Trevor Sharp - Publications

Affiliations: 
Pharmacology University of Oxford, Oxford, United Kingdom 
Area:
Depression, Schizophrenia, 5HT Signalling

113 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Lima J, Sharp T, Bannerman DM, McHugh SB. Enhanced discriminative aversive learning and amygdala responsivity in 5-HT transporter mutant mice. Translational Psychiatry. 9: 139. PMID 30996249 DOI: 10.1038/s41398-019-0476-8  0.44
2018 Barkus C, Ferland JN, Adams WK, Churchill GC, Cowen PJ, Bannerman DM, Rogers RD, Winstanley CA, Sharp T. The putative lithium-mimetic ebselen reduces impulsivity in rodent models. Journal of Psychopharmacology (Oxford, England). 269881118784876. PMID 29986609 DOI: 10.1177/0269881118784876  0.44
2017 Sengupta A, Bocchio M, Bannerman DM, Sharp T, Capogna M. Control of amygdala circuits by 5-HT neurons via 5-HT and glutamate co-transmission. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 28087766 DOI: 10.1523/JNEUROSCI.2238-16.2016  0.44
2016 Barkus C, Korn C, Stumpenhorst K, Laatikainen LM, Ballard D, Lee S, Sharp T, Harrison PJ, Bannerman DM, Weinberger DR, Chen J, Tunbridge EM. Genotype-Dependent Effects of COMT Inhibition on Cognitive Function in a Highly-Specific, Novel Mouse Model of Altered COMT Activity. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 27388330 DOI: 10.1038/npp.2016.119  0.76
2016 Bocchio M, McHugh SB, Bannerman DM, Sharp T, Capogna M. Serotonin, Amygdala and Fear: Assembling the Puzzle. Frontiers in Neural Circuits. 10: 24. PMID 27092057 DOI: 10.3389/fncir.2016.00024  0.44
2016 Pritchett D, Taylor AM, Barkus C, Engle SJ, Brandon NJ, Sharp T, Foster RG, Harrison PJ, Peirson SN, Bannerman DM. Searching for cognitive enhancement in the Morris watermaze: Better and worse performance in D-amino acid oxidase knockout (Dao(-/-) ) mice. The European Journal of Neuroscience. PMID 26833794 DOI: 10.1111/ejn.13192  0.76
2015 Hescham S, Jahanshahi A, Schweimer JV, Mitchell SN, Carter G, Blokland A, Sharp T, Temel Y. Fornix deep brain stimulation enhances acetylcholine levels in the hippocampus. Brain Structure & Function. PMID 26597361 DOI: 10.1007/s00429-015-1144-2  0.72
2015 Spain A, Howarth C, Khrapitchev AA, Sharp T, Sibson NR, Martin C. Neurovascular and neuroimaging effects of the hallucinogenic serotonin receptor agonist psilocin in the rat brain. Neuropharmacology. 99: 210-220. PMID 26192543 DOI: 10.1016/j.neuropharm.2015.07.018  0.4
2015 Couch Y, Xie Q, Lundberg L, Sharp T, Anthony DC. A Model of Post-Infection Fatigue Is Associated with Increased TNF and 5-HT2A Receptor Expression in Mice. Plos One. 10: e0130643. PMID 26147001 DOI: 10.1371/journal.pone.0130643  0.72
2015 Bocchio M, Fucsina G, Oikonomidis L, McHugh SB, Bannerman DM, Sharp T, Capogna M. Increased Serotonin Transporter Expression Reduces Fear and Recruitment of Parvalbumin Interneurons of the Amygdala. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 26052039 DOI: 10.1038/npp.2015.157  0.44
2015 Brouard JT, Schweimer JV, Houlton R, Burnham KE, Quérée P, Sharp T. Pharmacological Evidence for 5-HT6 Receptor Modulation of 5-HT Neuron Firing in Vivo. Acs Chemical Neuroscience. 6: 1241-7. PMID 25837696 DOI: 10.1021/acschemneuro.5b00061  0.72
2015 McHugh SB, Barkus C, Lima J, Glover LR, Sharp T, Bannerman DM. SERT and uncertainty: serotonin transporter expression influences information processing biases for ambiguous aversive cues in mice. Genes, Brain, and Behavior. 14: 330-6. PMID 25824641 DOI: 10.1111/gbb.12215  0.72
2015 Pritchett D, Hasan S, Tam SK, Engle SJ, Brandon NJ, Sharp T, Foster RG, Harrison PJ, Bannerman DM, Peirson SN. d-amino acid oxidase knockout (Dao(-/-) ) mice show enhanced short-term memory performance and heightened anxiety, but no sleep or circadian rhythm disruption. The European Journal of Neuroscience. 41: 1167-79. PMID 25816902 DOI: 10.1111/ejn.12880  0.72
