Derek McKay, PhD - Publications

Affiliations: 
University of Calgary, Calgary, Alberta, Canada 

125 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Mancini NL, Rajeev S, Jayme TS, Wang A, Keita ÅV, Workentine ML, Hamed S, Söderholm JD, Lopes F, Shutt TE, Shearer J, McKay DM. Crohn's disease pathobiont adherent-invasive E. coli disrupts epithelial mitochondrial networks with implications for gut permeability. Cellular and Molecular Gastroenterology and Hepatology. PMID 32992049 DOI: 10.1016/j.jcmgh.2020.09.013  0.64
2020 Lopes F, Vicentini FA, Cluny NL, Mathews AJ, Lee BH, Almishri WA, Griffin L, Gonçalves W, Pinho V, McKay DM, Hirota SA, Swain MG, Pittman QJ, Sharkey KA. Brain TNF drives post-inflammation depression-like behavior and persistent pain in experimental arthritis. Brain, Behavior, and Immunity. PMID 32592863 DOI: 10.1016/J.Bbi.2020.06.023  0.72
2020 Jayme TS, Leung G, Wang A, Workentine ML, Rajeev S, Shute A, Callejas BE, Mancini N, Beck PL, Panaccione R, McKay DM. Human interleukin-4-treated regulatory macrophages promote epithelial wound healing and reduce colitis in a mouse model. Science Advances. 6: eaba4376. PMID 32548267 DOI: 10.1126/sciadv.aba4376  0.64
2020 Mancini NL, Goudie L, Xu W, Sabouny R, Rajeev S, Wang A, Esquerre N, Al Rajabi A, Jayme TS, van Tilburg Bernandes E, Nasser Y, Ferraz JGP, Shutt T, Shearer J, McKay DM. Perturbed mitochondrial dynamics is a novel feature of colitis that can be targeted to lessen disease. Cellular and Molecular Gastroenterology and Hepatology. PMID 32298841 DOI: 10.1016/J.Jcmgh.2020.04.004  0.64
2020 Shute A, Wang A, Jayme TS, Strous M, McCoy KD, Buret AG, McKay DM. Worm expulsion is independent of alterations in composition of the colonic bacteria that occur during experimental -infection in mice. Gut Microbes. 1-14. PMID 31928118 DOI: 10.1080/19490976.2019.1688065  0.64
2019 Reyes JL, Lopes F, Leung G, Jayme TS, Matisz CE, Shute A, Burkhard R, Carneiro M, Workentine ML, Wang A, Petri B, Beck PL, Geuking MB, McKay DM. Macrophages treated with antigen from the tapeworm Hymenolepis diminuta condition CD25 T cells to suppress colitis. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201802160R. PMID 30668930 DOI: 10.1096/fj.201802160R  0.64
2018 Gonzalez MI, Lopes F, McKay DM, Reyes JL. Mast Cell Deficiency in Mice Results in Biomass Overgrowth and Delayed Expulsion of the Rat Tapeworm . Bioscience Reports. PMID 30341242 DOI: 10.1042/BSR20180687  0.4
2018 Wang SJ, Sharkey KA, McKay DM. Modulation of the immune response by helminths: a role for serotonin? Bioscience Reports. 38. PMID 30177522 DOI: 10.1042/Bsr20180027  0.72
2018 Matisz CE, Geuking MB, Lopes F, Petri B, Wang A, Sharkey KA, McKay DM. Helminth Antigen-Conditioned Dendritic Cells Generate Anti-Inflammatory CD4 T Cells Independent of Antigen Presentation via MHC II. The American Journal of Pathology. PMID 30121255 DOI: 10.1016/J.Ajpath.2018.07.008  0.72
2018 Yakymenko O, Schoultz I, Gullberg E, Ström M, Almer S, Wallon C, Wang A, Keita ÅV, Campbell BJ, McKay DM, Söderholm JD. Infliximab restores colonic barrier to adherent-invasive E. coli in Crohn's disease via effects on epithelial lipid rafts. Scandinavian Journal of Gastroenterology. 1-8. PMID 29688802 DOI: 10.1080/00365521.2018.1458146  0.64
2018 Arai T, Lopes F, Shute A, Wang A, McKay DM. Young mice expel the tapeworm Hymenolepis diminuta and are protected from colitis by triggering a memory response with worm antigen. American Journal of Physiology. Gastrointestinal and Liver Physiology. PMID 29351392 DOI: 10.1152/ajpgi.00295.2017  0.64
2018 Lopes F, Keita ÅV, Saxena A, Reyes JL, Mancini N, Rajabi AA, Wang A, Baggio C, Dicay M, van Dalen R, Ahn Y, Carneiro M, Peters N, Rho JM, MacNaughton W, ... ... McKay DM, et al. ER-stress mobilization of death-associated protein kinase-1-dependent xenophagy counteracts mitochondria stress-induced epithelial barrier dysfunction. The Journal of Biological Chemistry. PMID 29317503 DOI: 10.1074/jbc.RA117.000809  0.64
2017 Wang A, Arai T, Campbell A, Reyes JL, Lopes F, McKay DM. Triggering immunological memory against the tapeworm Hymenolepis diminuta to protect against colitis. Parasite Immunology. PMID 28892562 DOI: 10.1111/pim.12490  0.64
