| Year |
Citation |
Score |
| 2023 |
Kale VP, Hengst JA, Sharma AK, Golla U, Dovat S, Amin SG, Yun JK, Desai DH. Characterization of Anticancer Effects of the Analogs of DJ4, a Novel Selective Inhibitor of ROCK and MRCK Kinases. Pharmaceuticals (Basel, Switzerland). 16. PMID 37630974 DOI: 10.3390/ph16081060 |
0.359 |
|
| 2022 |
Hengst JA, Nduwumwami AJ, Yun JK. Regulatory Role of Sphingosine-1-Phosphate and C16:0 Ceramide, in Immunogenic Cell Death of Colon Cancer Cells Induced by Bak/Bax-Activation. Cancers. 14. PMID 36358599 DOI: 10.3390/cancers14215182 |
0.415 |
|
| 2021 |
Hengst JA, Nduwumwami AJ, Raup-Konsavage WM, Vrana KE, Yun JK. Inhibition of Sphingosine Kinase Activity Enhances Immunogenic Cell Surface Exposure of Calreticulin Induced by the Synthetic Cannabinoid 5-epi-CP-55,940. Cannabis and Cannabinoid Research. PMID 34846947 DOI: 10.1089/can.2021.0100 |
0.408 |
|
| 2021 |
Nduwumwami AJ, Hengst JA, Yun JK. Sphingosine kinase inhibition enhances dimerization of calreticulin at the cell surface in mitoxantrone-induced immunogenic cell death. The Journal of Pharmacology and Experimental Therapeutics. PMID 34158403 DOI: 10.1124/jpet.121.000629 |
0.383 |
|
| 2020 |
Hengst JA, Dick TE, Smith CD, Yun JK. Analysis of selective target engagement by small-molecule sphingosine kinase inhibitors using the Cellular Thermal Shift Assay (CETSA). Cancer Biology & Therapy. 1-12. PMID 32835586 DOI: 10.1080/15384047.2020.1798696 |
0.373 |
|
| 2020 |
Hengst JA, Hegde S, Paulson RF, Yun JK. Development of SKI-349, a Dual-Targeted Inhibitor of Sphingosine Kinase and Microtubule Polymerization. Bioorganic & Medicinal Chemistry Letters. 127453. PMID 32736077 DOI: 10.1016/J.Bmcl.2020.127453 |
0.469 |
|
| 2017 |
Hengst JA, Dick TE, Sharma A, Doi K, Hegde S, Tan SF, Geffert LM, Fox TE, Sharma AK, Desai D, Amin S, Kester M, Loughran TP, Paulson RF, Claxton DF, ... ... Yun JK, et al. SKI-178: A Multitargeted Inhibitor of Sphingosine Kinase and Microtubule Dynamics Demonstrating Therapeutic Efficacy in Acute Myeloid Leukemia Models. Cancer Translational Medicine. 3: 109-121. PMID 28890935 DOI: 10.4103/Ctm.Ctm_7_17 |
0.391 |
|
| 2016 |
Tan SF, Liu X, Fox TE, Barth BM, Sharma A, Turner SD, Awwad A, Dewey A, Doi K, Spitzer B, Shah MV, Morad SA, Desai D, Amin S, Zhu J, ... ... Yun J, et al. Acid ceramidase is upregulated in AML and represents a novel therapeutic target. Oncotarget. PMID 27825124 DOI: 10.18632/Oncotarget.13079 |
0.438 |
|
| 2016 |
Young MM, Takahashi Y, Fox TE, Yun JK, Kester M, Wang HG. Sphingosine Kinase 1 Cooperates with Autophagy to Maintain Endocytic Membrane Trafficking. Cell Reports. 17: 1532-1545. PMID 27806293 DOI: 10.1016/J.Celrep.2016.10.019 |
0.347 |
|
| 2016 |
Desai DH, Kale VP, Hengst JA, Dick TE, Colledge AL, Amin SG, Yun JK. Abstract 4805: In vitro characterization of novel inhibitors of ROCK and MRCK kinases as anticancer agents Cancer Research. 76: 4805-4805. DOI: 10.1158/1538-7445.Am2016-4805 |
0.456 |
|
| 2016 |
Dick TE, Hengst JA, Geffert LM, Paulson RF, Wang H, Claxton DF, Kester M, Loughran TP, Yun JK. Abstract 323: SKI-178, a single agent co-targeting sphingosine kinase 1 and microtubule dynamics, as a therapeutic strategy for treatment of acute myeloid leukemia Cancer Research. 76: 323-323. DOI: 10.1158/1538-7445.Am2016-323 |
0.348 |
|
| 2015 |
LeBlanc FR, Liu X, Hengst J, Fox T, Calvert V, Petricoin EF, Yun J, Feith DJ, Loughran TP. Sphingosine kinase inhibitors decrease viability and induce cell death in natural killer-large granular lymphocyte leukemia. Cancer Biology & Therapy. 0. PMID 26252351 DOI: 10.1080/15384047.2015.1078949 |
