| Year |
Citation |
Score |
| 2021 |
Rodriguez YA, Kaur S, Nolte E, Zheng Z, Blagg BSJ, Dobrowsky RT. Novologue Therapy Requires Heat Shock Protein 70 and Thioredoxin-Interacting Protein to Improve Mitochondrial Bioenergetics and Decrease Mitophagy in Diabetic Sensory Neurons. Acs Chemical Neuroscience. PMID 34340312 DOI: 10.1021/acschemneuro.1c00340 |
0.311 |
|
| 2018 |
You Z, Zhang Z, Blagg BSJ, Dobrowsky RT. KU-596 decreases mitochondrial superoxide and improves bioenergetics following downregulation of manganese superoxide dismutase in diabetic sensory neurons. Experimental Neurology. PMID 30557564 DOI: 10.1016/J.Expneurol.2018.12.006 |
0.405 |
|
| 2018 |
Zhang Z, You Z, Dobrowsky RT, Blagg BSJ. Synthesis and evaluation of a ring-constrained Hsp90 C-terminal inhibitor that exhibits neuroprotective activity. Bioorganic & Medicinal Chemistry Letters. PMID 29759728 DOI: 10.1016/J.Bmcl.2018.03.071 |
0.352 |
|
| 2017 |
Forsberg LK, Anyika M, You Z, Emery S, McMullen M, Dobrowsky RT, Blagg BSJ. Development of noviomimetics that modulate molecular chaperones and manifest neuroprotective effects. European Journal of Medicinal Chemistry. PMID 29137866 DOI: 10.1016/J.Ejmech.2017.10.038 |
0.344 |
|
| 2017 |
Zhang X, Li C, Fowler SC, Zhang Z, Blagg BSJ, Dobrowsky RT. Targeting Heat Shock Protein 70 to Ameliorate c-Jun Expression and Improve Demyelinating Neuropathy. Acs Chemical Neuroscience. PMID 29120605 DOI: 10.1021/Acschemneuro.7B00377 |
0.629 |
|
| 2016 |
Dobrowsky RT. Targeting the Diabetic Chaperome to Improve Peripheral Neuropathy. Current Diabetes Reports. 16: 71. PMID 27318486 DOI: 10.1007/S11892-016-0769-8 |
0.372 |
|
| 2016 |
Ghosh S, Shinogle HE, Galeva NA, Dobrowsky RT, Blagg BS. Endoplasmic Reticulum Resident Heat Shock Protein 90 (Hsp90) Isoform Glucose-Regulated Protein 94 (Grp94) Regulates Cell Polarity and Cancer Cell Migration by Affecting Intracellular Transport. The Journal of Biological Chemistry. PMID 26872972 DOI: 10.1074/Jbc.M115.688374 |
0.39 |
|
| 2016 |
Anyika M, McMullen M, Forsberg LK, Dobrowsky RT, Blagg BS. Development of Noviomimetics as C-Terminal Hsp90 Inhibitors. Acs Medicinal Chemistry Letters. 7: 67-71. PMID 26819668 DOI: 10.1021/Acsmedchemlett.5B00331 |
0.346 |
|
| 2016 |
Emery SM, Dobrowsky RT. Promoting Neuronal Tolerance of Diabetic Stress: Modulating Molecular Chaperones International Review of Neurobiology. DOI: 10.1016/Bs.Irn.2016.03.001 |
0.412 |
|
| 2015 |
Ma J, Pan P, Anyika M, Blagg BS, Dobrowsky RT. Modulating Molecular Chaperones Improves Mitochondrial Bioenergetics and Decreases the Inflammatory Transcriptome in Diabetic Sensory Neurons. Acs Chemical Neuroscience. PMID 26161583 DOI: 10.1021/Acschemneuro.5B00165 |
0.443 |
|
| 2015 |
Ghosh S, Shinogle HE, Garg G, Vielhauer GA, Holzbeierlein JM, Dobrowsky RT, Blagg BS. Hsp90 C-terminal inhibitors exhibit antimigratory activity by disrupting the Hsp90α/Aha1 complex in PC3-MM2 cells. Acs Chemical Biology. 10: 577-90. PMID 25402753 DOI: 10.1021/Cb5008713 |
0.357 |
|
| 2014 |
Ma J, Farmer KL, Pan P, Urban MJ, Zhao H, Blagg BS, Dobrowsky RT. Heat shock protein 70 is necessary to improve mitochondrial bioenergetics and reverse diabetic sensory neuropathy following KU-32 therapy. The Journal of Pharmacology and Experimental Therapeutics. 348: 281-92. PMID 24263156 DOI: 10.1124/Jpet.113.210435 |
