| Year |
Citation |
Score |
| 2023 |
Alexander SPH, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Buneman OP, Faccenda E, Harding SD, Spedding M, Cidlowski JA, Fabbro D, Davenport AP, Striessnig J, Davies JA, ... ... Hepler JR, et al. The Concise Guide to PHARMACOLOGY 2023/24: Introduction and Other Protein Targets. British Journal of Pharmacology. S1-S22. PMID 38123153 DOI: 10.1111/bph.16176 |
0.704 |
|
| 2023 |
Samadi M, Hales CA, Lustberg DJ, Farris S, Ross MR, Zhao M, Hepler JR, Harbin NH, Robinson ESJ, Banks PJ, Bashir ZI, Dudek SM. Mechanisms of mGluR-dependent plasticity in hippocampal area CA2. Hippocampus. PMID 36971428 DOI: 10.1002/hipo.23529 |
0.703 |
|
| 2022 |
Montanez-Miranda C, Bramlett SN, Hepler JR. RGS14 expression in CA2 hippocampus, amygdala, and basal ganglia: Implications for human brain physiology and disease. Hippocampus. PMID 36541898 DOI: 10.1002/hipo.23492 |
0.353 |
|
| 2022 |
Montanez-Miranda C, Perszyk RE, Harbin NH, Okalova J, Ramineni S, Traynelis SF, Hepler JR. . Molecular Pharmacology. PMID 36384958 DOI: 10.1124/molpharm.122.000614 |
0.351 |
|
| 2022 |
Friedman PA, Sneddon WB, Mamonova T, Montanez-Miranda C, Ramineni S, Harbin NH, Squires KE, Gefter JV, Magyar CE, Emlet DR, Hepler JR. RGS14 regulates hormone-sensitive NPT2A-mediated renal phosphate uptake via binding to the NHERF1 scaffolding protein. The Journal of Biological Chemistry. 101836. PMID 35307350 DOI: 10.1016/j.jbc.2022.101836 |
0.632 |
|
| 2021 |
Alexander SP, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Southan C, Buneman OP, Cidlowski JA, Christopoulos A, Davenport AP, Fabbro D, ... ... Hepler JR, et al. THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Introduction and Other Protein Targets. British Journal of Pharmacology. 178: S1-S26. PMID 34529830 DOI: 10.1111/bph.15537 |
0.704 |
|
| 2021 |
Harbin NH, Bramlett SN, Montanez-Miranda C, Terzioglu G, Hepler JR. RGS14 Regulation of Post-Synaptic Signaling and Spine Plasticity in Brain. International Journal of Molecular Sciences. 22. PMID 34201943 DOI: 10.3390/ijms22136823 |
0.418 |
|
| 2021 |
Foster SL, Lustberg DJ, Harbin NH, Bramlett SN, Hepler JR, Weinshenker D. RGS14 modulates locomotor behavior and ERK signaling induced by environmental novelty and cocaine within discrete limbic structures. Psychopharmacology. PMID 34184126 DOI: 10.1007/s00213-021-05892-x |
0.313 |
|
| 2020 |
Squires KE, Gerber KJ, Tillman MC, Lustberg DJ, Montañez-Miranda C, Zhao M, Ramineni S, Scharer CD, Saha RN, Shu FJ, Schroeder JP, Ortlund EA, Weinshenker D, Dudek SM, Hepler JR. Human genetic variants disrupt RGS14 nuclear shuttling and regulation of LTP in hippocampal neurons. The Journal of Biological Chemistry. 296: 100024. PMID 33410399 DOI: 10.1074/jbc.RA120.016009 |
0.809 |
|
| 2020 |
Squires KE, Gerber KJ, Tillman MC, Lustberg DJ, Montañez-Miranda C, Zhao M, Ramineni S, Scharer CD, Saha RN, Shu FJ, Schroeder JP, Ortlund EA, Weinshenker D, Dudek SM, Hepler JR. Human genetic variants disrupt RGS14 nuclear shuttling and regulation of LTP in hippocampal neurons. The Journal of Biological Chemistry. PMID 33154163 DOI: 10.1074/jbc.RA120.016009 |
0.81 |
|
| 2019 |
