Year |
Citation |
Score |
2009 |
Albertson TM, Ogawa M, Bugni JM, Hays LE, Chen Y, Wang Y, Treuting PM, Heddle JA, Goldsby RE, Preston BD. DNA polymerase epsilon and delta proofreading suppress discrete mutator and cancer phenotypes in mice. Proceedings of the National Academy of Sciences of the United States of America. 106: 17101-4. PMID 19805137 DOI: 10.1073/Pnas.0907147106 |
0.473 |
|
2005 |
Hernández LG, Heddle JA. A carcinogenic western diet does not induce somatic mutations in various target tissues of transgenic C56BL/6 mice. Mutation Research. 570: 185-96. PMID 15708577 DOI: 10.1016/J.Mrfmmm.2004.11.001 |
0.381 |
|
2005 |
Heddle JA, Bielas JH. Unifying concept of DNA repair: the polymerase scanning hypothesis. Environmental and Molecular Mutagenesis. 45: 143-9. PMID 15672383 DOI: 10.1002/Em.20112 |
0.665 |
|
2004 |
Newell LE, Heddle JA. The potent colon carcinogen, 1,2-dimethylhydrazine induces mutations primarily in the colon. Mutation Research. 564: 1-7. PMID 15474405 DOI: 10.1016/J.Mrgentox.2004.06.005 |
0.456 |
|
2004 |
Wang Y, Heddle JA. Spontaneous and induced chromosomal damage and mutations in Bloom Syndrome mice. Mutation Research. 554: 131-7. PMID 15450411 DOI: 10.1016/J.Mrfmmm.2004.04.004 |
0.45 |
|
2004 |
Trentin GA, Moody J, Shima N, Thompson LU, Heddle JA. Effect of dietary supplementation on the frequency of spontaneous lacZ mutations in the developing colon. Mutation Research. 551: 223-31. PMID 15225595 DOI: 10.1016/J.Mrfmmm.2004.04.006 |
0.423 |
|
2004 |
Trentin GA, Moody J, Torous DK, Thompson LU, Heddle JA. The influence of dietary flaxseed and other grains, fruits and vegetables on the frequency of spontaneous chromosomal damage in mice. Mutation Research. 551: 213-22. PMID 15225594 DOI: 10.1016/J.Mrfmmm.2004.04.005 |
0.397 |
|
2004 |
Bielas JH, Heddle JA. Quiescent murine cells lack global genomic repair but are proficient in transcription-coupled repair. Dna Repair. 3: 711-7. PMID 15177180 DOI: 10.1016/J.Dnarep.2004.02.010 |
0.709 |
|
2003 |
Bielas JH, Heddle JA. Elevated mutagenesis and decreased DNA repair at a transgene are associated with proliferation but not apoptosis in p53-deficient cells. Proceedings of the National Academy of Sciences of the United States of America. 100: 12853-8. PMID 14569010 DOI: 10.1073/Pnas.2235595100 |
0.7 |
|
2003 |
Thybaud V, Dean S, Nohmi T, de Boer J, Douglas GR, Glickman BW, Gorelick NJ, Heddle JA, Heflich RH, Lambert I, Martus HJ, Mirsalis JC, Suzuki T, Yajima N. In vivo transgenic mutation assays. Mutation Research. 540: 141-51. PMID 14550498 DOI: 10.1016/J.Mrgentox.2003.07.004 |
0.398 |
|
2003 |
Heddle JA, Martus HJ, Douglas GR. Treatment and sampling protocols for transgenic mutation assays. Environmental and Molecular Mutagenesis. 41: 1-6. PMID 12552586 DOI: 10.1002/Em.10131 |
0.42 |
|
2002 |
Cosentino L, Malling HV, Heddle JA. Response of the phiX174 am3, cs70 transgene to acute and chronic ENU exposure: implications for protocol design. Mutation Research. 518: 113-21. PMID 12113762 DOI: 10.1016/S1383-5718(02)00078-5 |
0.444 |
|
2002 |
Newell LE, Heddle JA. The effect of dietary restriction during development in utero on the frequency of spontaneous somatic mutations. Mutagenesis. 17: 289-92. PMID 12110623 DOI: 10.1093/Mutage/17.4.289 |
