Year |
Citation |
Score |
2024 |
McCluskey A, Prichard K, Chau N, Xue J, Krauss M, Sakoff JA, Gilbert J, Bahnik C, Muehlbauer M, Radetzki S, Robinson PJ, Haucke V. Inhibition clathrin mediated endocytosis: Pitstop 1 and Pitstop 2 chimeras. Chemmedchem. e202400253. PMID 38894585 DOI: 10.1002/cmdc.202400253 |
0.439 |
|
2023 |
Odell LR, Jones NC, Chau N, Robertson MJ, Ambrus JI, Deane FM, Young KA, Whiting A, Xue J, Prichard K, Daniel JA, Gorgani NN, O'Brien TJ, Robinson PJ, McCluskey A. The sulfonadyns: a class of aryl sulfonamides inhibiting dynamin I GTPase and clathrin mediated endocytosis are anti-seizure in animal models. Rsc Medicinal Chemistry. 14: 1492-1511. PMID 37593570 DOI: 10.1039/d2md00371f |
0.603 |
|
2022 |
Cossar PJ, Cardoso D, Mathwin D, Russell CC, Chiew B, Hamilton MP, Baker JR, Young KA, Chau N, Robinson PJ, McCluskey A. Wiskostatin and other carbazole scaffolds as off target inhibitors of dynamin I GTPase activity and endocytosis. European Journal of Medicinal Chemistry. 247: 115001. PMID 36577213 DOI: 10.1016/j.ejmech.2022.115001 |
0.455 |
|
2022 |
Odell LR, Robertson MJ, Young KA, McGeachie AB, Quan A, Robinson PJ, McCluskey A. Prodrugs of the Archetypal Dynamin Inhibitor Bis-T-22. Chemmedchem. e202200400. PMID 36351775 DOI: 10.1002/cmdc.202200400 |
0.317 |
|
2022 |
Russell CC, Prichard KL, O'Brien NS, McCluskey A, Robinson PJ, Baker JR. Synthesis of Phthaladyn-29 and Naphthalimide-10, GTP Site Directed Dynamin GTPase Inhibitors. Methods in Molecular Biology (Clifton, N.J.). 2417: 239-258. PMID 35099804 DOI: 10.1007/978-1-0716-1916-2_18 |
0.362 |
|
2022 |
Baker JR, O'Brien NS, Prichard KL, Robinson PJ, McCluskey A, Russell CC. Dynole 34-2 and Acrylo-Dyn 2-30, Novel Dynamin GTPase Chemical Biology Probes. Methods in Molecular Biology (Clifton, N.J.). 2417: 221-238. PMID 35099803 DOI: 10.1007/978-1-0716-1916-2_17 |
0.35 |
|
2021 |
Odell LR, Chau N, Russell CC, Young KA, Gilbert J, Robinson PJ, Sakoff JA, McCluskey A. Pyrimidyn based dynamin inhibitors as novel cytotoxic agents. Chemmedchem. PMID 34590434 DOI: 10.1002/cmdc.202100560 |
0.35 |
|
2016 |
Odell LR, Abdel-Hamid MK, Hill TA, Chau N, Young KA, Deane FM, Sakoff JA, Andersson S, Daniel JA, Robinson PJ, McCluskey A. Pyrimidine-Based Inhibitors of Dynamin I GTPase Activity: Competitive Inhibition at the Pleckstrin Homology Domain. Journal of Medicinal Chemistry. PMID 27997171 DOI: 10.1021/acs.jmedchem.6b01422 |
0.609 |
|
2016 |
Robertson MJ, Horatscheck A, Sauer S, von Kleist L, Baker JR, Stahlschmidt W, Nazaré M, Whiting A, Chau N, Robinson PJ, Haucke V, McCluskey A. 5-Aryl-2-(naphtha-1-yl)sulfonamido-thiazol-4(5H)-ones as clathrin inhibitors. Organic & Biomolecular Chemistry. PMID 27853797 DOI: 10.1039/c6ob02308h |
0.401 |
|
2015 |
Abdel-Hamid MK, Macgregor KA, Odell LR, Chau N, Mariana A, Whiting A, Robinson PJ, McCluskey A. 1,8-Naphthalimide derivatives: new leads against dynamin I GTPase activity. Organic & Biomolecular Chemistry. 13: 8016-28. PMID 26118967 DOI: 10.1039/c5ob00751h |
0.455 |
|
2015 |
