| Year |
Citation |
Score |
| 2019 |
Bielecki M, Howe GW, Kluger R. Competing Protonation and Halide Elimination as a Probe of the Character of Thiamin-Derived Reactive Intermediates Biochemistry. 58: 3566-3571. PMID 31385510 DOI: 10.1021/Acs.Biochem.9B00298 |
0.4 |
|
| 2019 |
Li Y, Kluger R. Metal-Catalyzed Site-Selective Monoacylation of Diols in Aqueous Media Synthesis. 51: 3784-3791. DOI: 10.1055/S-0037-1611907 |
0.338 |
|
| 2018 |
Bielecki M, Howe GW, Kluger R. Charge Dispersion and Its Effects on the Reactivity of Thiamin-Derived Breslow Intermediates. Biochemistry. 57: 3867-3872. PMID 29856601 DOI: 10.1021/Acs.Biochem.8B00463 |
0.337 |
|
| 2018 |
Li Y, Kluger R. Lead-Catalyzed Aqueous Benzoylation of Carbohydrates with an Acyl Phosphate Ester. The Journal of Organic Chemistry. PMID 29368510 DOI: 10.1021/Acs.Joc.7B03142 |
0.421 |
|
| 2017 |
Vandersteen AA, Howe GW, Lollar BS, Kluger R. Carbon Kinetic Isotope Effects and the Mechanisms of Acid-Catalyzed Decarboxylation of 2,4-Dimethoxybenzoic Acid and CO2 Incorporation into 1,3-Dimethoxybenzene Journal of the American Chemical Society. 139: 15049-15053. PMID 28982238 DOI: 10.1021/Jacs.7B07504 |
0.647 |
|
| 2017 |
Mundle SOC, Lollar BS, Kluger R. Determining Carbon Kinetic Isotope Effects Using Headspace Analysis of Evolved CO. Methods in Enzymology. 596: 501-522. PMID 28911782 DOI: 10.1016/Bs.Mie.2017.07.024 |
0.767 |
|
| 2017 |
Bielecki M, Kluger R. The Need for an Alternative to Radicals as the Cause of Fragmentation of a Thiamin-Derived Breslow Intermediate. Angewandte Chemie. 56: 6321-6323. PMID 28455906 DOI: 10.1002/Anie.201702240 |
0.343 |
|
| 2016 |
Heidari Y, Howe GW, Kluger R. The reactivity of lactyl-oxythiamin implies the role of the amino-pyrimidine in thiamin catalyzed decarboxylation Bioorganic Chemistry. 69: 153-158. PMID 27816798 DOI: 10.1016/J.Bioorg.2016.10.008 |
0.396 |
|
| 2016 |
Singh S, Dubinsky-Davidchik IS, Kluger R. Strain-promoted azide-alkyne cycloaddition for protein-protein coupling in the formation of a bis-hemoglobin as a copper-free oxygen carrier. Organic & Biomolecular Chemistry. PMID 27714247 DOI: 10.1039/C6Ob01817C |
0.33 |
|
| 2016 |
Wang A, Kluger R. Enhanced Nitrite Reductase Activity and Its Correlation with Oxygen Affinity in Hemoglobin bis-Tetramers. Biochemistry. PMID 27454142 DOI: 10.1021/Acs.Biochem.6B00542 |
0.321 |
|
| 2016 |
Howe GW, Vandersteen AA, Kluger R. How Acid-Catalyzed Decarboxylation of 2,4-Dimethoxybenzoic Acid Avoids Formation of Protonated CO2 Journal of the American Chemical Society. 138: 7568-7573. DOI: 10.1021/Jacs.6B01770 |
0.377 |
|
| 2015 |
Kluger R. Decarboxylation, CO2 and the reversion problem. Accounts of Chemical Research. 48: 2843-2849. PMID 26528892 DOI: 10.1021/Acs.Accounts.5B00306 |
0.348 |
|
| 2015 |
Singh S, Dubinsky-Davidchik IS, Yang Y, Kluger R. Subunit-directed click coupling via doubly cross-linked hemoglobin efficiently produces readily purified functional bis-tetrameric oxygen carriers. Organic & Biomolecular Chemistry. PMID 26400017 DOI: 10.1039/C5Ob01755F |
0.366 |
|
| 2015 |
Bielecki M, Howe GW, Kluger R. Lithium-stabilized nucleophilic addition of thiamin to a ketone provides an efficient route to mandelylthiamin, a critical pre-decarboxylation intermediate Bioorganic Chemistry. 62: 124-129. PMID 26333207 DOI: 10.1016/J.Bioorg.2015.08.004 |
0.366 |
|
| 2015 |
Siren EM, Singh S, Kluger R. Bioorthogonal phase-directed copper-catalyzed azide-alkyne cycloaddition (PDCuAAC) coupling of selectively cross-linked superoxide dismutase dimers produces a fully active bis-dimer. Organic & Biomolecular Chemistry. PMID 26308144 DOI: 10.1039/C5Ob01702E |
0.327 |
|
| 2015 |
Dhiman RS, Wang A, Kluger R. Solid-phase lanthanum catalysis of monoacylation of diols in water by acyl phosphate monoesters Canadian Journal of Chemistry. 93: 445-450. DOI: 10.1139/Cjc-2014-0406 |
0.754 |
|
| 2014 |
Howe GW, Kluger R. Decarboxylation without CO2: Why bicarbonate forms directly as trichloroacetate is converted to chloroform Journal of Organic Chemistry. 79: 10972-10980. PMID 25340631 DOI: 10.1021/Jo501990U |
0.345 |
|
| 2014 |
Wang A, Kluger R. Increasing efficiency in protein-protein coupling: subunit-directed acetylation and phase-directed CuAAC ("click coupling") in the formation of hemoglobin bis-tetramers. Biochemistry. 53: 6793-6799. PMID 25325574 DOI: 10.1021/Bi501054B |
0.318 |
|
| 2014 |