0.447 |
|
2001 |
Swiger RR, Cosentino L, Masumura KI, Nohmi T, Heddle JA. Further characterization and validation of gpt delta transgenic mice for quantifying somatic mutations in vivo. Environmental and Molecular Mutagenesis. 37: 297-303. PMID 11424179 DOI: 10.1002/Em.1036 |
0.435 |
|
2001 |
Heddle JA, Knize MG, Dawod D, Zhang XB. A test of the mutagenicity of cooked meats in vivo. Mutagenesis. 16: 103-7. PMID 11230550 DOI: 10.1093/Mutage/16.2.103 |
0.385 |
|
2000 |
Cosentino L, Heddle JA. Differential mutation of transgenic and endogenous loci in vivo. Mutation Research. 454: 1-10. PMID 11035154 DOI: 10.1016/S0027-5107(00)00125-1 |
0.432 |
|
2000 |
Shima N, Swiger RR, Heddle JA. Dietary restriction during murine development provides protection against MNU-induced mutations. Mutation Research. 470: 189-200. PMID 11027974 DOI: 10.1016/S1383-5718(00)00104-2 |
0.435 |
|
2000 |
Bielas JH, Heddle JA. Proliferation is necessary for both repair and mutation in transgenic mouse cells. Proceedings of the National Academy of Sciences of the United States of America. 97: 11391-6. PMID 11005832 DOI: 10.1073/Pnas.190330997 |
0.727 |
|
2000 |
Cruz-Munoz W, Kalair W, Cosentino L, Heddle JA. ENU induces mutations in the heart of lacZ transgenic mice. Mutation Research. 469: 23-34. PMID 10946239 DOI: 10.1016/S1383-5718(00)00056-5 |
0.491 |
|
1999 |
Cosentino L, Heddle JA. Effects of extended chronic exposures on endogenous and transgenic loci: implications for low-dose extrapolations. Environmental and Molecular Mutagenesis. 34: 208-15. PMID 10529746 DOI: 10.1002/(Sici)1098-2280(1999)34:2/3<208::Aid-Em21>3.0.Co;2-1 |
0.386 |
|
1999 |
Swiger RR, Cosentino L, Shima N, Bielas JH, Cruz-Munoz W, Heddle JA. The cII locus in the MutaMouse system. Environmental and Molecular Mutagenesis. 34: 201-7. PMID 10529745 DOI: 10.1002/(Sici)1098-2280(1999)34:2/3<201::Aid-Em20>3.0.Co;2-P |
0.697 |
|
1999 |
Cosentino L, Heddle JA. A comparison of the effects of diverse mutagens at the lacZ transgene and Dlb-1 locus in vivo. Mutagenesis. 14: 113-9. PMID 10474832 DOI: 10.1093/Mutage/14.1.113 |
0.452 |
|
1999 |
Heddle JA. Mutant manifestation: the time factor in somatic mutagenesis. Mutagenesis. 14: 1-3. PMID 10474815 DOI: 10.1093/Mutage/14.1.1 |
0.422 |
|
1999 |
Heddle JA. On clonal expansion and its effects on mutant frequencies, mutation spectra and statistics for somatic mutations in vivo. Mutagenesis. 14: 257-60. PMID 10374991 DOI: 10.1093/Mutage/14.3.257 |
0.42 |
|
1999 |
Sun B, Shima N, Heddle JA. Somatic mutation in the mammary gland: influence of time and estrus. Mutation Research. 427: 11-9. PMID 10354497 DOI: 10.1016/S0027-5107(99)00039-1 |
0.44 |
|
1999 |
Sun B, Heddle JA. The relationship between mutant frequency and time in vivo: simple predictions for any tissue, cell type, or mutagen. Mutation Research. 425: 179-83. PMID 10216210 DOI: 10.1016/S0027-5107(99)00040-8 |
0.344 |
|
1999 |
Paashuis-Lew YR, Heddle JA. Spontaneous mutation during fetal development and post-natal growth. Mutagenesis. 13: 613-7. PMID 9862193 DOI: 10.1093/Mutage/13.6.613 |
0.458 |
|
1998 |
Trentin GA, Moody J, Heddle JA. Effect of maternal folate levels on somatic mutation frequency in the developing colon. Mutation Research. 405: 81-7. PMID 9729293 DOI: 10.1016/S0027-5107(98)00147-X |
