John Raymond Hepler
Affiliations: | 1996- | Pharmacology | Emory University School of Medicine, Atlanta, GA, United States |
Area:
G protein signaling, RGS proteins, GPCRWebsite:
http://www.pharm.emory.edu/people/primary/hepler-john.htmlGoogle:
"John Raymond Hepler"Bio:
http://pharmacology.emory.edu/hepler/lab-members/hepler-cv.html
https://scholar.google.com/citations?hl=en&user=tGRPMs4AAAAJ
Mean distance: 15.72 (cluster 6) | S | N | B | C | P |
Cross-listing: Chemistry Tree
Parents
Sign in to add mentor| T. Kendall Harden | grad student | 1988 | UNC Chapel Hill (Chemistry Tree) | |
| (Identification and characterization of biochemical mechanisms involved in the regulation of cell surface receptor-mediated stimulation of phosphoinsitide hydrolysis.) | ||||
| Alfred G. Gilman | post-doc | 1990-1996 | UT Southwestern (Chemistry Tree) | |
Children
Sign in to add trainee| Mary Rose Branch | research assistant | Emory | |
| Nicole E. Brown | grad student | Emory | |
| Paul R. Evans | grad student | Emory | |
| Kyle Gerber | grad student | Emory | |
| Katherine E. Squires | grad student | Emory | |
| Susanne Hollinger | grad student | 2003 | Emory |
| Katherine H. Pedone | grad student | 2007 | Emory |
| Kelly L. McCoy | grad student | 2010 | Emory |
| Christopher P. Vellano | grad student | 2012 | Emory |
Collaborators
Sign in to add collaborator| Kendall J. Blumer | collaborator | ||
| Serena M. Dudek | collaborator | ||
| Ryohei Yasuda | collaborator |
BETA: Related publications
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Publications
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| Squires KE, Gerber KJ, Tillman MC, et al. (2020) Human genetic variants disrupt RGS14 nuclear shuttling and regulation of LTP in hippocampal neurons. The Journal of Biological Chemistry. 296: 100024 |
| Squires KE, Gerber KJ, Tillman MC, et al. (2020) Human genetic variants disrupt RGS14 nuclear shuttling and regulation of LTP in hippocampal neurons. The Journal of Biological Chemistry |
| Gerber KJ, Squires KE, Hepler JR. (2019) Correction: 14-3-3γ binds regulator of G protein signaling 14 (RGS14) at distinct sites to inhibit the RGS14:Gα-AlF signaling complex and RGS14 nuclear localization. The Journal of Biological Chemistry. 294: 12262 |
| Gerber KJ, Dammer EB, Duong DM, et al. (2019) Specific Proteomes of Hippocampal Regions CA2 and CA1 Reveal Proteins Linked to the Unique Physiology of Area CA2. Journal of Proteome Research |
| Gerber KJ, Squires KE, Hepler JR. (2018) 14-3-3γ binds RGS14 at distinct sites to inhibit the RGS14:Gαi-AlFsignaling complex and RGS14 nuclear localization. The Journal of Biological Chemistry |
| Evans PR, Parra-Bueno P, Smirnov MS, et al. (2018) RGS14 Restricts Plasticity in Hippocampal CA2 by Limiting Postsynaptic Calcium Signaling. Eneuro. 5 |
| Squires KE, Montañez-Miranda C, Pandya RR, et al. (2018) Genetic Analysis of Rare Human Variants of Regulators of G Protein Signaling Proteins and Their Role in Human Physiology and Disease. Pharmacological Reviews. 70: 446-474 |
| Evans PR, Gerber KJ, Dammer EB, et al. (2018) Interactome Analysis Reveals Regulator of G Protein Signaling 14 (RGS14) is a Novel Calcium/Calmodulin (Ca2+/CaM) and CaM Kinase II (CaMKII) Binding Partner. Journal of Proteome Research |
| Zou J, Salarian M, Chen Y, et al. (2017) Direct Visualization of Interaction between Calmodulin and Connexin45. The Biochemical Journal |
| Branch MR, Hepler JR. (2017) Endogenous RGS14 is a cytoplasmic-nuclear shuttling protein that localizes to juxtanuclear membranes and chromatin-rich regions of the nucleus. Plos One. 12: e0184497 |