0.493 |
|
| 2015 |
Kale VP, Hengst JA, Desai DH, Amin SG, Yun JK. The regulatory roles of ROCK and MRCK kinases in the plasticity of cancer cell migration. Cancer Letters. 361: 185-96. PMID 25796438 DOI: 10.1016/J.Canlet.2015.03.017 |
0.431 |
|
| 2015 |
Dick TE, Hengst JA, Fox TE, Colledge AL, Kale VP, Sung SS, Sharma A, Amin S, Loughran TP, Kester M, Wang HG, Yun JK. The apoptotic mechanism of action of the sphingosine kinase 1 selective inhibitor SKI-178 in human acute myeloid leukemia cell lines. The Journal of Pharmacology and Experimental Therapeutics. 352: 494-508. PMID 25563902 DOI: 10.1124/Jpet.114.219659 |
0.516 |
|
| 2015 |
Dick TE, Hengst J, Kale V, Colledge A, Yun JK. Abstract 2933: The apoptotic mechanism of action of SKI-178, a novel Sphingosine kinase 1 selective inhibitor Cancer Research. 75: 2933-2933. DOI: 10.1158/1538-7445.Am2015-2933 |
0.524 |
|
| 2014 |
Kale VP, Hengst JA, Desai DH, Dick TE, Choe KN, Colledge AL, Takahashi Y, Sung SS, Amin SG, Yun JK. A novel selective multikinase inhibitor of ROCK and MRCK effectively blocks cancer cell migration and invasion. Cancer Letters. 354: 299-310. PMID 25172415 DOI: 10.1016/J.Canlet.2014.08.032 |
0.502 |
|
| 2014 |
Kale VP, Desai D, Dick T, Choe K, Colledge A, Amin S, Hengst J, Yun J. Abstract 736: DJ4, a novel ROCK and MRCK inhibitor, potently inhibits migration and invasion of cancer cells Cancer Research. 74: 736-736. DOI: 10.1158/1538-7445.Am2014-736 |
0.457 |
|
| 2012 |
Young MM, Takahashi Y, Khan O, Park S, Hori T, Yun J, Sharma AK, Amin S, Hu CD, Zhang J, Kester M, Wang HG. Autophagosomal membrane serves as platform for intracellular death-inducing signaling complex (iDISC)-mediated caspase-8 activation and apoptosis. The Journal of Biological Chemistry. 287: 12455-68. PMID 22362782 DOI: 10.1074/Jbc.M111.309104 |
0.379 |
|
| 2012 |
Hengst JA, Yun JK. Sphingosine kinase: a key to solving the 'French Paradox'? British Journal of Pharmacology. 166: 1603-4. PMID 22335554 DOI: 10.1111/J.1476-5381.2012.01898.X |
0.427 |
|
| 2012 |
Madhunapantula SV, Hengst J, Gowda R, Fox TE, Yun JK, Robertson GP. Targeting sphingosine kinase-1 to inhibit melanoma. Pigment Cell & Melanoma Research. 25: 259-74. PMID 22236408 DOI: 10.1111/J.1755-148X.2012.00970.X |
0.485 |
|
| 2012 |
LeBlanc F, Liu X, Fox T, Shah M, Rogers A, Ryland L, Kester M, Yun J, Loughran TP. Targeting Sphingosine Kinase 1 in NK-LGL Leukemia Blood. 120: 1313-1313. DOI: 10.1182/Blood.V120.21.1313.1313 |
0.429 |
|
| 2011 |
Zhang Y, Cheng Y, Zhang L, Ren X, Huber-Keener KJ, Lee S, Yun J, Wang HG, Yang JM. Inhibition of eEF-2 kinase sensitizes human glioma cells to TRAIL and down-regulates Bcl-xL expression. Biochemical and Biophysical Research Communications. 414: 129-34. PMID 21945617 DOI: 10.1016/J.Bbrc.2011.09.038 |
0.576 |
|
| 2011 |
Sk UH, Prakasha Gowda AS, Crampsie MA, Yun JK, Spratt TE, Amin S, Sharma AK. Development of novel naphthalimide derivatives and their evaluation as potential melanoma therapeutics. European Journal of Medicinal Chemistry. 46: 3331-8. PMID 21609852 DOI: 10.1016/J.Ejmech.2011.04.058 |
0.392 |
|
| 2011 |
O'Neill SM, Yun JK, Fox TE, Kester M. Transcriptional regulation of the human neutral ceramidase gene. Archives of Biochemistry and Biophysics. 511: 21-30. PMID 21531200 DOI: 10.1016/J.Abb.2011.04.012 |
0.301 |
|
| 2011 |
