Year |
Citation |
Score |
2012 |
Jin Q, Davis RS, Bullion AM, Jin J, Wang Y, Widdowson KL, Palovich MR, Foley JJ, Schmidt DB, Buckley PT, Webb EF, Salmon M, Belmonte KE, Sarau HM, Busch-Petersen J. Tyrosine urea muscarinic acetylcholine receptor antagonists: achiral quaternary ammonium groups. Bioorganic & Medicinal Chemistry Letters. 22: 7087-91. PMID 23099092 DOI: 10.1016/j.bmcl.2012.09.085 |
0.444 |
|
2009 |
Lainé DI, Wan Z, Yan H, Zhu C, Xie H, Fu W, Busch-Petersen J, Neipp C, Davis R, Widdowson KL, Blaney FE, Foley J, Bacon AM, Webb EF, Luttmann MA, ... ... Belmonte K, et al. Design, synthesis, and structure-activity relationship of tropane muscarinic acetylcholine receptor antagonists. Journal of Medicinal Chemistry. 52: 5241-52. PMID 19630384 DOI: 10.1021/Jm900736E |
0.528 |
|
2009 |
Wan Z, Laine DI, Yan H, Zhu C, Widdowson KL, Buckley PT, Burman M, Foley JJ, Sarau HM, Schmidt DB, Webb EF, Belmonte KE, Palovich M. Discovery of (3-endo)-3-(2-cyano-2,2-diphenylethyl)-8,8-dimethyl-8-azoniabicyclo[3.2.1]octane bromide as an efficacious inhaled muscarinic acetylcholine receptor antagonist for the treatment of COPD. Bioorganic & Medicinal Chemistry Letters. 19: 4560-2. PMID 19616944 DOI: 10.1016/j.bmcl.2009.07.006 |
0.335 |
|
2009 |
Lainé DI, McCleland B, Thomas S, Neipp C, Underwood B, Dufour J, Widdowson KL, Palovich MR, Blaney FE, Foley JJ, Webb EF, Luttmann MA, Burman M, Belmonte K, Salmon M. Discovery of novel 1-azoniabicyclo[2.2.2]octane muscarinic acetylcholine receptor antagonists. Journal of Medicinal Chemistry. 52: 2493-505. PMID 19317446 DOI: 10.1021/Jm801601V |
0.501 |
|
2009 |
Budzik B, Wang Y, Shi D, Wang F, Xie H, Wan Z, Zhu C, Foley JJ, Nuthulaganti P, Kallal LA, Sarau HM, Morrow DM, Moore ML, Rivero RA, Palovich M, ... ... Belmonte KE, et al. M3 muscarinic acetylcholine receptor antagonists: SAR and optimization of bi-aryl amines. Bioorganic & Medicinal Chemistry Letters. 19: 1686-90. PMID 19243945 DOI: 10.1016/j.bmcl.2009.01.098 |
0.497 |
|
2008 |
Jin J, Wang Y, Shi D, Wang F, Fu W, Davis RS, Jin Q, Foley JJ, Sarau HM, Morrow DM, Moore ML, Rivero RA, Palovich M, Salmon M, Belmonte KE, et al. Muscarinic acetylcholine receptor antagonists: SAR and optimization of tyrosine ureas. Bioorganic & Medicinal Chemistry Letters. 18: 5481-6. PMID 18818072 DOI: 10.1016/j.bmcl.2008.09.020 |
0.516 |
|
2008 |
Jin J, Budzik B, Wang Y, Shi D, Wang F, Xie H, Wan Z, Zhu C, Foley JJ, Webb EF, Berlanga M, Burman M, Sarau HM, Morrow DM, Moore ML, ... ... Belmonte KE, et al. Discovery of biphenyl piperazines as novel and long acting muscarinic acetylcholine receptor antagonists. Journal of Medicinal Chemistry. 51: 5915-8. PMID 18798607 DOI: 10.1021/jm800935u |
0.505 |
|
2008 |
Jin J, Wang Y, Shi D, Wang F, Davis RS, Jin Q, Fu W, Foley JJ, Webb EF, Dehaas CJ, Berlanga M, Burman M, Sarau HM, Morrow DM, Rao P, ... ... Belmonte KE, et al. Discovery of novel and long acting muscarinic acetylcholine receptor antagonists. Journal of Medicinal Chemistry. 51: 4866-9. PMID 18680280 DOI: 10.1021/jm800634k |
0.399 |
|
2007 |
Lainé DI, Xie H, Buffet N, Foley JJ, Buckley P, Webb EF, Widdowson KL, Palovich MR, Belmonte KE. Discovery of novel 8-azoniabicyclo[3.2.1]octane carbamates as muscarinic acetylcholine receptor antagonists. Bioorganic & Medicinal Chemistry Letters. 17: 6066-9. PMID 17911022 DOI: 10.1016/j.bmcl.2007.09.071 |