0.38 |
|
| 2013 |
Pan P, Dobrowsky RT. Differential expression of neuregulin-1 isoforms and downregulation of erbin are associated with Erb B2 receptor activation in diabetic peripheral neuropathy. Acta Neuropathologica Communications. 1: 39. PMID 24252174 DOI: 10.1186/2051-5960-1-39 |
0.464 |
|
| 2012 |
Li C, Ma J, Zhao H, Blagg BS, Dobrowsky RT. Induction of heat shock protein 70 (Hsp70) prevents neuregulin-induced demyelination by enhancing the proteasomal clearance of c-Jun. Asn Neuro. 4: e00102. PMID 23240583 DOI: 10.1042/20120047 |
0.62 |
|
| 2012 |
Farmer K, Williams SJ, Novikova L, Ramachandran K, Rawal S, Blagg BS, Dobrowsky R, Stehno-Bittel L. KU-32, a novel drug for diabetic neuropathy, is safe for human islets and improves in vitro insulin secretion and viability. Experimental Diabetes Research. 2012: 671673. PMID 23197975 DOI: 10.1155/2012/671673 |
0.398 |
|
| 2012 |
Farmer KL, Li C, Dobrowsky RT. Diabetic peripheral neuropathy: should a chaperone accompany our therapeutic approach? Pharmacological Reviews. 64: 880-900. PMID 22885705 DOI: 10.1124/Pr.111.005314 |
0.597 |
|
| 2012 |
Kusuma BR, Zhang L, Sundstrom T, Peterson LB, Dobrowsky RT, Blagg BS. Synthesis and evaluation of novologues as C-terminal Hsp90 inhibitors with cytoprotective activity against sensory neuron glucotoxicity. Journal of Medicinal Chemistry. 55: 5797-812. PMID 22702513 DOI: 10.1021/Jm300544C |
0.424 |
|
| 2012 |
Urban MJ, Pan P, Farmer KL, Zhao H, Blagg BS, Dobrowsky RT. Modulating molecular chaperones improves sensory fiber recovery and mitochondrial function in diabetic peripheral neuropathy. Experimental Neurology. 235: 388-96. PMID 22465570 DOI: 10.1016/J.Expneurol.2012.03.005 |
0.415 |
|
| 2012 |
Zhang L, Zhao H, Blagg BS, Dobrowsky RT. C-terminal heat shock protein 90 inhibitor decreases hyperglycemia-induced oxidative stress and improves mitochondrial bioenergetics in sensory neurons. Journal of Proteome Research. 11: 2581-93. PMID 22413817 DOI: 10.1021/Pr300056M |
0.402 |
|
| 2012 |
Urban MJ, Dobrowsky RT, Blagg BS. Heat shock response and insulin-associated neurodegeneration. Trends in Pharmacological Sciences. 33: 129-37. PMID 22172248 DOI: 10.1016/J.Tips.2011.11.001 |
0.377 |
|
| 2011 |
Chowdhury SK, Dobrowsky RT, Fernyhough P. Nutrient excess and altered mitochondrial proteome and function contribute to neurodegeneration in diabetes. Mitochondrion. 11: 845-54. PMID 21742060 DOI: 10.1016/J.Mito.2011.06.007 |
0.396 |
|
| 2011 |
Akude E, Zherebitskaya E, Chowdhury SK, Smith DR, Dobrowsky RT, Fernyhough P. Diminished superoxide generation is associated with respiratory chain dysfunction and changes in the mitochondrial proteome of sensory neurons from diabetic rats. Diabetes. 60: 288-97. PMID 20876714 DOI: 10.2337/Db10-0818 |
0.339 |
|
| 2010 |
Haenchen SD, Utter JA, Bayless AM, Dobrowsky RT, Davido DJ. Role of a cdk5-associated protein, p35, in herpes simplex virus type 1 replication in vivo. Journal of Neurovirology. 16: 405-9. PMID 20839922 DOI: 10.3109/13550284.2010.513030 |
0.312 |
|
| 2010 |
Urban MJ, Li C, Yu C, Lu Y, Krise JM, McIntosh MP, Rajewski RA, Blagg BS, Dobrowsky RT. Inhibiting heat-shock protein 90 reverses sensory hypoalgesia in diabetic mice. Asn Neuro. 2: e00040. PMID 20711301 DOI: 10.1042/An20100015 |