0.414 |
|
1998 |
Tucker JD, Sorensen KJ, Chu CS, Nelson DO, Ramsey MJ, Urlando C, Heddle JA. The accumulation of chromosome aberrations and Dlb-1 mutations in mice with highly fractionated exposure to gamma radiation. Mutation Research. 400: 321-35. PMID 9685691 DOI: 10.1016/S0027-5107(98)00048-7 |
0.357 |
|
1998 |
Heddle JA. The role of proliferation in the origin of mutations in mammalian cells. Drug Metabolism Reviews. 30: 327-38. PMID 9606607 DOI: 10.3109/03602539808996316 |
0.448 |
|
1997 |
Paashuis-Lew Y, Zhang XB, Heddle JA. On the origin of spontaneous somatic mutations and sectored plaques detected in transgenic mice. Mutation Research. 373: 277-84. PMID 9042411 DOI: 10.1016/S0027-5107(96)00210-2 |
0.469 |
|
1997 |
Heddle JA, Cosentino L, Dawod G, Swiger RR, Paashuis-Lew Y. Why do stem cells exist? Environmental and Molecular Mutagenesis. 28: 334-41. PMID 8991061 DOI: 10.1002/(Sici)1098-2280(1996)28:4<334::Aid-Em6>3.0.Co;2-B |
0.412 |
|
1997 |
Cosentino L, Heddle JA. A test for neutrality of mutations of the lacZ transgene. Environmental and Molecular Mutagenesis. 28: 313-6. PMID 8991058 DOI: 10.1002/(Sici)1098-2280(1996)28:4<313::Aid-Em3>3.0.Co;2-C |
0.512 |
|
1997 |
Cosentino L, Shaver-Walker P, Heddle JA. The relationships among stem cells, crypts, and villi in the small intestine of mice as determined by mutation tagging. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 207: 420-8. PMID 8950516 DOI: 10.1002/(Sici)1097-0177(199612)207:4<420::Aid-Aja6>3.0.Co;2-J |
0.379 |
|
1996 |
Heddle JA, Swiger RR. Risk estimation from somatic mutation assays. Mutation Research. 365: 107-17. PMID 8898992 DOI: 10.1016/S0165-1110(96)90015-9 |
0.45 |
|
1996 |
Zhang XB, Felton JS, Tucker JD, Urlando C, Heddle JA. Intestinal mutagenicity of two carcinogenic food mutagens in transgenic mice: 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and amino(α)carboline Carcinogenesis. 17: 2259-2265. PMID 8895498 DOI: 10.1093/carcin/17.10.2259 |
0.318 |
|
1996 |
Urlando C, Krasnoshtein F, Heddle JA, Buchwald M. Assessment of the flexed-tail mouse as a possible model for Fanconi anemia: analysis of mitomycin C-induced micronuclei. Mutation Research. 370: 99-106. PMID 8879267 DOI: 10.1016/0165-1218(96)00044-4 |
0.369 |
|
1996 |
Zhang XB, Tao K, Urlando C, Shaver-Walker P, Heddle JA. Mutagenicity of high fat diets in the colon and small intestine of transgenic mice. Mutagenesis. 11: 43-8. PMID 8671714 DOI: 10.1093/Mutage/11.1.43 |
0.326 |
|
1996 |
Heddle JA, Shaver-Walker P, Tao KS, Zhang XB. Treatment protocols for transgenic mutation assays in vivo. Mutagenesis. 10: 467-70. PMID 8596464 DOI: 10.1093/Mutage/10.6.467 |
0.411 |
|
1996 |
Vomiero-Highton G, Heddle JA. An assay for loss of heterozygosity in vivo at the Dlb-1 locus. Mutagenesis. 10: 381-4. PMID 8544749 DOI: 10.1093/Mutage/10.5.381 |
0.467 |
|
1996 |
Shaver-Walker PM, Urlando C, Tao KS, Zhang XB, Heddle JA. Enhanced somatic mutation rates induced in stem cells of mice by low chronic exposure to ethylnitrosourea. Proceedings of the National Academy of Sciences of the United States of America. 92: 11470-4. PMID 8524785 DOI: 10.1073/Pnas.92.25.11470 |
0.403 |
|
1995 |