Mundle SO, Vandersteen AA, Lacrampe-Couloume G, Kluger R, Sherwood Lollar B. Pressure-monitored headspace analysis combined with compound-specific isotope analysis to measure isotope fractionation in gas-producing reactions. Rapid Communications in Mass Spectrometry : Rcm. 27: 1778-84. PMID 23821571 DOI: 10.1002/rcm.6625 |
0.696 |
|
| 2014 |
Kluger R, Lui FE. HBOCs from chemical modification of Hb Hemoglobin-Based Oxygen Carriers as Red Cell Substitutes and Oxygen Therapeutics. 159-183. DOI: 10.1007/978-3-642-40717-8_10 |
0.757 |
|
| 2013 |
Vandersteen AA, Mundle SOC, Lacrampe-Couloume G, Lollar BS, Kluger R. Carbon Kinetic Isotope Effects Reveal Variations in Reactivity of Intermediates in the Formation of Protonated Carbonic Acid Journal of Organic Chemistry. 78: 12176-12181. PMID 24256305 DOI: 10.1021/Jo402180Z |
0.804 |
|
| 2013 |
Lüdtke S, Neumann P, Erixon KM, Leeper F, Kluger R, Ficner R, Tittmann K. Sub-ångström-resolution crystallography reveals physical distortions that enhance reactivity of a covalent enzymatic intermediate. Nature Chemistry. 5: 762-7. PMID 23965678 DOI: 10.1038/Nchem.1728 |
0.35 |
|
| 2013 |
Kluger R. Analysis of claims of enhanced enzyme catalysis by inorganic colloidosomes. Bioorganic Chemistry. 49: 59-60. PMID 23886373 DOI: 10.1016/J.Bioorg.2013.06.004 |
0.333 |
|
| 2013 |
Kluger R, Howe GW, Mundle SOC. Avoiding CO2 in catalysis of decarboxylation Advances in Physical Organic Chemistry. 47: 85-128. DOI: 10.1016/B978-0-12-407754-6.00002-8 |
0.301 |
|
| 2013 |
Mundle SOC, Vandersteen AA, Lacrampe-Couloume G, Kluger R, Lollar BS. Pressure-monitored headspace analysis combined with compound-specific isotope analysis to measure isotope fractionation in gas-producing reactions Rapid Communications in Mass Spectrometry. 27: 1778-1784. DOI: 10.1002/Rcm.6625 |
0.609 |
|
| 2012 |
Vandersteen AA, Mundle SOC, Kluger R. Protonated carbonic acid and reactive intermediates in the acidic decarboxylation of indolecarboxylic acids. Journal of Organic Chemistry. 77: 6505-6509. PMID 22804752 DOI: 10.1021/Jo301032F |
0.756 |
|
| 2012 |
Lui FE, Yu B, Baron DM, Lei C, Zapol WM, Kluger R. Hemodynamic responses to a hemoglobin bis-tetramer and its polyethylene glycol conjugate. Transfusion. 52: 974-82. PMID 22070638 DOI: 10.1111/J.1537-2995.2011.03421.X |
0.772 |
|
| 2012 |
Howe GW, Bielecki M, Kluger R. Base-catalyzed decarboxylation of mandelylthiamin: Direct formation of bicarbonate as an alternative to formation of CO2 Journal of the American Chemical Society. 134: 20621-20623. DOI: 10.1021/Ja310952A |
0.351 |
|
| 2012 |
Mundle SOC, Howe GW, Kluger R. Origins of steric effects in general-base-catalyzed enolization: Solvation and electrostatic attraction Journal of the American Chemical Society. 134: 1066-1070. DOI: 10.1021/Ja2085959 |
0.375 |
|
| 2011 |
Mundle SO, Howe GW, Kluger R. Origins of steric effects in general-base-catalyzed enolization: solvation and electrostatic attraction. Journal of the American Chemical Society. 134: 1066-70. PMID 22122780 DOI: 10.1021/ja2085959 |
0.735 |
|
| 2011 |
Dhiman RS, Opinska LG, Kluger R. Biomimetic peptide bond formation in water with aminoacyl phosphate esters. Organic & Biomolecular Chemistry. 9: 5645-7. PMID 21735032 DOI: 10.1039/C1Ob05660C |
0.774 |
|
| 2011 |
Her S, Kluger R. Biomimetic protecting-group-free 2', 3'-selective aminoacylation of nucleosides and nucleotides. Organic and Biomolecular Chemistry. 9: 676-678. PMID 21132175 DOI: 10.1039/C0Ob00795A |
0.365 |
|
| 2011 |
Mundle SOC, Opiñska LG, Kluger R, Dicks AP. Investigating the Mechanism of Heteroaromatic Decarboxylation Using Solvent Kinetic Isotope Effects and Eyring Transition-State Theory Journal of Chemical Education. 88: 1004-1006. DOI: 10.1021/Ed100793R |
0.36 |
|
| 2010 |
Lui FE, Kluger R. Reviving artificial blood: meeting the challenge of dealing with NO scavenging by hemoglobin. Chembiochem : a European Journal of Chemical Biology. 11: 1816-24. PMID 20661989 DOI: 10.1002/Cbic.201000291 |
0.745 |
|
| 2010 |
Dhiman RS, Kluger R. Magnesium ion enhances lanthanum-promoted monobenzoylation of a monosaccharide in water. Organic & Biomolecular Chemistry. 8: 2006-8. PMID 20401373 DOI: 10.1039/B926851K |
0.763 |
|
| 2010 |
Kluger R. Red cell substitutes from hemoglobin — Do we start all over again? Current Opinion in Chemical Biology. 14: 538-543. PMID 20392662 DOI: 10.1016/J.Cbpa.2010.03.021 |
0.317 |
|
| 2010 |
Mundle SO, Lacrampe-Couloume G, Lollar BS, Kluger R. Hydrolytic decarboxylation of carboxylic acids and the formation of protonated carbonic acid. Journal of the American Chemical Society. 132: 2430-6. PMID 20121187 DOI: 10.1021/Ja910608M |
