Year |
Citation |
Score |
2015 |
Che T, Rodkey EA, Bethel CR, Shanmugam S, Ding Z, Pusztai-Carey M, Nottingham M, Chai W, Buynak JD, Bonomo RA, van den Akker F, Carey PR. Detecting a quasi-stable imine species on the reaction pathway of SHV-1 β-lactamase and 6β-(hydroxymethyl)penicillanic acid sulfone. Biochemistry. 54: 734-43. PMID 25536850 DOI: 10.1021/Bi501197T |
0.698 |
|
2014 |
Rodkey EA, Winkler ML, Bethel CR, Pagadala SR, Buynak JD, Bonomo RA, van den Akker F. Penam sulfones and β-lactamase inhibition: SA2-13 and the importance of the C2 side chain length and composition. Plos One. 9: e85892. PMID 24454944 DOI: 10.1371/Journal.Pone.0085892 |
0.695 |
|
2013 |
Rodkey EA, McLeod DC, Bethel CR, Smith KM, Xu Y, Chai W, Che T, Carey PR, Bonomo RA, van den Akker F, Buynak JD. β-Lactamase inhibition by 7-alkylidenecephalosporin sulfones: allylic transposition and formation of an unprecedented stabilized acyl-enzyme. Journal of the American Chemical Society. 135: 18358-69. PMID 24219313 DOI: 10.1021/Ja403598G |
0.706 |
|
2013 |
Winkler ML, Rodkey EA, Taracila MA, Drawz SM, Bethel CR, Papp-Wallace KM, Smith KM, Xu Y, Dwulit-Smith JR, Romagnoli C, Caselli E, Prati F, van den Akker F, Bonomo RA. Design and exploration of novel boronic acid inhibitors reveals important interactions with a clavulanic acid-resistant sulfhydryl-variable (SHV) β-lactamase. Journal of Medicinal Chemistry. 56: 1084-97. PMID 23252553 DOI: 10.1021/jm301490d |
0.692 |
|
2012 |
Rodkey EA, Drawz SM, Sampson JM, Bethel CR, Bonomo RA, van den Akker F. Crystal structure of a preacylation complex of the β-lactamase inhibitor sulbactam bound to a sulfenamide bond-containing thiol-β-lactamase. Journal of the American Chemical Society. 134: 16798-804. PMID 22974281 DOI: 10.1021/ja3073676 |
0.73 |
|
2012 |
Ke W, Rodkey EA, Sampson JM, Skalweit MJ, Sheri A, Pagadala SR, Nottingham MD, Buynak JD, Bonomo RA, van den Akker F. The importance of the trans-enamine intermediate as a β-lactamase inhibition strategy probed in inhibitor-resistant SHV β-lactamase variants. Chemmedchem. 7: 1002-8. PMID 22438274 DOI: 10.1002/Cmdc.201200006 |
0.666 |
|
2011 |
Rodkey EA, Sampson JM, Kalp M, Bethel CR, Buynak JD, Carey PR, Bonomo RA, van F, Akker d. β-Lactamase Inhibition: Mechanistic Details and Novel Inhibitors Biophysical Journal. 100: 552a. DOI: 10.1016/J.Bpj.2010.12.3212 |
0.769 |
|
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