Year |
Citation |
Score |
2022 |
Khanfar MA. Oxadiazol-based mTOR inhibitors with potent antiproliferative activities: synthetic and computational modeling. Molecular Diversity. PMID 34985718 DOI: 10.1007/s11030-021-10367-4 |
0.4 |
|
2020 |
Hagenow J, Hagenow S, Grau K, Khanfar M, Hefke L, Proschak E, Stark H. Reversible Small Molecule Inhibitors of MAO A and MAO B with Anilide Motifs. Drug Design, Development and Therapy. 14: 371-393. PMID 32099324 DOI: 10.2147/Dddt.S236586 |
0.323 |
|
2020 |
Thissera B, Visvanathan R, Khanfar MA, Qader MM, Hassan MH, Hassan HM, Bawazeer M, Behery FA, Yaseen M, Liyanage R, Abdelmohsen UR, Rateb ME. Sesbania grandiflora L. Poir leaves: A dietary supplement to alleviate type 2 diabetes through metabolic enzymes inhibition South African Journal of Botany. 130: 282-299. DOI: 10.1016/J.Sajb.2020.01.011 |
0.727 |
|
2019 |
Khanfar MA, Alqtaishat S. Discovery of potent IRAK-4 inhibitors as potential anti-inflammatory and anticancer agents using structure-based exploration of IRAK-4 pharmacophoric space coupled with QSAR analyses. Computational Biology and Chemistry. 79: 147-154. PMID 30818109 DOI: 10.1016/j.compbiolchem.2019.02.005 |
0.32 |
|
2018 |
El-Hawary SS, Sayed AM, Mohammed R, Khanfar MA, Rateb ME, Mohammed TA, Hajjar D, Hassan HM, Gulder TAM, Abdelmohsen UR. New Pim-1 Kinase Inhibitor From the Co-culture of Two Sponge-Associated Actinomycetes. Frontiers in Chemistry. 6: 538. PMID 30525020 DOI: 10.3389/Fchem.2018.00538 |
0.387 |
|
2017 |
Khanfar MA, Taha MO. Unsupervised pharmacophore modeling combined with QSAR analyses revealed novel low micromolar SIRT2 inhibitors. Journal of Molecular Recognition : Jmr. PMID 28299833 DOI: 10.1002/Jmr.2623 |
0.414 |
|
2017 |
Mohammad HK, Alzweiri MH, Khanfar MA, Al-Hiari YM. 6-Substituted nicotinic acid analogues, potent inhibitors of CAIII, used as therapeutic candidates in hyperlipidemia and cancer Medicinal Chemistry Research. 26: 1397-1404. DOI: 10.1007/S00044-017-1825-X |
0.358 |
|
2016 |
Mera WA, Alzihlif M, Taha MO, Khanfar MA. Discovery of Potent Bruton's Tyrosine Kinase Inhibitors Using Ligand Based Modeling. Anti-Cancer Agents in Medicinal Chemistry. PMID 27671297 DOI: 10.2174/1871520616666160926114416 |
0.397 |
|
2016 |
Alabed SJ, Khanfar M, Taha MO. Computer-aided discovery of new FGFR-1 inhibitors followed by in vitro validation. Future Medicinal Chemistry. 8: 1841-1869. PMID 27643626 DOI: 10.4155/Fmc-2016-0056 |
0.467 |
|
2016 |
Khanfar MA, Banat F, Alabed S, Alqtaishat S. Discovery of potent NEK2 inhibitors as potential anticancer agents using structure-based exploration of NEK2 pharmacophoric space coupled with QSAR analyses. Molecular Diversity. PMID 27599492 DOI: 10.1007/S11030-016-9696-5 |
0.439 |
|
2016 |
Khanfar MA, Al-Qtaishat S, Habash M, Taha MO. Discovery of potent adenosine A2a antagonists as potential anti-Parkinson disease agents. Non-linear QSAR analyses integrated with pharmacophore modeling. Chemico-Biological Interactions. 254: 93-101. PMID 27216633 DOI: 10.1016/J.Cbi.2016.05.023 |
0.369 |
|
2016 |