MacGregor JT, Farr S, Tucker JD, Heddle JA, Tice RR, Turteltaub KW. New molecular endpoints and methods for routine toxicity testing. Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology. 26: 156-73. PMID 7589905 DOI: 10.1006/Faat.1995.1087 |
0.391 |
|
1995 |
Zhang XB, Urlando C, Tao KS, Heddle JA. Factors affecting somatic mutation frequencies in vivo. Mutation Research. 338: 189-201. PMID 7565874 DOI: 10.1016/0921-8734(95)00024-Z |
0.438 |
|
1995 |
Cosentino L, Heddle JA. The induction of dominant somatic mutations at the Dlb-1 locus. Mutation Research. 346: 115-9. PMID 7533893 DOI: 10.1016/0165-7992(95)90059-4 |
0.421 |
|
1995 |
Heddle JA, Tao K, Swiger RR, Tucker JD. The transmission rate of the lacI transgene from the big blue™ mouse Mutation Research Letters. 348: 63-66. PMID 7477053 DOI: 10.1016/0165-7992(95)00047-X |
0.364 |
|
1994 |
Tao KS, Heddle JA. The accumulation and persistence of somatic mutations in vivo Mutagenesis. 9: 187-191. PMID 7934958 DOI: 10.1093/Mutage/9.3.187 |
0.478 |
|
1993 |
Heddle JA, Shepson PB, Gingerich JD, So KW. Mutagenicity of peroxyacetyl nitrate (PAN) in vivo: tests for somatic mutations and chromosomal aberrations. Environmental and Molecular Mutagenesis. 21: 58-66. PMID 8419154 DOI: 10.1002/Em.2850210108 |
0.441 |
|
1993 |
Tao KS, Urlando C, Heddle JA. Comparison of somatic mutation in a transgenic versus host locus. Proceedings of the National Academy of Sciences of the United States of America. 90: 10681-5. PMID 8248160 DOI: 10.1073/Pnas.90.22.10681 |
0.486 |
|
1993 |
Tao KS, Urlando C, Heddle JA. Mutagenicity of methyl methanesulfonate (MMS) in vivo at the Dlb-1 native locus and a lacI transgene. Environmental and Molecular Mutagenesis. 22: 293-6. PMID 8223513 DOI: 10.1002/Em.2850220419 |
0.49 |
|
1993 |
Heddle JA, Gingerich JD, Urlando C, Pagura M, Shepson P, Khan MA. Detection of somatic mutations in vivo in lung fibroblasts, I. Spontaneous frequencies in Chinese hamsters and F344 rats. Mutation Research. 272: 195-203. PMID 1281265 DOI: 10.1016/0165-1161(92)91532-V |
0.411 |
|
1992 |
Khan MA, Heddle JA. Optimization of the concurrent assay for gene mutations and chromosomal aberrations in vivo: expression time in rats. Environmental and Molecular Mutagenesis. 20: 165-71. PMID 1396607 DOI: 10.1002/Em.2850200305 |
0.422 |
|
1991 |
Heddle JA. Implications for genetic toxicology of the chromosomal breakage syndromes. Mutation Research. 247: 221-9. PMID 2011140 DOI: 10.1016/0027-5107(91)90018-J |
0.388 |
|
1991 |
Swierenga SH, Heddle JA, Sigal EA, Gilman JP, Brillinger RL, Douglas GR, Nestmann ER. Recommended protocols based on a survey of current practice in genotoxicity testing laboratories, IV. Chromosome aberration and sister-chromatid exchange in Chinese hamster ovary, V79 Chinese hamster lung and human lymphocyte cultures. Mutation Research. 246: 301-22. PMID 1996126 DOI: 10.1016/0027-5107(91)90050-X |
0.312 |
|
1991 |
Couch DB, Stuart E, Heddle JA. Effect of cholic acid on the colonic sister chromatid exchange frequency induced by 1,2-dimethylhydrazine in C57BL/6 mice. Environmental and Molecular Mutagenesis. 17: 1-3. PMID 1991454 DOI: 10.1002/Em.2850170102 |
0.368 |
|
1991 |
Khan MA, Heddle JA. Chemical induction of somatic gene mutations and chromosomal aberrations in lung fibroblasts of rats. Mutation Research. 263: 257-62. PMID 1861691 DOI: 10.1016/0165-7992(91)90010-2 |
