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Jim Thorpe - Publications

Affiliations: 
1996-1999 University of Reading, UK, Earley, England, United Kingdom 
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12/32 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2004 Hopcroft NH, Thorpe JH, Brogden AL, Gale BC, Cardin CJ. Conformational variation of the DNA Holliday junction Acta Crystallographica Section a Foundations of Crystallography. 60: s21-s21. DOI: 10.1107/S010876730409960X  0.691
2004 Teixeira SCM, Thorpe JH, Gale BC, Gan Y, Brogden AM, Cardin CJ. DNA-targeted drugs – untwisting the tangled web of interactions Acta Crystallographica Section a Foundations of Crystallography. 60: s136-s136. DOI: 10.1107/S0108767304097314  0.569
2003 Thorpe JH, Gale BC, Teixeira SC, Cardin CJ. Conformational and hydration effects of site-selective sodium, calcium and strontium ion binding to the DNA Holliday junction structure d(TCGGTACCGA)(4). Journal of Molecular Biology. 327: 97-109. PMID 12614611 DOI: 10.1016/S0022-2836(03)00088-3  0.732
2003 Thorpe JH, Teixeira SC, Gale BC, Cardin CJ. Crystal structure of the complementary quadruplex formed by d(GCATGCT) at atomic resolution. Nucleic Acids Research. 31: 844-9. PMID 12560479 DOI: 10.1093/Nar/Gkg168  0.74
2002 Teixeira SC, Thorpe JH, Todd AK, Powell HR, Adams A, Wakelin LP, Denny WA, Cardin CJ. Structural characterisation of bisintercalation in higher-order DNA at a junction-like quadruplex. Journal of Molecular Biology. 323: 167-71. PMID 12381312 DOI: 10.1016/S0022-2836(02)00923-3  0.746
2002 Thorpe JH, Teixeira SC, Gale BC, Cardin CJ. Structural characterization of a new crystal form of the four-way Holliday junction formed by the DNA sequence d(CCGGTACCGG)2: sequence versus lattice? Acta Crystallographica. Section D, Biological Crystallography. 58: 567-9. PMID 11856858 DOI: 10.1107/S0907444902001555  0.768
2000 Thorpe JH, Hobbs JR, Todd AK, Denny WA, Charlton P, Cardin CJ. Guanine specific binding at a DNA junction formed by d[CG(5-BrU)ACG](2) with a topoisomerase poison in the presence of Co(2+) ions. Biochemistry. 39: 15055-61. PMID 11106483 DOI: 10.1021/Bi001749P  0.756
2000 Hobbs JR, Thorpe JH, Denny WA, Charlton P, Cardin CJ. Guanine-specific binding at an intercalated DNA junction Acta Crystallographica Section a Foundations of Crystallography. 56: s439-s439. DOI: 10.1107/S0108767300029032  0.639
1999 Todd AK, Adams A, Powell HR, Wilcock DJ, Thorpe JH, Lausi A, Zanini F, Wakelin LP, Cardin CJ. Determination by MAD-DM of the structure of the DNA duplex d[ACGTACG(5-BrU)]2 at 1.46 A and 100 K. Acta Crystallographica. Section D, Biological Crystallography. 55: 729-35. PMID 10089302 DOI: 10.1107/S090744499801261X  0.687
1999 Todd AK, Adams A, Thorpe JH, Denny WA, Wakelin LP, Cardin CJ. Major groove binding and 'DNA-induced' fit in the intercalation of a derivative of the mixed topoisomerase I/II poison N-(2-(dimethylamino)ethyl)acridine-4-carboxamide (DACA) into DNA: X-ray structure complexed to d(CG(5-BrU)ACG)2 at 1.3-A resolution. Journal of Medicinal Chemistry. 42: 536-40. PMID 10052960 DOI: 10.1021/Jm980479U  0.664
1999 Benet S, Cardin CJ, Cardin DJ, Constantine SP, Heath P, Rashid H, Teixeira S, Thorpe JH, Todd AK. Syntheses and Crystal Structures of Heteroleptic Stannylenes and Germylenes Organometallics. 18: 389-398. DOI: 10.1021/OM980836Z  0.697