0.622 |
|
| 2010 |
Zhang L, Yu C, Vasquez FE, Galeva N, Onyango I, Swerdlow RH, Dobrowsky RT. Hyperglycemia alters the schwann cell mitochondrial proteome and decreases coupled respiration in the absence of superoxide production. Journal of Proteome Research. 9: 458-71. PMID 19905032 DOI: 10.1021/Pr900818G |
0.377 |
|
| 2010 |
Chowdhury SKR, Akude E, Zherebitskaya E, Smith DR, Dobrowsky RT, Fernyhough P. Abnormalities of mitochondrial physiology and phenotype in sensory neurons in diabetes Biochimica Et Biophysica Acta (Bba) - Bioenergetics. 1797: 76. DOI: 10.1016/J.Bbabio.2010.04.232 |
0.33 |
|
| 2009 |
McGuire JF, Rouen S, Siegfreid E, Wright DE, Dobrowsky RT. Caveolin-1 and altered neuregulin signaling contribute to the pathophysiological progression of diabetic peripheral neuropathy. Diabetes. 58: 2677-86. PMID 19675140 DOI: 10.2337/Db09-0594 |
0.413 |
|
| 2008 |
Yu C, Rouen S, Dobrowsky RT. Hyperglycemia and downregulation of caveolin-1 enhance neuregulin-induced demyelination. Glia. 56: 877-87. PMID 18338795 DOI: 10.1002/Glia.20662 |
0.417 |
|
| 2007 |
Seyb KI, Ansar S, Li G, Bean J, Michaelis ML, Dobrowsky RT. p35/Cyclin-dependent kinase 5 is required for protection against beta-amyloid-induced cell death but not tau phosphorylation by ceramide. Journal of Molecular Neuroscience : Mn. 31: 23-35. PMID 17416967 DOI: 10.1007/Bf02686115 |
0.581 |
|
| 2007 |
Christianson JA, Ryals JM, Johnson MS, Dobrowsky RT, Wright DE. Neurotrophic modulation of myelinated cutaneous innervation and mechanical sensory loss in diabetic mice. Neuroscience. 145: 303-13. PMID 17223273 DOI: 10.1016/J.Neuroscience.2006.11.064 |
0.392 |
|
| 2005 |
Dobrowsky RT, Rouen S, Yu C. Altered neurotrophism in diabetic neuropathy: spelunking the caves of peripheral nerve. The Journal of Pharmacology and Experimental Therapeutics. 313: 485-91. PMID 15608075 DOI: 10.1124/Jpet.104.079921 |
0.485 |
|
| 2003 |
Tan W, Rouen S, Barkus KM, Dremina YS, Hui D, Christianson JA, Wright DE, Yoon SO, Dobrowsky RT. Nerve growth factor blocks the glucose-induced down-regulation of caveolin-1 expression in Schwann cells via p75 neurotrophin receptor signaling. The Journal of Biological Chemistry. 278: 23151-62. PMID 12679365 DOI: 10.1074/Jbc.M212986200 |
0.539 |
|
| 2003 |
Li G, Faibushevich A, Turunen BJ, Yoon SO, Georg G, Michaelis ML, Dobrowsky RT. Stabilization of the cyclin-dependent kinase 5 activator, p35, by paclitaxel decreases beta-amyloid toxicity in cortical neurons. Journal of Neurochemistry. 84: 347-62. PMID 12558997 DOI: 10.1046/J.1471-4159.2003.01526.X |
0.568 |
|
| 2003 |
Chavez JA, Knotts TA, Wang LP, Li G, Dobrowsky RT, Florant GL, Summers SA. A role for ceramide, but not diacylglycerol, in the antagonism of insulin signal transduction by saturated fatty acids. The Journal of Biological Chemistry. 278: 10297-303. PMID 12525490 DOI: 10.1074/jbc.M212307200 |
0.528 |
|
| 2002 |
Michaelis ML, Dobrowsky RT, Li G. Tau neurofibrillary pathology and microtubule stability. Journal of Molecular Neuroscience : Mn. 19: 289-93. PMID 12540054 DOI: 10.1385/Jmn:19:3:289 |
0.559 |
|
| 2002 |