2015 Bocchio M, Fucsina G, Oikonomidis L, McHugh SB, Bannerman DM, Sharp T, Capogna M. Increased Serotonin Transporter Expression Reduces Fear and Recruitment of Parvalbumin Interneurons of the Amygdala Neuropsychopharmacology. DOI: 10.1038/npp.2015.157  0.72
2015 Spain A, Howarth C, Khrapitchev AA, Sharp T, Sibson NR, Martin C. Neurovascular and neuroimaging effects of the hallucinogenic serotonin receptor agonist psilocin in the rat brain Neuropharmacology. 99: 210-220. DOI: 10.1016/j.neuropharm.2015.07.018  0.72
2014 Couch Y, Martin CJ, Howarth C, Raley J, Khrapitchev AA, Stratford M, Sharp T, Sibson NR, Anthony DC. Corrigendum to "Systemic inflammation alters central 5-HT function as determined by pharmacological MRI" [Neuroimage 75 (2013) 177-186]. Neuroimage. 94: 413. PMID 28843644 DOI: 10.1016/j.neuroimage.2014.03.021  0.4
2014 Line SJ, Barkus C, Rawlings N, Jennings K, McHugh S, Sharp T, Bannerman DM. Reduced sensitivity to both positive and negative reinforcement in mice over-expressing the 5-hydroxytryptamine transporter. The European Journal of Neuroscience. 40: 3735-45. PMID 25283165 DOI: 10.1111/ejn.12744  0.72
2014 Schweimer JV, Coullon GS, Betts JF, Burnet PW, Engle SJ, Brandon NJ, Harrison PJ, Sharp T. Increased burst-firing of ventral tegmental area dopaminergic neurons in D-amino acid oxidase knockout mice in vivo. The European Journal of Neuroscience. 40: 2999-3009. PMID 25040393 DOI: 10.1111/ejn.12667  0.72
2014 Betts JF, Schweimer JV, Burnham KE, Burnet PW, Sharp T, Harrison PJ. D-amino acid oxidase is expressed in the ventral tegmental area and modulates cortical dopamine. Frontiers in Synaptic Neuroscience. 6: 11. PMID 24822045 DOI: 10.3389/fnsyn.2014.00011  0.72
2014 Barkus C, Line SJ, Huber A, Capitao L, Lima J, Jennings K, Lowry J, Sharp T, Bannerman DM, McHugh SB. Variation in serotonin transporter expression modulates fear-evoked hemodynamic responses and theta-frequency neuronal oscillations in the amygdala. Biological Psychiatry. 75: 901-8. PMID 24120093 DOI: 10.1016/j.biopsych.2013.09.003  0.72
2014 Couch Y, Martin CJ, Howarth C, Raley J, Khrapitchev AA, Stratford M, Sharp T, Sibson NR, Anthony DC. Corrigendum to "Systemic inflammation alters central 5-HT function as determined by pharmacological MRI" [Neuroimage 75 (2013) 177-186] Neuroimage. 94: 413. DOI: 10.1016/j.neuroimage.2014.03.021  0.72
2013 Le Masurier M, Zetterström T, Cowen P, Sharp T. Tyrosine-free amino acid mixtures reduce physiologically-evoked release of dopamine in a selective and activity-dependent manner. Journal of Psychopharmacology (Oxford, England). 28: 561-569. PMID 24108408 DOI: 10.1177/0269881113507642  0.72
2013 Lane TA, Boerner T, Bannerman DM, Kew JN, Tunbridge EM, Sharp T, Harrison PJ. Decreased striatal dopamine in group II metabotropic glutamate receptor (mGlu2/mGlu3) double knockout mice. Bmc Neuroscience. 14: 102. PMID 24053122 DOI: 10.1186/1471-2202-14-102  0.72
2013 Laatikainen LM, Sharp T, Harrison PJ, Tunbridge EM. Sexually dimorphic effects of catechol-O-methyltransferase (COMT) inhibition on dopamine metabolism in multiple brain regions. Plos One. 8: e61839. PMID 23613951 DOI: 10.1371/journal.pone.0061839  0.72
2013 Couch Y, Martin CJ, Howarth C, Raley J, Khrapitchev AA, Stratford M, Sharp T, Sibson NR, Anthony DC. Systemic inflammation alters central 5-HT function as determined by pharmacological MRI. Neuroimage. 75: 177-86. PMID 23473937 DOI: 10.1016/j.neuroimage.2013.02.046  0.72
2013 Singh N, Halliday AC, Thomas JM, Kuznetsova OV, Baldwin R, Woon EC, Aley PK, Antoniadou I, Sharp T, Vasudevan SR, Churchill GC. A safe lithium mimetic for bipolar disorder. Nature Communications. 4: 1332. PMID 23299882 DOI: 10.1038/ncomms2320  0.72
2013 Tan SK, Hartung H, Schievink S, Sharp T, Temel Y. High-frequency stimulation of the substantia nigra induces serotonin-dependent depression-like behavior in animal models. Biological Psychiatry. 73: e1-3. PMID 22939751 DOI: 10.1016/j.biopsych.2012.07.032  0.72
2013 Sharp T. Molecular and cellular mechanisms of antidepressant action. Current Topics in Behavioral Neurosciences. 14: 309-25. PMID 22865463 DOI: 10.1007/7854_2012_216  0.72