1998 Dahrouch M, Rivière-Baudet M, Satgé J, Mauzac M, Cardin CJ, Thorpe JH. Synthesis and Structure of Oligomeric Dimesitylgermyl-Substituted Carbodiimides; Characterization of Higher Oligomers Organometallics. 17: 623-629. DOI: 10.1021/Om970604K  0.478
Low-probability matches (unlikely to be authored by this person)
2020 Thorpe JH, Wall ID, Sinnamon RH, Taylor AN, Stavenger RA. Cocktailed fragment screening by X-ray crystallography of the antibacterial target undecaprenyl pyrophosphate synthase from Acinetobacter baumannii. Acta Crystallographica. Section F, Structural Biology Communications. 76: 40-46. PMID 31929185 DOI: 10.1107/S2053230X19017199  0.282
2005 Skarzynski T, Thorpe J. Industrial perspective on X-ray data collection and analysis. Acta Crystallographica. Section D, Biological Crystallography. 62: 102-7. PMID 16369099 DOI: 10.1107/S0907444905034281  0.201
2020 Hirst DJ, Brandt M, Bruton G, Christodoulou E, Cutler L, Deeks N, Goodacre JD, Jack T, Lindon M, Miah A, Page K, Parr N, Shukla L, Sims M, Thomas P, ... Thorpe J, et al. Structure-based optimisation of orally active & reversible MetAP-2 inhibitors maintaining a tight 'molecular budget'. Bioorganic & Medicinal Chemistry Letters. 127533. PMID 32919012 DOI: 10.1016/j.bmcl.2020.127533  0.179
2019 Walker AL, Bingham RP, Edgar EV, Ferrie A, Holmes DS, Liddle J, Polyakova O, Rella M, Smith KJ, Thorpe JH, Wang Y, White GV, Young RJ, Hovnanian A. Structure guided drug design to develop kallikrein 5 inhibitors to treat Netherton syndrome. Bioorganic & Medicinal Chemistry Letters. PMID 31005442 DOI: 10.1016/j.bmcl.2019.04.022  0.125
2019 Thorpe JH, Edgar EV, Smith KJ, Lewell XQ, Rella M, White GV, Polyakova O, Nassau P, Walker AL, Holmes DS, Pearce AC, Wang Y, Liddle J, Hovnanian A. Evaluation of a crystallographic surrogate for kallikrein 5 in the discovery of novel inhibitors for Netherton syndrome. Acta Crystallographica. Section F, Structural Biology Communications. 75: 385-391. PMID 31045568 DOI: 10.1107/S2053230X19003169  0.123
2021 Liddle J, Beneton V, Benson M, Bingham R, Bouillot A, Boullay AB, Brook E, Cryan J, Denis A, Edgar E, Ferrie A, Fouchet MH, Grillot D, Holmes DS, Howes A, ... ... Thorpe JH, et al. A potent and selective Kallikrein-5 inhibitor delivers high pharmacological activity in Netherton Syndrome patient skin. The Journal of Investigative Dermatology. PMID 33744298 DOI: 10.1016/j.jid.2021.01.029  0.106
2019 Walker AL, Denis A, Bingham RP, Boulliot A, Edgar EV, Ferrie A, Holmes DS, Laroze A, Liddle J, Fouchet MH, Moquette A, Nassau P, Pearce AC, Polyakova O, Smith KJ, ... ... Thorpe JH, et al. Design and development of a series of borocycles as selective, covalent kallikrein 5 inhibitors. Bioorganic & Medicinal Chemistry Letters. 126675. PMID 31521475 DOI: 10.1016/j.bmcl.2019.126675  0.1
2019 White GV, Edgar EV, Holmes DS, Lewell XQ, Liddle J, Polyakova O, Smith KJ, Thorpe JH, Walker AL, Wang Y, Young RJ, Hovnanian A. Kallikrein 5 inhibitors identified through structure based drug design in search for a treatment for Netherton Syndrome. Bioorganic & Medicinal Chemistry Letters. PMID 30691925 DOI: 10.1016/j.bmcl.2019.01.020  0.098
2005 Alvaro M, Cardin DJ, Colquhoun HM, Garcia H, Gilbert A, Lay AK, Thorpe JH. Complete filling of zeolite frameworks with polyalkynes formed in situ by transition-metal ion catalysts Chemistry of Materials. 17: 2546-2551. DOI: 10.1021/Cm040175Y  0.079
