Michael L. Shelanski, MD PhD - Related publications

Pathology and Cell Biology Columbia University, New York, NY 
Neural development, cytoskeleton
NOTE: We are testing a new system for identifying relevant work based on semantic analysis that identifies similarities between recently published papers and the current author's publications. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches.
50 most relevant papers in past 60 days:
Year Citation  Score
2021 Girotra P, Behl T, Sehgal A, Singh S, Bungau S. Investigation of the Molecular Role of Brain-Derived Neurotrophic Factor in Alzheimer's Disease. Journal of Molecular Neuroscience : Mn. PMID 34424488 DOI: 10.1007/s12031-021-01824-8   
2021 Cheng C, Reis SA, Adams ET, Fass DM, Angus SP, Stuhlmiller TJ, Richardson J, Olafson H, Wang ET, Patnaik D, Beauchamp RL, Feldman DA, Silva MC, Sur M, Johnson GL, et al. High-content image-based analysis and proteomic profiling identifies Tau phosphorylation inhibitors in a human iPSC-derived glutamatergic neuronal model of tauopathy. Scientific Reports. 11: 17029. PMID 34426604 DOI: 10.1038/s41598-021-96227-5   
2021 Jayaraman A, Htike TT, James R, Picon C, Reynolds R. TNF-mediated neuroinflammation is linked to neuronal necroptosis in Alzheimer's disease hippocampus. Acta Neuropathologica Communications. 9: 159. PMID 34625123 DOI: 10.1186/s40478-021-01264-w   
2021 Li X, Zhang X, Xing R, Qi F, Dong J, Li D, Tian X, Yu B, Huang M, Zhang L, Yuan X, Yang Y, Wu H, Zang L, Mao X, et al. Syringic acid demonstrates promising protective effect against tau fibrillization and cytotoxicity through regulation of endoplasmic reticulum stress-mediated pathway as a prelude to Alzheimer's disease. International Journal of Biological Macromolecules. PMID 34599991 DOI: 10.1016/j.ijbiomac.2021.09.173   
2021 Sharma C, Kim SR. Linking Oxidative Stress and Proteinopathy in Alzheimer's Disease. Antioxidants (Basel, Switzerland). 10. PMID 34439479 DOI: 10.3390/antiox10081231   
2021 Preeti K, Sood A, Fernandes V. Metabolic Regulation of Glia and Their Neuroinflammatory Role in Alzheimer's Disease. Cellular and Molecular Neurobiology. PMID 34515874 DOI: 10.1007/s10571-021-01147-7   
2021 Grundman J, Spencer B, Sarsoza F, Rissman RA. Transcriptome analyses reveal tau isoform-driven changes in transposable element and gene expression. Plos One. 16: e0251611. PMID 34587152 DOI: 10.1371/journal.pone.0251611   
2021 Wang H, Liu Y, Li J, Wang T, Hei Y, Li H, Wang X, Wang L, Zhao R, Liu W, Long Q. Tail-vein injection of MSC-derived small extracellular vesicles facilitates the restoration of hippocampal neuronal morphology and function in APP / PS1 mice. Cell Death Discovery. 7: 230. PMID 34482379 DOI: 10.1038/s41420-021-00620-y   
2021 Wu M, Liu CZ, Barrall EA, Rissman RA, Joiner WJ. Unbalanced regulation of α7 nAChRs by Ly6h and NACHO contributes to neurotoxicity in Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 34446574 DOI: 10.1523/JNEUROSCI.0494-21.2021   
2021 Jiang M, Zhang X, Yan X, Mizutani S, Kashiwazaki H, Ni J, Wu Z. GSK3β is involved in promoting Alzheimer's disease pathologies following chronic systemic exposure to Porphyromonas gingivalis lipopolysaccharide in amyloid precursor protein knock-in mice. Brain, Behavior, and Immunity. 98: 1-12. PMID 34391814 DOI: 10.1016/j.bbi.2021.08.213   
2021 Bai B, Vanderwall D, Li Y, Wang X, Poudel S, Wang H, Dey KK, Chen PC, Yang K, Peng J. Proteomic landscape of Alzheimer's Disease: novel insights into pathogenesis and biomarker discovery. Molecular Neurodegeneration. 16: 55. PMID 34384464 DOI: 10.1186/s13024-021-00474-z   