2016 Reyes JL, Lopes F, Leung G, Mancini NL, Matisz CE, Wang A, Thomson EA, Graves N, Gilleard J, McKay DM. Treatment with cestode parasite antigens recruits CCR2+ myeloid cells, the adoptive transfer of which ameliorates colitis. Infection and Immunity. PMID 27672083 DOI: 10.1128/IAI.00681-16  0.64
2016 Lopes F, Matisz C, Reyes JL, Jijon H, Al-Darmaki A, Kaplan GG, McKay DM. Helminth Regulation of Immunity: A Three-pronged Approach to Treat Colitis. Inflammatory Bowel Diseases. PMID 27575495 DOI: 10.1097/MIB.0000000000000889  0.4
2016 Reyes JL, Fernando MR, Lopes F, Leung G, Mancini NL, Matisz CE, Wang A, McKay DM. IL-22 Restrains Tapeworm-Mediated Protection against Experimental Colitis via Regulation of IL-25 Expression. Plos Pathogens. 12: e1005481. PMID 27055194 DOI: 10.1371/journal.ppat.1005481  0.72
2016 Fernando MR, Saxena A, Reyes JL, McKay DM. Butyrate enhances antibacterial effects while suppressing other features of alternative activation in IL-4-induced macrophages. American Journal of Physiology. Gastrointestinal and Liver Physiology. ajpgi.00440.2015. PMID 27012776 DOI: 10.1152/ajpgi.00440.2015  0.4
2015 Leung G, Petri B, Reyes JL, Wang A, Iannuzzi J, Mckay DM. Cryopreserved IL-4-treated macrophages attenuate murine colitis in an integrin β7-dependent manner. Molecular Medicine (Cambridge, Mass.). PMID 26701314 DOI: 10.2119/molmed.2015.00193  0.64
2015 Matisz CE, Leung G, Reyes JL, Wang A, Sharkey KA, McKay DM. Adoptive transfer of helminth antigen-pulsed dendritic cells protects against the development of experimental colitis in mice. European Journal of Immunology. PMID 26332354 DOI: 10.1002/Eji.201545579  0.4
2015 Lopes F, Graepel R, Reyes JL, Wang A, Petri B, McDougall JJ, Sharkey KA, McKay DM. Involvement of mast cells in α7 nicotinic receptor agonist-exacerbation of complete Freund's adjuvant-induced mono-arthritis in mice. Arthritis & Rheumatology (Hoboken, N.J.). PMID 26314943 DOI: 10.1002/Art.39411  0.72
2015 Lopes F, Reyes JL, Wang A, Leung G, McKay DM. Enteric epithelial cells support growth of Hymenolepis diminuta in vitro and trigger TH2-promoting events in a species-specific manner. International Journal For Parasitology. PMID 26151388 DOI: 10.1016/j.ijpara.2015.05.004  0.72
2015 Lopes F, Wang A, Smyth D, Reyes JL, Doering A, Schenck LP, Beck P, Waterhouse C, McKay DM. The Src kinase Fyn is protective in acute chemical-induced colitis and promotes recovery from disease. Journal of Leukocyte Biology. 97: 1089-99. PMID 25877924 DOI: 10.1189/jlb.3A0814-405RR  0.72
2015 Reyes JL, Wang A, Fernando MR, Graepel R, Leung G, van Rooijen N, Sigvardsson M, McKay DM. Splenic B cells from Hymenolepis diminuta-infected mice ameliorate colitis independent of T cells and via cooperation with macrophages. Journal of Immunology (Baltimore, Md. : 1950). 194: 364-78. PMID 25452561 DOI: 10.4049/jimmunol.1400738  0.72
2015 McKay DM. Not all parasites are protective. Parasite Immunology. 37: 324-32. PMID 25403350 DOI: 10.1111/pim.12160  0.72
2014 Wang A, Keita Ã…V, Phan V, McKay CM, Schoultz I, Lee J, Murphy MP, Fernando M, Ronaghan N, Balce D, Yates R, Dicay M, Beck PL, MacNaughton WK, Söderholm JD, ... McKay DM, et al. Targeting mitochondria-derived reactive oxygen species to reduce epithelial barrier dysfunction and colitis. The American Journal of Pathology. 184: 2516-27. PMID 25034594 DOI: 10.1016/j.ajpath.2014.05.019  0.72
2014 Fernando MR, Reyes JL, Iannuzzi J, Leung G, McKay DM. The pro-inflammatory cytokine, interleukin-6, enhances the polarization of alternatively activated macrophages. Plos One. 9: e94188. PMID 24736635 DOI: 10.1371/journal.pone.0094188  0.72
2013 D'Mello C, Riazi K, Le T, Stevens KM, Wang A, McKay DM, Pittman QJ, Swain MG. P-selectin-mediated monocyte-cerebral endothelium adhesive interactions link peripheral organ inflammation to sickness behaviors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 14878-88. PMID 24027287 DOI: 10.1523/Jneurosci.1329-13.2013  0.72
2013 Duncan M, Galic MA, Wang A, Chambers AP, McCafferty DM, McKay DM, Sharkey KA, Pittman QJ. Cannabinoid 1 receptors are critical for the innate immune response to TLR4 stimulation. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 305: R224-31. PMID 23739343 DOI: 10.1152/Ajpregu.00104.2013  0.72
