Andrew Harkin, Ph.D. - Publications

Affiliations: 
Pharmacy Trinity College - Dublin 
Area:
neuropharmacology, drugs of abuse, psychiatric drugs

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Year Citation  Score
2019 Ryan KM, Boyle NT, Harkin A, Connor TJ. Dexamethasone attenuates inflammatory-mediated suppression of β-adrenoceptor expression in rat primary mixed glia. Journal of Neuroimmunology. 338: 577082. PMID 31707103 DOI: 10.1016/J.Jneuroim.2019.577082  0.309
2019 Ryan KM, Allers KA, McLoughlin DM, Harkin A. Tryptophan metabolite concentrations in depressed patients before and after electroconvulsive therapy. Brain, Behavior, and Immunity. PMID 31606477 DOI: 10.1016/J.Bbi.2019.10.005  0.328
2019 Dempsey E, Abautret-Daly Á, Docherty NG, Medina C, Harkin A. Persistent Central Inflammation and Region Specific Cellular Activation Accompany Depression- and Anxiety-like Behaviours During the Resolution Phase of Experimental Colitis. Brain, Behavior, and Immunity. PMID 31063848 DOI: 10.1016/J.Bbi.2019.05.007  0.393
2019 O'Neill E, Chiara Goisis R, Haverty R, Harkin A. L-alpha-aminoadipic acid restricts dopaminergic neurodegeneration and motor deficits in an inflammatory model of Parkinson's disease in male rats. Journal of Neuroscience Research. PMID 30924171 DOI: 10.1002/Jnr.24420  0.333
2019 David J, Gormley S, McIntosh AL, Kebede V, Thuery G, Varidaki A, Coffey ET, Harkin A. L-alpha-amino adipic acid provokes depression-like behaviour and a stress related increase in dendritic spine density in the pre-limbic cortex and hippocampus in rodents. Behavioural Brain Research. PMID 30639510 DOI: 10.1016/J.Bbr.2019.01.015  0.374
2018 Finnegan M, Galligan T, Ryan K, Shanahan E, Harkin A, Daly L, McLoughlin DM. Ketamine Versus Midazolam for Depression Relapse Prevention Following Successful Electroconvulsive Therapy: A Randomized Controlled Pilot Trial. The Journal of Ect. PMID 30531397 DOI: 10.1097/Yct.0000000000000560  0.303
2018 Harkin A, McLoughlin DM. Ketamine and depression: A special kase for kynurenic acid? Brain, Behavior, and Immunity. PMID 30399405 DOI: 10.1016/J.Bbi.2018.11.004  0.313
2018 David J, O'Toole E, O'Reilly K, Thuery G, Assmann N, Finlay D, Harkin A. Inhibitors of the NMDA-nitric Oxides Signaling Pathway Protect Against Neuronal Atrophy and Synapse Loss Provoked by l-alpha Aminoadipic Acid-treated Astrocytes. Neuroscience. PMID 30267830 DOI: 10.1016/J.Neuroscience.2018.09.023  0.319
2018 Farrell C, Doolin K, O' Leary N, Jairaj C, Roddy D, Tozzi L, Morris D, Harkin A, Frodl T, Nemoda Z, Szyf M, Booij L, O'Keane V. DNA methylation differences at the glucocorticoid receptor gene in depression are related to functional alterations in hypothalamic-pituitary-adrenal axis activity and to early life emotional abuse. Psychiatry Research. 265: 341-348. PMID 29793048 DOI: 10.1016/J.Psychres.2018.04.064  0.312
2018 Doolin K, Allers KA, Pleiner S, Liesener A, Farrell C, Tozzi L, O'Hanlon E, Roddy D, Frodl T, Harkin A, O'Keane V. Altered tryptophan catabolite concentrations in major depressive disorder and associated changes in hippocampal subfield volumes. Psychoneuroendocrinology. 95: 8-17. PMID 29787958 DOI: 10.1016/J.Psyneuen.2018.05.019  0.35
2018 Yssel JD, O'Neill E, Nolan YM, Connor TJ, Harkin A. Treatment with the noradrenaline re-uptake inhibitor atomoxetine alone and in combination with the α2-adrenoceptor antagonist idazoxan attenuates loss of dopamine and associated motor deficits in the LPS inflammatory rat model of Parkinson's disease. Brain, Behavior, and Immunity. PMID 29339319 DOI: 10.1016/J.Bbi.2018.01.004  0.345
2018 Griffin ÉW, Yssel JD, O'Neill E, Ryan KJ, Boyle N, Harper P, Harkin A, Connor T. The β2-adrenoceptor agonist clenbuterol reduces the neuroinflammatory response, neutrophil infiltration and apoptosis following intra-striatal IL-1β administration to rats. Immunopharmacology and Immunotoxicology. 1-8. PMID 29303018 DOI: 10.1080/08923973.2017.1418882  0.314
2018 O'Reilly K, David J, Harkin A. ZL006 has antidepressant effects and attenuates changes in dendritic spines associated with astrocytic impairment in mice European Neuropsychopharmacology. 28. DOI: 10.1016/J.Euroneuro.2017.12.071  0.404
2017 Doolin K, Farrell C, Tozzi L, Harkin A, Frodl T, O'Keane V. Diurnal Hypothalamic-Pituitary-Adrenal Axis Measures and Inflammatory Marker Correlates in Major Depressive Disorder. International Journal of Molecular Sciences. 18. PMID 29064428 DOI: 10.3390/Ijms18102226  0.321
2017 Sherwin E, Lennon A, Harkin A. Regional Specific Modulation of Stress-Induced Neuronal Activation Associated with the PSD95/NOS Interaction Inhibitor ZL006 in the Wistar Kyoto Rat. The International Journal of Neuropsychopharmacology. 20: 833-843. PMID 28977524 DOI: 10.1093/Ijnp/Pyx053  0.335
2017 O'Farrell K, Fagan E, Connor TJ, Harkin A. Inhibition of the kynurenine pathway protects against reactive microglial-associated reductions in the complexity of primary cortical neurons. European Journal of Pharmacology. PMID 28688912 DOI: 10.1016/J.Ejphar.2017.07.008  0.353
2017 McIntosh AL, Gormley S, Tozzi L, Frodl T, Harkin A. Recent Advances in Translational Magnetic Resonance Imaging in Animal Models of Stress and Depression. Frontiers in Cellular Neuroscience. 11: 150. PMID 28596724 DOI: 10.3389/Fncel.2017.00150  0.301
2017 Abautret-Daly Á, Dempsey E, Parra-Blanco A, Medina C, Harkin A. Gut-brain actions underlying comorbid anxiety and depression associated with inflammatory bowel disease. Acta Neuropsychiatrica. 1-22. PMID 28270247 DOI: 10.1017/Neu.2017.3  0.317
2017 McLoughlin D, Finnegan M, Ryan K, Shanahan E, Harkin A, Daly L. The KEEP-WELL trial (NCT02414932) – ketamine for depression relapse prevention following ECT European Neuropsychopharmacology. 27. DOI: 10.1016/S0924-977X(17)31035-0  0.304
2016 Finnegan M, Ryan K, Shanahan E, Harkin A, Daly L, McLoughlin DM. Ketamine for depression relapse prevention following electroconvulsive therapy: protocol for a randomised pilot trial (the KEEP-WELL trial). Pilot and Feasibility Studies. 2: 38. PMID 27965856 DOI: 10.1186/S40814-016-0080-0  0.345
2016 Sherwin E, Gigliucci V, Harkin A. Regional specific modulation of neuronal activation associated with nitric oxide synthase inhibitors in an animal model of antidepressant activity. Behavioural Brain Research. 316: 18-28. PMID 27569181 DOI: 10.1016/J.Bbr.2016.08.049  0.342
2016 O'Neill E, Kwok B, Day JS, Connor TJ, Harkin A. Amitriptyline protects against TNF-α-induced atrophy and reduction in synaptic markers via a Trk-dependent mechanism. Pharmacology Research & Perspectives. 4: e00195. PMID 27069625 DOI: 10.1002/Prp2.195  0.343
2016 Gormley S, Rouine J, McIntosh A, Kerskens C, Harkin A. Glial fibrillary acidic protein (GFAP) immunoreactivity correlates with cortical perfusion parameters determined by bolus tracking arterial spin labelling (bt-ASL) magnetic resonance (MR) imaging in the Wistar Kyoto rat. Physiology & Behavior. PMID 27068181 DOI: 10.1016/J.Physbeh.2016.04.007  0.347
2016 Ryan KM, Griffin ÉW, Ryan KJ, Tanveer R, Vanattou-Saifoudine N, McNamee EN, Fallon E, Heffernan S, Harkin A, Connor TJ. Clenbuterol activates the central IL-1 system via the β2-adrenoceptor without provoking inflammatory response related behaviours in rats. Brain, Behavior, and Immunity. PMID 26928198 DOI: 10.1016/J.Bbi.2016.02.023  0.356
2016 Hughes MM, Connor TJ, Harkin A. Stress-related immune markers in depression: implications for treatment. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). PMID 26775294 DOI: 10.1093/Ijnp/Pyw001  0.349
