Valter Longo - Publications

Neuroscience University of Southern California, Los Angeles, CA, United States 
Neuroscience Biology

93 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Yen K, Mehta HH, Kim SJ, Lue Y, Hoang J, Guerrero N, Port J, Bi Q, Navarrete G, Brandhorst S, Lewis KN, Wan J, Swerdloff R, Mattison JA, Buffenstein R, ... ... Longo V, et al. The mitochondrial derived peptide humanin is a regulator of lifespan and healthspan. Aging. 12. PMID 32575074 DOI: 10.18632/aging.103534  0.4
2020 Di Tano M, Raucci F, Vernieri C, Caffa I, Buono R, Fanti M, Brandhorst S, Curigliano G, Nencioni A, de Braud F, Longo VD. Synergistic effect of fasting-mimicking diet and vitamin C against KRAS mutated cancers. Nature Communications. 11: 2332. PMID 32393788 DOI: 10.1038/s41467-020-16243-3  0.4
2019 Brandhorst S, Longo VD. Protein Quantity and Source, Fasting-Mimicking Diets, and Longevity. Advances in Nutrition (Bethesda, Md.). 10: S340-S350. PMID 31728501 DOI: 10.1093/advances/nmz079  0.4
2019 Brandhorst S, Longo VD. Dietary Restrictions and Nutrition in the Prevention and Treatment of Cardiovascular Disease. Circulation Research. 124: 952-965. PMID 30870119 DOI: 10.1161/CIRCRESAHA.118.313352  0.4
2019 Rangan P, Choi I, Wei M, Navarrete G, Guen E, Brandhorst S, Enyati N, Pasia G, Maesincee D, Ocon V, Abdulridha M, Longo VD. Fasting-Mimicking Diet Modulates Microbiota and Promotes Intestinal Regeneration to Reduce Inflammatory Bowel Disease Pathology. Cell Reports. 26: 2704-2719.e6. PMID 30840892 DOI: 10.1016/j.celrep.2019.02.019  0.44
2018 Yen K, Wan J, Mehta HH, Miller B, Christensen A, Levine ME, Salomon MP, Brandhorst S, Xiao J, Kim SJ, Navarrete G, Campo D, Harry GJ, Longo V, Pike CJ, et al. Humanin Prevents Age-Related Cognitive Decline in Mice and is Associated with Improved Cognitive Age in Humans. Scientific Reports. 8: 14212. PMID 30242290 DOI: 10.1038/s41598-018-32616-7  0.4
2017 Hine C, Kim HJ, Zhu Y, Harputlugil E, Longchamp A, Matos MS, Ramadoss P, Bauerle K, Brace L, Asara JM, Ozaki CK, Cheng SY, Singha S, Ahn KH, Kimmelman A, ... ... Longo VD, et al. Hypothalamic-Pituitary Axis Regulates Hydrogen Sulfide Production. Cell Metabolism. 25: 1320-1333.e5. PMID 28591635 DOI: 10.1016/j.cmet.2017.05.003  0.4
2017 Di Biase S, Shim HS, Kim KH, Vinciguerra M, Rappa F, Wei M, Brandhorst S, Cappello F, Mirzaei H, Lee C, Longo VD. Correction: Fasting regulates EGR1 and protects from glucose- and dexamethasone-dependent sensitization to chemotherapy. Plos Biology. 15: e1002603. PMID 28459830 DOI: 10.1371/journal.pbio.1002603  1
2017 Di Biase S, Shim HS, Kim KH, Vinciguerra M, Rappa F, Wei M, Brandhorst S, Cappello F, Mirzaei H, Lee C, Longo VD. Fasting regulates EGR1 and protects from glucose- and dexamethasone-dependent sensitization to chemotherapy. Plos Biology. 15: e2001951. PMID 28358805 DOI: 10.1371/journal.pbio.2001951  1