0.787 |
|
| 2010 |
Kluger R, Mundle SOC. The role of pre-association in Brønsted acid-catalyzed decarboxylation and related processes Advances in Physical Organic Chemistry. 44. DOI: 10.1016/S0065-3160(08)44007-8 |
0.303 |
|
| 2010 |
TAYLOR SD, KLUGER R. ChemInform Abstract: Heats of Reaction of Cyclic and Acyclic Phosphate and Phosphonate Esters. “Strain Discrepancy” and Steric Retardation. Cheminform. 23: no-no. DOI: 10.1002/chin.199231229 |
0.443 |
|
| 2009 |
Foot JS, Lui FE, Kluger R. Hemoglobin bis-tetramers via cooperative azide-alkyne coupling. Chemical Communications (Cambridge, England). 7315-7. PMID 20024213 DOI: 10.1039/B918860F |
0.78 |
|
| 2009 |
Lui FE, Kluger R. Enhancing nitrite reductase activity of modified hemoglobin: bis-tetramers and their PEGylated derivatives. Biochemistry. 48: 11912-9. PMID 19894773 DOI: 10.1021/Bi9014105 |
0.768 |
|
| 2009 |
Mundle SOC, Kluger R. Decarboxylation via addition of water to a carboxyl group: acid catalysis of pyrrole-2-carboxylic acid. Journal of the American Chemical Society. 131: 11674-11675. PMID 19645466 DOI: 10.1021/Ja905196N |
0.749 |
|
| 2009 |
Mundle SO, Rathgeber S, Lacrampe-Couloume G, Sherwood Lollar B, Kluger R. Internal return of carbon dioxide in decarboxylation: catalysis of separation and 12C/13C kinetic isotope effects. Journal of the American Chemical Society. 131: 11638-9. PMID 19642680 DOI: 10.1021/ja902686h |
0.713 |
|
| 2009 |
Mundle SOC, Rathgeber S, Lacrampe-Couloume G, Lollar BS, Kluger R. Internal return of carbon dioxide in decarboxylation: Catalysis of separation and12C/13C kinetic isotope effects Journal of the American Chemical Society. 131: 11638-11639. DOI: 10.1021/Ja902686H |
0.614 |
|
| 2008 |
Kluger R, Rathgeber S. Catalyzing separation of carbon dioxide in thiamin diphosphate-promoted decarboxylation. Febs Journal. 275: 6089-6100. PMID 19016847 DOI: 10.1111/J.1742-4658.2008.06739.X |
0.364 |
|
| 2008 |
Lui FE, Dong P, Kluger R. Polyethylene glycol conjugation enhances the nitrite reductase activity of native and cross-linked hemoglobin. Biochemistry. 47: 10773-80. PMID 18795797 DOI: 10.1021/Bi801116K |
0.776 |
|
| 2008 |
Wodzinska J, Kluger R. pKa-dependent formation of amides in water from an acyl phosphate monoester and amines. Journal of Organic Chemistry. 73: 4753-4754. PMID 18505289 DOI: 10.1021/Jo800667B |
0.43 |
|
| 2008 |
Hu D, Kluger R. Efficient generation of dendritic arrays of cross-linked hemoglobin: symmetry and redundancy. Organic and Biomolecular Chemistry. 6: 151-156. PMID 18075660 DOI: 10.1039/B714684A |
0.382 |
|
| 2007 |
Tzvetkova S, Kluger R. Biomimetic Aminoacylation of Ribonucleotides and RNA with Aminoacyl Phosphate Esters and Lanthanum Salts Journal of the American Chemical Society. 129: 15848-15854. PMID 18052163 DOI: 10.1021/Ja073976L |
0.342 |
|
| 2007 |
Gray IJ, Kluger R. Chelation-controlled regioselectivity in the lanthanum-promoted monobenzoylation of monosaccharides in water Carbohydrate Research. 342: 1998-2002. PMID 17572400 DOI: 10.1016/J.Carres.2007.05.024 |
0.391 |
|
| 2006 |
Kluger R, Ikeda G, Hu Q, Cao P, Drewry J. Accelerating unimolecular decarboxylation by preassociated acid catalysis in thiamin-derived intermediates: implicating Brønsted acids as carbanion traps in enzymes. Journal of the American Chemical Society. 128: 15856-64. PMID 17147398 DOI: 10.1021/Ja066249J |
0.416 |
|
| 2006 |
Kluger R, Yu D. Protein-enhanced decarboxylation of the covalent intermediate in benzoylformate decarboxylase--Desolvation or acid catalysis? Bioorganic Chemistry. 34: 337-344. PMID 16996103 DOI: 10.1016/J.Bioorg.2006.08.002 |
0.43 |
|
| 2006 |
Machius M, Wynn RM, Chuang JL, Li J, Kluger R, Yu D, Tomchick DR, Brautigam CA, Chuang DT. A versatile conformational switch regulates reactivity in human branched-chain alpha-ketoacid dehydrogenase. Structure (London, England : 1993). 14: 287-98. PMID 16472748 DOI: 10.1016/J.Str.2005.10.009 |
0.338 |
|
| 2006 |
Kluger R. CIC Medal Award Lecture — Molecular keystones: Lessons from bioorganic reaction mechanisms Canadian Journal of Chemistry. 84: 1093-1105. DOI: 10.1139/V06-149 |
0.321 |
|
| 2006 |
Gray IJ, Ren R, Westermann B, Kluger R. Lanthanum-catalyzed aqueous acylation of monosaccharides by benzoyl methyl phosphate Canadian Journal of Chemistry. 84: 620-624. DOI: 10.1139/V06-047 |
0.402 |
|
| 2005 |
Gourianov N, Kluger R. Conjoined hemoglobins. Loss of cooperativity and protein-protein interactions. Biochemistry. 44: 14989-14999. PMID 16274245 DOI: 10.1021/Bi0513812 |