2016 McIntosh A, Gormley S, Harkin A. P.4.019 Disrupting astrocyte function in the prelimbic cortex induces a depressive-like phenotype and alters cerebral perfusion European Neuropsychopharmacology. 26. DOI: 10.1016/S0924-977X(16)70109-X  0.346
2016 David J, McIntosh A, Harkin A. P.4.011 L-α-Aminoadipic acid provokes a reduction of astrocytes in the prelimbic cortex and depressive-like behaviour in mice European Neuropsychopharmacology. 26. DOI: 10.1016/S0924-977X(16)70101-5  0.337
2015 Morgese MG, Colaianna M, Mhillaj E, Zotti M, Schiavone S, D'Antonio P, Harkin A, Gigliucci V, Campolongo P, Trezza V, De Stradis A, Tucci P, Cuomo V, Trabace L. Soluble beta amyloid evokes alteration in brain norepinephrine levels: role of nitric oxide and interleukin-1. Frontiers in Neuroscience. 9: 428. PMID 26594145 DOI: 10.3389/Fnins.2015.00428  0.325
2015 Doucet MV, O'Toole E, Connor T, Harkin A. Small-molecule inhibitors at the PSD-95/nNOS interface protect against glutamate-induced neuronal atrophy in primary cortical neurons. Neuroscience. 301: 421-38. PMID 26071957 DOI: 10.1016/J.Neuroscience.2015.06.004  0.321
2015 Murray C, Griffin ÉW, O'Loughlin E, Lyons A, Sherwin E, Ahmed S, Stevenson NJ, Harkin A, Cunningham C. Interdependent and independent roles of type I interferons and IL-6 in innate immune, neuroinflammatory and sickness behaviour responses to systemic poly I:C. Brain, Behavior, and Immunity. 48: 274-86. PMID 25900439 DOI: 10.1016/J.Bbi.2015.04.009  0.301
2015 McIntosh A, Gormley S, Harkin A. P.2.a.013 Altered astrocyte function in the pre-limbic cortex and amygdala induces an anxiety and depressive-like phenotype in adult rats European Neuropsychopharmacology. 25. DOI: 10.1016/S0924-977X(15)30497-1  0.351
2014 Harkin A. Muscling in on depression. The New England Journal of Medicine. 371: 2333-4. PMID 25494274 DOI: 10.1056/Nejmcibr1411568  0.301
2014 Gigliucci V, Gormley S, Gibney S, Rouine J, Kerskens C, Connor TJ, Harkin A. Characterisation of the antidepressant properties of nitric oxide synthase inhibitors in the olfactory bulbectomised rat model of depression. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 24: 1349-61. PMID 24931298 DOI: 10.1016/J.Euroneuro.2014.05.003  0.358
2014 O'Donovan S, Dalton V, Harkin A, McLoughlin DM. Effects of brief pulse and ultrabrief pulse electroconvulsive stimulation on rodent brain and behaviour in the corticosterone model of depression. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 17: 1477-86. PMID 24607259 DOI: 10.1017/S1461145714000200  0.368
2014 Gibney SM, Fagan EM, Waldron AM, O'Byrne J, Connor TJ, Harkin A. Inhibition of stress-induced hepatic tryptophan 2,3-dioxygenase exhibits antidepressant activity in an animal model of depressive behaviour. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 17: 917-28. PMID 24472498 DOI: 10.1017/S1461145713001673  0.38
2014 Day JS, O'Neill E, Cawley C, Aretz NK, Kilroy D, Gibney SM, Harkin A, Connor TJ. Noradrenaline acting on astrocytic β₂-adrenoceptors induces neurite outgrowth in primary cortical neurons. Neuropharmacology. 77: 234-48. PMID 24126345 DOI: 10.1016/J.Neuropharm.2013.09.027  0.301
2014 Maria NI, Helden-Meeuwsen CGv, Brkic Z, Daele PLv, Hagen Mv, Gibney SM, Harkin A, Drexhage HA, Versnel MA. AB0186 Elevated Indoleamine-2,3-Dioxygenase (IDO) and Tryptophan Catabolism in Primary SjÖGren's Syndrome Patients, Positive for the Interferon Type I Signature: A Possible Link to Fatigue and Depression Annals of the Rheumatic Diseases. 73: 864-864. DOI: 10.1136/Annrheumdis-2014-Eular.3725  0.314
2014 O'toole E, Doucet M, Harkin A. Astrocytic dysfunction induced by l-alphaaminoadipic acid reduces measures of neuronal complexity in vitro; rescue by NMDA receptor antagonists Journal of Neuroimmunology. 275: 127-128. DOI: 10.1016/J.Jneuroim.2014.08.341  0.313
2014 Gormley S, Kerskens C, Harkin A. 106. Reduced cortical astroglial cell numbers coupled to reduced cortical cerebral blood perfusion in a genetically predisposed model of depression as assessed by magnetic resonance bolus tracking arterial spin labelling (MR-btASL) Brain, Behavior, and Immunity. 40: e31. DOI: 10.1016/J.Bbi.2014.06.126  0.32
2014 Sherwin E, Gormley S, McGuinness B, Harkin A. 105. Enhanced glucocorticoid sensitivity coupled with reduced microglial activation in a genetically predisposed animal model of depression Brain, Behavior, and Immunity. 40: e31. DOI: 10.1016/J.Bbi.2014.06.125  0.321
2013 Pertl MM, Hevey D, Boyle NT, Hughes MM, Collier S, O'Dwyer AM, Harkin A, Kennedy MJ, Connor TJ. C-reactive protein predicts fatigue independently of depression in breast cancer patients prior to chemotherapy. Brain, Behavior, and Immunity. 34: 108-19. PMID 23928287 DOI: 10.1016/J.Bbi.2013.07.177  0.351
2013 Ryan KJ, Griffin É, Yssel JD, Ryan KM, McNamee EN, Harkin A, Connor TJ. Stimulation of central β2-adrenoceptors suppresses NFκB activity in rat brain: a role for IκB. Neurochemistry International. 63: 368-78. PMID 23896303 DOI: 10.1016/J.Neuint.2013.07.006  0.312
2013 Gigliucci V, O'Dowd G, Casey S, Egan D, Gibney S, Harkin A. Ketamine elicits sustained antidepressant-like activity via a serotonin-dependent mechanism. Psychopharmacology. 228: 157-66. PMID 23455595 DOI: 10.1007/S00213-013-3024-X  0.333
2013 Doucet MV, Levine H, Dev KK, Harkin A. Small-molecule inhibitors at the PSD-95/nNOS interface have antidepressant-like properties in mice. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 38: 1575-84. PMID 23446451 DOI: 10.1038/Npp.2013.57  0.377
2013 Gibney SM, McGuinness B, Prendergast C, Harkin A, Connor TJ. Poly I:C-induced activation of the immune response is accompanied by depression and anxiety-like behaviours, kynurenine pathway activation and reduced BDNF expression. Brain, Behavior, and Immunity. 28: 170-81. PMID 23201589 DOI: 10.1016/J.Bbi.2012.11.010  0.388
2013 Ryan K, Harkin A, McLoughlin D. 116. The hippocampal miRNome in the chronic corticosterone model of depression Brain, Behavior, and Immunity. 32: e33-e34. DOI: 10.1016/J.Bbi.2013.07.128  0.366
2012 Beumer W, Gibney SM, Drexhage RC, Pont-Lezica L, Doorduin J, Klein HC, Steiner J, Connor TJ, Harkin A, Versnel MA, Drexhage HA. The immune theory of psychiatric diseases: a key role for activated microglia and circulating monocytes. Journal of Leukocyte Biology. 92: 959-75. PMID 22875882 DOI: 10.1189/Jlb.0212100  0.338
2012 Hughes MM, Carballedo A, McLoughlin DM, Amico F, Harkin A, Frodl T, Connor TJ. Tryptophan depletion in depressed patients occurs independent of kynurenine pathway activation. Brain, Behavior, and Immunity. 26: 979-87. PMID 22683764 DOI: 10.1016/J.Bbi.2012.05.010  0.374
2012 Doucet MV, Harkin A, Dev KK. The PSD-95/nNOS complex: new drugs for depression? Pharmacology & Therapeutics. 133: 218-29. PMID 22133842 DOI: 10.1016/J.Pharmthera.2011.11.005  0.357
2012 Vanattou-Saïfoudine N, Behan B, Harkin A. Dopamine D1 receptor-mediated intracellular responses in the hypothalamus after co-administration of caffeine with MDMA. Basic & Clinical Pharmacology & Toxicology. 110: 283-9. PMID 21967278 DOI: 10.1111/J.1742-7843.2011.00805.X  0.321
2011 Gibney S, McGuinness B, Prendergast C, Harkin A, Connor T. 149. Poly I:C-induced activation of the innate immune response is accompanied by symptoms of depression and anxiety Brain, Behavior, and Immunity. 25: S222. DOI: 10.1016/J.Bbi.2011.07.152  0.315