2013 Cowen PJ, Sharp T, Lau JYF. Behavioral Neurobiology of Depression and Its Treatment Current Topics in Behavioral Neurosciences. 14. DOI: 10.1007/978-3-642-35425-0  0.72
2013 Cowen PJ, Sharp T, Lau JYF. Preface Current Topics in Behavioral Neurosciences. 14: v-viii.  0.72
2012 Serres F, Rodriguez M, Rivet JM, Galizzi JP, Lockhart B, Sharp T, Millan MJ. Blockade of α2-adrenoceptors induces Arc gene expression in rat brain in a glutamate receptor-dependent manner: a combined qPCR, in situ hybridisation and immunocytochemistry study. Neuropharmacology. 63: 992-1001. PMID 22828637 DOI: 10.1016/j.neuropharm.2012.06.068  0.72
2012 Laatikainen LM, Sharp T, Bannerman DM, Harrison PJ, Tunbridge EM. Modulation of hippocampal dopamine metabolism and hippocampal-dependent cognitive function by catechol-O-methyltransferase inhibition. Journal of Psychopharmacology (Oxford, England). 26: 1561-8. PMID 22815336 DOI: 10.1177/0269881112454228  0.72
2012 Barkus C, Dawson LA, Sharp T, Bannerman DM. GluN1 hypomorph mice exhibit wide-ranging behavioral alterations. Genes, Brain, and Behavior. 11: 342-51. PMID 22300668 DOI: 10.1111/j.1601-183X.2012.00767.x  0.72
2012 Dekeyne A, Brocco M, Loiseau F, Gobert A, Rivet JM, Di Cara B, Cremers TI, Flik G, Fone KC, Watson DJ, Papp M, Sharp T, Serres F, Cespuglio R, Olivier B, et al. S32212, a novel serotonin type 2C receptor inverse agonist/α2-adrenoceptor antagonist and potential antidepressant: II. A behavioral, neurochemical, and electrophysiological characterization. The Journal of Pharmacology and Experimental Therapeutics. 340: 765-80. PMID 22178753 DOI: 10.1124/jpet.111.187534  0.72
2012 Hafizi S, Serres F, Pei Q, Totterdell S, Sharp T. Evidence for the differential co-localization of neurokinin-1 receptors with 5-HT receptor subtypes in rat forebrain. Journal of Psychopharmacology (Oxford, England). 26: 505-15. PMID 22057017 DOI: 10.1177/0269881111425969  0.72
2012 Tan SK, Hartung H, Visser-Vandewalle V, Steinbusch HW, Temel Y, Sharp T. A combined in vivo neurochemical and electrophysiological analysis of the effect of high-frequency stimulation of the subthalamic nucleus on 5-HT transmission. Experimental Neurology. 233: 145-53. PMID 21925498 DOI: 10.1016/j.expneurol.2011.08.027  0.72
2012 Harrison PJ, Pritchett D, Stumpenhorst K, Betts JF, Nissen W, Schweimer J, Lane T, Burnet PW, Lamsa KP, Sharp T, Bannerman DM, Tunbridge EM. Genetic mouse models relevant to schizophrenia: taking stock and looking forward. Neuropharmacology. 62: 1164-7. PMID 21864547 DOI: 10.1016/j.neuropharm.2011.08.009  0.72
2012 Jennings KA, Licht CL, Bruce A, Lesch KP, Knudsen GM, Sharp T. Genetic variation in 5-hydroxytryptamine transporter expression causes adaptive changes in 5-HTâ‚„ receptor levels. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 15: 1099-107. PMID 21846421 DOI: 10.1017/S1461145711001258  0.72
2012 Serres F, Millan MJ, Sharp T. Molecular adaptation to chronic antidepressant treatment: evidence for a more rapid response to the novel α₂-adrenoceptor antagonist/5-HT-noradrenaline reuptake inhibitor (SNRI), S35966, compared to the SNRI, venlafaxine. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 15: 617-29. PMID 21733241 DOI: 10.1017/S1461145711000733  0.72
2012 Tan SKH, Hartung H, Visser-Vandewalle1 V, Sharp T, Temel Y. Psychiatric aspects of parkinson’s disease in animal models of deep brain stimulation of the subthalamic nucleus Deep Brain Stimulation: a New Frontier in Psychiatry. 175-182. DOI: 10.1007/978-3-642-30991-5_16  0.72
2011 Schweimer JV, Mallet N, Sharp T, Ungless MA. Spike-timing relationship of neurochemically-identified dorsal raphe neurons during cortical slow oscillations. Neuroscience. 196: 115-23. PMID 21925244 DOI: 10.1016/j.neuroscience.2011.08.072  0.72
2011 Tan SK, Janssen ML, Jahanshahi A, Chouliaras L, Visser-Vandewalle V, Lim LW, Steinbusch HW, Sharp T, Temel Y. High frequency stimulation of the subthalamic nucleus increases c-fos immunoreactivity in the dorsal raphe nucleus and afferent brain regions. Journal of Psychiatric Research. 45: 1307-15. PMID 21641003 DOI: 10.1016/j.jpsychires.2011.04.011  0.72