O'Neill SM, Houck KL, Yun JK, Fox TE, Kester M. AP-1 binding transcriptionally regulates human neutral ceramidase. Archives of Biochemistry and Biophysics. 511: 31-9. PMID 21530485 DOI: 10.1016/J.Abb.2011.04.009 |
0.39 |
|
| 2010 |
Hengst JA, Wang X, Sk UH, Sharma AK, Amin S, Yun JK. Development of a sphingosine kinase 1 specific small-molecule inhibitor. Bioorganic & Medicinal Chemistry Letters. 20: 7498-502. PMID 21050755 DOI: 10.1016/J.Bmcl.2010.10.005 |
0.415 |
|
| 2010 |
Karelia N, Desai D, Hengst JA, Amin S, Rudrabhatla SV, Yun J. Selenium-containing analogs of SAHA induce cytotoxicity in lung cancer cells. Bioorganic & Medicinal Chemistry Letters. 20: 6816-9. PMID 20855208 DOI: 10.1016/J.Bmcl.2010.08.113 |
0.456 |
|
| 2010 |
Sharma AK, Sk UH, Gimbor MA, Hengst JA, Wang X, Yun J, Amin S. Synthesis and bioactivity of sphingosine kinase inhibitors and their novel aspirinyl conjugated analogs. European Journal of Medicinal Chemistry. 45: 4149-56. PMID 20598402 DOI: 10.1016/J.Ejmech.2010.06.005 |
0.46 |
|
| 2010 |
Hengst JA, Guilford JM, Conroy EJ, Wang X, Yun JK. Enhancement of sphingosine kinase 1 catalytic activity by deletion of 21 amino acids from the COOH-terminus. Archives of Biochemistry and Biophysics. 494: 23-31. PMID 19914200 DOI: 10.1016/J.Abb.2009.11.006 |
0.426 |
|
| 2010 |
Hengst JA, Wang X, Desai D, Amin S, Yun JK. Abstract B68: EGCG and theaflavin are direct inhibitors of the oncogenic lipid kinase, sphingosine kinase 1 Cancer Prevention Research. 3. DOI: 10.1158/1940-6207.Prev-10-B68 |
0.461 |
|
| 2010 |
Sk UH, Gowda ASP, Gimbor MA, Gowda R, Robertson GP, Spratt TE, Yun JK, Amin S, Sharma AK. Abstract 742: Development of novel naphthalimide derivatives as potential melanoma therapeutics Cancer Research. 70: 742-742. DOI: 10.1158/1538-7445.Am10-742 |
0.318 |
|
| 2009 |
Hengst JA, Guilford JM, Fox TE, Wang X, Conroy EJ, Yun JK. Sphingosine kinase 1 localized to the plasma membrane lipid raft microdomain overcomes serum deprivation induced growth inhibition. Archives of Biochemistry and Biophysics. 492: 62-73. PMID 19782042 DOI: 10.1016/J.Abb.2009.09.013 |
0.418 |
|
| 2008 |
Zhang R, Shah MV, Yang J, Nyland SB, Liu X, Yun JK, Albert R, Loughran TP. Network model of survival signaling in large granular lymphocyte leukemia. Proceedings of the National Academy of Sciences of the United States of America. 105: 16308-13. PMID 18852469 DOI: 10.1073/Pnas.0806447105 |
0.338 |
|
| 2008 |
Bayerl MG, Bruggeman RD, Conroy EJ, Hengst JA, King TS, Jimenez M, Claxton DF, Yun JK. Sphingosine kinase 1 protein and mRNA are overexpressed in non-Hodgkin lymphomas and are attractive targets for novel pharmacological interventions. Leukemia & Lymphoma. 49: 948-54. PMID 18452097 DOI: 10.1080/10428190801911654 |
0.457 |
|
| 2007 |
Itagaki K, Yun JK, Hengst JA, Yatani A, Hauser CJ, Spolarics Z, Deitch EA. Sphingosine 1-phosphate has dual functions in the regulation of endothelial cell permeability and Ca2+ metabolism. The Journal of Pharmacology and Experimental Therapeutics. 323: 186-91. PMID 17626797 DOI: 10.1124/Jpet.107.121210 |
0.326 |
|
| 2007 |
Francy JM, Nag A, Conroy EJ, Hengst JA, Yun JK. Sphingosine kinase 1 expression is regulated by signaling through PI3K, AKT2, and mTOR in human coronary artery smooth muscle cells. Biochimica Et Biophysica Acta. 1769: 253-65. PMID 17482291 DOI: 10.1016/J.Bbaexp.2007.03.005 |
0.418 |
|
| 2007 |