0.314 |
|
| 2005 |
Hu Q, Kluger R. Making thiamin work faster: acid-promoted separation of carbon dioxide. Journal of the American Chemical Society. 127: 12242-12243. PMID 16131200 DOI: 10.1021/Ja054165P |
0.352 |
|
| 2005 |
Alagic A, Koprianiuk A, Kluger R. Hemoglobin-superoxide dismutase-chemical linkages that create a dual-function protein. Journal of the American Chemical Society. 127: 8036-43. PMID 15926827 DOI: 10.1021/Ja050339R |
0.766 |
|
| 2005 |
Golbik R, Meshalkina LE, Sandalova T, Tittmann K, Fiedler E, Neef H, König S, Kluger R, Kochetov GA, Schneider G, Hübner G. Effect of coenzyme modification on the structural and catalytic properties of wild-type transketolase and of the variant E418A from Saccharomyces cerevisiae. Febs Journal. 272: 1326-1342. PMID 15752351 DOI: 10.1111/J.1742-4658.2005.04562.X |
0.33 |
|
| 2005 |
Ikeda G, Kluger R. Deuterium labeling as a test of intramolecular hydride mechanisms in the fragmentation of 2-(1-hydroxybenzyl)-N1′-methylthiamin Canadian Journal of Chemistry. 83: 1277-1280. DOI: 10.1139/V05-146 |
0.364 |
|
| 2004 |
Kluger R, Alagic A. Chemical cross-linking and protein-protein interactions-a review with illustrative protocols. Bioorganic Chemistry. 32: 451-72. PMID 15530987 DOI: 10.1016/J.Bioorg.2004.08.002 |
0.745 |
|
| 2004 |
Cameron LL, Wang SC, Kluger R. Biomimetic monoacylation of diols in water. Lanthanide-promoted reactions of methyl benzoyl phosphate. Journal of the American Chemical Society. 126: 10721-6. PMID 15327331 DOI: 10.1021/Ja049538L |
0.416 |
|
| 2004 |
Hu Q, Kluger R. Fragmentation of the Conjugate Base of 2-(1-Hydroxybenzyl)thiamin: Does Benzoylformate Decarboxylase Prevent Orbital Overlap To Avoid It? Journal of the American Chemical Society. 126: 68-69. PMID 14709063 DOI: 10.1021/Ja0390505 |
0.341 |
|
| 2004 |
Ikeda G, Kluger R. Fast fragmentation and slow protonation: a buffer‐dependent isotope effect in reactions of N‐methyl hydroxy(benzylthiamine) analyzed by the Keeffe–Jencks equations Journal of Physical Organic Chemistry. 17: 507-510. DOI: 10.1002/Poc.764 |
0.407 |
|
| 2003 |
Gourianov N, Kluger R. Cross-linked bis-hemoglobins: connections and oxygen binding. Journal of the American Chemical Society. 125: 10885-10892. PMID 12952468 DOI: 10.1021/Ja036596I |
0.302 |
|
| 2003 |
Ship NJ, Pezacki JP, Kluger R. Rates of release of nitric oxide from HbSNO and internal electron transfer. Bioorganic Chemistry. 31: 3-10. PMID 12697165 DOI: 10.1016/S0045-2068(02)00509-6 |
0.307 |
|
| 2002 |
Hu Q, Kluger R. Reactivity of intermediates in benzoylformate decarboxylase: avoiding the path to destruction. Journal of the American Chemical Society. 124: 14858-14859. PMID 12475322 DOI: 10.1021/Ja027976R |
0.373 |
|
| 2002 |
Kluger R, Cameron LL. Activation of acyl phosphate monoesters by lanthanide ions: enhanced reactivity of benzoyl methyl phosphate. Journal of the American Chemical Society. 124: 3303-8. PMID 11916414 DOI: 10.1021/Ja016600V |
0.412 |
|
| 2002 |
Moore IF, Kluger R. Substituent effects in carbon-nitrogen cleavage of thiamin derivatives. Fragmentation pathways and enzymic avoidance of cofactor destruction. Journal of the American Chemical Society. 124: 1669-73. PMID 11853442 DOI: 10.1021/Ja0173627 |
0.671 |
|
| 2002 |
Kluger R. 2001 Lemieux Award Lecture Organic chemistry and hemoglobin: Benefits from controlled alteration Canadian Journal of Chemistry. 80: 217-221. DOI: 10.1139/V01-200 |
0.331 |
|
| 2000 |
Moore IF, Kluger R. Decomposition of 2-(1-hydroxybenzyl)thiamin. Ruling out stepwise cationic fragmentation. Organic Letters. 2: 2035-6. PMID 10891223 DOI: 10.1021/Ol005927I |
0.648 |
|
| 2000 |
Kluger R, Stefano VD. Mechanism of site-directed protein cross-linking. protein-directed selectivity in reactions of hemoglobin with aryl trimesates. Journal of Organic Chemistry. 65: 214-219. PMID 10813918 DOI: 10.1021/Jo991514N |
0.402 |
|
| 1999 |
Kluger R, Paal K, Adamson JG. An ether-linked tetrafunctional acylating reagent and its cross-linking reactions with hemoglobin Canadian Journal of Chemistry. 77: 271-279. DOI: 10.1139/V98-236 |
0.351 |
|
| 1999 |
Kluger R, Lock-O'Brien aJ, Teytelboym A. Connecting Proteins by Design. Cross-Linked Bis-Hemoglobin Journal of the American Chemical Society. 121: 6780-6785. DOI: 10.1021/Ja9910107 |
0.317 |
|
| 1997 |
Kluger R, Li X. Efficient Chemical Introduction of a Disulfide Cross-Link and Conjugation Site into Human Hemoglobin at β-Lysine-82 Utilizing a Bifunctional Aminoacyl Phosphate Bioconjugate Chemistry. 8: 921-926. PMID 9404667 DOI: 10.1021/Bc970169A |