2017 Cheng CW, Villani V, Buono R, Wei M, Kumar S, Yilmaz OH, Cohen P, Sneddon JB, Perin L, Longo VD. Fasting-Mimicking Diet Promotes Ngn3-Driven β-Cell Regeneration to Reverse Diabetes. Cell. 168: 775-788.e12. PMID 28235195 DOI: 10.1016/j.cell.2017.01.040  0.4
2017 Brandhorst S, Harputlugil E, Mitchell JR, Longo VD. Protective effects of short-term dietary restriction in surgical stress and chemotherapy. Ageing Research Reviews. PMID 28216454 DOI: 10.1016/j.arr.2017.02.001  0.4
2017 Wei M, Brandhorst S, Shelehchi M, Mirzaei H, Cheng CW, Budniak J, Groshen S, Mack WJ, Guen E, Di Biase S, Cohen P, Morgan TE, Dorff T, Hong K, Michalsen A, ... ... Longo VD, et al. Fasting-mimicking diet and markers/risk factors for aging, diabetes, cancer, and cardiovascular disease. Science Translational Medicine. 9. PMID 28202779 DOI: 10.1126/scitranslmed.aai8700  0.44
2017 Lee AS, Brandhorst S, Rangel DF, Navarrete G, Cohen P, Longo VD, Chen J, Groshen S, Morgan TE, Dubeau L. Effects of Prolonged GRP78 Haploinsufficiency on Organ Homeostasis, Behavior, Cancer and Chemotoxic Resistance in Aged Mice. Scientific Reports. 7: 40919. PMID 28145503 DOI: 10.1038/srep40919  0.4
2017 Choi IY, Lee C, Longo VD. Nutrition and fasting mimicking diets in the prevention and treatment of autoimmune diseases and immunosenescence. Molecular and Cellular Endocrinology. PMID 28137612 DOI: 10.1016/j.mce.2017.01.042  1
2017 Nashiro K, Guevara-Aguirre J, Braskie MN, Hafzalla GW, Velasco R, Balasubramian P, Wei M, Thompson PM, Mather M, Nelson MD, Guevara A, Teran E, Longo VD. Brain structure and function associated with younger adults in growth hormone receptor deficient humans. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 28073935 DOI: 10.1523/JNEUROSCI.1929-16.2016  0.36
2016 Brandhorst S, Longo VD. Fasting and Caloric Restriction in Cancer Prevention and Treatment. Recent Results in Cancer Research. Fortschritte Der Krebsforschung. ProgrèS Dans Les Recherches Sur Le Cancer. 207: 241-66. PMID 27557543 DOI: 10.1007/978-3-319-42118-6_12  0.4
2016 Di Biase S, Lee C, Brandhorst S, Manes B, Buono R, Cheng CW, Cacciottolo M, Martin-Montalvo A, de Cabo R, Wei M, Morgan TE, Longo VD. Fasting-Mimicking Diet Reduces HO-1 to Promote T Cell-Mediated Tumor Cytotoxicity. Cancer Cell. 30: 136-46. PMID 27411588 DOI: 10.1016/j.ccell.2016.06.005  1
2016 Dorff TB, Groshen S, Garcia A, Shah M, Tsao-Wei D, Pham H, Cheng CW, Brandhorst S, Cohen P, Wei M, Longo V, Quinn DI. Safety and feasibility of fasting in combination with platinum-based chemotherapy. Bmc Cancer. 16: 360. PMID 27282289 DOI: 10.1186/s12885-016-2370-6  0.44
2016 Choi IY, Piccio L, Childress P, Bollman B, Ghosh A, Brandhorst S, Suarez J, Michalsen A, Cross AH, Morgan TE, Wei M, Paul F, Bock M, Longo VD. A Diet Mimicking Fasting Promotes Regeneration and Reduces Autoimmunity and Multiple Sclerosis Symptoms. Cell Reports. PMID 27239035 DOI: 10.1016/j.celrep.2016.05.009  1
2016 Mirzaei H, Di Biase S, Longo VD. Dietary Interventions, Cardiovascular Aging, and Disease: Animal Models and Human Studies. Circulation Research. 118: 1612-25. PMID 27174953 DOI: 10.1161/CIRCRESAHA.116.307473  1
