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Sean E. Rooney, Ph.D.

Affiliations: 
2003 Harvard University, Cambridge, MA, United States 
Area:
DNA repair, immunology, lymphoma
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"Sean Rooney"
Mean distance: 16.75 (cluster 31)
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Frederick W. Alt grad student 2003 Harvard
 (The role of artemis in V(D)J recombination, class switch recombination and tumor suppression.)

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Publications

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Wu P, van Overbeek M, Rooney S, et al. (2010) Apollo contributes to G overhang maintenance and protects leading-end telomeres. Molecular Cell. 39: 606-17
Mostoslavsky G, Fabian AJ, Rooney S, et al. (2006) Complete correction of murine Artemis immunodeficiency by lentiviral vector-mediated gene transfer. Proceedings of the National Academy of Sciences of the United States of America. 103: 16406-11
Rooney S, Alt FW, Sekiguchi J, et al. (2005) Artemis-independent functions of DNA-dependent protein kinase in Ig heavy chain class switch recombination and development. Proceedings of the National Academy of Sciences of the United States of America. 102: 2471-5
Rooney S, Chaudhuri J, Alt FW. (2004) The role of the non-homologous end-joining pathway in lymphocyte development. Immunological Reviews. 200: 115-31
Rooney S, Sekiguchi J, Whitlow S, et al. (2004) Artemis and p53 cooperate to suppress oncogenic N-myc amplification in progenitor B cells. Proceedings of the National Academy of Sciences of the United States of America. 101: 2410-5
Rooney S, Alt FW, Lombard D, et al. (2003) Defective DNA repair and increased genomic instability in Artemis-deficient murine cells. The Journal of Experimental Medicine. 197: 553-65
Rooney S, Sekiguchi J, Zhu C, et al. (2002) Leaky Scid phenotype associated with defective V(D)J coding end processing in Artemis-deficient mice. Molecular Cell. 10: 1379-90
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