Jarrar N, Alzweiri M, Al-Hiari Y, Farah S, Khanfar MA. Modified hummel-dreyer method and molecular modeling studies identified nicotinic acid analogues as carbonic anhydrase III ligands Letters in Drug Design and Discovery. 13: 401-410. DOI: 10.2174/1570180812666150821002900 |
0.309 |
|
2015 |
Khanfar MA, Bardaweel SK, Akl MR, El Sayed KA. Olive Oil-derived Oleocanthal as Potent Inhibitor of Mammalian Target of Rapamycin: Biological Evaluation and Molecular Modeling Studies. Phytotherapy Research : Ptr. 29: 1776-82. PMID 26248874 DOI: 10.1002/Ptr.5434 |
0.473 |
|
2015 |
Khanfar MA, Quinti L, Wang H, Nobles J, Kazantsev AG, Silverman RB. Design and Evaluation of 3-(Benzylthio)benzamide Derivatives as Potent and Selective SIRT2 Inhibitors. Acs Medicinal Chemistry Letters. 6: 607-11. PMID 26005542 DOI: 10.1021/Acsmedchemlett.5B00075 |
0.432 |
|
2015 |
Jaradat NJ, Khanfar MA, Habash M, Taha MO. Combining docking-based comparative intermolecular contacts analysis and k-nearest neighbor correlation for the discovery of new check point kinase 1 inhibitors. Journal of Computer-Aided Molecular Design. 29: 561-81. PMID 25956379 DOI: 10.1007/S10822-015-9848-1 |
0.449 |
|
2015 |
Taha MO, Khanfar MA. Oleuropein potently inhibits mammalian target of rapamycin: Possible involvement of tandem anomeric hyperconjugation-Michael reaction Medicinal Chemistry Research. 24: 616-623. DOI: 10.1007/S00044-014-1168-9 |
0.446 |
|
2014 |
Taha MO, Al-Sha'er MA, Khanfar MA, Al-Nadaf AH. Discovery of nanomolar phosphoinositide 3-kinase gamma (PI3Kγ) inhibitors using ligand-based modeling and virtual screening followed by in vitro analysis. European Journal of Medicinal Chemistry. 84: 454-65. PMID 25050878 DOI: 10.1016/J.Ejmech.2014.07.056 |
0.427 |
|
2014 |
Taha MO, Habash M, Khanfar MA. The use of docking-based comparative intermolecular contacts analysis to identify optimal docking conditions within glucokinase and to discover of new GK activators. Journal of Computer-Aided Molecular Design. 28: 509-47. PMID 24610240 DOI: 10.1007/S10822-014-9740-4 |
0.356 |
|
2014 |
Khanfar MA, Quinti L, Wang H, Choi SH, Kazantsev AG, Silverman RB. Development and characterization of 3-(benzylsulfonamido)benzamides as potent and selective SIRT2 inhibitors European Journal of Medicinal Chemistry. 76: 414-426. PMID 24602787 DOI: 10.1016/J.Ejmech.2014.02.003 |
0.432 |
|
2014 |
Al-Sha'er MA, Khanfar MA, Taha MO. Discovery of novel urokinase plasminogen activator (uPA) inhibitors using ligand-based modeling and virtual screening followed by in vitro analysis. Journal of Molecular Modeling. 20: 2080. PMID 24469103 DOI: 10.1007/S00894-014-2080-4 |
0.426 |
|
2013 |
Khanfar MA, Taha MO. Elaborate ligand-based modeling coupled with multiple linear regression and k nearest neighbor QSAR analyses unveiled new nanomolar mTOR inhibitors. Journal of Chemical Information and Modeling. 53: 2587-612. PMID 24050502 DOI: 10.1021/Ci4003798 |
0.434 |
|
2013 |
Eterović VA, Del Valle-Rodriguez A, Pérez D, Carrasco M, Khanfar MA, El Sayed KA, Ferchmin PA. Protective activity of (1S,2E,4R,6R,7E,11E)-2,7,11-cembratriene-4,6-diol analogues against diisopropylfluorophosphate neurotoxicity: preliminary structure-activity relationship and pharmacophore modeling. Bioorganic & Medicinal Chemistry. 21: 4678-86. PMID 23769165 DOI: 10.1016/J.Bmc.2013.05.018 |