2016 Lee C, Longo V. Dietary restriction with and without caloric restriction for healthy aging. F1000research. 5. PMID 26918181 DOI: 10.12688/f1000research.7136.1  1
2016 Balasubramanian P, Longo VD. Growth factors, aging and age-related diseases. Growth Hormone & Igf Research : Official Journal of the Growth Hormone Research Society and the International Igf Research Society. PMID 26883276 DOI: 10.1016/j.ghir.2016.01.001  1
2015 Hirschey MD, DeBerardinis RJ, Diehl AM, Drew JE, Frezza C, Green MF, Jones LW, Ko YH, Le A, Lea MA, Locasale JW, Longo VD, Lyssiotis CA, McDonnell E, Mehrmohamadi M, et al. Dysregulated metabolism contributes to oncogenesis. Seminars in Cancer Biology. PMID 26454069 DOI: 10.1016/j.semcancer.2015.10.002  0.4
2015 Brandhorst S, Choi IY, Wei M, Cheng CW, Sedrakyan S, Navarrete G, Dubeau L, Yap LP, Park R, Vinciguerra M, Di Biase S, Mirzaei H, Mirisola MG, Childress P, Ji L, ... ... Longo VD, et al. A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan. Cell Metabolism. PMID 26094889 DOI: 10.1016/j.cmet.2015.05.012  1
2015 Guevara-Aguirre J, Rosenbloom AL, Balasubramanian P, Teran E, Guevara-Aguirre M, Guevara C, Procel P, Alfaras I, De Cabo R, Di Biase S, Narvaez L, Saavedra J, Longo VD. GH Receptor Deficiency in Ecuadorian Adults Is Associated With Obesity and Enhanced Insulin Sensitivity. The Journal of Clinical Endocrinology and Metabolism. 100: 2589-96. PMID 25985182 DOI: 10.1210/jc.2015-1678  1
2015 Bianchi G, Martella R, Ravera S, Marini C, Capitanio S, Orengo A, Emionite L, Lavarello C, Amaro A, Petretto A, Pfeffer U, Sambuceti G, Pistoia V, Raffaghello L, Longo VD. Fasting induces anti-Warburg effect that increases respiration but reduces ATP-synthesis to promote apoptosis in colon cancer models. Oncotarget. 6: 11806-19. PMID 25909219  0.4
2015 Longo VD, Antebi A, Bartke A, Barzilai N, Brown-Borg HM, Caruso C, Curiel TJ, de Cabo R, Franceschi C, Gems D, Ingram DK, Johnson TE, Kennedy BK, Kenyon C, Klein S, et al. Interventions to Slow Aging in Humans: Are We Ready? Aging Cell. 14: 497-510. PMID 25902704 DOI: 10.1111/acel.12338  1
2015 Shim HS, Wei M, Brandhorst S, Longo VD. Starvation promotes REV1 SUMOylation and p53-dependent sensitization of melanoma and breast cancer cells. Cancer Research. 75: 1056-67. PMID 25614517 DOI: 10.1158/0008-5472.CAN-14-2249  0.44
2015 Shim HS, Longo VD. A protein restriction-dependent sulfur code for longevity. Cell. 160: 15-7. PMID 25594171 DOI: 10.1016/j.cell.2014.12.027  1
2014 Mattson MP, Allison DB, Fontana L, Harvie M, Longo VD, Malaisse WJ, Mosley M, Notterpek L, Ravussin E, Scheer FA, Seyfried TN, Varady KA, Panda S. Meal frequency and timing in health and disease. Proceedings of the National Academy of Sciences of the United States of America. 111: 16647-53. PMID 25404320 DOI: 10.1073/pnas.1413965111  1
2014 Mirzaei H, Suarez JA, Longo VD. Protein and amino acid restriction, aging and disease: from yeast to humans. Trends in Endocrinology and Metabolism: Tem. 25: 558-66. PMID 25153840 DOI: 10.1016/j.tem.2014.07.002  1