2010 Gleeson LC, Ryan KJ, Griffin EW, Connor TJ, Harkin A. The β2-adrenoceptor agonist clenbuterol elicits neuroprotective, anti-inflammatory and neurotrophic actions in the kainic acid model of excitotoxicity. Brain, Behavior, and Immunity. 24: 1354-61. PMID 20599496 DOI: 10.1016/J.Bbi.2010.06.015  0.374
2010 Vanattou-Saïfoudine N, McNamara R, Harkin A. Mechanisms mediating the ability of caffeine to influence MDMA ('Ecstasy')-induced hyperthermia in rats British Journal of Pharmacology. 160: 860-877. PMID 20590585 DOI: 10.1111/J.1476-5381.2010.00660.X  0.314
2010 McNamee EN, Ryan KM, Griffin EW, González-Reyes RE, Ryan KJ, Harkin A, Connor TJ. Noradrenaline acting at central beta-adrenoceptors induces interleukin-10 and suppressor of cytokine signaling-3 expression in rat brain: implications for neurodegeneration. Brain, Behavior, and Immunity. 24: 660-71. PMID 20193756 DOI: 10.1016/J.Bbi.2010.02.005  0.345
2010 O'Sullivan JB, Ryan KM, Harkin A, Connor TJ. Noradrenaline reuptake inhibitors inhibit expression of chemokines IP-10 and RANTES and cell adhesion molecules VCAM-1 and ICAM-1 in the CNS following a systemic inflammatory challenge. Journal of Neuroimmunology. 220: 34-42. PMID 20061033 DOI: 10.1016/J.Jneuroim.2009.12.007  0.324
2010 Gigliucci V, Buckley KN, Nunan J, O'Shea K, Harkin A. A role for serotonin in the antidepressant activity of NG-Nitro-L-arginine, in the rat forced swimming test. Pharmacology, Biochemistry, and Behavior. 94: 524-33. PMID 19945477 DOI: 10.1016/J.Pbb.2009.11.007  0.324
2010 Beumer W, Abautret-daly A, Helden-Meeuwsen CGv, Harkin A, Drexhage H, Versnel MA. The NOD mouse model for immune induced depressive-like behavior Brain Behavior and Immunity. 24. DOI: 10.1016/J.Bbi.2010.07.168  0.32
2009 O'Sullivan JB, Ryan KM, Curtin NM, Harkin A, Connor TJ. Noradrenaline reuptake inhibitors limit neuroinflammation in rat cortex following a systemic inflammatory challenge: implications for depression and neurodegeneration. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 12: 687-99. PMID 19046481 DOI: 10.1017/S146114570800967X  0.353
2008 Durkin S, Prendergast A, Harkin A. Reduced efficacy of fluoxetine following MDMA ("Ecstasy")-induced serotonin loss in rats Progress in Neuro-Psychopharmacology and Biological Psychiatry. 32: 1894-1901. PMID 18824064 DOI: 10.1016/J.Pnpbp.2008.09.008  0.348
2008 Connor TJ, Starr N, O'Sullivan JB, Harkin A. Induction of indolamine 2,3-dioxygenase and kynurenine 3-monooxygenase in rat brain following a systemic inflammatory challenge: a role for IFN-gamma? Neuroscience Letters. 441: 29-34. PMID 18584961 DOI: 10.1016/J.Neulet.2008.06.007  0.326
2008 McNamee EN, González-Reyes RE, Harkin A, Connor TJ. 125. Pharmacological enhancement of central noradrenergic tone induces IL-10 production and signalling in rat brain: A role for β-adrenoceptor activation Brain Behavior and Immunity. 22: 40. DOI: 10.1016/J.Bbi.2008.04.127  0.304
2007 Roche M, Harkin A, Kelly JP. Chronic fluoxetine treatment attenuates stressor-induced changes in temperature, heart rate, and neuronal activation in the olfactory bulbectomized rat. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 32: 1312-20. PMID 17119540 DOI: 10.1038/Sj.Npp.1301253  0.365
2006 McNamara R, Kerans A, O'Neill B, Harkin A. Caffeine promotes hyperthermia and serotonergic loss following co-administration of the substituted amphetamines, MDMA ("Ecstasy") and MDA ("Love") Neuropharmacology. 50: 69-80. PMID 16188283 DOI: 10.1016/J.Neuropharm.2005.08.006  0.328
2005 Connor TJ, Brewer C, Kelly JP, Harkin A. Acute stress suppresses pro-inflammatory cytokines TNF-alpha and IL-1 beta independent of a catecholamine-driven increase in IL-10 production. Journal of Neuroimmunology. 159: 119-28. PMID 15652410 DOI: 10.1016/J.Jneuroim.2004.10.016  0.305
2005 Connor TJ, Harkin A, Kelly JP. Methylenedioxymethamphetamine suppresses production of the proinflammatory cytokine tumor necrosis factor-alpha independent of a beta-adrenoceptor-mediated increase in interleukin-10. The Journal of Pharmacology and Experimental Therapeutics. 312: 134-43. PMID 15331655 DOI: 10.1124/Jpet.104.073023  0.311
2004 Harkin A, Connor TJ, Burns MP, Kelly JP. Nitric oxide synthase inhibitors augment the effects of serotonin re-uptake inhibitors in the forced swimming test. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 14: 274-81. PMID 15163436 DOI: 10.1016/J.Euroneuro.2003.08.010  0.355
2003 Harkin A, Hynes MJ, Masterson E, Kelly JP, O'Donnell JM, Connor TJ. A toxicokinetic study of nickel-induced immunosuppression in rats. Immunopharmacology and Immunotoxicology. 25: 655-70. PMID 14686805 DOI: 10.1081/Iph-120026448  0.306
2003 Harkin A, Shanahan E, Kelly JP, Connor TJ. Methylenendioxyamphetamine produces serotonin nerve terminal loss and diminished behavioural and neurochemical responses to the antidepressant fluoxetine. The European Journal of Neuroscience. 18: 1021-7. PMID 12925028 DOI: 10.1046/J.1460-9568.2003.02802.X  0.33
2003 Harkin A, Connor TJ, Walsh M, St John N, Kelly JP. Serotonergic mediation of the antidepressant-like effects of nitric oxide synthase inhibitors. Neuropharmacology. 44: 616-23. PMID 12668047 DOI: 10.1016/S0028-3908(03)00030-3  0.357
2003 Harkin A, Kelly JP, Leonard BE. A review of the relevance and validity of olfactory bulbectomy as a model of depression Clinical Neuroscience Research. 3: 253-262. DOI: 10.1016/S1566-2772(03)00087-2  0.345
2002 Harkin A, Houlihan DD, Kelly JP. Reduction in preference for saccharin by repeated unpredictable stress in mice and its prevention by imipramine. Journal of Psychopharmacology (Oxford, England). 16: 115-23. PMID 12095069 DOI: 10.1177/026988110201600201  0.31
2001 Harkin A, Connor TJ, Mulrooney J, Kelly JP, Leonard BE. Prior exposure to methylenedioxyamphetamine (MDA) induces serotonergic loss and changes in spontaneous exploratory and amphetamine-induced behaviors in rats. Life Sciences. 68: 1367-82. PMID 11388689 DOI: 10.1016/S0024-3205(00)01039-0  0.35
2001 Connor TJ, Dennedy MC, Harkin A, Kelly JP. Methylenedioxymethamphetamine-induced suppression of interleukin-1beta and tumour necrosis factor-alpha is not mediated by serotonin. European Journal of Pharmacology. 418: 147-52. PMID 11334877 DOI: 10.1016/S0014-2999(01)00928-1  0.329
2001 Harkin A, Morris K, Kelly JP, O'Donnell JM, Leonard BE. Modulation of MK-801-induced behaviour by noradrenergic agents in mice. Psychopharmacology. 154: 177-88. PMID 11314680 DOI: 10.1007/S002130000630  0.347
2000 Harkin A, Nally R, Kelly JP, Leonard BE. Effects of reboxetine and sertraline treatments alone and in combination on the binding properties of cortical NMDA and beta1-adrenergic receptors in an animal model of depression. Journal of Neural Transmission (Vienna, Austria : 1996). 107: 1213-27. PMID 11129111 DOI: 10.1016/S0924-977X(00)80279-5  0.371
2000 Kelliher P, Connor TJ, Harkin A, Sanchez C, Kelly JP, Leonard BE. Varying responses to the rat forced-swim test under diurnal and nocturnal conditions. Physiology & Behavior. 69: 531-9. PMID 10913793 DOI: 10.1016/S0031-9384(00)00213-4  0.317
2000 Harkin A, Nowak G, Paul IA. Corrigendum to: "Noradrenergic lesion antagonizes desipramine-induced adaptation of NMDA receptors" European Journal of Pharmacology. 397: 399. PMID 10844140 DOI: 10.1016/S0014-2999(00)00327-7  0.567
2000 Connor TJ, Kelliher P, Shen Y, Harkin A, Kelly JP, Leonard BE. Effect of subchronic antidepressant treatments on behavioral, neurochemical, and endocrine changes in the forced-swim test. Pharmacology, Biochemistry, and Behavior. 65: 591-7. PMID 10764911 DOI: 10.1016/S0091-3057(99)00192-6  0.378
