John Raymond Hepler

1996- Pharmacology Emory University School of Medicine, Atlanta, GA, United States 
G protein signaling, RGS proteins, GPCR
"John Raymond Hepler"

Mean distance: 15.72 (cluster 6)
Cross-listing: Chemistry Tree


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T. Kendall Harden grad student 1988 UNC Chapel Hill (Chemistry Tree)
 (Identification and characterization of biochemical mechanisms involved in the regulation of cell surface receptor-mediated stimulation of phosphoinsitide hydrolysis.)
Alfred G. Gilman post-doc 1990-1996 UT Southwestern (Chemistry Tree)


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Mary Rose Branch research assistant Emory
Nicole E. Brown grad student Emory
Paul R. Evans grad student Emory
Kyle Gerber grad student Emory
Katherine E. Squires grad student Emory
Susanne Hollinger grad student 2003 Emory
Katherine H. Pedone grad student 2007 Emory
Kelly L. McCoy grad student 2010 Emory
Christopher P. Vellano grad student 2012 Emory


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Kendall J. Blumer collaborator
Serena M. Dudek collaborator
Ryohei Yasuda collaborator
BETA: Related publications


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Gerber KJ, Dammer EB, Duong DM, et al. (2019) Specific Proteomes of Hippocampal Regions CA2 and CA1 Reveal Proteins Linked to the Unique Physiology of Area CA2. Journal of Proteome Research
Gerber KJ, Squires KE, Hepler JR. (2018) 14-3-3γ binds RGS14 at distinct sites to inhibit the RGS14:Gαi-AlFsignaling complex and RGS14 nuclear localization. The Journal of Biological Chemistry
Evans PR, Parra-Bueno P, Smirnov MS, et al. (2018) RGS14 Restricts Plasticity in Hippocampal CA2 by Limiting Postsynaptic Calcium Signaling. Eneuro. 5
Squires KE, Montañez-Miranda C, Pandya RR, et al. (2018) Genetic Analysis of Rare Human Variants of Regulators of G Protein Signaling Proteins and Their Role in Human Physiology and Disease. Pharmacological Reviews. 70: 446-474
Evans PR, Gerber KJ, Dammer EB, et al. (2018) Interactome Analysis Reveals Regulator of G Protein Signaling 14 (RGS14) is a Novel Calcium/Calmodulin (Ca2+/CaM) and CaM Kinase II (CaMKII) Binding Partner. Journal of Proteome Research
Zou J, Salarian M, Chen Y, et al. (2017) Direct Visualization of Interaction between Calmodulin and Connexin45. The Biochemical Journal
Branch MR, Hepler JR. (2017) Endogenous RGS14 is a cytoplasmic-nuclear shuttling protein that localizes to juxtanuclear membranes and chromatin-rich regions of the nucleus. Plos One. 12: e0184497
Squires KE, Gerber KJ, Pare JF, et al. (2017) Regulator of G protein signaling 14 (RGS14) is expressed pre- and postsynaptically in neurons of hippocampus, basal ganglia, and amygdala of monkey and human brain. Brain Structure & Function
Brown NE, Lambert NA, Hepler JR. (2016) RGS14 regulates the lifetime of Gα-GTP signaling but does not prolong Gβγ signaling following receptor activation in live cells. Pharmacology Research & Perspectives. 4: e00249
Gerber KJ, Squires KE, Hepler JR. (2015) Roles for Regulator of G protein Signaling (RGS) Proteins in Synaptic Signaling and Plasticity. Molecular Pharmacology
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