Monte S. Buchsbaum, M.D.
Area:
Schizophrenia, PET
Website:
http://directory.mssm.edu/faculty/facultyInfo.php?id=24393&deptid=32Google:
"Monte Buchsbaum"Bio:
Monte S. Buchsbaum, M.D., has joined the faculty of the University of California, San Diego as Distinguished Professor of Psychiatry and Radiology. He heads the new NeuroPET Center and leads an effort in developing an expanded research effort with positron emission tomography. Located in Sorrento Valley about 2 miles north of the main campus at 11388 Sorrento Valley Road and close to the UCSD MRI and MEG facilities, the Center will be capable of metabolic studies with fluorodeoxyglucose, and initial radioligand studies of the serotonin transporter with DASB, brain amyloid with PIB, and the dopamine receptor with raclopride. An expanded on-site radiochemistry facility will developed a repertoire of molecular probes for imaging. Coordination with MRI for anatomical analysis of images will be a central feature. Our team includes Dr. Carl Hoh, Chief of nuclear medicine at UCSD, Dr. Ramaiah Pichika, radiochemist, and Dr. William Eckelman, senior radiochemist and former head of PET at the NIH.
We warmly encourage relevant scientific collaborations. Populations of particular interest include the following: schizophrenia, Alzheimer’s disease and other dementias including HIV-related cognitive impairment, alcoholism and drug abuse/dependence, mood disorders, anxiety, panic and posttraumatic stress disorders, Parkinson’s disease, and traumatic brain injury. Patients with traumatic brain injury will also form part of a program to expand the clinical and forensic applications of FDG PET and registration with diffusion tensor images. Any investigative CNS applications that are relevant for NeuroPET scientific methods will be welcomed.
Dr. Buchsbaum was previously Director of the Neuroscience PET Laboratory at Mt. Sinai Hospital in New York City, has been a pioneer in brain-mapping studies of schizophrenia, both with topographic EEG and PET explorations of antipsychotic-drug effects and the role of the prefrontal cortex and attention in this complex disorder. Since 1980, the primary focus of Dr. Buchsbaum's research has been brain imaging, combining positron emission tomography, computerized EEG and evoked potential brain mapping, and later magnetic resonance imaging and diffusion tensor imaging. While in the Intramural Research Program at the National Institute of Mental Health, Dr. Buchsbaum published some of the first PET studies in psychiatry. In 1982, Dr. Buchsbaum left the NIMH to head the Brain Imaging Center at the University of California, Irvine (UCI) and carried out studies on the prefrontal cortex in schizophrenia using FDG-PET and EEG. In 1992, Dr. Buchsbaum moved to New York to head the Neuroscience PET laboratory, focusing on pharmacological response and PET-FDG. In 1998 he published the first report on diffusion tensor imaging in schizophrenia, extending his work on potential deficits in the prefrontal cortex in schizophrenia. He is Editor of Psychiatry Research and Co-Editor of Psychiatry Research: Neuroimaging. He has published over 470 research reports in scientific journals, the majority on positron emission tomography. He is included in the Institute of Scientific Information data base as one of the most highly-cited scientists (ISIHighlyCited.com).
To schedule a clinical PET scan or discuss current or potential grants
Phone: 858-323-2860
Email: mbuchsbaum@ucsd.edu
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Publications
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Mitelman SA, Buchsbaum MS, Christian BT, et al. (2020) Relationship between white matter glucose metabolism and fractional anisotropy in healthy and schizophrenia subjects. Psychiatry Research. Neuroimaging. 299: 111060 |
Mitelman SA, Buchsbaum MS, Christian BT, et al. (2019) Positive association between cerebral grey matter metabolism and dopamine D/D receptor availability in healthy and schizophrenia subjects: an F-fluorodeoxyglucose and F-fallypride positron emission tomography study. The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry. 1-43 |
Mitelman SA, Buchsbaum MS, Christian BT, et al. (2018) Dopamine receptor density and white mater integrity: F-fallypride positron emission tomography and diffusion tensor imaging study in healthy and schizophrenia subjects. Brain Imaging and Behavior |
Stout DM, Buchsbaum MS, Spadoni AD, et al. (2018) Multimodal canonical correlation reveals converging neural circuitry across trauma-related disorders of affect and cognition. Neurobiology of Stress. 9: 241-250 |
Chevallier E, Tanguy A, Krebs M, et al. (2018) F125. POOR OUTCOME SCHIZOPHRENIA (KRAEPELINIAN SUB-TYPE): SOCIAL COGNITIVE AND NEURODEVELOPMENTAL MARKERS Schizophrenia Bulletin. 44: S268-S269 |
Mitelman SA, Buchsbaum MS, Young DS, et al. (2017) Increased white matter metabolic rates in autism spectrum disorder and schizophrenia. Brain Imaging and Behavior |
Vyas NS, Buchsbaum MS, Lehrer DS, et al. (2017) D2/D3 dopamine receptor binding with [F-18]fallypride correlates of executive function in medication-naïve patients with schizophrenia. Schizophrenia Research |
Mitelman SA, Bralet MC, Mehmet Haznedar M, et al. (2017) Positron emission tomography assessment of cerebral glucose metabolic rates in autism spectrum disorder and schizophrenia. Brain Imaging and Behavior |
Buchsbaum M, Vyas N, Lehrer D, et al. (2017) 79. D2/D3 Dopamine Receptor Binding With [F-18] Fallypride Correlates of Executive Function in Medication-Naive Patients With Schizophrenia Schizophrenia Bulletin. 43: S44-S45 |
Mitelman SA, Bralet MC, Haznedar MM, et al. (2016) Diametrical relationship between gray and white matter volumes in autism spectrum disorder and schizophrenia. Brain Imaging and Behavior |
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