0.368 |
|
| 1997 |
Kluger R, Loo RW, Mazza V. Biomimetically Activated Amino Acids. Catalysis In The Hydrolysis Of Alanyl Ethyl Phosphate Journal of the American Chemical Society. 119: 12089-12094. DOI: 10.1021/Ja972406Q |
0.41 |
|
| 1996 |
Jones RT, Shih DT, Fujita TS, Song Y, Xiao H, Head C, Kluger R. A doubly cross-linked human hemoglobin. Effects of cross-links between different subunits. The Journal of Biological Chemistry. 271: 675-80. PMID 8557672 DOI: 10.1074/Jbc.271.2.675 |
0.305 |
|
| 1996 |
Rahil J, You S, Kluger R. Solvent-Accelerated Decarboxylation Of N-Carboxy-2-Imidazolidinone. Implications For Stability Of Intermediates In Biotin-Dependent Carboxylations Journal of the American Chemical Society. 118: 12495-12498. DOI: 10.1021/Ja962464W |
0.367 |
|
| 1996 |
Paal K, Jones RT, Kluger R. A Site-Specific Tetrafunctional Reagent for Protein Modification: Cross-Linked Hemoglobin with Two Sites for Further Reaction Journal of the American Chemical Society. 118: 10380-10383. DOI: 10.1021/Ja961833L |
0.405 |
|
| 1996 |
Kluger R, Shen L, Xiao H, Jones RT. Systematically Cross-Linked Human Hemoglobin : Functional Effects Of 10 A Spans Between Beta Subunits At Lysine-82 Journal of the American Chemical Society. 118: 8782-8786. DOI: 10.1021/Ja961443Z |
0.348 |
|
| 1994 |
Kluger R, Bearne SL. Inactivation of d-3-hydroxybutyrate dehydrogenase by fumaroyl bis(methyl phosphate) Bioorganic and Medicinal Chemistry. 2: 379-385. PMID 8000857 DOI: 10.1016/0968-0896(94)80004-9 |
0.623 |
|
| 1994 |
Kluger R. 1994 Syntex Award Lecture: Anionic Electrophiles, Protein Modification, and Artificial Blood Canadian Journal of Chemistry. 72: 2193-2197. DOI: 10.1139/V94-279 |
0.409 |
|
| 1994 |
Kluger R, Song Y. Changing a protein into a generalized acylating reagent. Reaction of nucleophiles with 3,5-dibromosalicyl trimesyl-((Lys-.beta.-82)-(Lys-.beta.-82))-hemoglobin Journal of Organic Chemistry. 59: 733-736. DOI: 10.1021/Jo00083A012 |
0.364 |
|
| 1993 |
Jones RT, Head CG, Fujita TS, Shih DT, Wodzinska J, Kluger R. Modification of human hemoglobin with methyl acyl phosphates derived from dicarboxylic acids. Systematic relationships between cross-linked structure and oxygen-binding properties. Biochemistry. 32: 215-23. PMID 8418841 DOI: 10.1021/Bi00052A028 |
0.339 |
|
| 1993 |
Guthrie JP, Kluger R. Electrostatic stabilization can explain the unexpected acidity of carbon acids in enzyme-catalyzed reactions Journal of the American Chemical Society. 115: 11569-11572. DOI: 10.1021/Ja00077A063 |
0.371 |
|
| 1993 |
Taylor SD, Kluger R. Hydrolysis of methylacetoin ethyl phosphate. Competing pathways for carbonyl hydrate participation in a model for biotin carboxylation Journal of the American Chemical Society. 115: 867-871. DOI: 10.1021/Ja00056A007 |
0.55 |
|
| 1993 |
Kluger R, Lam JF, Kim CS. Decomposition of 2-(1-hydroxybenzyl)thiamin in neutral aqueous solutions: Benzaldehyde and thiamin are not the products Bioorganic Chemistry. 21: 275-283. DOI: 10.1006/Bioo.1993.1023 |
0.327 |
|
| 1992 |
Kluger R, Wodzinska J, Jones RT, Head C, Fujita TS, Shih DT. Three-point cross-linking: potential red cell substitutes from the reaction of trimesoyl tris(methyl phosphate) with hemoglobin. Biochemistry. 31: 7551-9. PMID 1510941 DOI: 10.1021/Bi00148A016 |
0.307 |
|
| 1992 |
Taylor SD, Kluger R. Heats of reaction of cyclic and acyclic phosphate and phosphonate esters. Strain discrepancy and steric retardation Journal of the American Chemical Society. 114: 3067-3071. DOI: 10.1021/ja00034a045 |
0.41 |
|
| 1992 |
Kluger R. 7 Mechanisms of Enzymic Carbon–Carbon Bond Formation and Cleavage The Enzymes. 20: 271-315. DOI: 10.1016/S1874-6047(08)60025-6 |
0.376 |
|
| 1992 |
Bearne SL, Kluger R. Phosphoenol acetylphosphonates: Substrate analogues as inhibitors of phosphoenolpyruvate enzymes Bioorganic Chemistry. 20: 135-147. DOI: 10.1016/0045-2068(92)90034-Z |
0.612 |
|
| 1991 |
Kluger R, Taylor SD. Endocyclic cleavage in the alkaline hydrolysis of the cyclic phosphonate methyl propylphostonate: dianionic intermediates and barriers to pseudorotation Journal of the American Chemical Society. 113: 5714-5719. DOI: 10.1021/Ja00015A027 |
0.547 |
|
| 1991 |
Kluger R, Taylor SD. Mechanisms of carbonyl participation in phosphate ester hydrolysis and their relationship to mechanisms for the carboxylation of biotin Journal of the American Chemical Society. 113: 996-1001. DOI: 10.1021/Ja00003A038 |
0.558 |
|
| 1990 |