Daniel JA, Chau N, Abdel-Hamid MK, Hu L, von Kleist L, Whiting A, Krishnan S, Maamary P, Joseph SR, Simpson F, Haucke V, McCluskey A, Robinson PJ. Phenothiazine-derived antipsychotic drugs inhibit dynamin and clathrin-mediated endocytosis. Traffic (Copenhagen, Denmark). 16: 635-54. PMID 25693808 DOI: 10.1111/tra.12272 |
0.627 |
|
2014 |
Kockx M, Karunakaran D, Traini M, Xue J, Huang KY, Nawara D, Gaus K, Jessup W, Robinson PJ, Kritharides L. Pharmacological inhibition of dynamin II reduces constitutive protein secretion from primary human macrophages. Plos One. 9: e111186. PMID 25347775 DOI: 10.1371/journal.pone.0111186 |
0.311 |
|
2014 |
MacGregor KA, Abdel-Hamid MK, Odell LR, Chau N, Whiting A, Robinson PJ, McCluskey A. Development of quinone analogues as dynamin GTPase inhibitors. European Journal of Medicinal Chemistry. 85: 191-206. PMID 25084145 DOI: 10.1016/j.ejmech.2014.06.070 |
0.427 |
|
2014 |
Robertson MJ, Deane FM, Stahlschmidt W, von Kleist L, Haucke V, Robinson PJ, McCluskey A. Synthesis of the Pitstop family of clathrin inhibitors. Nature Protocols. 9: 1592-606. PMID 24922269 DOI: 10.1038/nprot.2014.106 |
0.306 |
|
2014 |
MacGregor KA, Robertson MJ, Young KA, von Kleist L, Stahlschmidt W, Whiting A, Chau N, Robinson PJ, Haucke V, McCluskey A. Development of 1,8-naphthalimides as clathrin inhibitors. Journal of Medicinal Chemistry. 57: 131-43. PMID 24299503 DOI: 10.1021/jm4015263 |
0.414 |
|
2013 |
McCluskey A, Daniel JA, Hadzic G, Chau N, Clayton EL, Mariana A, Whiting A, Gorgani NN, Lloyd J, Quan A, Moshkanbaryans L, Krishnan S, Perera S, Chircop M, von Kleist L, ... ... Robinson PJ, et al. Building a better dynasore: the dyngo compounds potently inhibit dynamin and endocytosis. Traffic (Copenhagen, Denmark). 14: 1272-89. PMID 24025110 DOI: 10.1111/Tra.12119 |
0.597 |
|
2013 |
McGeachie AB, Odell LR, Quan A, Daniel JA, Chau N, Hill TA, Gorgani NN, Keating DJ, Cousin MA, van Dam EM, Mariana A, Whiting A, Perera S, Novelle A, Young KA, ... ... Robinson PJ, et al. Pyrimidyn compounds: dual-action small molecule pyrimidine-based dynamin inhibitors. Acs Chemical Biology. 8: 1507-18. PMID 23642287 DOI: 10.1021/Cb400137P |
0.657 |
|
2013 |
Smith CM, Haucke V, McCluskey A, Robinson PJ, Chircop M. Inhibition of clathrin by pitstop 2 activates the spindle assembly checkpoint and induces cell death in dividing HeLa cancer cells. Molecular Cancer. 12: 4. PMID 23327284 DOI: 10.1186/1476-4598-12-4 |
0.305 |
|
2013 |
Gordon CP, Venn-Brown B, Robertson MJ, Young KA, Chau N, Mariana A, Whiting A, Chircop M, Robinson PJ, McCluskey A. Development of second-generation indole-based dynamin GTPase inhibitors. Journal of Medicinal Chemistry. 56: 46-59. PMID 23167654 DOI: 10.1021/jm300844m |
0.404 |
|
2012 |
Robertson MJ, Hadzic G, Ambrus J, Pomè DY, Hyde E, Whiting A, Mariana A, von Kleist L, Chau N, Haucke V, Robinson PJ, McCluskey A. The Rhodadyns, a New Class of Small Molecule Inhibitors of Dynamin GTPase Activity. Acs Medicinal Chemistry Letters. 3: 352-6. PMID 24900478 DOI: 10.1021/ml200284s |
0.459 |
|
2012 |
Daniel JA, Malladi CS, Kettle E, McCluskey A, Robinson PJ. Analysis of synaptic vesicle endocytosis in synaptosomes by high-content screening. Nature Protocols. 7: 1439-55. PMID 22767087 DOI: 10.1038/nprot.2012.070 |
