Yongjin Yoo, Ph.D.
Affiliations: | 2013-2018 | Biomedical Science | Seoual National University |
2018-2024 | Institute for Stem Cell Biology and Regenerative Medicine | Stanford University, Palo Alto, CA | |
2024- | Department of Neuroscience, College of Medicine | Korea University, Seoul, South Korea |
Area:
Neural stem cells, Microglia, ReprogrammingWebsite:
https://www.yongjinyoolab.comGoogle:
"https://scholar.google.com/citations?user=QSvHyfoAAAAJ&hl=en"Bio:
Yongjin earned his B.S. from Shanghai Jiao Tong University, majoring in Biotechnology. As an undergraduate researcher in the Wu Geng laboratory, he studied X-ray protein crystallography for the SUFU protein, one of the most conserved components of the Hedgehog signaling pathway.
Under the guidance of Dr. Murim Choi, he earned his Ph.D. in Biomedical Science from Seoul National University. His research during his graduate studies focused on neurodevelopmental disorders, where he utilized whole-exome sequencing to identify novel genetic mutations in Rett syndrome-like patients and investigated their pathophysiology using cell and animal models.
During his postdoctoral research fellow in the laboratory of Dr. Marius Wernig at Stanford University, his primary research focus revolved around microglia, the brain's immune cells. In collaboration with Dr. Yohei Shibuya, he devised a novel, highly efficient non-genetic method for microglial replacement. Furthermore, he applied this innovative approach to a Trem2-deficient Alzheimer's disease model, demonstrating its effectiveness in restoring Trem2 function amidst amyloid pathology. Additionally, he pioneered the development of a human stem cell-derived microglia chimera model, offering a valuable tool for investigating human microglia in vivo.
Yongjin was honored with the esteemed Druckenmiller Fellowship from the New York Stem Cell Foundation (2020-2023) and the Sammy Kuo Award from the Wu Tsai Neurosciences Institute for Neuroscience (2023). Additionally, he was also awarded the Postdoctoral Research Fellowship from the National Research Foundation of Korea (2020-2021).
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Parents
Sign in to add mentorMurim Choi | grad student | 2013-2018 | Seoul National Univerity |
Marius Wernig | post-doc | 2018-2024 | Stanford (Cell Biology Tree) |
Publications
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Mader MM, Napole A, Wu D, et al. (2024) Myeloid cell replacement is neuroprotective in chronic experimental autoimmune encephalomyelitis. Nature Neuroscience |
Susanto TT, Hung V, Levine AG, et al. (2023) RAPIDASH: A tag-free enrichment of ribosome-associated proteins reveals compositional dynamics in embryonic tissues and stimulated macrophages. Biorxiv : the Preprint Server For Biology |
Guo MG, Reynolds DL, Ang CE, et al. (2023) Integrative analyses highlight functional regulatory variants associated with neuropsychiatric diseases. Nature Genetics |
Yoo Y, Neumayer G, Shibuya Y, et al. (2023) A cell therapy approach to restore microglial Trem2 function in a mouse model of Alzheimer's disease. Cell Stem Cell. 30: 1392 |
Yoo Y, Neumayer G, Shibuya Y, et al. (2023) A cell therapy approach to restore microglial Trem2 function in a mouse model of Alzheimer's disease. Cell Stem Cell. 30: 1043-1053.e6 |
Mader MM, Napole A, Wu D, et al. (2023) Augmentation of a neuroprotective myeloid state by hematopoietic cell transplantation. Biorxiv : the Preprint Server For Biology |
Shibuya Y, Kumar KK, Mader MM, et al. (2022) Treatment of a genetic brain disease by CNS-wide microglia replacement. Science Translational Medicine. 14: eabl9945 |
Yoo Y, Park SY, Jo EB, et al. (2021) Overexpression of Replication-Dependent Histone Signifies a Subset of Dedifferentiated Liposarcoma with Increased Aggressiveness. Cancers. 13 |
Lee Y, Park S, Lee JS, et al. (2020) Genomic profiling of 553 uncharacterized neurodevelopment patients reveals a high proportion of recessive pathogenic variant carriers in an outbred population. Scientific Reports. 10: 1413 |
Salpietro V, Dixon CL, Guo H, et al. (2019) AMPA receptor GluA2 subunit defects are a cause of neurodevelopmental disorders. Nature Communications. 10: 3094 |