Gerber KJ, Squires KE, Hepler JR. Correction: 14-3-3γ binds regulator of G protein signaling 14 (RGS14) at distinct sites to inhibit the RGS14:Gα-AlF signaling complex and RGS14 nuclear localization. The Journal of Biological Chemistry. 294: 12262. PMID 31399537 DOI: 10.1074/Jbc.Aac119.101131 |
0.779 |
|
| 2019 |
Gerber KJ, Dammer EB, Duong DM, Deng Q, Dudek SM, Seyfried NT, Hepler JR. Specific Proteomes of Hippocampal Regions CA2 and CA1 Reveal Proteins Linked to the Unique Physiology of Area CA2. Journal of Proteome Research. PMID 31059263 DOI: 10.1021/Acs.Jproteome.9B00103 |
0.772 |
|
| 2019 |
Alqinyah M, Bodle C, Bou Dagher J, Chakravarti B, Choudhuri SP, Druey KM, Fisher RA, Gerber KJ, Hepler JR, Hooks SB, Kantheti HS, Karaj B, Lee J, Luo Z, Martemyanov K, et al. Regulators of G protein Signaling (RGS) proteins (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database Iuphar/Bps Guide to Pharmacology Cite. 2019. DOI: 10.2218/gtopdb/f891/2019.4 |
0.668 |
|
| 2018 |
Gerber KJ, Squires KE, Hepler JR. 14-3-3γ binds RGS14 at distinct sites to inhibit the RGS14:Gαi-AlFsignaling complex and RGS14 nuclear localization. The Journal of Biological Chemistry. PMID 30093406 DOI: 10.1074/Jbc.Ra118.002816 |
0.79 |
|
| 2018 |
Evans PR, Parra-Bueno P, Smirnov MS, Lustberg DJ, Dudek SM, Hepler JR, Yasuda R. RGS14 Restricts Plasticity in Hippocampal CA2 by Limiting Postsynaptic Calcium Signaling. Eneuro. 5. PMID 29911178 DOI: 10.1523/ENEURO.0353-17.2018 |
0.798 |
|
| 2018 |
Squires KE, Montañez-Miranda C, Pandya RR, Torres MP, Hepler JR. Genetic Analysis of Rare Human Variants of Regulators of G Protein Signaling Proteins and Their Role in Human Physiology and Disease. Pharmacological Reviews. 70: 446-474. PMID 29871944 DOI: 10.1124/Pr.117.015354 |
0.721 |
|
| 2018 |
Evans PR, Gerber KJ, Dammer EB, Duong DM, Goswami D, Lustberg DJ, Zou J, Yang JJ, Dudek SM, Griffin PR, Seyfried NT, Hepler JR. Interactome Analysis Reveals Regulator of G Protein Signaling 14 (RGS14) is a Novel Calcium/Calmodulin (Ca2+/CaM) and CaM Kinase II (CaMKII) Binding Partner. Journal of Proteome Research. PMID 29518331 DOI: 10.1021/Acs.Jproteome.8B00027 |
0.845 |
|
| 2017 |
Zou J, Salarian M, Chen Y, Zhuo Y, Brown NE, Hepler JR, Yang J. Direct Visualization of Interaction between Calmodulin and Connexin45. The Biochemical Journal. PMID 28963343 DOI: 10.1042/Bcj20170426 |
0.636 |
|
| 2017 |
Branch MR, Hepler JR. Endogenous RGS14 is a cytoplasmic-nuclear shuttling protein that localizes to juxtanuclear membranes and chromatin-rich regions of the nucleus. Plos One. 12: e0184497. PMID 28934222 DOI: 10.1371/Journal.Pone.0184497 |
0.825 |
|
| 2017 |
Squires KE, Gerber KJ, Pare JF, Branch MR, Smith Y, Hepler JR. Regulator of G protein signaling 14 (RGS14) is expressed pre- and postsynaptically in neurons of hippocampus, basal ganglia, and amygdala of monkey and human brain. Brain Structure & Function. PMID 28776200 DOI: 10.1007/S00429-017-1487-Y |
0.805 |
|
| 2016 |
Brown NE, Lambert NA, Hepler JR. RGS14 regulates the lifetime of Gα-GTP signaling but does not prolong Gβγ signaling following receptor activation in live cells. Pharmacology Research & Perspectives. 4: e00249. PMID 27713821 DOI: 10.1002/Prp2.249 |
0.737 |
|
| 2015 |
Gerber KJ, Squires KE, Hepler JR. Roles for Regulator of G protein Signaling (RGS) Proteins in Synaptic Signaling and Plasticity. Molecular Pharmacology. PMID 26655302 DOI: 10.1124/Mol.115.102210 |
