal. 108: 583-6. PMID 5667270 DOI: 10.1042/BJ1080583  0.058
1971 Leib WR, Stein WD. Rejection criterion for some forms of the conventional carrier. Journal of Theoretical Biology. 30: 219-22. PMID 5555276 DOI: 10.1016/0022-5193(71)90048-8  0.054
1981 Stein WD. Chapter 1 Permeability for lipophilic molecules New Comprehensive Biochemistry. 2: 1-28. DOI: 10.1016/S0167-7306(08)60029-0  0.053
2007 Komarek AC, Roth H, Cwik M, Stein WD, Baier J, Kriener M, Bourée F, Lorenz T, Braden M. Magnetoelastic coupling in RTi O3 (R=La,Nd,Sm,Gd,Y) investigated with diffraction techniques and thermal expansion measurements Physical Review B - Condensed Matter and Materials Physics. 75. DOI: 10.1103/Physrevb.75.224402  0.05
2021 Stein WD, Hoshen MB. During evolution from the earliest tetrapoda, newly-recruited genes are increasingly paralogues of existing genes and distribute non-randomly among the chromosomes. Bmc Genomics. 22: 794. PMID 34736418 DOI: 10.1186/s12864-021-08066-3  0.042
2003 STEIN WD. A comparison of some natural and synthetic melanins. Nature. 174: 601-2. PMID 13203587 DOI: 10.1038/174601A0  0.04
2015 Prokhnenko O, Stein WD, Bleif HJ, Fromme M, Bartkowiak M, Wilpert T. Time-of-flight Extreme Environment Diffractometer at the Helmholtz-Zentrum Berlin. The Review of Scientific Instruments. 86: 033102. PMID 25832206 DOI: 10.1063/1.4913656  0.038
1989 Stein WD. The cotransport systems. Current Opinion in Cell Biology. 1: 739-45. PMID 2697282 DOI: 10.1016/0955-0674(89)90043-4  0.027
2003 STEIN WD. Ultra-violet absorption investigation of melanins. Nature. 175: 472. PMID 14356206 DOI: 10.1038/175472A0  0.025
2012 Stein WD, Liebertz J, Becker P, Bohatý L, Braden M. Structural investigations of the tetraborates MB4O7 (M = Pb, Sr, Ba) European Physical Journal B. 85. DOI: 10.1140/epjb/e2012-21062-y  0.024
1984 Stein WD. Open ion channels behave as simple size-selective filters bearing fixed counter-ions Progress in Clinical and Biological Research. 168: 51-58. PMID 6096889  0.023
2003 STEIN WD. Chemical composition of the melanin granule and its relation to the mitochondrion. Nature. 175: 256-7. PMID 13235864 DOI: 10.1038/175256A0  0.021
2014 Bera AK, Lake B, Stein WD, Zander S. Magnetic correlations of the quasi-one-dimensional half-integer spin-chain antiferromagnets Sr M2 V2O8 (M = Co, Mn) Physical Review B - Condensed Matter and Materials Physics. 89. DOI: 10.1103/PhysRevB.89.094402  0.021
2014 Prokhnenko O, Lieutenant K, Cussen LD, Stein WD, Zendler C, Prokeš K. Probing static and dynamic correlations in matter under extreme conditions: Concept of multi-purpose instrument at the European Spallation Source Nuclear Instruments and Methods in Physics Research, Section a: Accelerators, Spectrometers, Detectors and Associated Equipment. 764: 30-41. DOI: 10.1016/j.nima.2014.07.013  0.019
1992 Freedman JC, Novak TS, Penefsky HS, Stein WD. Quantitative analysis of oxonol V fluorescence in submitochondrial particles. Annals of the New York Academy of Sciences. 671: 493-6. PMID 1337685  0.019
2007 Stein WD, Cousson A, Becker P, Bohatý L, Braden M. Temperature-dependent X-ray and neutron diffraction study of BiB 3O6 Zeitschrift Fur Kristallographie. 222: 680-689. DOI: 10.1524/zkri.2007.222.12.680  0.015
2013 Prokeš K, Mydosh JA, Prokhnenko O, Stein WD, Landsgesell S, Hermes W, Feyerherm R, Pöttgen R. Antiferromagnetic ordering in a mixed-valent cerium compound CeRuSn Physical Review B - Condensed Matter and Materials Physics. 87. DOI: 10.1103/Physrevb.87.094421  0.01
2005 Gössling A, Möller T, Stein WD, Becker P, Bohatý L, Grüninger M. Phonon modes of monoclinic BiB3O6 Physica Status Solidi (B) Basic Research. 242: R85-R87. DOI: 10.1002/pssb.200541164  0.01
1986 Stein WD. James Frederic Danielli: 13 November 1911-22 April 1984. Biographical Memoirs of Fellows of the Royal Society. Royal Society (Great Britain). 32: 115-35. PMID 11621256  0.01
1984 Stein WD. Preface Current Topics in Membranes and Transport. 21: xi-xvii. DOI: 10.1016/S0070-2161(08)60432-3  0.01
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