2000 Cryan JF, Harkin A, Naughton M, Kelly JP, Leonard BE. Characterization of D-fenfluramine-induced hypothermia: evidence for multiple sites of action. European Journal of Pharmacology. 390: 275-85. PMID 10708734 DOI: 10.1016/S0014-2999(00)00012-1  0.317
2000 Harkin A, Nowak G, Paul IA. Noradrenergic lesion antagonizes desipramine-induced adaptation of NMDA receptors. European Journal of Pharmacology. 389: 187-92. PMID 10688983 DOI: 10.1016/S0014-2999(99)00923-1  0.608
2000 Harkin A, Kelly JP, Frawley J, O'Donnell JM, Leonard BE. Test conditions influence the response to a drug challenge in rodents. Pharmacology, Biochemistry, and Behavior. 65: 389-98. PMID 10683478 DOI: 10.1016/S0091-3057(99)00210-5  0.307
2000 Connor TJ, Harkin A, Kelly JP, Leonard BE. Olfactory bulbectomy provokes a suppression of interleukin-1beta and tumour necrosis factor-alpha production in response to an in vivo challenge with lipopolysaccharide: effect of chronic desipramine treatment. Neuroimmunomodulation. 7: 27-35. PMID 10601816 DOI: 10.1159/000026417  0.371
1999 Connor TJ, Kelliher P, Harkin A, Kelly JP, Leonard BE. Reboxetine attenuates forced swim test-induced behavioural and neurochemical alterations in the rat. European Journal of Pharmacology. 379: 125-33. PMID 10497898 DOI: 10.1016/S0014-2999(99)00492-6  0.354
1999 Healy DG, Harkin A, Cryan JF, Kelly JP, Leonard BE. Metyrapone displays antidepressant-like properties in preclinical paradigms. Psychopharmacology. 145: 303-8. PMID 10494579 DOI: 10.1007/S002130051062  0.403
1999 Harkin AJ, Bruce KH, Craft B, Paul IA. Nitric oxide synthase inhibitors have antidepressant-like properties in mice. 1. Acute treatments are active in the forced swim test. European Journal of Pharmacology. 372: 207-13. PMID 10395013 DOI: 10.1016/S0014-2999(99)00191-0  0.572
1999 Redmond AM, Harkin A, Kelly JP, Leonard BE. Effects of acute and chronic antidepressant administration on phencyclidine (PCP) induced locomotor hyperactivity. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 9: 165-70. PMID 10082243 DOI: 10.1016/S0924-977X(98)00023-6  0.376
1999 Harkin A, Kelly JP, McNamara M, Connor TJ, Dredge K, Redmond A, Leonard BE. Activity and onset of action of reboxetine and effect of combination with sertraline in an animal model of depression. European Journal of Pharmacology. 364: 123-32. PMID 9932714 DOI: 10.1016/S0014-2999(98)00838-3  0.402
1999 Harkin A, Naughton M, Cryan J, Kelly J, Leonard B. Differential modification of d-fenfluramine-induced serotonergic responses by acute and chronic sertraline and fluoxetine administration to rats European Neuropsychopharmacology. 9: 242. DOI: 10.1016/S0924-977X(99)80211-9  0.311
Low-probability matches (unlikely to be authored by this person)
2010 Vanattou-Saïfoudine N, McNamara R, Harkin A. Caffeine promotes dopamine D1 receptor-mediated body temperature, heart rate and behavioural responses to MDMA ('ecstasy') Psychopharmacology. 211: 15-25. PMID 20437223 DOI: 10.1007/S00213-010-1864-1  0.3
2010 McNamee EN, Griffin EW, Ryan KM, Ryan KJ, Heffernan S, Harkin A, Connor TJ. Noradrenaline acting at beta-adrenoceptors induces expression of IL-1beta and its negative regulators IL-1ra and IL-1RII, and drives an overall anti-inflammatory phenotype in rat cortex. Neuropharmacology. 59: 37-48. PMID 20361987 DOI: 10.1016/J.Neuropharm.2010.03.014  0.299
2019 O'Reilly K, David J, Thuery G, Kebede V, Harkin A. Alterations in dendritic spines following stress and L-α-aminoadipic-acid-induced astrocytic impairment are rescued by ZL006 inhibition of PSD95/NOS European Neuropsychopharmacology. 29. DOI: 10.1016/J.Euroneuro.2018.11.851  0.297
1998 Connor TJ, Kelliher P, Shen Y, Harkin A, Kelly JP, Leonard BE. Effect of chronic antidepressant treatment on behavioural, neurochemical and endocrine changes following forced swim test exposure European Neuropsychopharmacology. 8. DOI: 10.1016/S0924-977X(98)80288-5  0.295
2018 O'Neill E, Harkin A. Targeting the noradrenergic system for anti-inflammatory and neuroprotective effects: implications for Parkinson's disease. Neural Regeneration Research. 13: 1332-1337. PMID 30106035 DOI: 10.4103/1673-5374.235219  0.295
2005 Roche M, Harkin A, Kelly JP. P.2.18 Altered physiological responses to stress in the olfactory bulbectomised rat: normalisation by chronic fl uoxetine treatment European Neuropsychopharmacology. 15. DOI: 10.1016/S0924-977X(05)80158-0  0.294
2005 Zueger M, Urani A, Chourbaji S, Zacher C, Roche M, Harkin A, Gass P. Olfactory bulbectomy in mice induces alterations in exploratory behavior Neuroscience Letters. 374: 142-146. PMID 15644281 DOI: 10.1016/J.Neulet.2004.10.040  0.291
2012 Vanattou-Saïfoudine N, McNamara R, Harkin A. Caffeine provokes adverse interactions with 3,4-methylenedioxymethamphetamine (MDMA, 'ecstasy') and related psychostimulants: mechanisms and mediators. British Journal of Pharmacology. 167: 946-59. PMID 22671762 DOI: 10.1111/J.1476-5381.2012.02065.X  0.29
2019 O'Neill E, Yssel JD, McNamara C, Harkin A. Pharmacological targeting of β -adrenoceptors is neuroprotective in the LPS inflammatory rat model of Parkinson's disease. British Journal of Pharmacology. PMID 31506926 DOI: 10.1111/Bph.14862  0.288
2007 McNamara R, Maginn M, Harkin A. Caffeine induces a profound and persistent tachycardia in response to MDMA ("Ecstasy") administration European Journal of Pharmacology. 555: 194-198. PMID 17126829 DOI: 10.1016/J.Ejphar.2006.10.063  0.288
2014 Frodl T, Carballedo A, Frey EM, O'Keane V, Skokauskas N, Morris D, Gill M, Hughes MM, Harkin A, Connor T. Expression of glucocorticoid inducible genes is associated with reductions in cornu ammonis and dentate gyrus volumes in patients with major depressive disorder. Development and Psychopathology. 26: 1209-17. PMID 25422956 DOI: 10.1017/S0954579414000972  0.286
2015 O'Farrell K, Harkin A. Stress-related regulation of the kynurenine pathway: Relevance to neuropsychiatric and degenerative disorders. Neuropharmacology. PMID 26690895 DOI: 10.1016/J.Neuropharm.2015.12.004  0.283
2011 Vanattou-Saïfoudine N, Gossen A, Harkin A. A role for adenosine A1 receptor blockade in the ability of caffeine to promote MDMA "ecstasy"-induced striatal dopamine release European Journal of Pharmacology. 650: 220-228. PMID 20951694 DOI: 10.1016/J.Ejphar.2010.10.012  0.282
2002 Harkin A, Connor TJ, O'Donnell JM, Kelly JP. Physiological and behavioral responses to stress: what does a rat find stressful? Lab Animal. 31: 42-50. PMID 11927961 DOI: 10.1038/5000150  0.281
2010 Gleeson L, Griffin E, Connor T, Harkin A. The beta2-adrenoceptor agonist clenbuterol attenuates kainic acid-induced neuroinflammation and apoptosis in the hippocampus which is coupled with increased expression of BDNF and NGF Brain, Behavior, and Immunity. 24: S3. DOI: 10.1016/J.Bbi.2010.07.008  0.279
2014 O'Neill E, Day J, Connor T, Harkin A. Noradrenaline-mediated protection against TNF-alpha-induced neuronal atrophy Journal of Neuroimmunology. 275: 167. DOI: 10.1016/J.Jneuroim.2014.08.448  0.277
2019 Ryan K, Allers K, McLoughlin D, Harkin A. Abstract # 4258 Plasma tryptophan metabolite concentrations in depression and the response to electroconvulsive therapy Brain, Behavior, and Immunity. 81: 14. DOI: 10.1016/J.Bbi.2019.08.052  0.277
2008 Vanattou-Saifoudine N, McNamara R, Harkin A. P.1.36 Caffeine exacerbates MDMA “Ecstasy”-induced hyperthermia: a role for dopamine D1 receptors European Neuropsychopharmacology. 18. DOI: 10.1016/S0924-977X(08)70037-3  0.273