2014 Lee C, Wan J, Miyazaki B, Fang Y, Guevara-Aguirre J, Yen K, Longo V, Bartke A, Cohen P. IGF-I regulates the age-dependent signaling peptide humanin. Aging Cell. 13: 958-61. PMID 25040290 DOI: 10.1111/acel.12243  1
2014 Cheng CW, Adams GB, Perin L, Wei M, Zhou X, Lam BS, Da Sacco S, Mirisola M, Quinn DI, Dorff TB, Kopchick JJ, Longo VD. Prolonged fasting reduces IGF-1/PKA to promote hematopoietic-stem-cell-based regeneration and reverse immunosuppression. Cell Stem Cell. 14: 810-23. PMID 24905167 DOI: 10.1016/j.stem.2014.04.014  1
2014 Mirzaei H, Longo VD. Acetyl-CoA synthetase is a conserved regulator of autophagy and life span. Cell Metabolism. 19: 555-7. PMID 24703691 DOI: 10.1016/j.cmet.2014.03.021  1
2014 Hu J, Wei M, Mirzaei H, Madia F, Mirisola M, Amparo C, Chagoury S, Kennedy B, Longo VD. Tor-Sch9 deficiency activates catabolism of the ketone body-like acetic acid to promote trehalose accumulation and longevity. Aging Cell. 13: 457-67. PMID 24649827 DOI: 10.1111/acel.12202  1
2014 Levine ME, Suarez JA, Brandhorst S, Balasubramanian P, Cheng CW, Madia F, Fontana L, Mirisola MG, Guevara-Aguirre J, Wan J, Passarino G, Kennedy BK, Wei M, Cohen P, Crimmins EM, ... Longo VD, et al. Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population. Cell Metabolism. 19: 407-17. PMID 24606898 DOI: 10.1016/j.cmet.2014.02.006  1
2014 Mirisola MG, Taormina G, Fabrizio P, Wei M, Hu J, Longo VD. Serine- and threonine/valine-dependent activation of PDK and Tor orthologs converge on Sch9 to promote aging. Plos Genetics. 10: e1004113. PMID 24516402 DOI: 10.1371/journal.pgen.1004113  0.36
2014 Longo VD, Mattson MP. Fasting: molecular mechanisms and clinical applications. Cell Metabolism. 19: 181-92. PMID 24440038 DOI: 10.1016/j.cmet.2013.12.008  1
2014 Mercken EM, Hu J, Krzysik-Walker S, Wei M, Li Y, McBurney MW, de Cabo R, Longo VD. SIRT1 but not its increased expression is essential for lifespan extension in caloric-restricted mice. Aging Cell. 13: 193-6. PMID 23941528 DOI: 10.1111/acel.12151  0.4
2014 Bai B, Joshi A, Brandhorst S, Longo VD, Conti PS, Leahy RM. A registration-based segmentation method with application to adiposity analysis of mice microCT images Progress in Biomedical Optics and Imaging - Proceedings of Spie. 9038. DOI: 10.1117/12.2043744  0.4
2013 Balasubramanian P, Longo VD. Aging, nutrient signaling, hematopoietic senescence, and cancer. Critical Reviews in Oncogenesis. 18: 559-71. PMID 24579735 DOI: 10.1615/CritRevOncog.2013010596  1
2013 Fontana L, Adelaiye RM, Rastelli AL, Miles KM, Ciamporcero E, Longo VD, Nguyen H, Vessella R, Pili R. Dietary protein restriction inhibits tumor growth in human xenograft models. Oncotarget. 4: 2451-61. PMID 24353195 DOI: 10.18632/oncotarget.1586  1
2013 Bartke A, Sun LY, Longo V. Somatotropic signaling: trade-offs between growth, reproductive development, and longevity. Physiological Reviews. 93: 571-98. PMID 23589828 DOI: 10.1152/physrev.00006.2012  1