2021 Shibasaki Y, Maeda N, Oshimi C, Shirakawa Y, Saito M. Quantifying scaling exponents for neurite morphology of in vitro-cultured human iPSC-derived neurons using discrete Loewner evolution: A statistical-physical approach to the neuropathology in Alzheimer's disease. Chaos (Woodbury, N.Y.). 31: 073140. PMID 34340345 DOI: 10.1063/5.0048559   
2021 Uddin MS, Kabir MT, Jalouli M, Rahman MA, Jeandet P, Behl T, Alexiou A, Albadrani GM, Abdel-Daim MM, Perveen A, Ashraf GM. Neuroinflammatory Signaling in the Pathogenesis of Alzheimer's Disease. Current Neuropharmacology. PMID 34525932 DOI: 10.2174/1570159X19666210826130210   
2021 Armijo E, Edwards G, Flores A, Vera J, Shahnawaz M, Moda F, Gonzalez C, Sanhueza M, Soto C. Induced Pluripotent Stem Cell-Derived Neural Precursors Improve Memory, Synaptic and Pathological Abnormalities in a Mouse Model of Alzheimer's Disease. Cells. 10. PMID 34359972 DOI: 10.3390/cells10071802   
2021 Ledreux A, Thomas S, Hamlett ED, Trautman C, Gilmore A, Rickman Hager E, Paredes DA, Margittai M, Fortea J, Granholm AC. Small Neuron-Derived Extracellular Vesicles from Individuals with Down Syndrome Propagate Tau Pathology in the Wildtype Mouse Brain. Journal of Clinical Medicine. 10. PMID 34501378 DOI: 10.3390/jcm10173931   
2021 Dai B, Zhong T, Chen ZX, Chen W, Zhang N, Liu XL, Wang LQ, Chen J, Liang Y. Myricetin slows liquid-liquid phase separation of Tau and activates ATG5-dependent autophagy to suppress Tau toxicity. The Journal of Biological Chemistry. 101222. PMID 34560101 DOI: 10.1016/j.jbc.2021.101222   
2021 Zhang Y, Zhang Y, Aman Y, Ng CT, Chau WH, Zhang Z, Yue M, Bohm C, Jia Y, Li S, Yuan Q, Griffin J, Chiu K, Wong DSM, Wang B, et al. Amyloid-β toxicity modulates tau phosphorylation through the PAX6 signalling pathway. Brain : a Journal of Neurology. PMID 34428276 DOI: 10.1093/brain/awab134   
2021 Chen YD, Huang PY, Chiang CS, Huang YS, Tang SC. Generation and Role of Calpain-Cleaved 17-kDa Tau Fragment in Acute Ischemic Stroke. Molecular Neurobiology. PMID 34414533 DOI: 10.1007/s12035-021-02519-2   
2021 Rea Martinez J, Šelo G, Fernández-Arche MÁ, Bermudez B, García-Giménez MD. Dual Role of Phenyl Amides from Hempseed on BACE 1, PPARγ, and PGC-1α in N2a-APP Cells. Journal of Natural Products. PMID 34460260 DOI: 10.1021/acs.jnatprod.1c00435   
2021 Sundaria N, Upadhyay A, Prasad A, Prajapati VK, Poluri KM, Mishra A. Neurodegeneration & Imperfect Ageing: Technological Limitations and Challenges? Mechanisms of Ageing and Development. 111574. PMID 34562507 DOI: 10.1016/j.mad.2021.111574   
2021 Chuang Y, Van I, Zhao Y, Xu Y. Icariin Ameliorate Alzheimer's Disease by Influencing SIRT1 and Inhibiting Aβ cascade Pathogenesis. Journal of Chemical Neuroanatomy. 102014. PMID 34407393 DOI: 10.1016/j.jchemneu.2021.102014   
2021 Hernández AE, García E. Mesenchymal Stem Cell Therapy for Alzheimer's Disease. Stem Cells International. 2021: 7834421. PMID 34512767 DOI: 10.1155/2021/7834421   
2021 Chung DC, Roemer S, Petrucelli L, Dickson DW. Cellular and pathological heterogeneity of primary tauopathies. Molecular Neurodegeneration. 16: 57. PMID 34425874 DOI: 10.1186/s13024-021-00476-x   
2021 Ismael S, Sindi G, Colvin RA, Lee D. Activity-dependent release of phosphorylated human tau from Drosophila neurons in primary culture. The Journal of Biological Chemistry. 101108. PMID 34473990 DOI: 10.1016/j.jbc.2021.101108   