2016 McGuiness B, Gibney SM, Beumer W, Versnel MA, Sillaber I, Harkin A, Drexhage HA. Exaggerated Increases in Microglia Proliferation, Brain Inflammatory Response and Sickness Behaviour upon Lipopolysaccharide Stimulation in Non-Obese Diabetic Mice. Neuroimmunomodulation. PMID 27529430 DOI: 10.1159/000446370  0.272
2010 Abautret-Daly A, Medina C, Connor T, Harkin A. Anxiety related behaviour in an animal model of experimental colitis is associated with a long-term systemic and central inflammatory response Brain, Behavior, and Immunity. 24: S55. DOI: 10.1016/J.Bbi.2010.07.183  0.272
2011 Ryan KJ, Griffin ÉW, Yssel JD, Ryan KM, Harkin A, Connor TJ. 150. Stimulation of central β2-adrenoceptors suppresses NF-κB activity in hippocampus and cortex: A role for IκB Brain Behavior and Immunity. 25. DOI: 10.1016/J.Bbi.2011.07.153  0.27
2011 Fagan E, Gibney S, Connor T, Harkin A. Interferon-gamma stimulated microglia induce neurotoxicity – A role for the kynurenine pathway? Brain, Behavior, and Immunity. 25: S219. DOI: 10.1016/J.Bbi.2011.07.141  0.27
2016 Harkin A, McIntosh A, Sherwin E, David J. Evaluation of NMDA signalling modifiers as putative antidepressants in animal models European Neuropsychopharmacology. 26. DOI: 10.1016/S0924-977X(16)30888-4  0.267
1999 Harkin A. Ng-Nitro-L-Arginine (L-Nna), A Nitric Oxide Synthase (Nos) Inhibitor, Potentiates The Action Of Imipramine In An Acute Stress Paradigm In Mice Behavioural Pharmacology. 10. DOI: 10.1097/00008877-199908001-00109  0.265
2015 Dempsey E, Abautret-Daly A, Downing J, Harkin A, Medina C. P.1.f.015 Evidence for central molecular changes and changes to neuronal activity in an animal model of inflammatory bowel disease European Neuropsychopharmacology. 25. DOI: 10.1016/S0924-977X(15)30254-6  0.265
2016 Maria NI, van Helden-Meeuwsen CG, Brkic Z, Paulissen SM, Steenwijk EC, Dalm VA, van Daele PL, van Hagen PM, Kroese FG, van Roon JA, Harkin A, Dik WA, Drexhage HA, Lubberts E, Versnel MA. Increased Tregs associated with elevated Indoleamine-2,3-dioxygenase activity and an imbalanced Kynurenine pathway in IFNpositive primary Sjögren's syndrome. Arthritis & Rheumatology (Hoboken, N.J.). PMID 26866723 DOI: 10.1002/Art.39629  0.263
2015 Rouine J, Kelly ME, Jennings-Murphy C, Duffy P, Gorman I, Gormley S, Kerskens CM, Harkin A. Investigation of the mechanisms mediating MDMA "Ecstasy"-induced increases in cerebro-cortical perfusion determined by btASL MRI. Psychopharmacology. 232: 1501-13. PMID 25366875 DOI: 10.1007/S00213-014-3790-0  0.263
2009 Gleeson L, Connor T, Harkin A. 47. Noradrenaline re-uptake inhibition influences neuroinflammatory and degenerative changes associated with the excitotoxin kainic acid Brain, Behavior, and Immunity. 23: S38. DOI: 10.1016/J.Bbi.2009.06.052  0.263
2004 Connole L, Harkin A, Maginn M. Adenosine A1 receptor blockade mimics caffeine's attenuation of ethanol-induced motor incoordination Basic and Clinical Pharmacology and Toxicology. 95: 299-304. PMID 15569276 DOI: 10.1111/J.1742-7843.2004.Pto950509.X  0.26
2010 Abautret-Daly A, Medina C, Connor TJ, Harkin A. Behavioural disturbances observed in experimental colitis are associated with activation of the kynurenine pathway and expression of hepatic tryptophan 2,3-dioxygenase Brain Behavior and Immunity. 24. DOI: 10.1016/J.Bbi.2010.07.165  0.259
2013 Rouine J, Gobbo OL, Campbell M, Gigliucci V, Ogden I, McHugh Smith K, Duffy P, Behan B, Byrne D, Kelly ME, Blau CW, Kerskens CM, Harkin A. MDMA 'ecstasy' increases cerebral cortical perfusion determined by bolus-tracking arterial spin labelling (btASL) MRI. British Journal of Pharmacology. 169: 974-87. PMID 23517012 DOI: 10.1111/Bph.12178  0.258
2010 Ryan KJ, Ryan KM, Griffin EW, McNamee EN, Harkin A, Connor TJ. A role for central IL-1beta in the suppression of locomotor activity induced the by the beta2-adrenoceptor agonist clenbuterol? Brain Behavior and Immunity. 24. DOI: 10.1016/J.Bbi.2010.07.007  0.257
2011 Fagan E, Gibney S, Connor T, Harkin A. 154. The serotonin transporter and monoamine oxidase A as novel pharmacological targets to inhibit microglial activation Brain, Behavior, and Immunity. 25: S223. DOI: 10.1016/J.Bbi.2011.07.157  0.256
2015 O'Farrell K, Lim E, Guillemin GJ, Harkin A. P.1.d.002 A role for glial-associated kynurenine pathway activation in modulating neuronal outgrowth and complexity European Neuropsychopharmacology. 25. DOI: 10.1016/S0924-977X(15)30211-X  0.256
2002 Harkin A, O'Donnell JM, Kelly JP. A study of VitalView for behavioural and physiological monitoring in laboratory rats. Physiology & Behavior. 77: 65-77. PMID 12213503 DOI: 10.1016/S0031-9384(02)00810-7  0.248
2017 Abautret-Daly Á, Dempsey E, Riestra S, de Francisco-García R, Parra-Blanco A, Rodrigo L, Medina C, Connor TJ, Harkin A. Association between psychological measures with inflammatory anddisease-related markers of inflammatory bowel disease. International Journal of Psychiatry in Clinical Practice. 1-10. PMID 28353360 DOI: 10.1080/13651501.2017.1306081  0.246
2011 Hughes M, McLoughlin D, Harkin A, Connor T. Comparison of kynurenine pathway activation and tryptophan depletion induced by activation of human T-cells and innate immune cells Brain, Behavior, and Immunity. 25: S208-S209. DOI: 10.1016/J.Bbi.2011.07.106  0.245
2004 Roche M, Shanahan E, Harkin A, Kelly IR. P.1.078 Chronic imipramine treatment reversesolfactory bulbectomized-induced hyperactivity species in three rodent species European Neuropsychopharmacology. 14. DOI: 10.1016/S0924-977X(04)80167-6  0.243
2009 Ryan KM, Harkin A, Connor TJ. 107. A systemic LPS challenge does not alter central Beta2-adrenoceptor expression or reponsiveness Brain Behavior and Immunity. 23. DOI: 10.1016/J.Bbi.2009.06.112  0.242
1998 Faherty CJ, Harkin AJ, Leonard BE. The functional sensitisation of sigma receptors following chronic selective serotonin reuptake inhibitor treatment. European Journal of Pharmacology. 346: 15-21. PMID 9617747 DOI: 10.1016/S0014-2999(98)00041-7  0.241
2014 Yssel J, Connor T, Harkin A. The anti-inflammatory actions of noradrenergic agents as a target to prevent neurodegeneration in Parkinson's disease Journal of Neuroimmunology. 275: 122-123. DOI: 10.1016/J.Jneuroim.2014.08.326  0.239
2020 Ryan KM, Harkin A. Regulation of β-adrenoceptors in brain glia: implications for neuroinflammatory and degenerative disorders. Neural Regeneration Research. 15: 2035-2036. PMID 32394954 DOI: 10.4103/1673-5374.282255  0.238
2016 Farrell C, O’Keane V, Harkin A, O’Leary N, Jairaj C, Booij L, Szyf M. Association of maternal emotional abuse with decreased serotonin transporter gene (SLC6A4) methylation European Neuropsychopharmacology. 26: S177. DOI: 10.1016/S0924-977X(16)31006-9  0.22
2023 Corrigan M, O'Rourke AM, Moran B, Fletcher JM, Harkin A. Inflammation in the pathogenesis of depression: a disorder of neuroimmune origin. Neuronal Signaling. 7: NS20220054. PMID 37457896 DOI: 10.1042/NS20220054  0.211
2019 Harkin A. A gut instinct for kynurenic acid. Brain, Behavior, and Immunity. PMID 30959175 DOI: 10.1016/J.Bbi.2019.04.017  0.209
2021 Ryan KM, Finnegan M, Harkin A, McLoughlin DM. PBMC telomerase activity in depression and the response to electroconvulsive therapy. European Archives of Psychiatry and Clinical Neuroscience. PMID 34268617 DOI: 10.1007/s00406-021-01294-4  0.206
2014 Connor TJ, Harkin A. Inflammation in the Pathogenesis of Depression Neuroinflammation and Cns Disorders. 261-288. DOI: 10.1002/9781118406557.ch11  0.195