2011 Hartung H, Tan SK, Steinbusch HM, Temel Y, Sharp T. High-frequency stimulation of the subthalamic nucleus inhibits the firing of juxtacellular labelled 5-HT-containing neurones. Neuroscience. 186: 135-45. PMID 21515342 DOI: 10.1016/j.neuroscience.2011.04.004  0.72
2011 Sharp T, Cowen PJ. 5-HT and depression: is the glass half-full? Current Opinion in Pharmacology. 11: 45-51. PMID 21377932 DOI: 10.1016/j.coph.2011.02.003  0.72
2011 Tan SK, Hartung H, Sharp T, Temel Y. Serotonin-dependent depression in Parkinson's disease: a role for the subthalamic nucleus? Neuropharmacology. 61: 387-99. PMID 21251918 DOI: 10.1016/j.neuropharm.2011.01.006  0.72
2011 Fabre V, Massart R, Rachalski A, Jennings K, Brass A, Sharp T, Lesch KP, Lanfumey L, Hamon M. Differential gene expression in mutant mice overexpressing or deficient in the serotonin transporter: a focus on urocortin 1. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 21: 33-44. PMID 21075611 DOI: 10.1016/j.euroneuro.2010.10.004  0.72
2011 Hoyle D, Juhasz G, Aso E, Chase D, del Rio J, Fabre V, Hamon M, Lanfumey L, Lesch KP, Maldonado R, Serra MA, Sharp T, Tordera R, Toro C, Deakin JF. Shared changes in gene expression in frontal cortex of four genetically modified mouse models of depression. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 21: 3-10. PMID 21030216 DOI: 10.1016/j.euroneuro.2010.09.011  0.72
2011 Line SJ, Barkus C, Coyle C, Jennings KA, Deacon RM, Lesch KP, Sharp T, Bannerman DM. Opposing alterations in anxiety and species-typical behaviours in serotonin transporter overexpressor and knockout mice. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 21: 108-16. PMID 20863670 DOI: 10.1016/j.euroneuro.2010.08.005  0.72
2011 Kanarik M, Alttoa A, Matrov D, Kõiv K, Sharp T, Panksepp J, Harro J. Brain responses to chronic social defeat stress: effects on regional oxidative metabolism as a function of a hedonic trait, and gene expression in susceptible and resilient rats. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 21: 92-107. PMID 20656462 DOI: 10.1016/j.euroneuro.2010.06.015  0.72
2010 Jennings KA, Lesch KP, Sharp T, Cragg SJ. Non-linear relationship between 5-HT transporter gene expression and frequency sensitivity of 5-HT signals. Journal of Neurochemistry. 115: 965-73. PMID 20854367 DOI: 10.1111/j.1471-4159.2010.07001.x  0.72
2010 Burnham KE, Bannerman DM, Dawson LA, Southam E, Sharp T, Baxter MG. Fos expression in the brains of rats performing an attentional set-shifting task. Neuroscience. 171: 485-95. PMID 20849932 DOI: 10.1016/j.neuroscience.2010.09.008  0.72
2010 Fitzgerald PJ, Barkus C, Feyder M, Wiedholz LM, Chen YC, Karlsson RM, Machado-Vieira R, Graybeal C, Sharp T, Zarate C, Harvey-White J, Du J, Sprengel R, Gass P, Bannerman D, et al. Does gene deletion of AMPA GluA1 phenocopy features of schizoaffective disorder? Neurobiology of Disease. 40: 608-21. PMID 20699120 DOI: 10.1016/j.nbd.2010.08.005  0.72
2010 Sesia T, Bulthuis V, Tan S, Lim LW, Vlamings R, Blokland A, Steinbusch HW, Sharp T, Visser-Vandewalle V, Temel Y. Deep brain stimulation of the nucleus accumbens shell increases impulsive behavior and tissue levels of dopamine and serotonin. Experimental Neurology. 225: 302-9. PMID 20615406 DOI: 10.1016/j.expneurol.2010.06.022  0.72
2010 Elizalde N, Pastor PM, Garcia-García AL, Serres F, Venzala E, Huarte J, Ramírez MJ, Del Rio J, Sharp T, Tordera RM. Regulation of markers of synaptic function in mouse models of depression: chronic mild stress and decreased expression of VGLUT1. Journal of Neurochemistry. 114: 1302-14. PMID 20550627 DOI: 10.1111/j.1471-4159.2010.06854.x  0.72
2010 Licht CL, Knudsen GM, Sharp T. Effects of the 5-HT(4) receptor agonist RS67333 and paroxetine on hippocampal extracellular 5-HT levels. Neuroscience Letters. 476: 58-61. PMID 20381585 DOI: 10.1016/j.neulet.2010.04.002  0.72