0.811 |
|
| 2015 |
Evans PR, Dudek SM, Hepler JR. Regulator of G Protein Signaling 14: A Molecular Brake on Synaptic Plasticity Linked to Learning and Memory. Progress in Molecular Biology and Translational Science. 133: 169-206. PMID 26123307 DOI: 10.1016/Bs.Pmbts.2015.03.006 |
0.815 |
|
| 2015 |
Brown NE, Blumer JB, Hepler JR. Bioluminescence resonance energy transfer to detect protein-protein interactions in live cells. Methods in Molecular Biology (Clifton, N.J.). 1278: 457-65. PMID 25859969 DOI: 10.1007/978-1-4939-2425-7_30 |
0.638 |
|
| 2015 |
Brown NE, Goswami D, Branch MR, Ramineni S, Ortlund EA, Griffin PR, Hepler JR. Integration of G protein α (Gα) signaling by the regulator of G protein signaling 14 (RGS14). The Journal of Biological Chemistry. 290: 9037-49. PMID 25666614 DOI: 10.1074/Jbc.M114.634329 |
0.833 |
|
| 2015 |
Evans PR, Dudek SM, Hepler JR. Regulator of G Protein Signaling 14: A Molecular Brake on Synaptic Plasticity Linked to Learning and Memory Progress in Molecular Biology and Translational Science. 133: 169-206. DOI: 10.1016/bs.pmbts.2015.03.006 |
0.764 |
|
| 2014 |
Hepler JR. G protein coupled receptor signaling complexes in live cells. Cellular Logistics. 4: e29392. PMID 25279251 DOI: 10.4161/Cl.29392 |
0.484 |
|
| 2014 |
Ghil S, McCoy KL, Hepler JR. Regulator of G protein signaling 2 (RGS2) and RGS4 form distinct G protein-dependent complexes with protease activated-receptor 1 (PAR1) in live cells. Plos One. 9: e95355. PMID 24743392 DOI: 10.1371/Journal.Pone.0095355 |
0.702 |
|
| 2014 |
Evans PR, Lee SE, Smith Y, Hepler JR. Postnatal developmental expression of regulator of G protein signaling 14 (RGS14) in the mouse brain. The Journal of Comparative Neurology. 522: 186-203. PMID 23817783 DOI: 10.1002/Cne.23395 |
0.666 |
|
| 2013 |
Zhao P, Nunn C, Ramineni S, Hepler JR, Chidiac P. The Ras-binding domain region of RGS14 regulates its functional interactions with heterotrimeric G proteins Journal of Cellular Biochemistry. 114: 1414-1423. PMID 23255434 DOI: 10.1002/Jcb.24483 |
0.448 |
|
| 2013 |
Vellano CP, Brown NE, Blumer JB, Hepler JR. Assembly and function of the regulator of G protein signaling 14 (RGS14)·H-Ras signaling complex in live cells are regulated by Gαi1 and Gαi-linked G protein-coupled receptors. The Journal of Biological Chemistry. 288: 3620-31. PMID 23250758 DOI: 10.1074/Jbc.M112.440057 |
0.803 |
|
| 2012 |
McCoy KL, Gyoneva S, Vellano CP, Smrcka AV, Traynelis SF, Hepler JR. Protease-activated receptor 1 (PAR1) coupling to G(q/11) but not to G(i/o) or G(12/13) is mediated by discrete amino acids within the receptor second intracellular loop. Cellular Signalling. 24: 1351-60. PMID 22306780 DOI: 10.1016/J.Cellsig.2012.01.011 |
0.795 |
|
| 2011 |
Vellano CP, Lee SE, Dudek SM, Hepler JR. RGS14 at the interface of hippocampal signaling and synaptic plasticity. Trends in Pharmacological Sciences. 32: 666-74. PMID 21906825 DOI: 10.1016/J.Tips.2011.07.005 |
0.824 |
|
| 2011 |
Vellano CP, Maher EM, Hepler JR, Blumer JB. G protein-coupled receptors and resistance to inhibitors of cholinesterase-8A (Ric-8A) both regulate the regulator of g protein signaling 14 RGS14·Gαi1 complex in live cells. The Journal of Biological Chemistry. 286: 38659-69. PMID 21880739 DOI: 10.1074/Jbc.M111.274928 |
