Kevin T Bush, Ph.D. - Publications

Affiliations: 
1999- UCSD School of Medicine, San Diego, CA, United States 
Area:
kidney development, drug transporters, organic anion transporter

40 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Nigam AK, Li JG, Lall K, Shi D, Bush KT, Bhatnagar V, Abagyan R, Nigam SK. Unique metabolite preferences of the drug transporters OAT1 and OAT3 analyzed by machine learning. The Journal of Biological Chemistry. PMID 31896576 DOI: 10.1074/jbc.RA119.010729  1
2019 Rosenthal SB, Bush KT, Nigam SK. A Network of SLC and ABC Transporter and DME Genes Involved in Remote Sensing and Signaling in the Gut-Liver-Kidney Axis. Scientific Reports. 9: 11879. PMID 31417100 DOI: 10.1038/s41598-019-47798-x  1
2019 Nigam SK, Bush KT. Uraemic syndrome of chronic kidney disease: altered remote sensing and signalling. Nature Reviews. Nephrology. PMID 30728454 DOI: 10.1038/s41581-019-0111-1  1
2018 Ye M, Xu L, Fu M, Chen D, Mattina T, Zufardi O, Rossi E, Bush KT, Nigam SK, Grossfeld P. Gene-targeted deletion in mice of the Ets-1 transcription factor, a candidate gene in the Jacobsen syndrome kidney "critical region," causes abnormal kidney development. American Journal of Medical Genetics. Part A. PMID 30422383 DOI: 10.1002/ajmg.a.40481  1
2017 Bush KT, Wu W, Lun C, Nigam SK. The drug transporter OAT3 (SLC22A8) regulates endogenous metabolite flow through the gut-liver-kidney axis. The Journal of Biological Chemistry. PMID 28765282 DOI: 10.1074/jbc.M117.796516  1
2017 Wu W, Bush KT, Nigam SK. Key Role for the Organic Anion Transporters, OAT1 and OAT3, in the in vivo Handling of Uremic Toxins and Solutes. Scientific Reports. 7: 4939. PMID 28694431 DOI: 10.1038/s41598-017-04949-2  1
2016 Liu HC, Goldenberg A, Chen Y, Lun C, Wu W, Bush KT, Balac N, Rodriguez P, Abagyan R, Nigam SK. Analysis of Molecular Properties of Drugs Interacting with SLC22 Transporters OAT1, OAT3, OCT1, and OCT2: A Machine-Learning Approach. The Journal of Pharmacology and Experimental Therapeutics. PMID 27488918 DOI: 10.1124/jpet.116.232660  0.48
2016 Liu HC, Jamshidi N, Chen Y, Eraly SA, Cho SY, Bhatnagar V, Wu W, Bush KT, Abagyan R, Palsson BO, Nigam SK. Construction and Evaluation of an Organic Anion Transporter 1 (OAT1)-Centered Metabolic Network. The Journal of Biological Chemistry. PMID 27440044 DOI: 10.1074/jbc.M116.745216  0.48
2016 Martovetsky G, Bush KT, Nigam SK. Transcription factor-mediated regulation of kidney versus liver specification of Slc and Abc drug transporters, tight junction molecules and signature biomarkers. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 27044799 DOI: 10.1124/dmd.115.068254  1
2015 Kumar N, Richter J, Cutts J, Bush KT, Trujillo C, Nigam SK, Gaasterland T, Brafman D, Willert K. Generation of an expandable intermediate mesoderm restricted progenitor cell line from human pluripotent stem cells. Elife. 4. PMID 26554899 DOI: 10.7554/eLife.08413  1
2015 Zhu C, Nigam KB, Date RC, Bush KT, Springer SA, Saier MH, Wu W, Nigam SK. Evolutionary Analysis and Classification of OATs, OCTs, OCTNs, and Other SLC22 Transporters: Structure-Function Implications and Analysis of Sequence Motifs. Plos One. 10: e0140569. PMID 26536134 DOI: 10.1371/journal.pone.0140569  1
2015 Wu W, Bush KT, Liu HC, Zhu C, Abagyan R, Nigam SK. Shared Ligands between Organic Anion Transporters (Oat1 and Oat6) and Odorant Receptors. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 26358290 DOI: 10.1124/dmd.115.065250  1
2014 Bush KT, Martovetsky G, Nigam SK. Relevance of ureteric bud development and branching to tissue engineering, regeneration and repair in acute and chronic kidney disease. Current Opinion in Organ Transplantation. 19: 153-61. PMID 24503495 DOI: 10.1097/MOT.0000000000000053  1
