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Lori Ferrins, Ph.D. - Publications

Affiliations: 
2015- Northeastern University, Boston, MA, United States 
Area:
Trypanosomiasis
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28 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Klug DM, Tse EG, Silva DG, Cao Y, Charman SA, Chauhan J, Crighton E, Dichiara M, Drake C, Drewry D, da Silva Emery F, Ferrins L, Graves L, Hopkins E, Kresina TAC, et al. Open Source Antibiotics: Simple Diarylimidazoles Are Potent against Methicillin-Resistant . Acs Infectious Diseases. PMID 37991879 DOI: 10.1021/acsinfecdis.3c00286  0.45
2023 Ferrins L, Buskes MJ, Kapteyn MM, Engels HN, Enos SE, Lu C, Klug DM, Singh B, Quotadamo A, Bachovchin K, Tear WF, Spaulding AE, Forbes KC, Bag S, Rivers M, et al. Corrigendum: Identification of novel anti-amoebic pharmacophores from kinase inhibitor chemotypes. Frontiers in Microbiology. 14: 1304196. PMID 37954236 DOI: 10.3389/fmicb.2023.1304196  0.647
2023 Boby ML, Fearon D, Ferla M, Filep M, Koekemoer L, Robinson MC, Chodera JD, Lee AA, London N, von Delft A, von Delft F, Achdout H, Aimon A, Alonzi DS, Arbon R, ... ... Ferrins L, et al. Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors. Science (New York, N.Y.). 382: eabo7201. PMID 37943932 DOI: 10.1126/science.abo7201  0.373
2023 Dichiara M, Simpson QJ, Quotadamo A, Jalani HB, Huang AX, Millard CC, Klug DM, Tse EG, Todd MH, Silva DG, da Silva Emery F, Carlson JE, Zheng SL, Vleminckx M, Matheeussen A, ... ... Ferrins L, et al. Structure-Property Optimization of a Series of Imidazopyridines for Visceral Leishmaniasis. Acs Infectious Diseases. PMID 37417544 DOI: 10.1021/acsinfecdis.3c00040  0.673
2023 Ferrins L, Buskes MJ, Kapteyn MM, Engels HN, Enos SE, Lu C, Klug DM, Singh B, Quotadamo A, Bachovchin K, Tear WF, Spaulding AE, Forbes KC, Bag S, Rivers M, et al. Identification of novel anti-amoebic pharmacophores from kinase inhibitor chemotypes. Frontiers in Microbiology. 14: 1149145. PMID 37234530 DOI: 10.3389/fmicb.2023.1149145  0.718
2023 Sanders BC, Pokhrel S, Labbe AD, Mathews II, Cooper CJ, Davidson RB, Phillips G, Weiss KL, Zhang Q, O'Neill H, Kaur M, Schmidt JG, Reichard W, Surendranathan S, Parvathareddy J, ... ... Ferrins L, et al. Potent and selective covalent inhibition of the papain-like protease from SARS-CoV-2. Nature Communications. 14: 1733. PMID 36977673 DOI: 10.1038/s41467-023-37254-w  0.359
2022 Sanders B, Pokhrel S, Labbe A, Mathews I, Cooper C, Davidson R, Phillips G, Weiss K, Zhang Q, O'Neill H, Kaur M, Ferrins L, Schmidt J, Reichard W, Surendranathan S, et al. Potent and Selective Covalent Inhibition of the Papain-like Protease from SARS-CoV-2. Research Square. PMID 35898342 DOI: 10.21203/rs.3.rs-1840200/v1  0.364
2021 Klug DM, Mavrogiannaki EM, Forbes KC, Silva L, Diaz-Gonzalez R, Pérez-Moreno G, Ceballos-Pérez G, Garcia-Hernández R, Bosch-Navarrete C, Cordón-Obras C, Gómez-Liñán C, Saura A, Momper JD, Martinez-Martinez MS, Manzano P, ... ... Ferrins L, et al. Lead Optimization of 3,5-Disubstituted-7-Azaindoles for the Treatment of Human African Trypanosomiasis. Journal of Medicinal Chemistry. PMID 34156862 DOI: 10.1021/acs.jmedchem.1c00674  0.74