2010 Burnham KE, Baxter MG, Bainton JR, Southam E, Dawson LA, Bannerman DM, Sharp T. Activation of 5-HT(6) receptors facilitates attentional set shifting. Psychopharmacology. 208: 13-21. PMID 19902184 DOI: 10.1007/s00213-009-1701-6  0.72
2009 Quérée P, Peters S, Sharp T. Further pharmacological characterization of 5-HT(2C) receptor agonist-induced inhibition of 5-HT neuronal activity in the dorsal raphe nucleus in vivo. British Journal of Pharmacology. 158: 1477-85. PMID 19845681 DOI: 10.1111/j.1476-5381.2009.00406.x  0.72
2009 Temel Y, Tan S, Visser-Vandewalle V, Sharp T. Parkinson's disease, DBS and suicide: a role for serotonin? Brain : a Journal of Neurology. 132: e126; author reply e. PMID 19553275 DOI: 10.1093/brain/awp150  0.72
2009 Walton ME, Groves J, Jennings KA, Croxson PL, Sharp T, Rushworth MF, Bannerman DM. Comparing the role of the anterior cingulate cortex and 6-hydroxydopamine nucleus accumbens lesions on operant effort-based decision making. The European Journal of Neuroscience. 29: 1678-91. PMID 19385990 DOI: 10.1111/j.1460-9568.2009.06726.x  0.72
2009 Preece MA, Taylor MJ, Raley J, Blamire A, Sharp T, Sibson NR. Evidence that increased 5-HT release evokes region-specific effects on blood-oxygenation level-dependent functional magnetic resonance imaging responses in the rat brain. Neuroscience. 159: 751-9. PMID 19174180 DOI: 10.1016/j.neuroscience.2008.12.032  0.72
2008 Kaya AH, Vlamings R, Tan S, Lim LW, Magill PJ, Steinbusch HW, Visser-Vandewalle V, Sharp T, Temel Y. Increased electrical and metabolic activity in the dorsal raphe nucleus of Parkinsonian rats. Brain Research. 1221: 93-7. PMID 18565496 DOI: 10.1016/j.brainres.2008.05.019  0.72
2008 Pringle A, Jennings KA, Line S, Bannerman DM, Higgs S, Sharp T. Mice overexpressing the 5-hydroxytryptamine transporter show no alterations in feeding behaviour and increased non-feeding responses to fenfluramine. Psychopharmacology. 200: 291-300. PMID 18560807 DOI: 10.1007/s00213-008-1206-8  0.44
2008 Dekeyne A, Mannoury la Cour C, Gobert A, Brocco M, Lejeune F, Serres F, Sharp T, Daszuta A, Soumier A, Papp M, Rivet JM, Flik G, Cremers TI, Muller O, Lavielle G, et al. S32006, a novel 5-HT2C receptor antagonist displaying broad-based antidepressant and anxiolytic properties in rodent models. Psychopharmacology. 199: 549-68. PMID 18523738 DOI: 10.1007/s00213-008-1177-9  0.72
2007 Sharp T, Boothman L, Raley J, Quérée P. Important messages in the 'post': recent discoveries in 5-HT neurone feedback control. Trends in Pharmacological Sciences. 28: 629-36. PMID 17996955 DOI: 10.1016/j.tips.2007.10.009  0.72
2007 Temel Y, Boothman LJ, Blokland A, Magill PJ, Steinbusch HW, Visser-Vandewalle V, Sharp T. Inhibition of 5-HT neuron activity and induction of depressive-like behavior by high-frequency stimulation of the subthalamic nucleus. Proceedings of the National Academy of Sciences of the United States of America. 104: 17087-92. PMID 17942692 DOI: 10.1073/pnas.0704144104  0.72
2007 Preece MA, Sibson NR, Raley JM, Blamire A, Styles P, Sharp T. Region-specific effects of a tyrosine-free amino acid mixture on amphetamine-induced changes in BOLD fMRI signal in the rat brain. Synapse (New York, N.Y.). 61: 925-32. PMID 17701967 DOI: 10.1002/syn.20442  0.72
2007 Hughes ZA, Starr KR, Scott CM, Newson MJ, Sharp T, Watson JM, Hagan JJ, Dawson LA. Simultaneous blockade of 5-HT1A/B receptors and 5-HT transporters results in acute increases in extracellular 5-HT in both rats and guinea pigs: in vivo characterization of the novel 5-HT1A/B receptor antagonist/5-HT transport inhibitor SB-649915-B. Psychopharmacology. 192: 121-33. PMID 17265079 DOI: 10.1007/s00213-006-0691-x  0.72
2007 Stark AD, Jordan S, Allers KA, Bertekap RL, Chen R, Mistry Kannan T, Molski TF, Yocca FD, Sharp T, Kikuchi T, Burris KD. Interaction of the novel antipsychotic aripiprazole with 5-HT1A and 5-HT 2A receptors: functional receptor-binding and in vivo electrophysiological studies. Psychopharmacology. 190: 373-82. PMID 17242925 DOI: 10.1007/s00213-006-0621-y  0.72