2013 Keita AV, Carlsson AH, Cigéhn M, Ericson AC, McKay DM, Söderholm JD. Vasoactive intestinal polypeptide regulates barrier function via mast cells in human intestinal follicle-associated epithelium and during stress in rats. Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society. 25: e406-17. PMID 23600853 DOI: 10.1111/nmo.12127  0.72
2013 Graepel R, Leung G, Wang A, Villemaire M, Jirik FR, Sharkey KA, McDougall JJ, McKay DM. Murine autoimmune arthritis is exaggerated by infection with the rat tapeworm, Hymenolepis diminuta. International Journal For Parasitology. 43: 593-601. PMID 23583716 DOI: 10.1016/J.Ijpara.2013.02.006  0.72
2013 Leung G, Wang A, Fernando M, Phan VC, McKay DM. Bone marrow-derived alternatively activated macrophages reduce colitis without promoting fibrosis: participation of IL-10. American Journal of Physiology. Gastrointestinal and Liver Physiology. 304: G781-92. PMID 23494123 DOI: 10.1152/ajpgi.00055.2013  0.72
2013 Prescott D, Atkinson B, Döring A, Brown S, Petri B, McKay DM, Waterhouse CC. Loss of phosphoinositide 3-kinase P110γ is protective in the acute phase but detrimental in the resolution phase of hapten-induced colitis. Inflammatory Bowel Diseases. 19: 489-500. PMID 23282580 DOI: 10.1097/MIB.0b013e31827feb84  0.72
2013 Hernandez JL, Leung G, McKay DM. Cestode regulation of inflammation and inflammatory diseases. International Journal For Parasitology. 43: 233-43. PMID 23058631 DOI: 10.1016/j.ijpara.2012.09.005  0.72
2012 Smyth D, Leung G, Fernando M, McKay DM. Reduced surface expression of epithelial E-cadherin evoked by interferon-gamma is Fyn kinase-dependent. Plos One. 7: e38441. PMID 22715382 DOI: 10.1371/journal.pone.0038441  0.72
2012 Schoultz I, McKay CM, Graepel R, Phan VC, Wang A, Söderholm J, McKay DM. Indomethacin-induced translocation of bacteria across enteric epithelia is reactive oxygen species-dependent and reduced by vitamin C. American Journal of Physiology. Gastrointestinal and Liver Physiology. 303: G536-45. PMID 22700821 DOI: 10.1152/ajpgi.00125.2012  0.72
2012 Smyth D, McKay CM, Gulbransen BD, Phan VC, Wang A, McKay DM. Interferon-gamma signals via an ERK1/2-ARF6 pathway to promote bacterial internalization by gut epithelia. Cellular Microbiology. 14: 1257-70. PMID 22463716 DOI: 10.1111/j.1462-5822.2012.01796.x  0.72
2012 Gulbransen BD, Bashashati M, Hirota SA, Gui X, Roberts JA, MacDonald JA, Muruve DA, McKay DM, Beck PL, Mawe GM, Thompson RJ, Sharkey KA. Activation of neuronal P2X7 receptor-pannexin-1 mediates death of enteric neurons during colitis. Nature Medicine. 18: 600-4. PMID 22426419 DOI: 10.1038/Nm.2679  0.72
2012 McKay DM, MacNaughton WK. Mechanisms and Consequences of Intestinal Inflammation Physiology of the Gastrointestinal Tract. 2: 2075-2099. DOI: 10.1016/B978-0-12-382026-6.00078-6  0.72
2011 Schoultz I, Söderholm JD, McKay DM. Is metabolic stress a common denominator in inflammatory bowel disease? Inflammatory Bowel Diseases. 17: 2008-18. PMID 21830276 DOI: 10.1002/ibd.21556  0.72
2011 Prescott D, McKay DM. Aspirin-triggered lipoxin enhances macrophage phagocytosis of bacteria while inhibiting inflammatory cytokine production. American Journal of Physiology. Gastrointestinal and Liver Physiology. 301: G487-97. PMID 21659618 DOI: 10.1152/ajpgi.00042.2011  0.72
2011 Matisz CE, McDougall JJ, Sharkey KA, McKay DM. Helminth parasites and the modulation of joint inflammation. Journal of Parasitology Research. 2011: 942616. PMID 21584243 DOI: 10.1155/2011/942616  0.72
2011 MacEachern SJ, Patel BA, McKay DM, Sharkey KA. Nitric oxide regulation of colonic epithelial ion transport: a novel role for enteric glia in the myenteric plexus. The Journal of Physiology. 589: 3333-48. PMID 21558161 DOI: 10.1113/Jphysiol.2011.207902  0.72
2011 Flynn AN, Wang A, McKay DM, Buret AG. Apoptosis-inducing factor contributes to epithelial cell apoptosis induced by enteropathogenic Escherichia coli. Canadian Journal of Physiology and Pharmacology. 89: 143-8. PMID 21326346 DOI: 10.1139/y11-002  0.72
2011 Smyth D, Phan V, Wang A, McKay DM. Interferon-γ-induced increases in intestinal epithelial macromolecular permeability requires the Src kinase Fyn. Laboratory Investigation; a Journal of Technical Methods and Pathology. 91: 764-77. PMID 21321534 DOI: 10.1038/labinvest.2010.208  0.72