Sprott KM, Chumley MJ, Hanson JM, Dobrowsky RT. Decreased activity and enhanced nuclear export of CCAAT-enhancer-binding protein beta during inhibition of adipogenesis by ceramide. The Biochemical Journal. 365: 181-91. PMID 12071851 DOI: 10.1042/Bj20020215 |
0.738 |
|
| 2001 |
Grigsby RJ, Dobrowsky RT. Inhibition of ceramide production reverses TNF-induced insulin resistance Biochemical and Biophysical Research Communications. 287: 1121-1124. PMID 11587538 DOI: 10.1006/Bbrc.2001.5694 |
0.364 |
|
| 2001 |
Bilderback TR, Gazula VR, Dobrowsky RT. Phosphoinositide 3-kinase regulates crosstalk between Trk A tyrosine kinase and p75NTR-dependent sphingolipid signaling pathways Journal of Neurochemistry. 76: 1540-1551. PMID 11238738 DOI: 10.1046/J.1471-4159.2001.00171.X |
0.372 |
|
| 2000 |
Dobrowsky RT, Carter BD. p75 Neurotrophin receptor signaling: Mechanisms for neurotrophic modulation of cell stress? Journal of Neuroscience Research. 61: 237-243. PMID 10900070 DOI: 10.1002/1097-4547(20000801)61:3<237::Aid-Jnr1>3.0.Co;2-M |
0.351 |
|
| 2000 |
Dobrowsky RT. Sphingolipid signalling domains. Floating on rafts or buried in caves? Cellular Signalling. 12: 81-90. PMID 10679576 DOI: 10.1016/S0898-6568(99)00072-8 |
0.323 |
|
| 1999 |
Bilderback TR, Gazula VR, Lisanti MP, Dobrowsky RT. Caveolin interacts with Trk A and p75(NTR) and regulates neurotrophin signaling pathways Journal of Biological Chemistry. 274: 257-263. PMID 9867838 DOI: 10.1074/Jbc.274.1.257 |
0.35 |
|
| 1998 |
Dobrowsky RT, Carter BD. Coupling of the p75 neurotrophin receptor to sphingolipid signaling Annals of the New York Academy of Sciences. 845: 32-45. PMID 9668341 DOI: 10.1111/J.1749-6632.1998.Tb09660.X |
0.414 |
|
| 1997 |
Bilderback TR, Grigsby RJ, Dobrowsky RT. Association of p75(NTR) with caveolin and localization of neurotrophin- induced sphingomyelin hydrolysis to caveolae Journal of Biological Chemistry. 272: 10922-10927. PMID 9099750 DOI: 10.1074/Jbc.272.16.10922 |
0.334 |
|
| 1996 |
Casaccia-Bonnefil P, Carter BD, Dobrowsky RT, Chao MV. Death of oligodendrocytes mediated by the interaction of nerve growth factor with its receptor p75. Nature. 383: 716-9. PMID 8878481 DOI: 10.1038/383716A0 |
0.425 |
|
| 1995 |
Dobrowsky RT, Jenkins GM, Hannun YA. Neurotrophins induce sphingomyelin hydrolysis. Modulation by co-expression of p75NTR with Trk receptors. The Journal of Biological Chemistry. 270: 22135-42. PMID 7673191 DOI: 10.1074/Jbc.270.38.22135 |
0.414 |
|
| 1994 |
Dobrowsky RT, Werner MH, Castellino AM, Chao MV, Hannun YA. Activation of the sphingomyelin cycle through the low-affinity neurotrophin receptor. Science (New York, N.Y.). 265: 1596-9. PMID 8079174 DOI: 10.1126/Science.8079174 |
0.389 |
|
| 1994 |
Wolff RA, Dobrowsky RT, Bielawska A, Obeid LM, Hannun YA. Role of ceramide-activated protein phosphatase in ceramide-mediated signal transduction Journal of Biological Chemistry. 269: 19605-19609. PMID 8034729 |
0.3 |
|
| 1990 |
Khan WA, Dobrowsky R, el Touny S, Hannun YA. Protein kinase C and platelet inhibition by D-erythro-sphingosine: comparison with N,N-dimethylsphingosine and commercial preparation. Biochemical and Biophysical Research Communications. 172: 683-91. PMID 2241961 DOI: 10.1016/0006-291X(90)90728-6 |
0.332 |
|
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