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Annissa J. Huhn, Ph.D. - Publications

Affiliations: 
2012 Biochemistry and Molecular Biology Wake Forest University, Winston-Salem, NC, United States 
Area:
Biochemistry
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14 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Wilson JE, Patel G, Patel C, Brucelle F, Huhn A, Gardberg AS, Poy F, Cantone N, Bommi-Reddy A, Sims RJ, Cummings RT, Levell JR. Discovery of CPI-1612: A Potent, Selective, and Orally Bioavailable EP300/CBP Histone Acetyltransferase Inhibitor. Acs Medicinal Chemistry Letters. 11: 1324-1329. PMID 32551019 DOI: 10.1021/Acsmedchemlett.0C00155  0.389
2020 Harvey EP, Hauseman ZJ, Cohen DT, Rettenmaier TJ, Lee S, Huhn AJ, Wales TE, Seo HS, Luccarelli J, Newman CE, Guerra RM, Bird GH, Dhe-Paganon S, Engen JR, Wells JA, et al. Identification of a Covalent Molecular Inhibitor of Anti-apoptotic BFL-1 by Disulfide Tethering. Cell Chemical Biology. PMID 32413285 DOI: 10.1016/J.Chembiol.2020.04.004  0.453
2020 Wilson JE, Huhn A, Gardberg AS, Poy F, Brucelle F, Vivat V, Patel G, Patel C, Cummings R, Sims R, Levell J, Audia JE, Bommi-Reddy A, Cantone N. Early Drug Discovery Efforts Towards the Identification of EP300/CBP Histone Acetyltransferase (HAT) Inhibitors. Chemmedchem. PMID 32181984 DOI: 10.1002/Cmdc.202000007  0.367
2019 Gardberg AS, Huhn AJ, Cummings R, Bommi-Reddy A, Poy F, Setser J, Vivat V, Brucelle F, Wilson J. Make the right measurement: Discovery of an allosteric inhibition site for p300-HAT. Structural Dynamics (Melville, N.Y.). 6: 054702. PMID 31649965 DOI: 10.1063/1.5119336  0.412
2019 Bommi-Reddy A, Wilson J, Huhn AJ, Terzo E, Poy F, Park S, Steinbaugh MJ, Bryant BM, Conery AR, Cummings R, Levell J, Sims RJ. Abstract 4722: Efficacy of a novel EP300/CBP histone acetyltransferase inhibitor in hormone responsive breast cancer Cancer Research. 79: 4722-4722. DOI: 10.1158/1538-7445.Am2019-4722  0.36
2017 Guerra RM, Huhn AJ, Harvey EP, Bird GH, Walensky LD. Abstract 2024: Reactivating apoptosis in BFL-1/A1 driven cancer with cysteine-reactive stapled peptide inhibitors Cancer Research. 77: 2024-2024. DOI: 10.1158/1538-7445.Am2017-2024  0.349
2016 Huhn AJ, Guerra RM, Harvey EP, Bird GH, Walensky LD. Selective Covalent Targeting of Anti-Apoptotic BFL-1 by Cysteine-Reactive Stapled Peptide Inhibitors. Cell Chemical Biology. PMID 27617850 DOI: 10.1016/J.Chembiol.2016.07.022  0.501
2016 Lee S, Wales TE, Escudero S, Cohen DT, Luccarelli J, Gallagher CG, Cohen NA, Huhn AJ, Bird GH, Engen JR, Walensky LD. Allosteric inhibition of antiapoptotic MCL-1. Nature Structural & Molecular Biology. PMID 27159560 DOI: 10.1038/Nsmb.3223  0.503
2016 Huhn AJ, Guerra RM, Bird GH, Walensky LD. Abstract 3845: A novel selectivity determinant informs the development of next-generation stapled peptide inhibitors of anti-apoptotic BFL-1/A1 Cancer Research. 76: 3845-3845. DOI: 10.1158/1538-7445.Am2016-3845  0.421
2016 Lee S, Wales TE, Gallagher C, Cohen DT, Escudero S, Luccarelli J, Huhn AJ, Cohen NA, Bird GH, Engen JR, Walensky LD. Abstract 3553: A novel allosteric mechanism for molecular inhibition of anti-apoptotic MCL-1 Cancer Research. 76: 3553-3553. DOI: 10.1158/1538-7445.Am2016-3553  0.511
2015 Edwards AL, Wachter F, Lammert M, Huhn AJ, Luccarelli J, Bird GH, Walensky LD. Cellular Uptake and Ultrastructural Localization Underlie the Pro-apoptotic Activity of a Hydrocarbon-stapled BIM BH3 Peptide. Acs Chemical Biology. PMID 26151238 DOI: 10.1021/Acschembio.5B00214  0.304
2014 Huhn AJ, Parsonage D, Horita DA, Torti FM, Torti SV, Hollis T. The high-molecular-weight kininogen domain 5 is an intrinsically unstructured protein and its interaction with ferritin is metal mediated. Protein Science : a Publication of the Protein Society. 23: 1013-22. PMID 24810540 DOI: 10.1002/Pro.2486  0.507
2012 Tesfay L, Huhn AJ, Hatcher H, Torti FM, Torti SV. Ferritin blocks inhibitory effects of two-chain high molecular weight kininogen (HKa) on adhesion and survival signaling in endothelial cells. Plos One. 7: e40030. PMID 22768328 DOI: 10.1371/Journal.Pone.0040030  0.421
2010 Huhn AJ, Parsonage D, Torti SV, Hollis T. Abstract 1285: The effects of the HK5-ferritin interaction and iron on tumor angiogenesis Cancer Research. 70: 1285-1285. DOI: 10.1158/1538-7445.Am10-1285  0.528
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