2011 Wallon C, Persborn M, Jönsson M, Wang A, Phan V, Lampinen M, Vicario M, Santos J, Sherman PM, Carlson M, Ericson AC, McKay DM, Söderholm JD. Eosinophils express muscarinic receptors and corticotropin-releasing factor to disrupt the mucosal barrier in ulcerative colitis. Gastroenterology. 140: 1597-607. PMID 21277851 DOI: 10.1053/j.gastro.2011.01.042  0.72
2011 Shi M, Wang A, Prescott D, Waterhouse CC, Zhang S, McDougall JJ, Sharkey KA, McKay DM. Infection with an intestinal helminth parasite reduces Freund's complete adjuvant-induced monoarthritis in mice. Arthritis and Rheumatism. 63: 434-44. PMID 20967852 DOI: 10.1002/Art.30098  0.72
2010 Wang A, Fernando M, Leung G, Phan V, Smyth D, McKay DM. Exacerbation of oxazolone colitis by infection with the helminth Hymenolepis diminuta: involvement of IL-5 and eosinophils. The American Journal of Pathology. 177: 2850-9. PMID 21037078 DOI: 10.2353/ajpath.2010.100537  0.72
2010 Sproule-Willoughby KM, Stanton MM, Rioux KP, McKay DM, Buret AG, Ceri H. In vitro anaerobic biofilms of human colonic microbiota. Journal of Microbiological Methods. 83: 296-301. PMID 20920538 DOI: 10.1016/j.mimet.2010.09.020  0.72
2010 Klompus M, Ho W, Sharkey KA, McKay DM. Antisecretory effects of neuropeptide Y in the mouse colon are region-specific and are lost in DSS-induced colitis. Regulatory Peptides. 165: 138-45. PMID 20561896 DOI: 10.1016/J.Regpep.2010.05.014  0.72
2010 Hunter MM, Wang A, Parhar KS, Johnston MJ, Van Rooijen N, Beck PL, McKay DM. In vitro-derived alternatively activated macrophages reduce colonic inflammation in mice. Gastroenterology. 138: 1395-405. PMID 20044996 DOI: 10.1053/j.gastro.2009.12.041  0.72
2010 Johnston MJ, Wang A, Catarino ME, Ball L, Phan VC, MacDonald JA, McKay DM. Extracts of the rat tapeworm, Hymenolepis diminuta, suppress macrophage activation in vitro and alleviate chemically induced colitis in mice. Infection and Immunity. 78: 1364-75. PMID 20028812 DOI: 10.1128/IAI.01349-08  0.72
2010 Lewis K, Lutgendorff F, Phan V, Söderholm JD, Sherman PM, McKay DM. Enhanced translocation of bacteria across metabolically stressed epithelia is reduced by butyrate. Inflammatory Bowel Diseases. 16: 1138-48. PMID 20024905 DOI: 10.1002/ibd.21177  0.72
2010 Melon A, Wang A, Phan V, McKay DM. Infection with Hymenolepis diminuta is more effective than daily corticosteroids in blocking chemically induced colitis in mice. Journal of Biomedicine & Biotechnology. 2010: 384523. PMID 20011066 DOI: 10.1155/2010/384523  0.72
2010 McKay DM. The immune response to and immunomodulation by Hymenolepis diminuta. Parasitology. 137: 385-94. PMID 19691904 DOI: 10.1017/S0031182009990886  0.72
2009 Fichna J, Schicho R, Andrews CN, Bashashati M, Klompus M, McKay DM, Sharkey KA, Zjawiony JK, Janecka A, Storr MA. Salvinorin A inhibits colonic transit and neurogenic ion transport in mice by activating kappa-opioid and cannabinoid receptors. Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society. 21: 1326-e128. PMID 19650775 DOI: 10.1111/J.1365-2982.2009.01369.X  0.72
2009 Lewis K, McKay DM. Metabolic stress evokes decreases in epithelial barrier function. Annals of the New York Academy of Sciences. 1165: 327-37. PMID 19538324 DOI: 10.1111/j.1749-6632.2009.04036.x  0.72
2009 Hirota CL, McKay DM. Loss of Ca-mediated ion transport during colitis correlates with reduced ion transport responses to a Ca-activated K channel opener. British Journal of Pharmacology. 156: 1085-97. PMID 19298254 DOI: 10.1111/j.1476-5381.2009.00122.x  0.72
2009 Beaurepaire C, Smyth D, McKay DM. Interferon-gamma regulation of intestinal epithelial permeability. Journal of Interferon & Cytokine Research : the Official Journal of the International Society For Interferon and Cytokine Research. 29: 133-44. PMID 19196071 DOI: 10.1089/jir.2008.0057  0.72
2009 McKay DM. The therapeutic helminth? Trends in Parasitology. 25: 109-14. PMID 19167926 DOI: 10.1016/j.pt.2008.11.008  0.72
2009 Johnston MJ, MacDonald JA, McKay DM. Parasitic helminths: a pharmacopeia of anti-inflammatory molecules. Parasitology. 136: 125-47. PMID 19079844 DOI: 10.1017/S0031182008005210  0.72
