Frederick W. Alt, PhD
Affiliations: | Genetics | Harvard University, Cambridge, MA, United States |
Area:
DNA repair, immunology, lymphomaWebsite:
https://www.hms.harvard.edu/dms/bbs/fac/Alt.phpGoogle:
"Frederick W. Alt"Bio:
https://genetics.hms.harvard.edu/faculty-staff/frederick-w-alt
https://www.hhmi.org/scientists/frederick-w-alt
http://searchworks.stanford.edu/view/761131
Mean distance: 14.7 (cluster 31) | S | N | B | C | P |
Cross-listing: Chemistry Tree - Cell Biology Tree
Parents
Sign in to add mentor| Robert T. Schimke | grad student | 1977 | Stanford | |
| (The molecular mechanism of dihydrofolate reductase overproduction in methotrexate-resistant variants of culture murine cells) | ||||
| David Baltimore | post-doc | 1982 | MIT (Chemistry Tree) | |
Children
Sign in to add trainee| Amelia Chang | grad student | ||
| George Yancopoulos | grad student | Columbia University Medical School | |
| Yang Xu | grad student | 1994 | Harvard (Stem Cell Tree) |
| Darryll D. Dudley | grad student | 2003 | Harvard |
| Sean E. Rooney | grad student | 2003 | Harvard |
| David H. Jung | grad student | 2006 | Harvard |
| Cristian Boboila | grad student | 2005-2011 | Harvard |
| Tingting Zhang-Kharas | grad student | 2005-2011 | Harvard (Chemistry Tree) |
| Suprawee Tepsuporn | grad student | 2013 | Harvard |
| Uttiya Basu | post-doc | Harvard | |
| Jayanta Chaudhuri | post-doc | (MathTree) | |
| Huan Chen | post-doc | Harvard (Cell Biology Tree) | |
| Bjoern Schwer | post-doc | ||
| Adam Yongxin Ye | post-doc | 2018- | Harvard Medical School (GenetiTree) |
| Ronald A. DePinho | post-doc | 1984-1988 | Columbia |
| Angela K. Eggleston | post-doc | 1999-1999 | Harvard Medical School - Boston Children's Hospital (Chemistry Tree) |
| Shan Zha | post-doc | 2004-2009 | Harvard - Boston Children's Hospital (Chemistry Tree) |
| Richard L Frock | post-doc | 2010-2017 | Harvard Medical School - Boston Children's Hospital (Cell Biology Tree) |
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Publications
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| Du L, Oksenych V, Wan H, et al. (2024) Orientation Regulation of Class-switch Recombination in Human B Cells. Journal of Immunology (Baltimore, Md. : 1950) |
| Zhang Y, Li X, Ba Z, et al. (2024) Molecular basis for differential Igk versus Igh V(D)J joining mechanisms. Nature |
| Sharma P, Zhang X, Ly K, et al. (2024) The lipid globotriaosylceramide promotes germinal center B cell responses and antiviral immunity. Science (New York, N.Y.). 383: eadg0564 |
| Sharma P, Zhang X, Ly K, et al. (2023) The lipid Gb3 promotes germinal center B cell responses and anti-viral immunity. Biorxiv : the Preprint Server For Biology |
| Liang Z, Zhao L, Ye AY, et al. (2023) Contribution of the IGCR1 regulatory element and the 3' CTCF-binding elements to regulation of V(D)J recombination. Proceedings of the National Academy of Sciences of the United States of America. 120: e2306564120 |
| Liang Z, Zhao L, Yongxin Ye A, et al. (2023) Contribution of the IGCR1 regulatory element and the 3 CBEs to Regulation of V(D)J Recombination. Biorxiv : the Preprint Server For Biology |
| Luo S, Jing C, Ye AY, et al. (2022) Humanized V(D)J-rearranging and TdT-expressing mouse vaccine models with physiological HIV-1 broadly neutralizing antibody precursors. Proceedings of the National Academy of Sciences of the United States of America. 120: e2217883120 |
| Luo S, Zhang J, Kreutzberger AJB, et al. (2022) An Antibody from Single Human V-rearranging Mouse Neutralizes All SARS-CoV-2 Variants Through BA.5 by Inhibiting Membrane Fusion. Science Immunology. eadd5446 |
| Vincendeau E, Wei W, Zhang X, et al. (2022) SHLD1 is dispensable for 53BP1-dependent V(D)J recombination but critical for productive class switch recombination. Nature Communications. 13: 3707 |
| Zhang Y, Zhang X, Dai HQ, et al. (2022) The role of chromatin loop extrusion in antibody diversification. Nature Reviews. Immunology |