0.414 |
|
1990 |
Mavournin KH, Blakey DH, Cimino MC, Salamone MF, Heddle JA. The in vivo micronucleus assay in mammalian bone marrow and peripheral blood. A report of the U.S. Environmental Protection Agency Gene-Tox Program. Mutation Research. 239: 29-80. PMID 2195332 DOI: 10.1016/0165-1110(90)90030-F |
0.305 |
|
1990 |
Heddle JA, Bouch A, Khan MA, Gingerich JD. Concurrent detection of gene mutations and chromosomal aberrations induced in vivo in somatic cells. Mutagenesis. 5: 179-84. PMID 2188072 DOI: 10.1093/Mutage/5.2.179 |
0.482 |
|
1988 |
Couch DB, Stuart E, Heddle JA. Effect of oral administration of mutagens found in food on the frequency of sister chromatid exchanges in the colonic epithelium of mice. Environmental and Molecular Mutagenesis. 10: 205-9. PMID 3691492 DOI: 10.1002/Em.2850100211 |
0.344 |
|
1988 |
Kaul HK, Couch DB, Gingerich JD, Bruce WR, Heddle JA. Genotoxicity of two fecal steroids in murine colonic epithelium assessed by the sister chromatid exchange technique. Mutagenesis. 2: 441-4. PMID 3328036 DOI: 10.1093/Mutage/2.6.441 |
0.311 |
|
1986 |
Couch DB, Gingerich JD, Stuart E, Heddle JA. Induction of sister chromatid exchanges in murine colonic tissue. Environmental Mutagenesis. 8: 579-87. PMID 3732197 DOI: 10.1002/Em.2860080409 |
0.376 |
|
1985 |
Goddard AD, Heddle JA, Gallie BL, Phillips RA. Radiation sensitivity of fibroblasts of bilateral retinoblastoma patients as determined by micronucleus induction in vitro. Mutation Research. 152: 31-8. PMID 4047082 DOI: 10.1016/0027-5107(85)90043-0 |
0.407 |
|
1984 |
Liu-Lee VW, Heddle JA, Arlett CF, Broughton B. Genetic effects of specific DNA lesions in mammalian cells. Mutation Research. 127: 139-47. PMID 6749159 DOI: 10.1016/0027-5107(84)90015-0 |
0.449 |
|
1984 |
Duncan AM, Heddle JA. The frequency and distribution of apoptosis induced by three non-carcinogenic agents in mouse colonic crypts. Cancer Letters. 23: 307-11. PMID 6744255 DOI: 10.1016/0304-3835(84)90098-3 |
0.336 |
|
1984 |
Ronen A, Gingerich JD, Duncan AM, Heddle JA. Autoradiographic assay of mutants resistant to diphtheria toxin in mammalian cells in vitro. Proceedings of the National Academy of Sciences of the United States of America. 81: 6124-8. PMID 6592605 DOI: 10.1073/Pnas.81.19.6124 |
0.409 |
|
1984 |
Liu-Lee VW, Heddle JA, Arlett CF. Repair of 8-methoxypsoralen monoadducts in mouse lymphoma cells. Mutation Research. 132: 73-8. PMID 6472320 DOI: 10.1016/0167-8817(84)90068-3 |
0.415 |
|
1984 |
Raj AS, Heddle JA, Newmark HL, Katz M. Caffeic acid as an inhibitor of DMBA-induced chromosomal breakage in mice assessed by bone-marrow micronucleus test. Mutation Research. 124: 247-53. PMID 6419093 DOI: 10.1016/0165-1218(83)90196-9 |
0.312 |
|
1983 |
Heddle JA, Hite M, Kirkhart B, Mavournin K, MacGregor JT, Newell GW, Salamone MF. The induction of micronuclei as a measure of genotoxicity. A report of the U.S. environmental protection agency Gene-Tox program Mutation Research/Reviews in Genetic Toxicology. 123: 61-118. PMID 6888413 DOI: 10.1016/0165-1110(83)90047-7 |
0.36 |
|
1983 |
Douglas GR, Grant CE, Bell RD, Salamone MF, Heddle JA, Nestmann ER. Comparative mammalian in vitro and in vivo studies on the mutagenic activity of rhodamine WT. Mutation Research. 118: 117-25. PMID 6865999 DOI: 10.1016/0165-1218(83)90121-0 |