2020 O'Neill E, Griffin ÉW, O'Sullivan R, Murray C, Ryan L, Yssel J, Harkin A, Cunningham C. Acute neuroinflammation, sickness behavior and working memory in response to acute systemic challenge with LPS following noradrenergic lesion in mice. Brain, Behavior, and Immunity. PMID 33307172 DOI: 10.1016/j.bbi.2020.12.002  0.192
2020 O'Neill E, Griffin ÉW, O'Sullivan R, Murray C, Ryan L, Yssel J, Harkin A, Cunningham C. Acute neuroinflammation, sickness behavior and working memory in response to acute systemic challenge with LPS following noradrenergic lesion in mice. Brain, Behavior, and Immunity. PMID 33307172 DOI: 10.1016/j.bbi.2020.12.002  0.192
1996 Harkin AJ, Kelly JP, Leonard BE. Single or repeated administration of selective serotonin reuptake inhibitors fail to modulate apomorphine-induced responses in the rat Journal of Serotonin Research. 3: 49-58.  0.188
2007 Garland MR, Hallahan B, McNamara M, Carney PA, Grimes H, Hibbeln JR, Harkin A, Conroy RM. Lipids and essential fatty acids in patients presenting with self-harm. The British Journal of Psychiatry : the Journal of Mental Science. 190: 112-7. PMID 17267926 DOI: 10.1192/Bjp.Bp.105.019562  0.187
2008 Roche M, Shanahan E, Harkin A, Kelly JP. Trans-species assessment of antidepressant activity in a rodent model of depression. Pharmacological Reports : Pr. 60: 404-8. PMID 18622066  0.186
1996 Harkin A. Molecules and Mental Illness Human Psychopharmacology-Clinical and Experimental. 11: 72-72. DOI: 10.1002/(Sici)1099-1077(199601)11:1<72::Aid-Hup744>3.0.Co;2-A  0.182
2021 O'Reilly K, O'Farrell K, Midttun O, Rakovets Y, David-Bercholz J, Harkin A. Kynurenic Acid Protects Against Reactive Glial-associated Reductions in the Complexity of Primary Cortical Neurons. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. PMID 33389453 DOI: 10.1007/s11481-020-09976-x  0.165
2021 Roddy D, Kelly JR, Farrell C, Doolin K, Roman E, Nasa A, Frodl T, Harkin A, O'Mara S, O'Hanlon E, O'Keane V. Amygdala substructure volumes in Major Depressive Disorder. Neuroimage. Clinical. 31: 102781. PMID 34384996 DOI: 10.1016/j.nicl.2021.102781  0.158
2020 Ryan KM, Allers KA, Harkin A, McLoughlin DM. Blood plasma B vitamins in depression and the therapeutic response to electroconvulsive therapy. Brain, Behavior, & Immunity - Health. 4: 100063. PMID 34589848 DOI: 10.1016/j.bbih.2020.100063  0.147
1995 Harkin AJ, Kelly JP, Leonard BE. The comparative effects of long-term administration of sertraline, paroxetine, citalopram, fluoxetine and amitriptyline on monoamine content in rat brain Journal of Serotonin Research. 2: 181-190.  0.145
1997 De Souza I, Kelly JP, Harkin AJ, Leonard BE. An appraisal of the pharmacological and toxicological effects of a single oral administration of 3,4-methylenedioxymethamphetamine (MDMA) in the rat. Pharmacology & Toxicology. 80: 207-10. PMID 9181598 DOI: 10.1111/J.1600-0773.1997.Tb01961.X  0.137
2014 Cuartero MI, Ballesteros I, de la Parra J, Harkin AL, Abautret-Daly A, Sherwin E, Fernández-Salguero P, Corbí AL, Lizasoain I, Moro MA. L-kynurenine/aryl hydrocarbon receptor pathway mediates brain damage after experimental stroke. Circulation. 130: 2040-51. PMID 25359166 DOI: 10.1161/CIRCULATIONAHA.114.011394  0.136
2021 Kelly JR, Gillan CM, Prenderville J, Kelly C, Harkin A, Clarke G, O'Keane V. Psychedelic Therapy's Transdiagnostic Effects: A Research Domain Criteria (RDoC) Perspective. Frontiers in Psychiatry. 12: 800072. PMID 34975593 DOI: 10.3389/fpsyt.2021.800072  0.131
2022 Kelly JR, Clarke G, Harkin A, Corr SC, Galvin S, Pradeep V, Cryan JF, O'Keane V, Dinan TG. Seeking the Psilocybiome: Psychedelics meet the microbiota-gut-brain axis. International Journal of Clinical and Health Psychology : Ijchp. 23: 100349. PMID 36605409 DOI: 10.1016/j.ijchp.2022.100349  0.124
2023 Maher R, Moreno-Borrallo A, Jindal D, Mai BT, Ruiz-Hernandez E, Harkin A. Intranasal Polymeric and Lipid-Based Nanocarriers for CNS Drug Delivery. Pharmaceutics. 15. PMID 36986607 DOI: 10.3390/pharmaceutics15030746  0.116
2023 Plini ERG, Melnychuk MC, Harkin A, Dahl MJ, McAuslan M, Kühn S, Boyle RT, Whelan R, Andrews R, Düzel S, Drewelies J, Wagner GG, Lindenberger U, Norman K, Robertson IH, et al. Dietary Tyrosine Intake (FFQ) Is Associated with Locus Coeruleus, Attention and Grey Matter Maintenance: An MRI Structural Study on 398 Healthy Individuals of the Berlin Aging Study-II. The Journal of Nutrition, Health & Aging. 27: 1174-1187. PMID 38151868 DOI: 10.1007/s12603-023-2005-y  0.11
1996 Harkin A, Kelly J, Leonard B. 5-HT uptake inhibitors attenuate the neurochemical effects of 3,4 methylenedioxymethamphetamine European Neuropsychopharmacology. 6: 45-46. DOI: 10.1016/0924-977X(96)87510-9  0.108
2003 Harkin AJ, O'Donnell JM, Kelly JP. A combined and comparative study of physiologic and behavioral parameters in a systemic toxicity test. Contemporary Topics in Laboratory Animal Science / American Association For Laboratory Animal Science. 42: 31-8. PMID 19757623  0.108
2023 Grandjean J, Desrosiers-Gregoire G, Anckaerts C, Angeles-Valdez D, Ayad F, Barrière DA, Blockx I, Bortel A, Broadwater M, Cardoso BM, Célestine M, Chavez-Negrete JE, Choi S, Christiaen E, Clavijo P, ... ... Harkin A, et al. A consensus protocol for functional connectivity analysis in the rat brain. Nature Neuroscience. PMID 36973511 DOI: 10.1038/s41593-023-01286-8  0.102
2023 Grandjean J, Desrosiers-Gregoire G, Anckaerts C, Angeles-Valdez D, Ayad F, Barrière DA, Blockx I, Bortel A, Broadwater M, Cardoso BM, Célestine M, Chavez-Negrete JE, Choi S, Christiaen E, Clavijo P, ... ... Harkin A, et al. Author Correction: A consensus protocol for functional connectivity analysis in the rat brain. Nature Neuroscience. PMID 37072562 DOI: 10.1038/s41593-023-01328-1  0.099
2024 Pennel KAF, Hatthakarnkul P, Wood CS, Lian GY, Al-Badran SSF, Quinn JA, Legrini A, Inthagard J, Alexander PG, van Wyk H, Kurniawan A, Hashmi U, Gillespie MA, Mills M, Ammar A, ... ... Harkin A, et al. JAK/STAT3 represents a therapeutic target for colorectal cancer patients with stromal-rich tumors. Journal of Experimental & Clinical Cancer Research : Cr. 43: 64. PMID 38424636 DOI: 10.1186/s13046-024-02958-4  0.095
1881 Harkin A. The pathology and treatment of acute rheumatism The Dublin Journal of Medical Science. 72: 296-313. DOI: 10.1007/BF02949526  0.09
2023 Sullivan M, Fernandez-Aranda F, Camacho-Barcia L, Harkin A, Macrì S, Mora-Maltas B, Jiménez-Murcia S, O'Leary A, Ottomana AM, Presta M, Slattery D, Scholtz S, Glennon JC. Insulin and disorders of behavioural flexibility. Neuroscience and Biobehavioral Reviews. 150: 105169. PMID 37059405 DOI: 10.1016/j.neubiorev.2023.105169  0.088
1884 Harkin A. THE PATHOLOGY AND TREATMENT OF CHOLERA The Lancet. 124: 270-271.  0.084
2011 Paul J, Briggs A, Harkin A, Haydon AM, Iveson T, Masterson M, Midgley RA, Cassidy J. SCOT: Short Course Oncology Therapy-A comparison of 12 and 24 weeks of adjuvant chemotherapy in colorectal cancer. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 29: e14145. PMID 28023214 DOI: 10.1200/Jco.2011.29.15_Suppl.E14145  0.081
2023 Lemanska A, Harkin A, Iveson T, Kelly C, Saunders M, Faithfull S. The association of clinical and patient factors with chemotherapy-induced peripheral neuropathy (CIPN) in colorectal cancer: secondary analysis of the SCOT trial. Esmo Open. 8: 102063. PMID 37988949 DOI: 10.1016/j.esmoop.2023.102063  0.08