Kluger R, Grant AS, Bearne SL, Trachsel MR. Dicarboxylic acid bis(methyl phosphates): anionic biomimetic crosslinking reagents Journal of Organic Chemistry. 55: 2864-2868. DOI: 10.1021/Jo00296A056 |
0.663 |
|
| 1990 |
Kluger R, Taylor SD. On the origins of enhanced reactivity of five-membered cyclic phosphate esters. The relative contributions of enthalpic and entropic factors Journal of the American Chemical Society. 112: 6669-6671. DOI: 10.1021/Ja00174A033 |
0.521 |
|
| 1990 |
Kluger R, Trachsel MR. Differentiation of diastereomeric salts of hydroxyethyl(thiamin) and analysis of stereochemical requirements in pyruvate decarboxylase Bioorganic Chemistry. 18: 136-143. DOI: 10.1016/0045-2068(90)90035-4 |
0.358 |
|
| 1990 |
KLUGER R, TAYLOR SD. ChemInform Abstract: Origins of Enhanced Reactivity of Five-Membered Cyclic Phosphate Esters. The Relative Contributions of Enthalpic and Entropic Factors. Cheminform. 21. DOI: 10.1002/chin.199051078 |
0.424 |
|
| 1989 |
Kluger R, Hunt JC. Carboxylic acid participation in amide hydrolysis. Competition between acid-catalyzed dehydration and anhydride formation Journal of the American Chemical Society. 111: 5921-5925. DOI: 10.1021/Ja00197A062 |
0.342 |
|
| 1989 |
Kluger R, Hunt JC. Circumventive catalysis: contrasting reaction patterns of tertiary and primary amines with cyclic anhydrides and the avoidance of intermediates Journal of the American Chemical Society. 111: 3325-3328. DOI: 10.1021/Ja00191A033 |
0.347 |
|
| 1989 |
Thatcher RJG, Kluger R. Mechanism and Catalysis of Nucleophilic Substitution in Phosphate Esters Advances in Physical Organic Chemistry. 25: 99-265. DOI: 10.1016/S0065-3160(08)60019-2 |
0.379 |
|
| 1989 |
Kluger R. Mechanisms for the enzyme-catalyzed ATP-dependent carboxylation of biotin involving phosphorylated tetrahedral intermediates Bioorganic Chemistry. 17: 287-293. DOI: 10.1016/0045-2068(89)90031-X |
0.387 |
|
| 1989 |
Bearne SL, Gish G, Karimian K, Kluger R. Direct selective pyrophosphorylation of the primary hydroxyl group in (hydroxyethyl)thiamin by modified phosphoric acid-cresol solutions and evaluation of extension of the method to nucleosides Bioorganic Chemistry. 17: 224-230. DOI: 10.1016/0045-2068(89)90022-9 |
0.644 |
|
| 1987 |
Kluger R, Thatcher GRJ, Stallings WC. Synthesis, structure, and hydrolysis of esters of strained and unstrained N-phosphonylureas Canadian Journal of Chemistry. 65: 1838-1844. DOI: 10.1139/V87-309 |
0.302 |
|
| 1987 |
Kluger R, Karimian K, Kitamura K. Chiral intermediates in thiamin catalysis. Stereochemical course of the decarboxylation step in the conversion of pyruvate to acetaldehyde Journal of the American Chemical Society. 109: 6368-6371. DOI: 10.1021/Ja00255A022 |
0.304 |
|
| 1987 |
Kluger R, Thatcher GRJ, Stallings WC. Synthesis, structure, and hydrolysis of esters of strained and unstrained N-phosphonylureas Canadian Journal of Chemistry. 65: 1838-1844. |
0.492 |
|
| 1986 |
Kluger R, Brandl M. Secondary .beta.-deuterium isotope effects in decarboxylation and elimination reactions of .alpha.-lactylthiamin: intrinsic isotope effects of pyruvate decarboxylase. Journal of the American Chemical Society. 108: 7828-7832. PMID 22283294 DOI: 10.1021/Ja00284A056 |
0.376 |
|
| 1986 |
Ueno H, Pospischil MA, Manning JM, Kluger R. Site-specific modification of hemoglobin by methyl acetyl phosphate Archives of Biochemistry and Biophysics. 244: 795-800. PMID 3947090 DOI: 10.1016/0003-9861(86)90648-X |
0.339 |
|
| 1986 |
Ueno H, Pospischil MA, Kluger R, Manning JM. Methyl acetyl phosphate: A novel acetylating agent Its site-specific modification of human hemoglobin A Journal of Chromatography A. 359: 193-201. PMID 3733926 DOI: 10.1016/0021-9673(86)80073-5 |
0.316 |
|
| 1986 |
Kluger R, Tsui W. Reaction of the anionic acetylation agent methyl acetyl phosphate with D-3-hydroxybutyrate dehydrogenase. Biochemistry and Cell Biology. 64: 434-440. PMID 3718711 DOI: 10.1139/O86-061 |
0.38 |
|
| 1986 |
Kluger R, Thatcher GRJ. Exocyclic cleavage in the alkaline hydrolysis of methyl ethylene phosphate: pseudorotation of a pentavalent intermediate or reaction via a hexavalent intermediate? Journal of Organic Chemistry. 51: 207-212. DOI: 10.1021/Jo00352A014 |
0.399 |
|
| 1986 |
Thatcher GRJ, Poirier R, Kluger R. Enzymic carboxyl transfer from N-carboxybiotin. A molecular orbital evaluation of conformational effects in promoting reactivity Journal of the American Chemical Society®. 108: 2699-2704. DOI: 10.1021/Ja00270A031 |
0.524 |
|
| 1986 |