0.396 |
|
2006 |
Mazzone SB, Mori N, Burman M, Palovich M, Belmonte KE, Canning BJ. Fluorescent styryl dyes FM1-43 and FM2-10 are muscarinic receptor antagonists: intravital visualization of receptor occupancy. The Journal of Physiology. 575: 23-35. PMID 16728454 DOI: 10.1113/jphysiol.2006.106351 |
0.579 |
|
2006 |
Fryer AD, Stein LH, Nie Z, Curtis DE, Evans CM, Hodgson ST, Jose PJ, Belmonte KE, Fitch E, Jacoby DB. Neuronal eotaxin and the effects of CCR3 antagonist on airway hyperreactivity and M2 receptor dysfunction. The Journal of Clinical Investigation. 116: 228-36. PMID 16374515 DOI: 10.1172/Jci25423 |
0.685 |
|
2006 |
Waters CM, Long J, Gorshkova I, Fujiwara Y, Connell M, Belmonte KE, Tigyi G, Natarajan V, Pyne S, Pyne NJ. Cell migration activated by platelet-derived growth factor receptor is blocked by an inverse agonist of the sphingosine 1-phosphate receptor-1. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 20: 509-11. PMID 16319133 DOI: 10.1096/fj.05-4810fje |
0.498 |
|
2006 |
Rahaman M, Costello RW, Belmonte KE, Gendy SS, Walsh MT. Neutrophil sphingosine 1-phosphate and lysophosphatidic acid receptors in pneumonia. American Journal of Respiratory Cell and Molecular Biology. 34: 233-41. PMID 16224106 DOI: 10.1165/rcmb.2005-0126OC |
0.59 |
|
2005 |
Belmonte KE. Cholinergic pathways in the lungs and anticholinergic therapy for chronic obstructive pulmonary disease. Proceedings of the American Thoracic Society. 2: 297-304; discussion . PMID 16267352 DOI: 10.1513/pats.200504-043SR |
0.552 |
|
2000 |
Belmonte KE, McKinnon LA, Nathanson NM. Developmental expression of muscarinic acetylcholine receptors in chick retina: selective induction of M2 muscarinic receptor expression in ovo by a factor secreted by muller glial cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 8417-25. PMID 11069949 |
0.429 |
|
2000 |
Evans CM, Belmonte KE, Costello RW, Jacoby DB, Gleich GJ, Fryer AD. Substance P-induced airway hyperreactivity is mediated by neuronal M(2) receptor dysfunction. American Journal of Physiology. Lung Cellular and Molecular Physiology. 279: L477-86. PMID 10956622 DOI: 10.1152/Ajplung.2000.279.3.L477 |
0.68 |
|
1999 |
Costello RW, Evans CM, Yost BL, Belmonte KE, Gleich GJ, Jacoby DB, Fryer AD. Antigen-induced hyperreactivity to histamine: role of the vagus nerves and eosinophils. The American Journal of Physiology. 276: L709-14. PMID 10330026 DOI: 10.1152/Ajplung.1999.276.5.L709 |
0.684 |
|
1998 |
Belmonte KE, Fryer AD, Costello RW. Role of insulin in antigen-induced airway eosinophilia and neuronal M2 muscarinic receptor dysfunction. Journal of Applied Physiology (Bethesda, Md. : 1985). 85: 1708-18. PMID 9804573 DOI: 10.1152/Jappl.1998.85.5.1708 |
0.702 |
|
1998 |
Costello RW, Fryer AD, Belmonte KE, Jacoby DB. Effects of tachykinin NK1 receptor antagonists on vagal hyperreactivity and neuronal M2 muscarinic receptor function in antigen challenged guinea-pigs. British Journal of Pharmacology. 124: 267-76. PMID 9641542 DOI: 10.1038/Sj.Bjp.0701822 |
0.733 |
|
1997 |
Belmonte KE, Jacoby DB, Fryer AD. Increased function of inhibitory neuronal M2 muscarinic receptors in diabetic rat lungs. British Journal of Pharmacology. 121: 1287-94. PMID 9257905 DOI: 10.1038/Sj.Bjp.0701274 |
0.611 |
|
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