2007 Hajós M, Allers KA, Jennings K, Sharp T, Charette G, Sík A, Kocsis B. Neurochemical identification of stereotypic burst-firing neurons in the rat dorsal raphe nucleus using juxtacellular labelling methods. The European Journal of Neuroscience. 25: 119-26. PMID 17241273 DOI: 10.1111/j.1460-9568.2006.05276.x  0.72
2006 Boothman L, Raley J, Denk F, Hirani E, Sharp T. In vivo evidence that 5-HT(2C) receptors inhibit 5-HT neuronal activity via a GABAergic mechanism. British Journal of Pharmacology. 149: 861-9. PMID 17043669 DOI: 10.1038/sj.bjp.0706935  0.4
2006 Jennings KA, Loder MK, Sheward WJ, Pei Q, Deacon RM, Benson MA, Olverman HJ, Hastie ND, Harmar AJ, Shen S, Sharp T. Increased expression of the 5-HT transporter confers a low-anxiety phenotype linked to decreased 5-HT transmission. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 8955-64. PMID 16943551 DOI: 10.1523/JNEUROSCI.5356-05.2006  0.72
2006 Boothman LJ, Mitchell SN, Sharp T. Investigation of the SSRI augmentation properties of 5-HT(2) receptor antagonists using in vivo microdialysis. Neuropharmacology. 50: 726-32. PMID 16434063 DOI: 10.1016/j.neuropharm.2005.11.020  0.72
2006 Sharp T. Neuroscience. A new molecule to brighten the mood. Science (New York, N.Y.). 311: 45-6. PMID 16400139 DOI: 10.1126/science.1122819  0.72
2006 Serres F, Sartori SB, Halton A, Pei Q, Rochat C, Singewald N, Sharp T, Millan MJ, Millan M. Stereoselective and region-specific induction of immediate early gene expression in rat parietal cortex by blockade of neurokinin 1 receptors. Journal of Psychopharmacology (Oxford, England). 20: 570-6. PMID 16204322 DOI: 10.1177/0269881105059327  0.72
2006 Le Masurier M, Oldenzeil W, Lehman C, Cowen P, Sharp T. Effect of acute tyrosine depletion in using a branched chain amino-acid mixture on dopamine neurotransmission in the rat brain. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 31: 310-7. PMID 16034439 DOI: 10.1038/sj.npp.1300835  0.72
2006 Sharp T, Zetterström T. Chapter 1.1 What did we learn from microdialysis? Handbook of Behavioral Neuroscience. 16: 5-16. DOI: 10.1016/S1569-7339(06)16001-4  0.72
2005 Tordera RM, Pei Q, Sharp T. Evidence for increased expression of the vesicular glutamate transporter, VGLUT1, by a course of antidepressant treatment. Journal of Neurochemistry. 94: 875-83. PMID 15992385 DOI: 10.1111/j.1471-4159.2005.03192.x  0.72
2005 Boothman LJ, Sharp T. A role for midbrain raphe gamma aminobutyric acid neurons in 5-hydroxytryptamine feedback control. Neuroreport. 16: 891-6. PMID 15931057 DOI: 10.1097/00001756-200506210-00004  0.72
2005 Denk F, Walton ME, Jennings KA, Sharp T, Rushworth MF, Bannerman DM. Differential involvement of serotonin and dopamine systems in cost-benefit decisions about delay or effort. Psychopharmacology. 179: 587-96. PMID 15864561 DOI: 10.1007/s00213-004-2059-4  0.44
2005 Austin VC, Blamire AM, Allers KA, Sharp T, Styles P, Matthews PM, Sibson NR. Confounding effects of anesthesia on functional activation in rodent brain: a study of halothane and alpha-chloralose anesthesia. Neuroimage. 24: 92-100. PMID 15588600 DOI: 10.1016/j.neuroimage.2004.08.011  0.72
2004 Pei Q, Sprakes M, Millan MJ, Rochat C, Sharp T. The novel monoamine reuptake inhibitor and potential antidepressant, S33005, induces Arc gene expression in cerebral cortex. European Journal of Pharmacology. 495: 227-33. PMID 15838995  0.72
2004 Tunbridge EM, Bannerman DM, Sharp T, Harrison PJ. Catechol-o-methyltransferase inhibition improves set-shifting performance and elevates stimulated dopamine release in the rat prefrontal cortex. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 5331-5. PMID 15190105 DOI: 10.1523/JNEUROSCI.1124-04.2004  0.72
2004 Sartori SB, Burnet PW, Sharp T, Singewald N. Evaluation of the effect of chronic antidepressant treatment on neurokinin-1 receptor expression in the rat brain. Neuropharmacology. 46: 1177-83. PMID 15111024 DOI: 10.1016/j.neuropharm.2004.02.013  0.72