THATCHER GRJ, POIRIER R, KLUGER R. ChemInform Abstract: Enzymic Carboxyl Transfer from N-Carboxybiotin. A MO Evaluation of Conformational Effects in Promoting Reactivity. Chemischer Informationsdienst. 17. DOI: 10.1002/Chin.198637071 |
0.538 |
|
| 1986 |
Kluger R, Thatcher GRJ. Exocyclic Cleavage in the Alkaline Hydrolysis of Methyl Ethylene Phosphate: Pseudorotation of a Pentavalent Intermediate or Reaction via a Hexavalent Intermediate? Cheminform. 17. DOI: 10.1002/Chin.198626141 |
0.399 |
|
| 1986 |
KLUGER R, THATCHER GRJ. ChemInform Abstract: Exocyclic Cleavage in the Alkaline Hydrolysis of Methyl Ethylene Phosphate. Chemischer Informationsdienst. 17. DOI: 10.1002/chin.198605239 |
0.497 |
|
| 1986 |
Kluger R, Thatcher GRJ. Exocyclic cleavage in the alkaline hydrolysis of methyl ethylene phosphate: Pseudorotation of a pentavalent intermediate or reaction via a hexavalent intermediate? Journal of Organic Chemistry. 51: 207-212. |
0.563 |
|
| 1985 |
Kluger R, Thatcher GRJ. Exocyclic cleavage in the alkaline hydrolysis of methyl ethylene phosphate. Evidence against the significance of stereoelectronic acceleration in reactions of cyclic phosphates Journal of the American Chemical Society. 107: 6006-6011. DOI: 10.1021/Ja00307A027 |
0.396 |
|
| 1985 |
Kluger R, Stergiopoulos V, Gish G, Karimian K. Chiral intermediates in thiamin catalysis: Resolution and pyrophosphorylation of hydroxyethylthiamin Bioorganic Chemistry. 13: 227-234. DOI: 10.1016/0045-2068(85)90025-2 |
0.36 |
|
| 1985 |
Kluger R, Hunt JC. Aminolysis Of Maleic Anhydride. Kinetics And Thermodynamics Of Amide Formation Cheminform. 16. DOI: 10.1002/Chin.198502088 |
0.333 |
|
| 1985 |
Kluger R, Thatcher GRJ. Exocyclic cleavage in the alkaline hydrolysis of methyl ethylene phosphate. Evidence against the significance of stereoelectronic acceleration in reactions of cyclic phosphates Journal of the American Chemical Society. 107: 6006-6011. |
0.539 |
|
| 1984 |
Kluger R, Brandl M. Structural effects on reactivity in intramolecular catalysis. The hydrolysis of N-alkylated monoamides derived from norbornene-2,3-dicarboxylic acid Canadian Journal of Chemistry. 62: 2515-2520. DOI: 10.1139/V84-430 |
0.331 |
|
| 1984 |
Kluger R, Hunt JC. Aminolysis of maleic anhydride kinetics and thermodynamics of amide formation Journal of the American Chemical Society. 106: 5667-5670. DOI: 10.1021/Ja00331A042 |
0.333 |
|
| 1982 |
Kluger R, Chin J. Carboxylic acid participation in amide hydrolysis. Evidence that separation of a nonbonded complex can be rate determining Journal of the American Chemical Society. 104: 2891-2897. DOI: 10.1021/Ja00374A032 |
0.538 |
|
| 1981 |
Kluger R, Tsui W. Inhibition of bacterial D-3-hydroxybutyrate dehydrogenase by substrates and substrate analogues. Biochemistry and Cell Biology. 59: 810-815. PMID 7317814 DOI: 10.1139/O81-112 |
0.301 |
|
| 1981 |
Kluger R, Chin J, Smyth T. Thiamin-catalyzed decarboxylation of pyruvate. Synthesis and reactivity analysis of the central, elusive intermediate, .alpha.-lactylthiamin Journal of the American Chemical Society. 103: 884-888. DOI: 10.1021/Ja00394A027 |
0.513 |
|
| 1980 |
Kluger R, Tsui W. Amino group reactions of the sulfhydryl reagent methyl methanesulfonothioate. Inactivation of D-3-hydroxybutyrate dehydrogenase and reaction with amines in water Biochemistry and Cell Biology. 58: 629-632. PMID 7459689 DOI: 10.1139/O80-086 |
0.395 |
|
| 1979 |
Kluger R, Chin J, Choy WW. Carboxylic acid participation in amide hydrolysis. Reactivity of intermediates in the internally catalyzed hydrolysis of N-substituted 2,3-dimethylmaleamic acids Journal of the American Chemical Society. 101: 6976-6980. DOI: 10.1021/Ja00517A033 |
0.57 |
|
| 1979 |
Kluger R, Pike DC. Chemical synthesis of a proposed enzyme-generated "reactive intermediate analog" derived from thiamin diphosphate. Self-activation of pyruvate dehydrogenase by conversion of the analog to its components Journal of the American Chemical Society. 101: 6425-6428. DOI: 10.1021/Ja00515A044 |
0.315 |
|
| 1978 |
Kluger R, Pire DC, Chin J. Kinetics and mechanism of the reaction of dimethyl acetylphosphonate with water. Expulsion of a phosphonate ester from a carbonyl hydrate Canadian Journal of Chemistry. 56: 1792-1795. DOI: 10.1139/V78-291 |
0.574 |
|
| 1978 |
Kluger R, Chin J. Rates of formation and decomposition of tetrahedral intermediates in the hydrolysis of dimethyl aroylphosphonates. Substituent effects on a model for carboxylate ester hydrolysis Journal of the American Chemical Society. 100: 7382-7388. DOI: 10.1021/Ja00491A040 |