2009 McKay DM, Wallace JL. Acetic acid induced ulceration in rats is not affected by infection with Hymenolepis diminuta. The Journal of Parasitology. 95: 481-2. PMID 18767911 DOI: 10.1645/GE-1776.1  0.72
2008 Reardon C, Wang A, McKay DM. Transient local depletion of Foxp3+ regulatory T cells during recovery from colitis via Fas/Fas ligand-induced death. Journal of Immunology (Baltimore, Md. : 1950). 180: 8316-26. PMID 18523298  0.72
2008 Lewis K, Caldwell J, Phan V, Prescott D, Nazli A, Wang A, Soderhölm JD, Perdue MH, Sherman PM, McKay DM. Decreased epithelial barrier function evoked by exposure to metabolic stress and nonpathogenic E. coli is enhanced by TNF-alpha. American Journal of Physiology. Gastrointestinal and Liver Physiology. 294: G669-78. PMID 18187519 DOI: 10.1152/ajpgi.00382.2007  0.72
2008 Verdu EF, Huang X, Natividad J, Lu J, Blennerhassett PA, David CS, McKay DM, Murray JA. Gliadin-dependent neuromuscular and epithelial secretory responses in gluten-sensitive HLA-DQ8 transgenic mice. American Journal of Physiology. Gastrointestinal and Liver Physiology. 294: G217-25. PMID 18006603 DOI: 10.1152/ajpgi.00225.2007  0.72
2008 Wallon C, Yang PC, Keita AV, Ericson AC, McKay DM, Sherman PM, Perdue MH, Söderholm JD. Corticotropin-releasing hormone (CRH) regulates macromolecular permeability via mast cells in normal human colonic biopsies in vitro. Gut. 57: 50-8. PMID 17525093 DOI: 10.1136/gut.2006.117549  0.72
2007 Hunter MM, Wang A, McKay DM. Helminth infection enhances disease in a murine TH2 model of colitis. Gastroenterology. 132: 1320-30. PMID 17408663 DOI: 10.1053/j.gastro.2007.01.038  0.72
2007 Reardon C, McKay DM. TGF-beta suppresses IFN-gamma-STAT1-dependent gene transcription by enhancing STAT1-PIAS1 interactions in epithelia but not monocytes/macrophages. Journal of Immunology (Baltimore, Md. : 1950). 178: 4284-95. PMID 17371985 DOI: 10.4049/jimmunol.178.7.4284  0.72
2007 McKay DM, Watson JL, Wang A, Caldwell J, Prescott D, Ceponis PM, Di Leo V, Lu J. Phosphatidylinositol 3'-kinase is a critical mediator of interferon-gamma-induced increases in enteric epithelial permeability. The Journal of Pharmacology and Experimental Therapeutics. 320: 1013-22. PMID 17178936 DOI: 10.1124/jpet.106.113639  0.72
2007 Persaud R, Wang A, Reardon C, McKay DM. Characterization of the immuno-regulatory response to the tapeworm Hymenolepis diminuta in the non-permissive mouse host. International Journal For Parasitology. 37: 393-403. PMID 17092505 DOI: 10.1016/j.ijpara.2006.09.012  0.72
2006 Hirota CL, McKay DM. M3 muscarinic receptor-deficient mice retain bethanechol-mediated intestinal ion transport and are more sensitive to colitis. Canadian Journal of Physiology and Pharmacology. 84: 1153-61. PMID 17218980 DOI: 10.1139/y06-068  0.72
2006 Hirota CL, McKay DM. Cholinergic regulation of epithelial ion transport in the mammalian intestine British Journal of Pharmacology. 149: 463-479. PMID 16981004 DOI: 10.1038/sj.bjp.0706889  0.72
2006 Zareie M, Johnson-Henry K, Jury J, Yang PC, Ngan BY, McKay DM, Soderholm JD, Perdue MH, Sherman PM. Probiotics prevent bacterial translocation and improve intestinal barrier function in rats following chronic psychological stress. Gut. 55: 1553-60. PMID 16638791 DOI: 10.1136/gut.2005.080739  0.72
2006 Jandu N, Ceponis PJ, Kato S, Riff JD, McKay DM, Sherman PM. Conditioned medium from enterohemorrhagic Escherichia coli-infected T84 cells inhibits signal transducer and activator of transcription 1 activation by gamma interferon. Infection and Immunity. 74: 1809-18. PMID 16495555 DOI: 10.1128/IAI.74.3.1809-1818.2006  0.72
2006 Yang PC, Jury J, Söderholm JD, Sherman PM, McKay DM, Perdue MH. Chronic psychological stress in rats induces intestinal sensitization to luminal antigens. The American Journal of Pathology. 168: 104-14; quiz 363. PMID 16400013 DOI: 10.2353/ajpath.2006.050575  0.72
2006 McKay DM. The beneficial helminth parasite? Parasitology. 132: 1-12. PMID 16393348 DOI: 10.1017/S003118200500884X  0.72
2006 Nazli A, Wang A, Steen O, Prescott D, Lu J, Perdue MH, Söderholm JD, Sherman PM, McKay DM. Enterocyte cytoskeleton changes are crucial for enhanced translocation of nonpathogenic Escherichia coli across metabolically stressed gut epithelia. Infection and Immunity. 74: 192-201. PMID 16368973 DOI: 10.1128/IAI.74.1.192-201.2006  0.72