2007 Bogan YM, Harkin AL, Gillespie J, Kennedy DJ, Hess P, Slater JW. The influence of size on domoic acid concentration in king scallop, Pecten maximus (L.) Harmful Algae. 6: 15-28. DOI: 10.1016/j.hal.2006.05.005  0.075
2017 Tropea D, Harkin A. Editorial: Biology of Brain Disorders. Frontiers in Cellular Neuroscience. 11: 366. PMID 29209175 DOI: 10.3389/Fncel.2017.00366  0.073
2017 Tropea D, Harkin A. Editorial: Biology of Brain Disorders. Frontiers in Cellular Neuroscience. 11: 366. PMID 29209175 DOI: 10.3389/Fncel.2017.00366  0.073
2017 Tropea D, Harkin A. Editorial: Biology of Brain Disorders. Frontiers in Cellular Neuroscience. 11: 366. PMID 29209175 DOI: 10.3389/Fncel.2017.00366  0.073
2019 Gray V, Briggs S, Palles C, Jaeger E, Iveson T, Kerr R, Saunders MP, Paul J, Harkin A, McQueen J, Summers MG, Johnstone E, Wang H, Gatcombe L, Maughan TS, et al. Pattern Recognition Receptor Polymorphisms as Predictors of Oxaliplatin Benefit in Colorectal Cancer. Journal of the National Cancer Institute. PMID 30649440 DOI: 10.1093/Jnci/Djy215  0.065
2020 Roseweir AK, Park JH, Hoorn ST, Powell AG, Aherne S, Roxburgh CS, McMillan DC, Horgan PG, Ryan E, Sheahan K, Vermeulen L, Paul J, Harkin A, Graham J, Sansom O, et al. Histological phenotypic subtypes predict recurrence risk and response to adjuvant chemotherapy in patients with stage III colorectal cancer. The Journal of Pathology. Clinical Research. PMID 32401426 DOI: 10.1002/cjp2.171  0.065
2021 Hanna CR, Robles-Zurita JA, Briggs A, Harkin A, Kelly C, McQueen J, Allan K, Pearson S, Hollander H, Glimelius B, Salazar R, Segelov E, Saunders M, Iveson T, Jones RJ, et al. Three Versus Six Months of Adjuvant Doublet Chemotherapy for Patients With Colorectal Cancer: A Multi-Country Cost-Effectiveness and Budget Impact Analysis. Clinical Colorectal Cancer. PMID 33992542 DOI: 10.1016/j.clcc.2021.04.001  0.063
1861 Harkin A. On the use of chlorate of potass in the treatment of consumption and scrofula The Dublin Quarterly Journal of Medical Science. 32: 338-344. DOI: 10.1007/BF02956718  0.063
1887 Harkin A. THE TREATMENT OF EPISTAXIS BY COUNTER-IRRITATION OVER THE HEPATIC REGION The Lancet. 129: 954.  0.062
2021 Iveson TJ, Sobrero AF, Yoshino T, Souglakos I, Ou FS, Meyers JP, Shi Q, Grothey A, Saunders MP, Labianca R, Yamanaka T, Boukovinas I, Hollander NH, Galli F, Yamazaki K, ... ... Harkin A, et al. Duration of Adjuvant Doublet Chemotherapy (3 or 6 months) in Patients With High-Risk Stage II Colorectal Cancer. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. JCO2001330. PMID 33439695 DOI: 10.1200/JCO.20.01330  0.06
1989 Anderson BO, Sun JH, Moore EE, Thompson LL, Harkin AH, Bartle EJ. The development and evaluation of a clinical test of surgical resident proficiency Surgery. 106: 347-353. PMID 2763033 DOI: 10.1002/bjs.1800760938  0.059
2022 Johansen E, Harkin A, Keating F, Sanchez A, Buzwell S. Fairer Sex: The Role of Relationship Equity in Female Sexual Desire. Journal of Sex Research. 1-10. PMID 35622971 DOI: 10.1080/00224499.2022.2079111  0.055
2010 Hollenbeck D, Martini KM, Langner A, Harkin A, Ross DS, Thurston GM. Model for evaluating patterned charge-regulation contributions to electrostatic interactions between low-dielectric spheres. Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics. 82: 031402. PMID 21230072 DOI: 10.1103/Physreve.82.031402  0.053
2006 Bogan YM, Kennedy D, Harkin AL, Gillespie J, Hess P, Slater JW. Comparison of domoic acid concentration in king scallops, Pecten maximus from seabed and suspended culture systems Journal of Shellfish Research. 25: 129-135. DOI: 10.2983/0730-8000(2006)25[129:CODACI]2.0.CO;2  0.053
1886 Harkin A. ON VICARIOUS BLEEDING FROM THE UNDER LIP,. WITH CASES, AND REMARKS ON THE MODERN TREATMENT OF HÆMORRHOIDS The Lancet. 128: 813-814.  0.053
2018 Iveson TJ, Kerr RS, Saunders MP, Cassidy J, Hollander NH, Tabernero J, Haydon A, Glimelius B, Harkin A, Allan K, McQueen J, Scudder C, Boyd KA, Briggs A, Waterston A, et al. 3 versus 6 months of adjuvant oxaliplatin-fluoropyrimidine combination therapy for colorectal cancer (SCOT): an international, randomised, phase 3, non-inferiority trial. The Lancet. Oncology. 19: 562-578. PMID 29611518 DOI: 10.1016/S1470-2045(18)30093-7  0.052
2020 Alexander PG, Roseweir AK, Pennel KAF, van Wyk HC, Powell AGMT, McMillan DC, Horgan PG, Kelly C, Hay J, Sansom O, Harkin A, Roxburgh CSD, Graham J, Church DN, Tomlinson I, et al. The Glasgow Microenvironment Score associates with prognosis and adjuvant chemotherapy response in colorectal cancer. British Journal of Cancer. PMID 33223535 DOI: 10.1038/s41416-020-01168-x  0.052
1880 Harkin A. On some important therapeutic effects of chlorate of potassium. part II The Dublin Journal of Medical Science. 70: 403-408. DOI: 10.1007/BF02944938  0.049
2018 Robles-Zurita J, Boyd KA, Briggs AH, Iveson T, Kerr RS, Saunders MP, Cassidy J, Hollander NH, Tabernero J, Segelov E, Glimelius B, Harkin A, Allan K, McQueen J, Pearson S, et al. SCOT: a comparison of cost-effectiveness from a large randomised phase III trial of two durations of adjuvant Oxaliplatin combination chemotherapy for colorectal cancer. British Journal of Cancer. PMID 30420616 DOI: 10.1038/S41416-018-0319-Z  0.047
1890 Harkin A. The vagus treatment of cholera, as exemplified in returns from the cholera hospitals of Malta, during the epidemic of 1887 The Dublin Journal of Medical Science. 89: 226-240. DOI: 10.1007/BF02953124  0.046
2019 Law PJ, Timofeeva M, Fernandez-Rozadilla C, Broderick P, Studd J, Fernandez-Tajes J, Farrington S, Svinti V, Palles C, Orlando G, Sud A, Holroyd A, Penegar S, Theodoratou E, Vaughan-Shaw P, ... ... Harkin A, et al. Association analyses identify 31 new risk loci for colorectal cancer susceptibility. Nature Communications. 10: 2154. PMID 31089142 DOI: 10.1038/S41467-019-09775-W  0.046
1977 Harkin A. The fair employment (northern ireland) act 1976 Industrial Law Journal. 6: 103-105. DOI: 10.1093/ilj/6.1.103  0.045
2016 Yadav V, Harkin AV, Robertson ML, Conrad JC. Hysteretic memory in pH-response of water contact angle on poly(acrylic acid) brushes. Soft Matter. PMID 26979270 DOI: 10.1039/C5Sm03134F  0.041
2024 Frei AL, McGuigan A, Sinha RRAK, Jabbar F, Gneo L, Tomasevic T, Harkin A, Iveson T, Saunders MP, Oien KA, Maka N, Pezzella F, Campo L, Browne M, Glaire M, et al. Multiplex analysis of intratumoural immune infiltrate and prognosis in patients with stage II-III colorectal cancer from the SCOT and QUASAR 2 trials: a retrospective analysis. The Lancet. Oncology. 25: 198-211. PMID 38301689 DOI: 10.1016/S1470-2045(23)00560-0  0.041
2020 André T, Meyerhardt J, Iveson T, Sobrero A, Yoshino T, Souglakos I, Grothey A, Niedzwiecki D, Saunders M, Labianca R, Yamanaka T, Boukovinas I, Vernerey D, Meyers J, Harkin A, et al. Effect of duration of adjuvant chemotherapy for patients with stage III colon cancer (IDEA collaboration): final results from a prospective, pooled analysis of six randomised, phase 3 trials. The Lancet. Oncology. 21: 1620-1629. PMID 33271092 DOI: 10.1016/S1470-2045(20)30527-1  0.04
2001 Harkin A, Kaper TJ, Nadim ALI. Coupled pulsation and translation of two gas bubbles in a liquid Journal of Fluid Mechanics. 445: 377-411. DOI: 10.1017/S0022112001005857  0.039
2021 Fontana E, Meyers J, Sobrero A, Iveson T, Shields AF, Taieb J, Yoshino T, Souglakos I, Smyth EC, Lordick F, Moehler M, Giraut A, Harkin A, Labianca R, Meyerhardt J, et al. Early-Onset Colorectal Adenocarcinoma in the IDEA Database: Treatment Adherence, Toxicities, and Outcomes With 3 and 6 Months of Adjuvant Fluoropyrimidine and Oxaliplatin. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. JCO2102008. PMID 34752136 DOI: 10.1200/JCO.21.02008  0.039