2021 Klug DM, Mavrogiannaki EM, Forbes KC, Silva L, Diaz-Gonzalez R, Pérez-Moreno G, Ceballos-Pérez G, Garcia-Hernández R, Bosch-Navarrete C, Cordón-Obras C, Gómez-Liñán C, Saura A, Momper JD, Martinez-Martinez MS, Manzano P, ... ... Ferrins L, et al. Lead Optimization of 3,5-Disubstituted-7-Azaindoles for the Treatment of Human African Trypanosomiasis. Journal of Medicinal Chemistry. PMID 34156862 DOI: 10.1021/acs.jmedchem.1c00674  0.74
2021 Dahlin JL, Auld DS, Rothenaigner I, Haney S, Sexton JZ, Nissink JWM, Walsh J, Lee JA, Strelow JM, Willard FS, Ferrins L, Baell JB, Walters MA, Hua BK, Hadian K, et al. Nuisance compounds in cellular assays. Cell Chemical Biology. PMID 33592188 DOI: 10.1016/j.chembiol.2021.01.021  0.681
2020 Klug DM, Diaz-Gonzalez R, DeLano TJ, Mavrogiannaki EM, Buskes MJ, Dalton RM, Fisher JK, Schneider KM, Hilborne V, Fritsche MG, Simpson QJ, Tear WF, Devine WG, Pérez-Moreno G, Ceballos-Pérez G, ... ... Ferrins L, et al. Structure-property studies of an imidazoquinoline chemotype with antitrypanosomal activity. Rsc Medicinal Chemistry. 11: 950-959. PMID 33479690 DOI: 10.1039/d0md00103a  0.735
2020 Varghese S, Rahmani R, Russell S, Deora GS, Ferrins L, Toynton A, Jones A, Sykes M, Kessler A, Eufrásio A, Cordeiro AT, Sherman J, Rodriguez A, Avery VM, Piggott MJ, et al. Discovery of Potent -Ethylurea Pyrazole Derivatives as Dual Inhibitors of and . Acs Medicinal Chemistry Letters. 11: 278-285. PMID 32184957 DOI: 10.1021/Acsmedchemlett.9B00218  0.807
2020 Buskes MJ, Clements M, Bachovchin KA, Jalani HB, Leonard A, Bag S, Klug DM, Singh B, Campbell RF, Sciotti RJ, El-Sakkary N, Caffrey CR, Pollastri MP, Ferrins L. Structure-Bioactivity Relationships of Lapatinib Derived Analogs against . Acs Medicinal Chemistry Letters. 11: 258-265. PMID 32184954 DOI: 10.1021/Acsmedchemlett.9B00455  0.783
2020 Singh B, Bernatchez JA, McCall LI, Calvet CM, Ackermann J, Souza JM, Thomas D, Silva EM, Bachovchin KA, Klug DM, Jalani HB, Bag S, Buskes MJ, Leed SE, Roncal NE, ... ... Ferrins L, et al. Scaffold and Parasite Hopping: Discovery of New Protozoal Proliferation Inhibitors. Acs Medicinal Chemistry Letters. 11: 249-257. PMID 32184953 DOI: 10.1021/Acsmedchemlett.9B00453  0.79
2019 Tear W, Bag S, Díaz González R, Ceballos-Perez G, Rojas-Barros DI, Cordon-Obras C, Pérez-Moreno G, García-Hernández R, Martínez-Martínez MS, Ruiz-Perez LM, Gamarro F, Gonzalez-Pacanowska D, Caffrey CR, Ferrins L, Manzano P, et al. Selectivity and Physicochemical Optimization of Repurposed Pyrazolo[1,5-b]pyridazines for the Treatment of Human African Trypanosomiasis. Journal of Medicinal Chemistry. PMID 31846577 DOI: 10.1021/Acs.Jmedchem.9B01741  0.706
2019 Klug DM, Tschiegg L, Díaz González R, Rojas-Barros DI, Perez-Moreno G, Ceballos-Perez G, García-Hernández R, Martínez-Martínez MS, Manzano P, Ruiz-Perez LM, Caffrey CR, Gamarro F, Gonzalez-Pacanowska D, Ferrins L, Navarro M, et al. Hit-to-lead optimization of benzoxazepinoindazoles as human African trypanosomiasis therapeutics. Journal of Medicinal Chemistry. PMID 31670951 DOI: 10.1021/Acs.Jmedchem.9B01506  0.784
2019 Klug DM, Diaz-Gonzalez R, Pérez-Moreno G, Ceballos-Pérez G, García-Hernández R, Gomez-Pérez V, Ruiz-Pérez LM, Rojas-Barros DI, Gamarro F, González-Pacanowska D, Martínez-Martínez MS, Manzano P, Ferrins L, Caffrey CR, Navarro M, et al. Evaluation of a class of isatinoids identified from a high-throughput screen of human kinase inhibitors as anti-Sleeping Sickness agents. Plos Neglected Tropical Diseases. 13: e0007129. PMID 30735501 DOI: 10.1371/Journal.Pntd.0007129  0.714