2013 Brandhorst S, Wei M, Hwang S, Morgan TE, Longo VD. Short-term calorie and protein restriction provide partial protection from chemotoxicity but do not delay glioma progression. Experimental Gerontology. 48: 1120-8. PMID 23454633 DOI: 10.1016/j.exger.2013.02.016  0.44
2013 Parrella E, Maxim T, Maialetti F, Zhang L, Wan J, Wei M, Cohen P, Fontana L, Longo VD. Protein restriction cycles reduce IGF-1 and phosphorylated Tau, and improve behavioral performance in an Alzheimer's disease mouse model. Aging Cell. 12: 257-68. PMID 23362919 DOI: 10.1111/acel.12049  0.4
2013 Hu J, Wei M, Mirisola MG, Longo VD. Assessing chronological aging in Saccharomyces cerevisiae. Methods in Molecular Biology (Clifton, N.J.). 965: 463-72. PMID 23296677 DOI: 10.1007/978-1-62703-239-1_30  0.36
2013 Gonidakis S, Longo VD. Assessing chronological aging in bacteria. Methods in Molecular Biology (Clifton, N.J.). 965: 421-37. PMID 23296675 DOI: 10.1007/978-1-62703-239-1_28  1
2012 Safdie F, Brandhorst S, Wei M, Wang W, Lee C, Hwang S, Conti PS, Chen TC, Longo VD. Fasting enhances the response of glioma to chemo- and radiotherapy. Plos One. 7: e44603. PMID 22984531 DOI: 10.1371/journal.pone.0044603  1
2012 Longo VD, Shadel GS, Kaeberlein M, Kennedy B. Replicative and chronological aging in Saccharomyces cerevisiae. Cell Metabolism. 16: 18-31. PMID 22768836 DOI: 10.1016/j.cmet.2012.06.002  1
2012 Pfaffenbach KT, Pong M, Morgan TE, Wang H, Ott K, Zhou B, Longo VD, Lee AS. GRP78/BiP is a novel downstream target of IGF-1 receptor mediated signaling. Journal of Cellular Physiology. 227: 3803-11. PMID 22422508 DOI: 10.1002/jcp.24090  1
2012 Lee C, Raffaghello L, Longo VD. Starvation, detoxification, and multidrug resistance in cancer therapy. Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy. 15: 114-22. PMID 22391012 DOI: 10.1016/j.drup.2012.01.004  1
2012 Lee C, Raffaghello L, Brandhorst S, Safdie FM, Bianchi G, Martin-Montalvo A, Pistoia V, Wei M, Hwang S, Merlino A, Emionite L, de Cabo R, Longo VD. Fasting cycles retard growth of tumors and sensitize a range of cancer cell types to chemotherapy. Science Translational Medicine. 4: 124ra27. PMID 22323820 DOI: 10.1126/scitranslmed.3003293  1
2011 Wei M, Madia F, Longo VD. Studying age-dependent genomic instability using the S. cerevisiae chronological lifespan model. Journal of Visualized Experiments : Jove. PMID 21989366 DOI: 10.3791/3030  0.36
2011 Lee C, Longo VD. Fasting vs dietary restriction in cellular protection and cancer treatment: from model organisms to patients. Oncogene. 30: 3305-16. PMID 21516129 DOI: 10.1038/onc.2011.91  1
2011 Gonidakis S, Finkel SE, Longo VD. Lifespan extension and paraquat resistance in a ubiquinone-deficient Escherichia coli mutant depend on transcription factors ArcA and TdcA. Aging. 3: 291-303. PMID 21464517  1
2011 Sehati S, Clement MH, Martins J, Xu L, Longo VD, Valentine JS, Gralla EB. Metabolic alterations in yeast lacking copper-zinc superoxide dismutase. Free Radical Biology & Medicine. 50: 1591-8. PMID 21397007 DOI: 10.1016/j.freeradbiomed.2011.03.004  1