0.341 |
|
2013 |
Khanfar MA, AbuKhader MM, Alqtaishat S, Taha MO. Pharmacophore modeling, homology modeling, and in silico screening reveal mammalian target of rapamycin inhibitory activities for sotalol, glyburide, metipranolol, sulfamethizole, glipizide, and pioglitazone. Journal of Molecular Graphics & Modelling. 42: 39-49. PMID 23545333 DOI: 10.1016/J.Jmgm.2013.02.009 |
0.384 |
|
2013 |
Khanfar MA, El Sayed KA. The Veratrum alkaloids jervine, veratramine, and their analogues as prostate cancer migration and proliferation inhibitors: Biological evaluation and pharmacophore modeling Medicinal Chemistry Research. 22: 4775-4786. DOI: 10.1007/s00044-013-0495-6 |
0.443 |
|
2012 |
Sayed KAE, Elnagar AY, Khanfar M. Abstract 4778: Computer-assisted molecular design use for the discovery and optimization of rationally-designed anticancer natural products. Discovery of olive oil-derived oleocanthal as a c-Met inhibitor and optimization of Veratrum alkaloids as Hedgehog signaling inhibitors Cancer Research. 72: 4778-4778. DOI: 10.1158/1538-7445.Am2012-4778 |
0.789 |
|
2011 |
Hassan HM, Elnagar AY, Khanfar MA, Sallam AA, Mohammed R, Shaala LA, Youssef DT, Hifnawy MS, El Sayed KA. Design of semisynthetic analogues and 3D-QSAR study of eunicellin-based diterpenoids as prostate cancer migration and invasion inhibitors. European Journal of Medicinal Chemistry. 46: 1122-30. PMID 21334794 DOI: 10.1016/J.Ejmech.2011.01.028 |
0.785 |
|
2011 |
Mudit M, Khanfar M, Shah GV, Sayed KA. Methods for evaluation of structural and biological properties of antiinvasive natural products. Methods in Molecular Biology (Clifton, N.J.). 716: 55-71. PMID 21318900 DOI: 10.1007/978-1-61779-012-6_4 |
0.788 |
|
2011 |
Baraka HN, Khanfar MA, Williams JC, El-Giar EM, El Sayed KA. Bioactive natural, biocatalytic, and semisynthetic tobacco cembranoids. Planta Medica. 77: 467-76. PMID 21049399 DOI: 10.1055/S-0030-1250478 |
0.425 |
|
2010 |
Khanfar MA, Hill RA, Kaddoumi A, El Sayed KA. Discovery of novel GSK-3β inhibitors with potent in vitro and in vivo activities and excellent brain permeability using combined ligand- and structure-based virtual screening. Journal of Medicinal Chemistry. 53: 8534-45. PMID 21082766 DOI: 10.1021/Jm100941J |
0.378 |
|
2010 |
Khanfar MA, El Sayed KA. Phenylmethylene hydantoins as prostate cancer invasion and migration inhibitors. CoMFA approach and QSAR analysis. European Journal of Medicinal Chemistry. 45: 5397-405. PMID 20869139 DOI: 10.1016/J.Ejmech.2010.08.066 |
0.564 |
|
2010 |
Abraham I, Jain S, Wu CP, Khanfar MA, Kuang Y, Dai CL, Shi Z, Chen X, Fu L, Ambudkar SV, El Sayed K, Chen ZS. Marine sponge-derived sipholane triterpenoids reverse P-glycoprotein (ABCB1)-mediated multidrug resistance in cancer cells. Biochemical Pharmacology. 80: 1497-506. PMID 20696137 DOI: 10.1016/J.Bcp.2010.08.001 |
0.524 |
|
2010 |