2007 Bogan YM, Kennedy DJ, Harkin AL, Gillespie J, Vause BJ, Beukers-Stewart BD, Hess P, Slater JW. Variation in domoic acid concentration in king scallop (Pecten maximus) from fishing grounds around the Isle of Man Harmful Algae. 6: 81-92. DOI: 10.1016/j.hal.2006.07.002  0.039
2020 Paoletti X, Lewsley LA, Daniele G, Cook A, Yanaihara N, Tinker A, Kristensen G, Ottevanger PB, Aravantinos G, Miller A, Boere IA, Fruscio R, Reyners AKL, Pujade-Lauraine E, Harkin A, et al. Assessment of Progression-Free Survival as a Surrogate End Point of Overall Survival in First-Line Treatment of Ovarian Cancer: A Systematic Review and Meta-analysis. Jama Network Open. 3: e1918939. PMID 31922558 DOI: 10.1001/jamanetworkopen.2019.18939  0.037
2019 Iveson T, Boyd KA, Kerr RS, Robles-Zurita J, Saunders MP, Briggs AH, Cassidy J, Hollander NH, Tabernero J, Haydon A, Glimelius B, Harkin A, Allan K, McQueen J, Pearson S, et al. 3-month versus 6-month adjuvant chemotherapy for patients with high-risk stage II and III colorectal cancer: 3-year follow-up of the SCOT non-inferiority RCT. Health Technology Assessment (Winchester, England). 23: 1-88. PMID 31852579 DOI: 10.3310/Hta23640  0.037
2023 Frei AL, McGuigan A, Sinha RR, Glaire MA, Jabbar F, Gneo L, Tomasevic T, Harkin A, Iveson TJ, Saunders M, Oein K, Maka N, Pezella F, Campo L, Hay J, et al. Accounting for intensity variation in image analysis of large-scale multiplexed clinical trial datasets. The Journal of Pathology. Clinical Research. PMID 37697694 DOI: 10.1002/cjp2.342  0.036
2021 Blinman P, Martin A, Jefford M, Goldstein D, Boadle D, Morris M, Tebbutt N, Aiken C, Harkin A, Segelov E, Haydon A, Iveson T, Stockler MR. Patients' Preferences for 3 Months vs 6 Months of Adjuvant Chemotherapy for Colon Cancer. Jnci Cancer Spectrum. 5: pkaa107. PMID 34159294 DOI: 10.1093/jncics/pkaa107  0.034
2008 DeVille REL, Harkin A, Holzer M, Josić K, Kaper TJ. Analysis of a renormalization group method and normal form theory for perturbed ordinary differential equations Physica D: Nonlinear Phenomena. 237: 1029-1052. DOI: 10.1016/J.Physd.2007.12.009  0.032
2023 Saunders MP, Iype R, Kelly C, Crosby J, Kerr R, Harkin A, Allan K, McQueen J, Pearson SR, Cassidy J, Medley LC, Raouf S, Harrison M, Brewster A, Rees C, et al. SCOT: Tumor Sidedness and the Influence of Adjuvant Chemotherapy Duration on Disease Free Survival (DFS). Clinical Colorectal Cancer. PMID 36967267 DOI: 10.1016/j.clcc.2023.02.005  0.029
1884 Harkin A. SOME OBSERVATIONS ON THE SPINAL CORD IN HEALTH AND DISEASE AT THE REGION OF THE FOURTH AND FIFTH DORSAL VERTEBRÆ The Lancet. 124: 995-997.  0.029
2024 Gallois C, Shi Q, Pederson LD, André T, Iveson TJ, Sobrero AF, Alberts S, de Gramont A, Meyerhardt JA, George T, Schmoll HE, Souglakos I, Harkin A, Labianca R, Sinicrope FA, et al. Oxaliplatin-Based Adjuvant Chemotherapy in Older Patients With Stage III Colon Cancer: An ACCENT/IDEA Pooled Analysis of 12 Trials. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. JCO2301326. PMID 38547438 DOI: 10.1200/JCO.23.01326  0.029
1888 Harkin A. THERAPEUTICS v. FXTEMPORANEOUS PHARMACY The Lancet. 131: 598.  0.029
2024 Plini ERG, Melnychuk MC, Harkin A, Dahl MJ, McAuslan M, Kühn S, Boyle RT, Whelan R, Andrews R, Düzel S, Dreweilies J, Wagner GG, Lindenberger U, Norman K, Robertson IH, et al. Erratum to: Dietary Tyrosine Intake (FFQ) Is Associated with Locus Coeruleus, Attention and Grey Matter Maintenance: An MRI Structural Study on 398 Healthy Individuals of the Berlin Aging Study-II. The Journal of Nutrition, Health & Aging. 27: 1288. PMID 38242606 DOI: 10.1007/s12603-023-2034-6  0.028
2011 Harkin A. Some Observations on Rheumatism and Gout, with a New Departure in their Cure. British Medical Journal. 2: 554-6. PMID 20750319 DOI: 10.1136/bmj.2.1134.554  0.028
2007 Ben-Yakar A, Harkin A, Ashmore J, Byer RL, Stone HA. Thermal and fluid processes of a thin melt zone during femtosecond laser ablation of glass: The formation of rims by single laser pulses Journal of Physics D: Applied Physics. 40: 1447-1459. DOI: 10.1088/0022-3727/40/5/021  0.026
1999 Harkin A, Nadim A, Kaper TJ. On acoustic cavitation of slightly subcritical bubbles Physics of Fluids. 11: 274-287. DOI: 10.1063/1.869878  0.024
2023 Harkin A. Chlorate of Potash in the Hæmorrhagic Diathesis. Buffalo Medical and Surgical Journal. 19: 453-454. PMID 36663891  0.023
2024 Domingo E, Kelly C, Hay J, Sansom O, Maka N, Oien K, Iveson T, Saunders M, Kerr R, Tomlinson I, Edwards J, Harkin A, Nowak M, Koelzer V, Easton A, et al. Prognostic and Predictive Value of Immunoscore in Stage III Colorectal Cancer: Pooled Analysis of Cases From the SCOT and IDEA-HORG Studies. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. JCO2301648. PMID 38484206 DOI: 10.1200/JCO.23.01648  0.022
2013 Harkin AA, Kaper TJ, Nadim A. Energy transfer between the shape and volume modes of a nonspherical gas bubble Physics of Fluids. 25. DOI: 10.1063/1.4807392  0.015
2011 Mercovich RA, Harkin A, Messinger D. Automatic clustering of multispectral imagery by maximization of the graph modularity Proceedings of Spie - the International Society For Optical Engineering. 8048. DOI: 10.1117/12.884146  0.015
1996 Mescall FM, Kane MT, Keyes WM, Quinlan LR, Hynes AC, Jordan FM, McGarvey C, Kelly JP, O'Donnell JM, Kelliher P, Cotton KD, Hollywood MA, Thornbury KD, McHale NG, Curran AK, ... ... Harkin AJ, et al. Royal academy of medicine in ireland section of biomedical sciences - Proceedings of summer meeting held june 1995 Irish Journal of Medical Science. 165: 224-238. DOI: 10.1007/BF02940256  0.013
1996 Sharma S, Sharma SC, Byrne PD, Lyons JB, Boylan JF, McShane AJ, Galligan ES, Sweetman SF, Clements BA, Lowe AS, McCormack KJM, Walsh DM, Baxter GD, Allen JM, Kelleher S, ... ... Harkin AJ, et al. Royal academy of medicine in Ireland section of biomedical sciences - Proceedings of winter meeting held in Trinity College Dublin, 1996 Irish Journal of Medical Science. 165: 304-314. DOI: 10.1007/BF02943100  0.013
2003 Ben-Yakar A, Byer RL, Harkin A, Ashmore J, Stone HA, Shen M, Mazur E. Morphology of femtosecond-laser-ablated borosilicate glass surfaces Applied Physics Letters. 83: 3030-3032. DOI: 10.1063/1.1619560  0.011
2010 Mercovich RA, Harkin A, Messinger D. Utilizing the graph modularity to blind cluster multispectral satellite imagery 2010 Western New York Image Processing Workshop, Wnyipw 2010 - Proceedings. 66-69.  0.01
1989 Harkin AM. Smoking and cancer World of Irish Nursing. 18: 5-6. PMID 2623894  0.01
1988 Harkin AM, Hurley M. National survey on public knowledge of AIDS in Ireland Health Education Research. 3: 25-29.  0.01
1986 Hu E, Mangiaracina S, Peters M, Harkin A, Hackwood S, Beni G. INFERENCE IN INTELLIGENT MACHINES: APPLICATION TO A THERMAL EVAPORATOR . 1966-1972.  0.01
1917 Harkin AQ. “The nutons.” Folklore. 28: 328. DOI: 10.1080/0015587X.1917.9719001  0.01
1892 Harkin A. On epistaxis and the hemorrhoidal flux: their pathogenic unity and identity of cure The Dublin Journal of Medical Science. 93: 461-476. DOI: 10.1007/BF02965734  0.01
1892 Harkin A. "OPERATION FOR SPASMODIC TORTICOLLIS." The Lancet. 139: 1053.  0.01
1892 Harkin A. OPERATION FOR SPASMODIC TORTICOLLIS The Lancet. 139: 938.  0.01
1883 Harkin A. Infantile diarrhœa The Dublin Journal of Medical Science. 75: 307-312. DOI: 10.1007/BF02986188  0.01
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