2006 Watson JL, McKay DM. The immunophysiological impact of bacterial CpG DNA on the gut. Clinica Chimica Acta; International Journal of Clinical Chemistry. 364: 1-11. PMID 16153626 DOI: 10.1016/j.cca.2005.05.017  0.72
2006 McKay DM, Webb RA. Cestode infection: Immunological considerations from host and tapeworm perspectives Parasitic Flatworms: Molecular Biology, Biochemistry, Immunology and Physiology. 193-209.  0.72
2005 Howe KL, Reardon C, Wang A, Nazli A, McKay DM. Transforming growth factor-beta regulation of epithelial tight junction proteins enhances barrier function and blocks enterohemorrhagic Escherichia coli O157:H7-induced increased permeability. The American Journal of Pathology. 167: 1587-97. PMID 16314472  0.72
2005 Zareie M, Riff J, Donato K, McKay DM, Perdue MH, Soderholm JD, Karmali M, Cohen MB, Hawkins J, Sherman PM. Novel effects of the prototype translocating Escherichia coli, strain C25 on intestinal epithelial structure and barrier function. Cellular Microbiology. 7: 1782-97. PMID 16309464 DOI: 10.1111/j.1462-5822.2005.00595.x  0.72
2005 Watson JL, Vicario M, Wang A, Moreto M, McKay DM. Immune cell activation and subsequent epithelial dysfunction by Staphylococcus enterotoxin B is attenuated by the green tea polyphenol (-)-epigallocatechin gallate. Cellular Immunology. 237: 7-16. PMID 16213476 DOI: 10.1016/j.cellimm.2005.08.030  0.72
2005 Wang A, McKay DM. Immune modulation by a high molecular weight fraction from the rat tapeworm Hymenolepis diminuta Parasitology. 130: 575-585. PMID 15991500 DOI: 10.1017/S0031182004006985  0.72
2005 McKay DM. Good bug, bad bug: in the case of enteric inflammatory disease does the epithelium decide? MemóRias Do Instituto Oswaldo Cruz. 100: 205-10. PMID 15962124  0.72
2005 Hunter MM, Wang A, Hirota CL, McKay DM. Neutralizing anti-IL-10 antibody blocks the protective effect of tapeworm infection in a murine model of chemically induced colitis. Journal of Immunology (Baltimore, Md. : 1950). 174: 7368-75. PMID 15905584  0.72
2004 Söderholm JD, Streutker C, Yang PC, Paterson C, Singh PK, McKay DM, Sherman PM, Croitoru K, Perdue MH. Increased epithelial uptake of protein antigens in the ileum of Crohn's disease mediated by tumour necrosis factor alpha. Gut. 53: 1817-24. PMID 15542521 DOI: 10.1136/gut.2004.041426  0.72
2004 Howe KL, Wang A, Hunter MM, Stanton BA, McKay DM. TGFbeta down-regulation of the CFTR: a means to limit epithelial chloride secretion. Experimental Cell Research. 298: 473-84. PMID 15265695 DOI: 10.1016/j.yexcr.2004.04.026  0.72
2004 Watson JL, Ansari S, Cameron H, Wang A, Akhtar M, McKay DM. Green tea polyphenol (-)-epigallocatechin gallate blocks epithelial barrier dysfunction provoked by IFN-gamma but not by IL-4. American Journal of Physiology. Gastrointestinal and Liver Physiology. 287: G954-61. PMID 15231486 DOI: 10.1152/ajpgi.00302.2003  0.72
2004 Musch MW, Petrof EO, Kojima K, Ren H, McKay DM, Chang EB. Bacterial superantigen-treated intestinal epithelial cells upregulate heat shock proteins 25 and 72 and are resistant to oxidant cytotoxicity. Infection and Immunity. 72: 3187-94. PMID 15155620 DOI: 10.1128/IAI.72.6.3187-3194.2004  0.72
2004 McKay DM. CAG Research Committee Report: another stellar year for Canadian gastrointestinal research. Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie. 18: 347-56. PMID 15152287  0.72
2004 Green CL, Ho W, Sharkey KA, McKay DM. Dextran sodium sulfate-induced colitis reveals nicotinic modulation of ion transport via iNOS-derived NO. American Journal of Physiology. Gastrointestinal and Liver Physiology. 287: G706-14. PMID 15087277 DOI: 10.1152/Ajpgi.00076.2004  0.72
2004 Nazli A, Yang PC, Jury J, Howe K, Watson JL, Söderholm JD, Sherman PM, Perdue MH, McKay DM. Epithelia under metabolic stress perceive commensal bacteria as a threat. The American Journal of Pathology. 164: 947-57. PMID 14982848 DOI: 10.1016/S0002-9440(10)63182-3  0.72
2004 Hunter MM, McKay DM. Review article: Helminths as therapeutic agents for inflammatory bowel disease Alimentary Pharmacology and Therapeutics. 19: 167-177. PMID 14723608 DOI: 10.1111/j.0269-2813.2004.01803.x  0.72