2004 Pei Q, Sprakes M, Millan MJ, Rochat C, Sharp T. The novel monoamine reuptake inhibitor and potential antidepressant, S33005, induces Arc gene expression in cerebral cortex. European Journal of Pharmacology. 489: 179-85. PMID 15087240 DOI: 10.1016/j.ejphar.2004.03.002  0.72
2004 Millan MJ, Brocco M, Papp M, Serres F, La Rochelle CD, Sharp T, Peglion JL, Dekeyne A. S32504, a novel naphtoxazine agonist at dopamine D3/D2 receptors: III. Actions in models of potential antidepressive and anxiolytic activity in comparison with ropinirole. The Journal of Pharmacology and Experimental Therapeutics. 309: 936-50. PMID 14978196 DOI: 10.1124/jpet.103.062463  0.72
2004 Pei Q, Tordera R, Sprakes M, Sharp T. Glutamate receptor activation is involved in 5-HT2 agonist-induced Arc gene expression in the rat cortex. Neuropharmacology. 46: 331-9. PMID 14975688 DOI: 10.1016/j.neuropharm.2003.09.017  0.72
2004 Le Masurier M, Cowen PJ, Sharp T. Fos immunocytochemical studies on the neuroanatomical sites of action of acute tyrosine depletion in the rat brain. Psychopharmacology. 171: 435-40. PMID 14745483 DOI: 10.1007/s00213-003-1607-7  0.72
2004 Le Masurier M, Houston G, Cowen P, Grasby P, Sharp T, Hume S. Tyrosine-free amino acid mixture attenuates amphetamine-induced displacement of [11C]raclopride in striatum in vivo: a rat PET study. Synapse (New York, N.Y.). 51: 151-7. PMID 14618682 DOI: 10.1002/syn.10285  0.72
2003 Lawrence NS, Sharp T, Peters SP, Gray JA, Young AM. GABA transmission in the ventral pallidum is not involved in the control of latent inhibition in the rat. Neuroscience. 122: 267-75. PMID 14596867 DOI: 10.1016/S0306-4522(03)00552-9  0.72
2003 Allers KA, Sharp T. Neurochemical and anatomical identification of fast- and slow-firing neurones in the rat dorsal raphe nucleus using juxtacellular labelling methods in vivo. Neuroscience. 122: 193-204. PMID 14596860 DOI: 10.1016/S0306-4522(03)00518-9  0.72
2003 Pei Q, Zetterström TS, Sprakes M, Tordera R, Sharp T. Antidepressant drug treatment induces Arc gene expression in the rat brain. Neuroscience. 121: 975-82. PMID 14580947 DOI: 10.1016/S0306-4522(03)00504-9  0.72
2003 Hirani E, Sharp T, Sprakes M, Grasby P, Hume S. Fenfluramine evokes 5-HT2A receptor-mediated responses but does not displace [11C]MDL 100907: small animal PET and gene expression studies. Synapse (New York, N.Y.). 50: 251-60. PMID 14515343 DOI: 10.1002/syn.10268  0.72
2003 Harris LW, Sharp T, Gartlon J, Jones DN, Harrison PJ. Long-term behavioural, molecular and morphological effects of neonatal NMDA receptor antagonism. The European Journal of Neuroscience. 18: 1706-10. PMID 14511349 DOI: 10.1046/j.1460-9568.2003.02902.x  0.72
2003 Boothman LJ, Allers KA, Rasmussen K, Sharp T. Evidence that central 5-HT2A and 5-HT2B/C receptors regulate 5-HT cell firing in the dorsal raphe nucleus of the anaesthetised rat. British Journal of Pharmacology. 139: 998-1004. PMID 12839874 DOI: 10.1038/sj.bjp.0705328  0.72
2003 Hajós M, Gartside SE, Varga V, Sharp T. In vivo inhibition of neuronal activity in the rat ventromedial prefrontal cortex by midbrain-raphe nuclei: role of 5-HT1A receptors. Neuropharmacology. 45: 72-81. PMID 12814660 DOI: 10.1016/S0028-3908(03)00139-4  0.72
2003 Castro E, Tordera RM, Hughes ZA, Pei Q, Sharp T. Use of Arc expression as a molecular marker of increased postsynaptic 5-HT function after SSRI/5-HT1A receptor antagonist co-administration. Journal of Neurochemistry. 85: 1480-7. PMID 12787067 DOI: 10.1046/j.1471-4159.2003.01782.x  0.72
2003 Tordera R, Pei Q, Newson M, Gray K, Sprakes M, Sharp T. Effect of different 5-HT1A receptor antagonists in combination with paroxetine on expression of the immediate-early gene Arc in rat brain. Neuropharmacology. 44: 893-902. PMID 12726821 DOI: 10.1016/S0028-3908(03)00096-0  0.72
2003 Taylor M, Bhagwagar Z, Cowen PJ, Sharp T. GABA and mood disorders. Psychological Medicine. 33: 387-93. PMID 12701660 DOI: 10.1017/S0033291702006876  0.72