2021 Nisa FY, Rahman MA, Hossen MA, Khan MF, Khan MAN, Majid M, Sultana F, Haque MA. Role of neurotoxicants in the pathogenesis of Alzheimer's disease: a mechanistic insight. Annals of Medicine. 53: 1476-1501. PMID 34433343 DOI: 10.1080/07853890.2021.1966088   
2021 Sharma A, Anand JS, Kumar Y. Immunotherapeutics for AD: A Work in Progress. Cns & Neurological Disorders Drug Targets. PMID 34477533 DOI: 10.2174/1871527320666210903101522   
2021 Paumier A, Boisseau S, Jacquier-Sarlin M, Pernet-Gallay K, Buisson A, Albrieux M. Astrocyte-neuron interplay is critical for Alzheimer's disease pathogenesis and is rescued by TRPA1 channel blockade. Brain : a Journal of Neurology. PMID 34302466 DOI: 10.1093/brain/awab281   
2021 Lee SI, Jeong W, Lim H, Cho S, Lee H, Jang Y, Cho J, Bae S, Lin YT, Tsai LH, Moon DW, Seo J. APOE4-carrying human astrocytes oversupply cholesterol to promote neuronal lipid raft expansion and Aβ generation. Stem Cell Reports. PMID 34450034 DOI: 10.1016/j.stemcr.2021.07.017   
2021 Wan T, Fu M, Jiang Y, Jiang W, Li P, Zhou S. Research Progress on Mechanism of Neuroprotective Roles of Apelin-13 in Prevention and Treatment of Alzheimer's Disease. Neurochemical Research. PMID 34518975 DOI: 10.1007/s11064-021-03448-1   
2021 Zhao M, Jiang XF, Zhang HQ, Sun JH, Pei H, Ma LN, Cao Y, Li H. Interactions between glial cells and the blood-brain barrier and their role in Alzheimer's disease. Ageing Research Reviews. 101483. PMID 34610479 DOI: 10.1016/j.arr.2021.101483   
2021 Ryu WI, Cohen BM, Sonntag KC. Hypothesis and Theory: Characterizing Abnormalities of Energy Metabolism Using a Cellular Platform as a Personalized Medicine Approach for Alzheimer's Disease. Frontiers in Cell and Developmental Biology. 9: 697578. PMID 34395428 DOI: 10.3389/fcell.2021.697578   
2021 Zhong J, Ren X, Liu W, Wang S, Lv Y, Nie L, Lin R, Tian X, Yang X, Zhu F, Liu J. Discovery of Novel Markers for Identifying Cognitive Decline Using Neuron-Derived Exosomes. Frontiers in Aging Neuroscience. 13: 696944. PMID 34512304 DOI: 10.3389/fnagi.2021.696944   
2021 Pont C, Ginex T, Griñán-Ferré C, Scheiner M, Mattellone A, Martínez N, Arce EM, Soriano-Fernández Y, Naldi M, De Simone A, Barenys M, Gómez-Catalán J, Pérez B, Sabate R, Andrisano V, et al. From virtual screening hits targeting a cryptic pocket in BACE-1 to a nontoxic brain permeable multitarget anti-Alzheimer lead with disease-modifying and cognition-enhancing effects. European Journal of Medicinal Chemistry. 225: 113779. PMID 34418785 DOI: 10.1016/j.ejmech.2021.113779   
2021 Lo CH. Recent advances in cellular biosensor technology to investigate tau oligomerization. Bioengineering & Translational Medicine. 6: e10231. PMID 34589603 DOI: 10.1002/btm2.10231   
2021 Zhang Z, Yang X, Song YQ, Tu J. Autophagy in Alzheimer's Disease Pathogenesis: Therapeutic Potential and Future Perspectives. Ageing Research Reviews. 101464. PMID 34551326 DOI: 10.1016/j.arr.2021.101464   
2021 Eggert S, Kins S, Endres K, Brigadski T. Brothers in arms: proBDNF/BDNF and sAPPα/Aβ-signaling and their common interplay with ADAM10, TrkB, p75NTR, sortilin, and sorLA in the progression of Alzheimer's disease. Biological Chemistry. PMID 34619027 DOI: 10.1515/hsz-2021-0330   
2021 Russell JC, Lei H, Chaliparambil RK, Fish S, Markiewicz SM, Lee TI, Noori A, Kaeberlein M. Generation and characterization of a tractable C. elegans model of tauopathy. Geroscience. PMID 34536202 DOI: 10.1007/s11357-021-00436-9   
2021 Song Z, Luo D, Wang Y, Zheng Y, Chen P, Xia X, He C, Yu W, Li P, Xiao C, Cheng S. Neuroprotective Effect of Danggui Shaoyao San via the Mitophagy-Apoptosis Pathway in a Rat Model of Alzheimer's Disease. Evidence-Based Complementary and Alternative Medicine : Ecam. 2021: 3995958. PMID 34621321 DOI: 10.1155/2021/3995958   