2003 Lu J, Wang A, Ansari S, Hershberg RM, McKay DM. Colonic bacterial superantigens evoke an inflammatory response and exaggerate disease in mice recovering from colitis. Gastroenterology. 125: 1785-95. PMID 14724831 DOI: 10.1053/j.gastro.2003.09.020  0.72
2003 McKay DM, Daniels S. Canadian Association of Gastroenterology - Canadian Institutes of Health Research - pharmaceutical partner postdoctoral operating fellowship programme: an outstanding success that continues to excel! Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie. 17: 437-9. PMID 12915917  0.72
2003 Ceponis PJ, McKay DM, Menaker RJ, Galindo-Mata E, Jones NL. Helicobacter pylori infection interferes with epithelial Stat6-mediated interleukin-4 signal transduction independent of cagA, cagE, or VacA. Journal of Immunology (Baltimore, Md. : 1950). 171: 2035-41. PMID 12902508  0.72
2003 Sanchez AL, Langdon CM, Akhtar M, Lu J, Richards CD, Bercik P, McKay DM. Adenoviral transfer of the murine oncostatin M gene suppresses dextran-sodium sulfate-induced colitis. Journal of Interferon & Cytokine Research : the Official Journal of the International Society For Interferon and Cytokine Research. 23: 193-201. PMID 12856331 DOI: 10.1089/107999003765027393  0.72
2003 Akhtar M, Watson JL, Nazli A, McKay DM. Bacterial DNA evokes epithelial IL-8 production by a MAPK-dependent, NF-kappaB-independent pathway. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 17: 1319-21. PMID 12832293 DOI: 10.1096/fj.03-0950fje  0.72
2003 McKay D. The Canadian Association of Gastroenterology Research Committee report: continued commitment to promoting excellence in gastrointestinal related research. Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie. 17: 385-7. PMID 12813606  0.72
2003 McKay DM, Khan WI. STAT-6 is an absolute requirement for murine rejection of Hymenolepis diminuta. The Journal of Parasitology. 89: 188-9. PMID 12659328 DOI: 10.1645/0022-3395(2003)089[0188:SIAARF]2.0.CO;2  0.72
2003 Ceponis PJ, McKay DM, Ching JC, Pereira P, Sherman PM. Enterohemorrhagic Escherichia coli O157:H7 disrupts Stat1-mediated gamma interferon signal transduction in epithelial cells. Infection and Immunity. 71: 1396-404. PMID 12595457 DOI: 10.1128/IAI.71.3.1396-1404.2003  0.72
2003 Watson JL, McKay DM. Superantigen-induced changes in epithelial ion transport and barrier function. Use of an in vitro model. Methods in Molecular Biology (Clifton, N.J.). 214: 219-43. PMID 12489464  0.72
2003 Croitoru K, Greenberg G, McKay D, Sinclair P. Meeting report: Research topics in gastrointestinal disease III | Troisième rapport sur les sujets de recherche en gastro-entérologie Canadian Journal of Gastroenterology. 17: 730-732.  0.72
2002 Mori N, Suzuki R, Furuno T, McKay DM, Wada M, Teshima R, Bienenstock J, Nakanishi M. Nerve-mast cell (RBL) interaction: RBL membrane ruffling occurs at the contact site with an activated neurite American Journal of Physiology - Cell Physiology. 283: C1738-C1744. PMID 12388097  0.72
2002 Howe K, Gauldie J, McKay DM. TGF-beta effects on epithelial ion transport and barrier: reduced Cl- secretion blocked by a p38 MAPK inhibitor. American Journal of Physiology. Cell Physiology. 283: C1667-74. PMID 12388073 DOI: 10.1152/ajpcell.00414.2001  0.72
2002 McKay DM. The CAG Research Committee report: investment in excellence. Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie. 16: 565-72. PMID 12226686  0.72
2002 Rachlis A, Watson JL, Lu J, McKay DM. Nitric oxide reduces bacterial superantigen-immune cell activation and consequent epithelial abnormalities. Journal of Leukocyte Biology. 72: 339-46. PMID 12149425  0.72
2002 Jones N, Perdue MH, Sherman PM, McKay DM. Bacterial interactions with host epithelium in vitro. Methods in Molecular Biology (Clifton, N.J.). 188: 383-400. PMID 11987560 DOI: 10.1385/1-59259-185-X:383  0.72
2002 McKay DM, Perdue MH. Establishing epithelial-immune cell co-cultures. Effects on epithelial ion transport and permeability. Methods in Molecular Biology (Clifton, N.J.). 188: 359-71. PMID 11987557 DOI: 10.1385/1-59259-185-X:359  0.72
2002 Sayer B, Lu J, Green C, Söderholm JD, Akhtar M, McKay DM. Dextran sodium sulphate-induced colitis perturbs muscarinic cholinergic control of colonic epithelial ion transport. British Journal of Pharmacology. 135: 1794-800. PMID 11934821 DOI: 10.1038/sj.bjp.0704633  0.72