2003 Singewald N, Salchner P, Sharp T. Induction of c-Fos expression in specific areas of the fear circuitry in rat forebrain by anxiogenic drugs. Biological Psychiatry. 53: 275-83. PMID 12586446 DOI: 10.1016/S0006-3223(02)01574-3  0.72
2003 Varga V, Kocsis B, Sharp T. Electrophysiological evidence for convergence of inputs from the medial prefrontal cortex and lateral habenula on single neurons in the dorsal raphe nucleus. The European Journal of Neuroscience. 17: 280-6. PMID 12542664 DOI: 10.1046/j.1460-9568.2003.02465.x  0.72
2002 Meller R, Harrison PJ, Sharp T. Studies on the role of calcium in the 5-HT-stimulated release of glutamate from C6 glioma cells. European Journal of Pharmacology. 445: 13-9. PMID 12065189 DOI: 10.1016/S0014-2999(02)01718-1  0.72
2002 Hajós-Korcsok E, Sharp T. Electrical stimulation of the dorsal and median raphe nuclei increases extracellular noradrenaline in rat hippocampus: Evidence for a 5-HT-independent mechanism. Pharmacology, Biochemistry, and Behavior. 71: 807-13. PMID 11888571 DOI: 10.1016/S0091-3057(01)00718-3  0.72
2002 Meller R, Harrison PJ, Elliott JM, Sharp T. In vitro evidence that 5-hydroxytryptamine increases efflux of glial glutamate via 5-HT(2A) receptor activation. Journal of Neuroscience Research. 67: 399-405. PMID 11813245 DOI: 10.1002/jnr.10126  0.72
2001 Dawe GS, Huff KD, Vandergriff JL, Sharp T, O'Neill MJ, Rasmussen K. Olanzapine activates the rat locus coeruleus: in vivo electrophysiology and c-Fos immunoreactivity. Biological Psychiatry. 50: 510-20. PMID 11600104 DOI: 10.1016/S0006-3223(01)01171-4  0.72
2001 McTavish SF, Raumann B, Cowen PJ, Sharp T. Tyrosine depletion attenuates the behavioural stimulant effects of amphetamine and cocaine in rats. European Journal of Pharmacology. 424: 115-9. PMID 11476757 DOI: 10.1016/S0014-2999(01)01105-0  0.72
2001 Hajós M, Hoffmann WE, Tetko IV, Hyland B, Sharp T, Villa AE. Different tonic regulation of neuronal activity in the rat dorsal raphe and medial prefrontal cortex via 5-HT(1A) receptors. Neuroscience Letters. 304: 129-32. PMID 11343819 DOI: 10.1016/S0304-3940(01)01751-7  0.72
2001 Burnet PW, Miller R, Lewis LJ, Pei Q, Sharp T, Harrison PJ. Electroconvulsive shock increases tachykinin NK(1) receptors, but not the encoding mRNA, in rat cortex. European Journal of Pharmacology. 413: 213-9. PMID 11226395 DOI: 10.1016/S0014-2999(01)00777-4  0.72
2000 Patel S, Churchill GC, Sharp T, Galione A. Widespread distribution of binding sites for the novel Ca2+-mobilizing messenger, nicotinic acid adenine dinucleotide phosphate, in the brain. The Journal of Biological Chemistry. 275: 36495-7. PMID 11010959 DOI: 10.1074/jbc.C000458200  0.72
2000 Rabiner EA, Gunn RN, Castro ME, Sargent PA, Cowen PJ, Koepp MJ, Meyer JH, Bench CJ, Harrison PJ, Pazos A, Sharp T, Grasby PM. beta-blocker binding to human 5-HT(1A) receptors in vivo and in vitro: implications for antidepressant therapy. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 23: 285-93. PMID 10942852 DOI: 10.1016/S0893-133X(00)00109-3  0.72
2000 Castro ME, Harrison PJ, Pazos A, Sharp T. Affinity of (+/-)-pindolol, (-)-penbutolol, and (-)-tertatolol for pre- and postsynaptic serotonin 5-HT(1A) receptors in human and rat brain. Journal of Neurochemistry. 75: 755-62. PMID 10899952 DOI: 10.1046/j.1471-4159.2000.0750755.x  0.72
2000 Singewald N, Sharp T. Neuroanatomical targets of anxiogenic drugs in the hindbrain as revealed by Fos immunocytochemistry. Neuroscience. 98: 759-70. PMID 10891619  0.32
1999 Burnet PW, Sharp T, LeCorre SM, Harrison PJ. Expression of 5-HT receptors and the 5-HT transporter in rat brain after electroconvulsive shock. Neuroscience Letters. 277: 79-82. PMID 10624814  0.76
1998 Ainsworth K, Smith SE, Zetterström TS, Pei Q, Franklin M, Sharp T. Effect of antidepressant drugs on dopamine D1 and D2 receptor expression and dopamine release in the nucleus accumbens of the rat. Psychopharmacology. 140: 470-7. PMID 9888623  0.32
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