Fox TE, Houck KL, O'Neill SM, Nagarajan M, Stover TC, Pomianowski PT, Unal O, Yun JK, Naides SJ, Kester M. Ceramide recruits and activates protein kinase C zeta (PKC zeta) within structured membrane microdomains. The Journal of Biological Chemistry. 282: 12450-7. PMID 17308302 DOI: 10.1074/Jbc.M700082200 |
0.524 |
|
| 2006 |
French KJ, Upson JJ, Keller SN, Zhuang Y, Yun JK, Smith CD. Antitumor activity of sphingosine kinase inhibitors. The Journal of Pharmacology and Experimental Therapeutics. 318: 596-603. PMID 16632640 DOI: 10.1124/Jpet.106.101345 |
0.523 |
|
| 2006 |
Reese BE, Krissinger D, Yun JK, Billingsley ML. Elucidation of stannin function using microarray analysis: implications for cell cycle control. Gene Expression. 13: 41-52. PMID 16572589 DOI: 10.3727/000000006783991944 |
0.361 |
|
| 2006 |
Billingsley ML, Yun J, Reese BE, Davidson CE, Buck-Koehntop BA, Veglia G. Functional and structural properties of stannin: roles in cellular growth, selective toxicity, and mitochondrial responses to injury. Journal of Cellular Biochemistry. 98: 243-50. PMID 16453279 DOI: 10.1002/Jcb.20809 |
0.428 |
|
| 2005 |
Davidson CE, Reese BE, Billingsley ML, Yun JK. The protein stannin binds 14-3-3zeta and modulates mitogen-activated protein kinase signaling. Brain Research. Molecular Brain Research. 138: 256-63. PMID 15923056 DOI: 10.1016/J.Molbrainres.2005.04.018 |
0.505 |
|
| 2005 |
Reese BE, Davidson C, Billingsley ML, Yun J. Protein kinase C epsilon regulates tumor necrosis factor-alpha-induced stannin gene expression. The Journal of Pharmacology and Experimental Therapeutics. 314: 61-9. PMID 15798003 DOI: 10.1124/Jpet.105.084236 |
0.494 |
|
| 2004 |
Davidson CE, Reese BE, Billingsley ML, Yun JK. Stannin, a protein that localizes to the mitochondria and sensitizes NIH-3T3 cells to trimethyltin and dimethyltin toxicity. Molecular Pharmacology. 66: 855-63. PMID 15269288 DOI: 10.1124/Mol.104.001719 |
0.302 |
|
| 2003 |
French KJ, Schrecengost RS, Lee BD, Zhuang Y, Smith SN, Eberly JL, Yun JK, Smith CD. Discovery and evaluation of inhibitors of human sphingosine kinase. Cancer Research. 63: 5962-9. PMID 14522923 |
0.346 |
|
| 2002 |
Yun JK, Kester M. Regulatory role of sphingomyelin metabolites in hypoxia-induced vascular smooth muscle cell proliferation. Archives of Biochemistry and Biophysics. 408: 78-86. PMID 12485605 DOI: 10.1016/S0003-9861(02)00526-X |
0.446 |
|
| 2001 |
Bourbon NA, Yun J, Berkey D, Wang Y, Kester M. Inhibitory actions of ceramide upon PKC-epsilon/ERK interactions. American Journal of Physiology. Cell Physiology. 280: C1403-11. PMID 11350735 DOI: 10.1152/Ajpcell.2001.280.6.C1403 |
0.576 |
|
| 2000 |
Bourbon NA, Yun J, Kester M. Ceramide directly activates protein kinase C zeta to regulate a stress-activated protein kinase signaling complex. The Journal of Biological Chemistry. 275: 35617-23. PMID 10962008 DOI: 10.1074/Jbc.M007346200 |
0.552 |
|
| 2000 |
Charles R, Sandirasegarane L, Yun J, Bourbon N, Wilson R, Rothstein RP, Levison SW, Kester M. Ceramide-coated balloon catheters limit neointimal hyperplasia after stretch injury in carotid arteries. Circulation Research. 87: 282-8. PMID 10948061 DOI: 10.1161/01.Res.87.4.282 |
0.498 |
|
| 1998 |
Judware R, McCormick TS, Mohr S, Yun JK, Lapetina EG. Propensity for macrophage apoptosis is related to the pattern of expression and function of integrin extracellular matrix receptors Biochemical and Biophysical Research Communications. 246: 507-512. PMID 9610392 DOI: 10.1006/Bbrc.1998.8650 |
0.321 |
|
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