2011 Guevara-Aguirre J, Balasubramanian P, Guevara-Aguirre M, Wei M, Madia F, Cheng CW, Hwang D, Martin-Montalvo A, Saavedra J, Ingles S, de Cabo R, Cohen P, Longo VD. Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans. Science Translational Medicine. 3: 70ra13. PMID 21325617 DOI: 10.1126/scitranslmed.3001845  1
2010 Raffaghello L, Safdie F, Bianchi G, Dorff T, Fontana L, Longo VD. Fasting and differential chemotherapy protection in patients. Cell Cycle (Georgetown, Tex.). 9: 4474-6. PMID 21088487  0.4
2010 Balasubramanian P, Longo VD. Linking Klotho, Nrf2, MAP kinases and aging. Aging. 2: 632-3. PMID 21076180  1
2010 Gonidakis S, Finkel SE, Longo VD. Genome-wide screen identifies Escherichia coli TCA-cycle-related mutants with extended chronological lifespan dependent on acetate metabolism and the hypoxia-inducible transcription factor ArcA. Aging Cell. 9: 868-81. PMID 20707865 DOI: 10.1111/j.1474-9726.2010.00618.x  1
2010 Gonidakis S, Finkel SE, Longo VD. E. coli hypoxia-inducible factor ArcA mediates lifespan extension in a lipoic acid synthase mutant by suppressing acetyl-CoA synthetase. Biological Chemistry. 391: 1139-47. PMID 20707605 DOI: 10.1515/BC.2010.120  1
2010 Michán S, Li Y, Chou MM, Parrella E, Ge H, Long JM, Allard JS, Lewis K, Miller M, Xu W, Mervis RF, Chen J, Guerin KI, Smith LE, McBurney MW, ... ... Longo VD, et al. SIRT1 is essential for normal cognitive function and synaptic plasticity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 9695-707. PMID 20660252 DOI: 10.1523/JNEUROSCI.0027-10.2010  1
2010 Fabrizio P, Hoon S, Shamalnasab M, Galbani A, Wei M, Giaever G, Nislow C, Longo VD. Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation. Plos Genetics. 6: e1001024. PMID 20657825 DOI: 10.1371/journal.pgen.1001024  1
2010 Finch CE, Morgan TE, Longo VD, de Magalhaes JP. Cell resilience in species life spans: a link to inflammation? Aging Cell. 9: 519-26. PMID 20415721 DOI: 10.1111/j.1474-9726.2010.00578.x  1
2010 Fontana L, Partridge L, Longo VD. Extending healthy life span--from yeast to humans. Science (New York, N.Y.). 328: 321-6. PMID 20395504 DOI: 10.1126/science.1172539  1
2010 Blagosklonny MV, Campisi J, Sinclair DA, Bartke A, Blasco MA, Bonner WM, Bohr VA, Brosh RM, Brunet A, Depinho RA, Donehower LA, Finch CE, Finkel T, Gorospe M, Gudkov AV, ... ... Longo V, et al. Impact papers on aging in 2009. Aging. 2: 111-21. PMID 20351400 DOI: v2/n3/full/100132.html  1
2010 Lee C, Safdie FM, Raffaghello L, Wei M, Madia F, Parrella E, Hwang D, Cohen P, Bianchi G, Longo VD. Reduced levels of IGF-I mediate differential protection of normal and cancer cells in response to fasting and improve chemotherapeutic index. Cancer Research. 70: 1564-72. PMID 20145127 DOI: 10.1158/0008-5472.CAN-09-3228  1
2010 Parrella E, Longo VD. Insulin/IGF-I and related signaling pathways regulate aging in nondividing cells: from yeast to the mammalian brain. Thescientificworldjournal. 10: 161-77. PMID 20098959 DOI: 10.1100/tsw.2010.8  0.32