1987 Thorpe JH. Continuing medical education a primer. New York Praeger, 1986. Adrienne B. Rosof. William C. Felch M.D. MöBius: a Journal For Continuing Education Professionals in Health Sciences. 7: 53-55. DOI: 10.1002/chp.4760070210  0.076
1976 THORPE JH. Proctosigmoidoscopy from the Other End Annals of Internal Medicine. 84: 497. DOI: 10.7326/0003-4819-84-4-497_1  0.061
2019 Harris PA, Marinis JM, Lich JD, Berger SB, Chirala A, Cox JA, Eidam PM, Finger JN, Gough PJ, Jeong JU, Kang J, Kasparcova V, Leister LK, Mahajan MK, Miller G, ... ... Thorpe JH, et al. Identification of a RIP1 Kinase Inhibitor Clinical Candidate (GSK3145095) for the Treatment of Pancreatic Cancer. Acs Medicinal Chemistry Letters. 10: 857-862. PMID 31223438 DOI: 10.1021/Acsmedchemlett.9B00108  0.052
2015 Lewis HD, Liddle J, Coote JE, Atkinson SJ, Barker MD, Bax BD, Bicker KL, Bingham RP, Campbell M, Chen YH, Chung CW, Craggs PD, Davis RP, Eberhard D, Joberty G, ... ... Thorpe J, et al. Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation. Nature Chemical Biology. 11: 189-91. PMID 25622091 DOI: 10.1038/Nchembio.1735  0.047
2019 Walker AL, Denis A, Bingham RP, Bouillot A, Edgar EV, Ferrie A, Holmes DS, Laroze A, Liddle J, Fouchet MH, Moquette A, Nassau P, Pearce AC, Polyakova O, Smith KJ, ... ... Thorpe JH, et al. Corrigendum to 'Design and development of a series of borocycles as selective, covalent kallikrein 5 inhibitors' [Bioorg. Med. Chem. Lett. 29 (2019) 126675]. Bioorganic & Medicinal Chemistry Letters. 126771. PMID 31859161 DOI: 10.1016/j.bmcl.2019.126771  0.023
2019 Harris PA, Faucher N, George N, Eidam PM, King BW, White G, Anderson NA, Bandyopadhyay D, Beal AM, Beneton V, Berger SB, Campobasso N, Campos S, Capriotti CA, Cox JA, ... ... Thorpe JH, et al. Discovery and Lead-optimization of 4,5-Dihydropyrazoles as Mono-Kinase Selective, Orally Bioavailable and Efficacious Inhibitors of Receptor Interacting Protein 1 (RIP1) Kinase. Journal of Medicinal Chemistry. PMID 31013427 DOI: 10.1021/Acs.Jmedchem.9B00318  0.015
2018 Wang W, Marinis JM, Beal AM, Savadkar S, Wu Y, Khan M, Taunk PS, Wu N, Su W, Wu J, Ahsan A, Kurz E, Chen T, Yaboh I, Li F, ... ... Thorpe JH, et al. RIP1 Kinase Drives Macrophage-Mediated Adaptive Immune Tolerance in Pancreatic Cancer. Cancer Cell. 34: 757-774.e7. PMID 30423296 DOI: 10.1016/J.Ccell.2018.10.006  0.011
2020 Wang W, Marinis JM, Beal AM, Savadkar S, Wu Y, Khan M, Taunk PS, Wu N, Su W, Wu J, Ahsan A, Kurz E, Chen T, Yaboh I, Li F, ... ... Thorpe JH, et al. RIP1 Kinase Drives Macrophage-Mediated Adaptive Immune Tolerance in Pancreatic Cancer. Cancer Cell. 38: 585-590. PMID 33049209 DOI: 10.1016/j.ccell.2020.09.020  0.01
1989 Thorpe JH. Hospital CME: The joint commission's standard Journal of Continuing Education in the Health Professions. 9: 205-206. PMID 10296946 DOI: 10.1002/chp.4750090311  0.01
1989 Thorpe JH. Recruiting for medicine (I) Annals of Internal Medicine. 111: 1046-1047. PMID 2491516 DOI: 10.7326/0003-4819-111-12-1046_2  0.01
1986 Thorpe JH. AHME after three decades MöBius: a Journal For Continuing Education Professionals in Health Sciences. 6: 79-81. DOI: 10.1002/chp.4760060415  0.01
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