2002 Leddin DJ, McKay DM. Planning for Canadian digestive disease week 2003 Canadian Journal of Gastroenterology. 16: 491-492.  0.72
2001 McKay DM. Bacterial superantigens: Provocateurs of gut dysfunction and inflammation? Trends in Immunology. 22: 497-501. PMID 11525940 DOI: 10.1016/S1471-4906(01)02000-2  0.72
2001 Yu LC, Yang PC, Berin MC, Di Leo V, Conrad DH, McKay DM, Satoskar AR, Perdue MH. Enhanced transepithelial antigen transport in intestine of allergic mice is mediated by IgE/CD23 and regulated by interleukin-4. Gastroenterology. 121: 370-81. PMID 11487546 DOI: 10.1053/gast.2001.26470  0.72
2001 Reardon C, Sanchez A, Hogaboam CM, McKay DM. Tapeworm infection reduces epithelial ion transport abnormalities in murine dextran sulfate sodium-induced colitis Infection and Immunity. 69: 4417-4423. PMID 11401981 DOI: 10.1128/IAI.69.7.4417-4423.2001  0.72
2001 Zareie M, Singh PK, Irvine EJ, Sherman PM, McKay DM, Perdue MH. Monocyte/macrophage activation by normal bacteria and bacterial products: implications for altered epithelial function in Crohn's disease. The American Journal of Pathology. 158: 1101-9. PMID 11238058 DOI: 10.1016/S0002-9440(10)64057-6  0.72
2000 McKay DM, Botelho F, Ceponis PJM, Richards CD. Superantigen immune stimulation activates epithelial STAT-1 and PI 3-K: PI 3-K regulation of permeability American Journal of Physiology - Gastrointestinal and Liver Physiology. 279: G1094-G1103. PMID 11053007  0.72
2000 Ceponis PJM, Botelho F, Richards CD, McKay DM. Interleukins 4 and 13 increase intestinal epithelial permeability by a phosphatidylinositol 3-kinase pathway. Lack of evidence for STAT 6 involvement Journal of Biological Chemistry. 275: 29132-29137. PMID 10871612 DOI: 10.1074/JBC.M003516200  0.72
2000 Benjamin MA, McKay DM, Yang PC, Cameron H, Perdue MH. Glucagon-like peptide-2 enhances intestinal epithelial barrier function of both transcellular and paracellular pathways in the mouse. Gut. 47: 112-9. PMID 10861272 DOI: 10.1136/gut.47.1.112  0.72
2000 Diaz-Granados N, Howe K, Lu J, McKay DM. Dextran sulfate sodium-induced colonic histopathology, but not altered epithelial ion transport, is reduced by inhibition of phosphodiesterase activity American Journal of Pathology. 156: 2169-2177. PMID 10854237  0.72
1999 Donnelly GAE, Lu J, Takeda T, McKay DM. Colonic epithelial physiology is altered in response to the bacterial superantigen Yersinia pseudotuberculosis mitogen Journal of Infectious Diseases. 180: 1590-1596. PMID 10515820 DOI: 10.1086/315075  0.72
1999 McKay DM, Lu J, Jedrzkiewicz S, Ho W, Sharkey KA. Nitric oxide participates in the recovery of normal jejunal epithelial ion transport following exposure to the superantigen, Staphylococcus aureus enterotoxin B. Journal of Immunology (Baltimore, Md. : 1950). 163: 4519-26. PMID 10510395  0.72
1999 Radojevic N, McKay DM, Merger M, Vallance BA, Collins SM, Croitoru K. Characterization of enteric functional changes evoked by in vivo anti-CD3 T cell activation. The American Journal of Physiology. 276: R715-23. PMID 10070131 DOI: 10.1152/ajpregu.1999.276.3.R715  0.72
1998 McKay DM, Benjamin MA, Lu J. CD4T cells mediate superantigen-induced abnormalities in murine jejunal ion transport. American Journal of Physiology. Gastrointestinal and Liver Physiology. 275: G29-G38. PMID 29585157 DOI: 10.1152/ajpgi.1998.275.1.G29  0.36
1996 Philpott DJ, McKay DM, Sherman PM, Perdue MH. Infection of T84 cells with enteropathogenic Escherichia coli alters barrier and transport functions American Journal of Physiology - Gastrointestinal and Liver Physiology. 270. PMID 8928793  0.72
1994 McKay DM, Ramage JR, Rangachari PK, Perdue MH. Effect of region, temperature and neuronal blockade on sodium and 51Cr-EDTA transport across canine gastrointestinal mucosae in vitro Comparative Biochemistry and Physiology, Part A. 107: 711-717. PMID 7911414 DOI: 10.1016/0300-9629(94)90373-5  0.72
1990 Shaw C, McKay D, Johnston CF, Halton DW, Fairweather I, Kitabgi P, Buchanan KD. Differential processing of the neurotensin/neuromedin N precursor in the mouse. Peptides. 11: 227-35. PMID 2356154 DOI: 10.1016/0196-9781(90)90075-G  0.72
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