2014 Nigam SK, Bush KT. Growth factor-heparan sulfate "switches" regulating stages of branching morphogenesis. Pediatric Nephrology (Berlin, Germany). 29: 727-35. PMID 24488503 DOI: 10.1007/s00467-013-2725-z  1
2013 Tee JB, Choi Y, Dnyanmote A, Decambre M, Ito C, Bush KT, Nigam SK. GDNF-independent ureteric budding: role of PI3K-independent activation of AKT and FOSB/JUN/AP-1 signaling. Biology Open. 2: 952-9. PMID 24143282 DOI: 10.1242/bio.20135595  1
2012 Bush KT, Crawford BE, Garner OB, Nigam KB, Esko JD, Nigam SK. N-sulfation of heparan sulfate regulates early branching events in the developing mammary gland. The Journal of Biological Chemistry. 287: 42064-70. PMID 23060443 DOI: 10.1074/jbc.M112.423327  1
2012 Gallegos TF, Martovetsky G, Kouznetsova V, Bush KT, Nigam SK. Organic anion and cation SLC22 "drug" transporter (Oat1, Oat3, and Oct1) regulation during development and maturation of the kidney proximal tubule. Plos One. 7: e40796. PMID 22808265 DOI: 10.1371/journal.pone.0040796  1
2012 Zhang X, Bush KT, Nigam SK. In vitro culture of embryonic kidney rudiments and isolated ureteric buds. Methods in Molecular Biology (Clifton, N.J.). 886: 13-21. PMID 22639247 DOI: 10.1007/978-1-61779-851-1_2  1
2011 Ahn SY, Jamshidi N, Mo ML, Wu W, Eraly SA, Dnyanmote A, Bush KT, Gallegos TF, Sweet DH, Palsson BØ, Nigam SK. Linkage of organic anion transporter-1 to metabolic pathways through integrated "omics"-driven network and functional analysis. The Journal of Biological Chemistry. 286: 31522-31. PMID 21757732 DOI: 10.1074/jbc.M111.272534  1
2011 Torres AM, Dnyanmote AV, Bush KT, Wu W, Nigam SK. Deletion of multispecific organic anion transporter Oat1/Slc22a6 protects against mercury-induced kidney injury. The Journal of Biological Chemistry. 286: 26391-5. PMID 21652719 DOI: 10.1074/jbc.M111.249292  1
2011 Garner OB, Bush KT, Nigam KB, Yamaguchi Y, Xu D, Esko JD, Nigam SK. Stage-dependent regulation of mammary ductal branching by heparan sulfate and HGF-cMet signaling. Developmental Biology. 355: 394-403. PMID 21586278 DOI: 10.1016/j.ydbio.2011.04.035  1
2010 Crawford BE, Garner OB, Bishop JR, Zhang DY, Bush KT, Nigam SK, Esko JD. Loss of the heparan sulfate sulfotransferase, Ndst1, in mammary epithelial cells selectively blocks lobuloalveolar development in mice. Plos One. 5: e10691. PMID 20502530 DOI: 10.1371/journal.pone.0010691  1
2010 Rosines E, Johkura K, Zhang X, Schmidt HJ, Decambre M, Bush KT, Nigam SK. Constructing kidney-like tissues from cells based on programs for organ development: toward a method of in vitro tissue engineering of the kidney. Tissue Engineering. Part A. 16: 2441-55. PMID 20214453 DOI: 10.1089/ten.TEA.2009.0548  1
2009 Choi Y, Tee JB, Gallegos TF, Shah MM, Oishi H, Sakurai H, Kitamura S, Wu W, Bush KT, Nigam SK. Neuropeptide Y functions as a facilitator of GDNF-induced budding of the Wolffian duct. Development (Cambridge, England). 136: 4213-24. PMID 19934016 DOI: 10.1242/dev.037580  1
2009 Wu W, Kitamura S, Truong DM, Rieg T, Vallon V, Sakurai H, Bush KT, Vera DR, Ross RS, Nigam SK. Beta1-integrin is required for kidney collecting duct morphogenesis and maintenance of renal function. American Journal of Physiology. Renal Physiology. 297: F210-7. PMID 19439520 DOI: 10.1152/ajprenal.90260.2008  1
2009 Wu W, Baker ME, Eraly SA, Bush KT, Nigam SK. Analysis of a large cluster of SLC22 transporter genes, including novel USTs, reveals species-specific amplification of subsets of family members. Physiological Genomics. 38: 116-24. PMID 19417012 DOI: 10.1152/physiolgenomics.90309.2008  1