2021 Utz J, Berner J, Muñoz LE, Oberstein TJ, Kornhuber J, Herrmann M, Maler JM, Spitzer P. Cerebrospinal Fluid of Patients With Alzheimer's Disease Contains Increased Percentages of Synaptophysin-Bearing Microvesicles. Frontiers in Aging Neuroscience. 13: 682115. PMID 34295239 DOI: 10.3389/fnagi.2021.682115   
2021 Argueti-Ostrovsky S, Alfahel L, Kahn J, Israelson A. All Roads Lead to Rome: Different Molecular Players Converge to Common Toxic Pathways in Neurodegeneration. Cells. 10. PMID 34572087 DOI: 10.3390/cells10092438   
2021 Ding Y, Zhang H, Liu Z, Li Q, Guo Y, Chen Y, Chang Y, Cui H. Carnitine palmitoyltransferase 1 (CPT1) alleviates oxidative stress and apoptosis of hippocampal neuron in response to beta-Amyloid peptide fragment Aβ. Bioengineered. 12: 5440-5449. PMID 34424821 DOI: 10.1080/21655979.2021.1967032   
2021 Rather MA, Khan A, Alshahrani S, Rashid H, Qadri M, Rashid S, Alsaffar RM, Kamal MA, Rehman MU. Inflammation and Alzheimer's Disease: Mechanisms and Therapeutic Implications by Natural Products. Mediators of Inflammation. 2021: 9982954. PMID 34381308 DOI: 10.1155/2021/9982954   
2021 Luo R, Fan Y, Yang J, Ye M, Zhang DF, Guo K, Li X, Bi R, Xu M, Yang LX, Li Y, Ran X, Jiang HY, Zhang C, Tan L, et al. A novel missense variant in ACAA1 contributes to early-onset Alzheimer's disease, impairs lysosomal function, and facilitates amyloid-β pathology and cognitive decline. Signal Transduction and Targeted Therapy. 6: 325. PMID 34465723 DOI: 10.1038/s41392-021-00748-4   
2021 Prasad R, Jung H, Tan A, Song Y, Moon S, Shaker MR, Sun W, Lee J, Ryu H, Lim HK, Jho EH. Hypermethylation of Mest promoter causes aberrant Wnt signaling in patients with Alzheimer's disease. Scientific Reports. 11: 20075. PMID 34625606 DOI: 10.1038/s41598-021-99562-9   
2021 Takata K, Ginhoux F, Shimohama S. Roles of microglia in Alzheimer's disease and impact of new findings on microglial heterogeneity as a target for therapeutic intervention. Biochemical Pharmacology. 192: 114754. PMID 34480881 DOI: 10.1016/j.bcp.2021.114754   
2021 Shang Y, Ding S. Flavonoids from Scutellaria baicalensis Georgi Stems and Leaves Regulate the Brain Tau Hyperphosphorylation at M|ultiple Sites Induced by Composited Aβ in Rats. Cns & Neurological Disorders Drug Targets. PMID 34455972 DOI: 10.2174/1871527320666210827112609   
2021 Lagomarsino VN, Pearse RV, Liu L, Hsieh YC, Fernandez MA, Vinton EA, Paull D, Felsky D, Tasaki S, Gaiteri C, Vardarajan B, Lee H, Muratore CR, Benoit CR, Chou V, et al. Stem cell-derived neurons reflect features of protein networks, neuropathology, and cognitive outcome of their aged human donors. Neuron. PMID 34473944 DOI: 10.1016/j.neuron.2021.08.003   
2021 Xu H, Liu X, Li W, Xi Y, Su P, Meng B, Shao X, Tang B, Yang Q, Mao Z. p38 MAPK-mediated loss of nuclear RNase III enzyme Drosha underlies amyloid beta-induced neuronal stress in Alzheimer's disease. Aging Cell. e13434. PMID 34528746 DOI: 10.1111/acel.13434   
2021 Festa BP, Barbosa AD, Rob M, Rubinsztein DC. The pleiotropic roles of autophagy in Alzheimer's disease: From pathophysiology to therapy. Current Opinion in Pharmacology. 60: 149-157. PMID 34419832 DOI: 10.1016/j.coph.2021.07.011   
2021 Scialò C, Celauro L, Zattoni M, Tran TH, Bistaffa E, Moda F, Kammerer R, Buratti E, Legname G. The Cellular Prion Protein Increases the Uptake and Toxicity of TDP-43 Fibrils. Viruses. 13. PMID 34452489 DOI: 10.3390/v13081625