Khanfar MA, Youssef DT, El Sayed KA. 3D-QSAR studies of latrunculin-based actin polymerization inhibitors using CoMFA and CoMSIA approaches. European Journal of Medicinal Chemistry. 45: 3662-8. PMID 20684858 DOI: 10.1016/J.Ejmech.2010.05.012 |
0.381 |
|
2010 |
Hassan HM, Khanfar MA, Elnagar AY, Mohammed R, Shaala LA, Youssef DT, Hifnawy MS, El Sayed KA. Pachycladins A-E, prostate cancer invasion and migration inhibitory Eunicellin-based diterpenoids from the red sea soft coral Cladiella pachyclados. Journal of Natural Products. 73: 848-53. PMID 20420415 DOI: 10.1021/Np900787P |
0.775 |
|
2010 |
Khanfar MA, Youssef DT, El Sayed KA. Semisynthetic latrunculin derivatives as inhibitors of metastatic breast cancer: biological evaluations, preliminary structure-activity relationship and molecular modeling studies. Chemmedchem. 5: 274-85. PMID 20043312 DOI: 10.1002/Cmdc.200900430 |
0.459 |
|
2010 |
Abdel Bar FM, Khanfar MA, Elnagar AY, Badria FA, Zaghloul AM, Ahmad KF, Sylvester PW, El Sayed KA. Design and pharmacophore modeling of biaryl methyl eugenol analogs as breast cancer invasion inhibitors. Bioorganic & Medicinal Chemistry. 18: 496-507. PMID 20034800 DOI: 10.1016/J.Bmc.2009.12.019 |
0.771 |
|
2009 |
Bar FM, Khanfar MA, Elnagar AY, Liu H, Zaghloul AM, Badria FA, Sylvester PW, Ahmad KF, Raisch KP, El Sayed KA. Rational design and semisynthesis of betulinic acid analogues as potent topoisomerase inhibitors. Journal of Natural Products. 72: 1643-50. PMID 19691293 DOI: 10.1021/Np900312U |
0.762 |
|
2009 |
Khanfar MA, Asal BA, Mudit M, Kaddoumi A, El Sayed KA. The marine natural-derived inhibitors of glycogen synthase kinase-3beta phenylmethylene hydantoins: In vitro and in vivo activities and pharmacophore modeling. Bioorganic & Medicinal Chemistry. 17: 6032-9. PMID 19616957 DOI: 10.1016/J.Bmc.2009.06.054 |
0.76 |
|
2009 |
Shah GV, Muralidharan A, Thomas S, Gokulgandhi M, Mudit M, Khanfar M, El Sayed K. Identification of a small molecule class to enhance cell-cell adhesion and attenuate prostate tumor growth and metastasis. Molecular Cancer Therapeutics. 8: 509-20. PMID 19276166 DOI: 10.1158/1535-7163.Mct-08-0693 |
0.767 |
|
2009 |
Mudit M, Khanfar M, Muralidharan A, Thomas S, Shah GV, van Soest RW, El Sayed KA. Discovery, design, and synthesis of anti-metastatic lead phenylmethylene hydantoins inspired by marine natural products. Bioorganic & Medicinal Chemistry. 17: 1731-8. PMID 19195897 DOI: 10.1016/J.Bmc.2008.12.053 |
0.79 |
|
2009 |
Mudit M, Khanfar M, Muralidharan A, Thomas S, Shah GV, van Soest RW, El Sayed KA. Erratum to “Discovery, design, and synthesis of anti-metastatic lead phenylmethylene hydantoins inspired by marine natural products” [Bioorg. Med. Chem. 17 (2009) 1731–1738] Bioorganic & Medicinal Chemistry. 17: 3216-3217. DOI: 10.1016/J.Bmc.2008.12.073 |
0.738 |
|
2008 |
Sayed KA, Khanfar MA, Shallal HM, Muralidharan A, Awate B, Youssef DT, Liu Y, Zhou YD, Nagle DG, Shah G. Latrunculin A and its C-17-O-carbamates inhibit prostate tumor cell invasion and HIF-1 activation in breast tumor cells. Journal of Natural Products. 71: 396-402. PMID 18298079 DOI: 10.1021/Np070587W |
0.441 |
|
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