2008 Nigam SK, Wu W, Bush KT. Organogenesis forum lecture: In vitro kidney development, tissue engineering and systems biology. Organogenesis. 4: 137-43. PMID 19279725  1
2007 Nigam SK, Bush KT, Bhatnagar V. Drug and toxicant handling by the OAT organic anion transporters in the kidney and other tissues. Nature Clinical Practice. Nephrology. 3: 443-8. PMID 17653123 DOI: 10.1038/ncpneph0558  1
2007 Monte JC, Sakurai H, Bush KT, Nigam SK. The developmental nephrome: systems biology in the developing kidney. Current Opinion in Nephrology and Hypertension. 16: 3-9. PMID 17143064 DOI: 10.1097/MNH.0b013e3280118a5a  1
2006 Meyer TN, Schwesinger C, Sampogna RV, Vaughn DA, Stuart RO, Steer DL, Bush KT, Nigam SK. Rho kinase acts at separate steps in ureteric bud and metanephric mesenchyme morphogenesis during kidney development. Differentiation; Research in Biological Diversity. 74: 638-47. PMID 17177859 DOI: 10.1111/j.1432-0436.2006.00102.x  1
2006 Bush KT, Vaughn DA, Li X, Rosenfeld MG, Rose DW, Mendoza SA, Nigam SK. Development and differentiation of the ureteric bud into the ureter in the absence of a kidney collecting system. Developmental Biology. 298: 571-84. PMID 16934795 DOI: 10.1016/j.ydbio.2006.07.006  1
2005 Sakurai H, Bush KT, Nigam SK. Heregulin induces glial cell line-derived neurotrophic growth factor-independent, non-branching growth and differentiation of ureteric bud epithelia. The Journal of Biological Chemistry. 280: 42181-7. PMID 16183643 DOI: 10.1074/jbc.M507962200  1
2004 Meyer TN, Schwesinger C, Bush KT, Stuart RO, Rose DW, Shah MM, Vaughn DA, Steer DL, Nigam SK. Spatiotemporal regulation of morphogenetic molecules during in vitro branching of the isolated ureteric bud: toward a model of branching through budding in the developing kidney. Developmental Biology. 275: 44-67. PMID 15464572 DOI: 10.1016/j.ydbio.2004.07.022  1
2004 Steer DL, Shah MM, Bush KT, Stuart RO, Sampogna RV, Meyer TN, Schwesinger C, Bai X, Esko JD, Nigam SK. Regulation of ureteric bud branching morphogenesis by sulfated proteoglycans in the developing kidney. Developmental Biology. 272: 310-27. PMID 15282150 DOI: 10.1016/j.ydbio.2004.04.029  1
2004 Shah MM, Sampogna RV, Sakurai H, Bush KT, Nigam SK. Branching morphogenesis and kidney disease. Development (Cambridge, England). 131: 1449-62. PMID 15023929 DOI: 10.1242/dev.01089  1
2004 Eraly SA, Bush KT, Sampogna RV, Bhatnagar V, Nigam SK. The molecular pharmacology of organic anion transporters: from DNA to FDA? Molecular Pharmacology. 65: 479-87. PMID 14978224 DOI: 10.1124/mol.65.3.479  1
2004 Bush KT, Sakurai H, Steer DL, Leonard MO, Sampogna RV, Meyer TN, Schwesinger C, Qiao J, Nigam SK. TGF-beta superfamily members modulate growth, branching, shaping, and patterning of the ureteric bud. Developmental Biology. 266: 285-98. PMID 14738877 DOI: 10.1016/j.ydbio.2003.10.023  1
2003 Stuart RO, Bush KT, Nigam SK. Changes in gene expression patterns in the ureteric bud and metanephric mesenchyme in models of kidney development. Kidney International. 64: 1997-2008. PMID 14633122 DOI: 10.1046/j.1523-1755.2003.00383.x  1
2003 Li X, Oghi KA, Zhang J, Krones A, Bush KT, Glass CK, Nigam SK, Aggarwal AK, Maas R, Rose DW, Rosenfeld MG. Eya protein phosphatase activity regulates Six1-Dach-Eya transcriptional effects in mammalian organogenesis. Nature. 426: 247-54. PMID 14628042 DOI: 10.1038/nature02083  1
2002 Steer DL, Bush KT, Meyer TN, Schwesinger C, Nigam SK. A strategy for in vitro propagation of rat nephrons. Kidney International. 62: 1958-65. PMID 12427120 DOI: 10.1046/j.1523-1755.2002.00694.x  1
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