0.57 |
|
| 1977 |
Kluger R, Pike DC. Active site generated analogues of reactive intermediates in enzymic reactions. Potent inhibition of pyruvate dehydrogenase by a phosphonate analogue of pyruvate1. Journal of the American Chemical Society. 99: 4504-4506. PMID 864125 DOI: 10.1021/Ja00455A052 |
0.356 |
|
| 1977 |
Kluger R, Lam C-. General base catalysis in acidic solutions. Acceleration of intramolecular phosphonate-assisted amide hydrolysis Canadian Journal of Chemistry. 55: 1042-1042. DOI: 10.1139/V77-091 |
0.334 |
|
| 1976 |
Kluger R, Adawadkar PD. A reaction proceeding through intramolecular phosphorylation of a urea. A chemical mechanism for enzymic carboxylation of biotin involving cleavage of adenosines 5'-triphosphate. Journal of the American Chemical Society. 98: 3741-3742. PMID 1270712 DOI: 10.1021/Ja00428A077 |
0.37 |
|
| 1976 |
Kluger R, Chan JLW. Amide-phosphate interactions: acid catalysis in amide-assisted hydrolysis of phosphonate esters Journal of the American Chemical Society. 98: 4913-4917. DOI: 10.1021/Ja00432A036 |
0.349 |
|
| 1975 |
Hammons G, Westheimer FH, Nakaoka K, Kluger R. Proton-exchange reactions of acetone and butanone. Resolution of steps in catalysis by acetoacetate decarboxylase. Journal of the American Chemical Society. 97: 1568-72. PMID 1133393 DOI: 10.1021/Ja00839A050 |
0.67 |
|
| 1975 |
Kluger R, Wayda A. Models for the Role of Magnesium in Enzymic Catalysis. The Effect of Magnesium Ion on the General Base Catalyzed Enolization of Methyl Acetonylphosphonate Canadian Journal of Chemistry. 53: 2354-2358. DOI: 10.1139/V75-330 |
0.354 |
|
| 1975 |
Kluger R, Lam CH. Effects of leaving group basicity on the hydrolysis of aryl-substituted maleanilinic acids Journal of the American Chemical Society. 97: 5536-5540. DOI: 10.1021/Ja00852A036 |
0.346 |
|
| 1975 |
Hammons G, Westheimer F, Nakaoka K, Kluger R. Additions and Corrections - Proton-Exchange Reactions of Acetone and Butanone. Resolution of Steps in Catalysis by Acetoacetate Decarboxylase. Journal of the American Chemical Society. 97: 4152-4152. DOI: 10.1021/Ja00847A610 |
0.694 |
|
| 1975 |
Kluger R, Lam C-. The Effects Of Leaving Group Basicity On The Hydrolysis Of Aryl-Substituted Maleanilinic Acids Cheminform. 6. DOI: 10.1002/Chin.197549174 |
0.346 |
|
| 1973 |
Kluger R, Wasserstein P. Additions and Corrections - Mechanism of Metal Ion Promoted Hydrogen Exchange Reactions. Magnesium(II) and Acetonyl Phosphonate Journal of the American Chemical Society. 95: 4473-4473. DOI: 10.1021/Ja00794A608 |
0.314 |
|
| 1973 |
Kluger R, Wasserstein P. Mechanism of metal ion promoted hydrogen exchange reactions. Magnesium(II) and acetonyl phosphonate. Journal of the American Chemical Society. 95: 1071-1074. DOI: 10.1021/Ja00785A013 |
0.309 |
|
| 1972 |
Kluger R, Wasserstein P. Hydrolysis of acetyl dimethyl phosphate, a reactive acyl phosphate. Biochemistry. 11: 1544-1546. PMID 5021606 DOI: 10.1021/Bi00758A600 |
0.363 |
|
| 1970 |
KLUGER R, COVITZ F, DENNIS E, WILLIAMS LD, WESTHEIMER FH. ChemInform Abstract: PH-ABHAENGIGE PRODUKT- UND GESCHWINDIGKEITSPROFILE BEI HYDROLYSE VON METHYLAETHYLENPHOSPHAT(I), GESCHWINDIGKEITSBESTIMMENDE PSEUDOROTATION Chemischer Informationsdienst. Organische Chemie. 1. DOI: 10.1002/Chin.197002122 |
0.685 |
|
| 1969 |
Kluger R, Covitz F, Dennis E, Williams LD, Westheimer FH. pH-product and pH-rate profiles for the hydrolysis of methyl ethylene phosphate. Rate-limiting pseudorotation Journal of the American Chemical Society. 91: 6066-6072. DOI: 10.1021/Ja01050A023 |
0.704 |
|
| 1969 |
Kluger R, Westheimer FH. The pH-rate profile for the hydrolysis of some esters of a bicyclic phosphinic acid. Evidence for rate-limiting pseudorotation Journal of the American Chemical Society. 91: 4143-4150. DOI: 10.1021/Ja01043A022 |
0.668 |
|
| 1967 |
Kluger R, Kerst F, Lee DG, Dennis EA, Westheimer FH. Hydrolysis of Esters of Bicycloheptyl- and -heptenylphsophinic Acids Journal of the American Chemical Society. 89: 3718-3719. DOI: 10.1021/Ja00991A601 |
0.758 |
|
| 1967 |
Kluger R, Kerst F, Lee DG, Westheimer FH. Some substituted 7-ethoxy-7-phosphabicycloheptene and-heptane 7-oxides Journal of the American Chemical Society. 89: 3919-3920. DOI: 10.1021/Ja00991A054 |
0.704 |
|
| 1967 |
Kluger R, Kerst F, Lee DG, Westheimer FH. Some substituted 7-ethoxy-7-phosphabicycloheptene and -heptane 7-oxides [18] Journal of the American Chemical Society. 89: 3919-3920. |
0.619 |
|
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