2010 Ge H, Wei M, Fabrizio P, Hu J, Cheng C, Longo VD, Li LM. Comparative analyses of time-course gene expression profiles of the long-lived sch9Delta mutant. Nucleic Acids Research. 38: 143-58. PMID 19880387 DOI: 10.1093/nar/gkp849  0.36
2010 Fontana L, Partridge L, Longo VD. Dietary restriction: Theory fails to satiate - Response Science. 329: 1015. DOI: 10.1126/science.329.5995.1015  1
2009 Safdie FM, Dorff T, Quinn D, Fontana L, Wei M, Lee C, Cohen P, Longo VD. Fasting and cancer treatment in humans: A case series report. Aging. 1: 988-1007. PMID 20157582  1
2009 Madia F, Wei M, Yuan V, Hu J, Gattazzo C, Pham P, Goodman MF, Longo VD. Oncogene homologue Sch9 promotes age-dependent mutations by a superoxide and Rev1/Polzeta-dependent mechanism. The Journal of Cell Biology. 186: 509-23. PMID 19687253 DOI: 10.1083/jcb.200906011  0.36
2009 Wei M, Fabrizio P, Madia F, Hu J, Ge H, Li LM, Longo VD. Tor1/Sch9-regulated carbon source substitution is as effective as calorie restriction in life span extension. Plos Genetics. 5: e1000467. PMID 19424415 DOI: 10.1371/journal.pgen.1000467  0.36
2008 Parrella E, Longo VD. The chronological life span of Saccharomyces cerevisiae to study mitochondrial dysfunction and disease. Methods (San Diego, Calif.). 46: 256-62. PMID 18930829 DOI: 10.1016/j.ymeth.2008.10.004  0.32
2008 Li Y, Xu W, McBurney MW, Longo VD. SirT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons. Cell Metabolism. 8: 38-48. PMID 18590691 DOI: 10.1016/j.cmet.2008.05.004  0.4
2008 Raffaghello L, Lee C, Safdie FM, Wei M, Madia F, Bianchi G, Longo VD. Starvation-dependent differential stress resistance protects normal but not cancer cells against high-dose chemotherapy. Proceedings of the National Academy of Sciences of the United States of America. 105: 8215-20. PMID 18378900 DOI: 10.1073/pnas.0708100105  1
2008 Wei M, Fabrizio P, Hu J, Ge H, Cheng C, Li L, Longo VD. Life span extension by calorie restriction depends on Rim15 and transcription factors downstream of Ras/PKA, Tor, and Sch9. Plos Genetics. 4: e13. PMID 18225956 DOI: 10.1371/journal.pgen.0040013  0.36
2008 Madia F, Gattazzo C, Wei M, Fabrizio P, Burhans WC, Weinberger M, Galbani A, Smith JR, Nguyen C, Huey S, Comai L, Longo VD. Longevity mutation in SCH9 prevents recombination errors and premature genomic instability in a Werner/Bloom model system. The Journal of Cell Biology. 180: 67-81. PMID 18195102 DOI: 10.1083/jcb.200707154  1
2007 Cheng C, Fabrizio P, Ge H, Wei M, Longo VD, Li LM. Significant and systematic expression differentiation in long-lived yeast strains. Plos One. 2: e1095. PMID 17971858 DOI: 10.1371/journal.pone.0001095  0.36
2005 Skulachev VP, Longo VD. Aging as a mitochondria-mediated atavistic program: can aging be switched off? Annals of the New York Academy of Sciences. 1057: 145-64. PMID 16399892 DOI: 10.1196/annals.1356.009  1