2018 Bachovchin KA, Sharma A, Bag S, Klug DM, Schneider KM, Singh B, Jalani HB, Buskes M, Mehta N, Tanghe S, Momper JD, Sciotti RJ, Rodriguez A, Mensa-Wilmot K, Pollastri MP, ... Ferrins L, et al. Improvement of Aqueous Solubility of Lapatinib-derived Analogs: Identification of a Quinolinimine as a Lead for Human African Trypanosomiasis Drug Development. Journal of Medicinal Chemistry. PMID 30565932 DOI: 10.1021/Acs.Jmedchem.8B01365  0.747
2018 Ferrins L, Sharma A, Thomas SM, Mehta N, Erath J, Tanghe S, Leed SE, Rodriguez A, Mensa-Wilmot K, Sciotti RJ, Gillingwater K, Pollastri MP. Anilinoquinoline based inhibitors of trypanosomatid proliferation. Plos Neglected Tropical Diseases. 12: e0006834. PMID 30475800 DOI: 10.1371/Journal.Pntd.0006834  0.782
2018 Mehta N, Ferrins L, Leed SE, Sciotti RJ, Pollastri MP. Optimization of Physicochemical Properties for 4-Anilinoquinoline Inhibitors of Plasmodium falciparum Proliferation. Acs Infectious Diseases. PMID 29301082 DOI: 10.1021/Acsinfecdis.7B00212  0.765
2017 Ferrins L, Pollastri MP. The Importance of Collaboration between Industry, Academics, and Nonprofits in Tropical Disease Drug Discovery. Acs Infectious Diseases. PMID 29134797 DOI: 10.1021/Acsinfecdis.7B00208  0.635
2016 Russell S, Rahmani R, Jones AJ, Newson H, Neilde K, Cotillo I, Rahmani Khajouei M, Ferrins L, Qureishi S, Nguyen N, Martínez-Martínez MS, Weaver DF, Kaiser M, Riley J, Thomas J, et al. Hit-to-Lead Optimisation of a Novel Class of Potent, Broad-Spectrum Trypanosomacides. Journal of Medicinal Chemistry. PMID 27548560 DOI: 10.1021/Acs.Jmedchem.6B00442  0.82
2016 Stoessel D, Nowell CJ, Jones AJ, Ferrins L, Ellis KM, Riley J, Rahmani R, Read KD, McConville MJ, Avery VM, Baell JB, Creek DJ. Metabolomics and lipidomics reveal perturbation of sphingolipid metabolism by a novel anti-trypanosomal 3-(oxazolo[4,5-b]pyridine-2-yl)anilide Metabolomics. 12. DOI: 10.1007/S11306-016-1062-1  0.799
2015 Rahmani R, Ban K, Jones AJ, Ferrins L, Ganame D, Sykes ML, Avery VM, White KL, Ryan E, Kaiser M, Charman SA, Baell JB. 6-Arylpyrazine-2-carboxamides: A New Core for Trypanosoma brucei Inhibitors. Journal of Medicinal Chemistry. 58: 6753-65. PMID 26247439 DOI: 10.1021/Acs.Jmedchem.5B00438  0.829
2014 Ferrins L, Gazdik M, Rahmani R, Varghese S, Sykes ML, Jones AJ, Avery VM, White KL, Ryan E, Charman SA, Kaiser M, Bergström CA, Baell JB. Pyridyl benzamides as a novel class of potent inhibitors for the kinetoplastid Trypanosoma brucei. Journal of Medicinal Chemistry. 57: 6393-402. PMID 24978605 DOI: 10.1021/Jm500191U  0.815
2013 Ferrins L, Rahmani R, Baell JB. Drug discovery and human African trypanosomiasis: a disease less neglected? Future Medicinal Chemistry. 5: 1801-41. PMID 24144414 DOI: 10.4155/Fmc.13.162  0.786
2013 Ferrins L, Rahmani R, Sykes ML, Jones AJ, Avery VM, Teston E, Almohaywi B, Yin J, Smith J, Hyland C, White KL, Ryan E, Campbell M, Charman SA, Kaiser M, et al. 3-(Oxazolo[4,5-b]pyridin-2-yl)anilides as a novel class of potent inhibitors for the kinetoplastid Trypanosoma brucei, the causative agent for human African trypanosomiasis. European Journal of Medicinal Chemistry. 66: 450-65. PMID 23831695 DOI: 10.1016/J.Ejmech.2013.05.007  0.816
2013 Baell JB, Ferrins L, Falk H, Nikolakopoulos G. PAINS: Relevance to tool compound discovery and fragment-based screening Australian Journal of Chemistry. 66: 1483-1494. DOI: 10.1071/Ch13551  0.631
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