0.401 |
|
1981 |
Raj AS, Heddle JA. Simultaneous detection of chromosomal aberrations and sister-chromatid exchanges: experience with DNA intercalating agents. Mutation Research. 78: 253-60. PMID 7432360 DOI: 10.1016/0165-1218(80)90106-8 |
0.393 |
|
1981 |
Heddle JA, Salamone MF. Chromosomal aberrations and bone marrow toxicity Environmental Health Perspectives. 23-27. PMID 7238453 DOI: 10.1289/Ehp.813923 |
0.359 |
|
1981 |
Heddle JA, Arlett CF. Untransformed xeroderma pigmentosum cells are not hypersensitive to sister-chromatid exchange production by ethyl methanesulphonate--implications for the use of transformed cell lines and for the mechanism by which SCE arise. Mutation Research. 72: 119-25. PMID 6255322 DOI: 10.1016/0027-5107(80)90227-4 |
0.313 |
|
1980 |
Raj AS, Heddle JA. The effect of superoxide dismutase, catalase and L-cysteine on spontaneous and on mitomycin C induced chromosomal breakage in Fanconi's anemia and normal fibroblasts as measured by the micronucleus method. Mutation Research. 78: 59-66. PMID 6991929 DOI: 10.1016/0165-1218(80)90026-9 |
0.358 |
|
1980 |
Krepinsky AB, Heddle JA, German J. Sensitivity of Bloom's syndrome lymphocytes to ethyl methanesulfonate. Human Genetics. 50: 151-6. PMID 511130 DOI: 10.1007/Bf00390236 |
0.322 |
|
1977 |
Countryman PI, Heddle JA. The production of micronuclei from chromosome aberrations in irradiated cultures of human lymphocytes. Mutation Research. 41: 321-32. PMID 796719 DOI: 10.1016/0027-5107(76)90105-6 |
0.369 |
|
1977 |
Ashwood-Smith MJ, Grant EL, Heddle JA, Friedman GB. Chromosome damage in Chinese hamster cells sensitized to near-ultraviolet light by psoralen and angelicin. Mutation Research. 43: 377-85. PMID 561302 DOI: 10.1016/0027-5107(77)90059-8 |
0.383 |
|
1977 |
Heddle JA, Carrano AV. The DNA content of micronuclei induced in mouse bone marrow by gamma-irradiation: evidence that micronuclei arise from acentric chromosomal fragments. Mutation Research. 44: 63-9. PMID 331097 DOI: 10.1016/0027-5107(77)90115-4 |
0.356 |
|
1975 |
Heddle J, Athanasiou K. Mutation rate, genome size and their relation to the rec concept Mutation Research/Environmental Mutagenesis and Related Subjects. 31: 333. DOI: 10.1038/258359A0 |
0.386 |
|
1973 |
Carrano AV, Heddle JA. The fate of chromosome aberrations. Journal of Theoretical Biology. 38: 289-304. PMID 4689998 DOI: 10.1016/0022-5193(73)90176-8 |
0.349 |
|
1970 |
Heddle JA, Bodycote DJ. On the formation of chromosomal aberrations. Mutation Research. 9: 117-26. PMID 5410804 DOI: 10.1016/0027-5107(70)90075-8 |
0.372 |
|
1969 |
Heddle JA. Influence of false twins on the ratios of twin and single sister chromatid exchanges. Journal of Theoretical Biology. 22: 151-62. PMID 5797565 DOI: 10.1016/0022-5193(69)90084-8 |
0.308 |
|
1969 |
Heddle JA. The predicted ratios of single to twin sister chromatid exchanges. Mutation Research. 6: 57-65. PMID 5708073 DOI: 10.1016/0027-5107(68)90102-4 |
0.307 |
|
1969 |
Heddle JA, Whissell D, Bodycote DJ. Changes in chromosome structure induced by radiations: a test of the two chief hypotheses. Nature. 221: 1158-1160. PMID 4975284 DOI: 10.1038/2211158A0 |
0.316 |
|
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