2005 Longo VD, Mitteldorf J, Skulachev VP. Programmed and altruistic ageing. Nature Reviews. Genetics. 6: 866-72. PMID 16304601 DOI: 10.1038/nrg1706  1
2005 Fabrizio P, Gattazzo C, Battistella L, Wei M, Cheng C, McGrew K, Longo VD. Sir2 blocks extreme life-span extension. Cell. 123: 655-67. PMID 16286010 DOI: 10.1016/j.cell.2005.08.042  1
2004 Wallace MA, Liou LL, Martins J, Clement MH, Bailey S, Longo VD, Valentine JS, Gralla EB. Superoxide inhibits 4Fe-4S cluster enzymes involved in amino acid biosynthesis. Cross-compartment protection by CuZn-superoxide dismutase. The Journal of Biological Chemistry. 279: 32055-62. PMID 15166213 DOI: 10.1074/jbc.M403590200  1
2004 Fabrizio P, Pletcher SD, Minois N, Vaupel JW, Longo VD. Chronological aging-independent replicative life span regulation by Msn2/Msn4 and Sod2 in Saccharomyces cerevisiae. Febs Letters. 557: 136-42. PMID 14741356 DOI: 10.1016/S0014-5793(03)01462-5  1
2003 Gendron CM, Minois N, Fabrizio P, Longo VD, Pletcher SD, Vaupel JW. Biodemographic trajectories of age-specific reproliferation from stationary phase in the yeast Saccharomyces cerevisiae seem multiphasic. Mechanisms of Ageing and Development. 124: 1059-63. PMID 14659594 DOI: 10.1016/j.mad.2003.08.003  1
2003 Longo VD, Finch CE. Evolutionary medicine: from dwarf model systems to healthy centenarians? Science (New York, N.Y.). 299: 1342-6. PMID 12610293 DOI: 10.1126/science.1077991  1
2003 Fabrizio P, Liou LL, Moy VN, Diaspro A, Valentine JS, Gralla EB, Longo VD. SOD2 functions downstream of Sch9 to extend longevity in yeast. Genetics. 163: 35-46. PMID 12586694  1
2002 Longo VD, Finch CE. Genetics of aging and diseases: from rare mutations and model systems to disease prevention. Archives of Neurology. 59: 1706-8. PMID 12433254 DOI: 10.1001/archneur.59.11.1706  1
2002 Xie Z, Wei M, Morgan TE, Fabrizio P, Han D, Finch CE, Longo VD. Peroxynitrite mediates neurotoxicity of amyloid beta-peptide1-42- and lipopolysaccharide-activated microglia. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 3484-92. PMID 11978825  1
2001 Fabrizio P, Pozza F, Pletcher SD, Gendron CM, Longo VD. Regulation of longevity and stress resistance by Sch9 in yeast. Science (New York, N.Y.). 292: 288-90. PMID 11292860 DOI: 10.1126/science.1059497  1
2000 Longo VD, Viola KL, Klein WL, Finch CE. Reversible inactivation of superoxide-sensitive aconitase in Abeta1-42-treated neuronal cell lines. Journal of Neurochemistry. 75: 1977-85. PMID 11032887 DOI: 10.1046/j.1471-4159.2000.0751977.x  1
1999 Longo VD, Liou LL, Valentine JS, Gralla EB. Mitochondrial superoxide decreases yeast survival in stationary phase. Archives of Biochemistry and Biophysics. 365: 131-42. PMID 10222047 DOI: 10.1006/abbi.1999.1158  1
1997 Longo VD, Ellerby LM, Bredesen DE, Valentine JS, Gralla EB. Human Bcl-2 reverses survival defects in yeast lacking superoxide dismutase and delays death of wild-type yeast. The Journal of Cell Biology. 137: 1581-8. PMID 9199172 DOI: 10.1083/jcb.137.7.1581  1
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