0.51 |
|
2011 |
Chircop M, Perera S, Mariana A, Lau H, Ma MP, Gilbert J, Jones NC, Gordon CP, Young KA, Morokoff A, Sakoff J, O'Brien TJ, McCluskey A, Robinson PJ. Inhibition of dynamin by dynole 34-2 induces cell death following cytokinesis failure in cancer cells. Molecular Cancer Therapeutics. 10: 1553-62. PMID 21750222 DOI: 10.1158/1535-7163.MCT-11-0067 |
0.314 |
|
2010 |
Odell LR, Howan D, Gordon CP, Robertson MJ, Chau N, Mariana A, Whiting AE, Abagyan R, Daniel JA, Gorgani NN, Robinson PJ, McCluskey A. The pthaladyns: GTP competitive inhibitors of dynamin I and II GTPase derived from virtual screening. Journal of Medicinal Chemistry. 53: 5267-80. PMID 20575553 DOI: 10.1021/Jm100442U |
0.64 |
|
2010 |
Joshi S, Perera S, Gilbert J, Smith CM, Mariana A, Gordon CP, Sakoff JA, McCluskey A, Robinson PJ, Braithwaite AW, Chircop M. The dynamin inhibitors MiTMAB and OcTMAB induce cytokinesis failure and inhibit cell proliferation in human cancer cells. Molecular Cancer Therapeutics. 9: 1995-2006. PMID 20571068 DOI: 10.1158/1535-7163.MCT-10-0161 |
0.303 |
|
2010 |
Hill TA, Mariana A, Gordon CP, Odell LR, Robertson MJ, McGeachie AB, Chau N, Daniel JA, Gorgani NN, Robinson PJ, McCluskey A. Iminochromene inhibitors of dynamins I and II GTPase activity and endocytosis. Journal of Medicinal Chemistry. 53: 4094-102. PMID 20426422 DOI: 10.1021/jm100119c |
0.613 |
|
2009 |
Hill TA, Gordon CP, McGeachie AB, Venn-Brown B, Odell LR, Chau N, Quan A, Mariana A, Sakoff JA, Chircop M, Robinson PJ, McCluskey A. Inhibition of dynamin mediated endocytosis by the dynoles--synthesis and functional activity of a family of indoles. Journal of Medicinal Chemistry. 52: 3762-73. PMID 19459681 DOI: 10.1021/jm900036m |
0.492 |
|
2009 |
Odell LR, Chau N, Mariana A, Graham ME, Robinson PJ, McCluskey A. Azido and diazarinyl analogues of bis-tyrphostin as asymmetrical inhibitors of dynamin GTPase. Chemmedchem. 4: 1182-8. PMID 19437476 DOI: 10.1002/cmdc.200900054 |
0.383 |
|
2007 |
Quan A, McGeachie AB, Keating DJ, van Dam EM, Rusak J, Chau N, Malladi CS, Chen C, McCluskey A, Cousin MA, Robinson PJ. Myristyl trimethyl ammonium bromide and octadecyl trimethyl ammonium bromide are surface-active small molecule dynamin inhibitors that block endocytosis mediated by dynamin I or dynamin II. Molecular Pharmacology. 72: 1425-39. PMID 17702890 DOI: 10.1124/Mol.107.034207 |
0.434 |
|
2005 |
Hill T, Odell LR, Edwards JK, Graham ME, McGeachie AB, Rusak J, Quan A, Abagyan R, Scott JL, Robinson PJ, McCluskey A. Small molecule inhibitors of dynamin I GTPase activity: development of dimeric tyrphostins. Journal of Medicinal Chemistry. 48: 7781-8. PMID 16302817 DOI: 10.1021/Jm040208L |
0.442 |
|
2004 |
Hill TA, Odell LR, Quan A, Abagyan R, Ferguson G, Robinson PJ, McCluskey A. Long chain amines and long chain ammonium salts as novel inhibitors of dynamin GTPase activity. Bioorganic & Medicinal Chemistry Letters. 14: 3275-8. PMID 15149689 DOI: 10.1016/J.Bmcl.2004.03.096 |
0.41 |
|
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