0.757 |
|
| 2011 |
Vellano CP, Shu FJ, Ramineni S, Yates CK, Tall GG, Hepler JR. Activation of the regulator of G protein signaling 14-Gαi1-GDP signaling complex is regulated by resistance to inhibitors of cholinesterase-8A. Biochemistry. 50: 752-62. PMID 21158412 DOI: 10.1021/Bi101910N |
0.761 |
|
| 2010 |
Lee SE, Simons SB, Heldt SA, Zhao M, Schroeder JP, Vellano CP, Cowan DP, Ramineni S, Yates CK, Feng Y, Smith Y, Sweatt JD, Weinshenker D, Ressler KJ, Dudek SM, ... Hepler JR, et al. RGS14 is a natural suppressor of both synaptic plasticity in CA2 neurons and hippocampal-based learning and memory. Proceedings of the National Academy of Sciences of the United States of America. 107: 16994-8. PMID 20837545 DOI: 10.1073/Pnas.1005362107 |
0.805 |
|
| 2010 |
Jernigan KK, Cselenyi CS, Thorne CA, Hanson AJ, Tahinci E, Hajicek N, Oldham WM, Lee LA, Hamm HE, Hepler JR, Kozasa T, Linder ME, Lee E. Gbetagamma activates GSK3 to promote LRP6-mediated beta-catenin transcriptional activity. Science Signaling. 3: ra37. PMID 20460648 DOI: 10.1126/Scisignal.2000647 |
0.731 |
|
| 2010 |
McCoy KL, Traynelis SF, Hepler JR. PAR1 and PAR2 couple to overlapping and distinct sets of G proteins and linked signaling pathways to differentially regulate cell physiology. Molecular Pharmacology. 77: 1005-15. PMID 20215560 DOI: 10.1124/Mol.109.062018 |
0.7 |
|
| 2010 |
Shu FJ, Ramineni S, Hepler JR. RGS14 is a multifunctional scaffold that integrates G protein and Ras/Raf MAPkinase signalling pathways. Cellular Signalling. 22: 366-76. PMID 19878719 DOI: 10.1016/J.Cellsig.2009.10.005 |
0.439 |
|
| 2009 |
McCoy KL, Hepler JR. Regulators of G protein signaling proteins as central components of G protein-coupled receptor signaling complexes. Progress in Molecular Biology and Translational Science. 86: 49-74. PMID 20374713 DOI: 10.1016/S1877-1173(09)86003-1 |
0.728 |
|
| 2009 |
Yuan H, Vance KM, Junge CE, Geballe MT, Snyder JP, Hepler JR, Yepes M, Low CM, Traynelis SF. The serine protease plasmin cleaves the amino-terminal domain of the NR2A subunit to relieve zinc inhibition of the N-methyl-D-aspartate receptors. The Journal of Biological Chemistry. 284: 12862-73. PMID 19240037 DOI: 10.1074/Jbc.M805123200 |
0.35 |
|
| 2008 |
Mannaioni G, Orr AG, Hamill CE, Yuan H, Pedone KH, McCoy KL, Berlinguer Palmini R, Junge CE, Lee CJ, Yepes M, Hepler JR, Traynelis SF. Plasmin potentiates synaptic N-methyl-D-aspartate receptor function in hippocampal neurons through activation of protease-activated receptor-1. The Journal of Biological Chemistry. 283: 20600-11. PMID 18474593 DOI: 10.1074/Jbc.M803015200 |
0.782 |
|
| 2007 |
Gu S, He J, Ho WT, Ramineni S, Thal DM, Natesh R, Tesmer JJ, Hepler JR, Heximer SP. Unique hydrophobic extension of the RGS2 amphipathic helix domain imparts increased plasma membrane binding and function relative to other RGS R4/B subfamily members. The Journal of Biological Chemistry. 282: 33064-75. PMID 17848575 DOI: 10.1074/Jbc.M702685200 |
0.391 |
|
| 2007 |
Pedone KH, Hepler JR. The importance of N-terminal polycysteine and polybasic sequences for G14alpha and G16alpha palmitoylation, plasma membrane localization, and signaling function. The Journal of Biological Chemistry. 282: 25199-212. PMID 17620339 DOI: 10.1074/Jbc.M610297200 |
0.8 |
|
| 2007 |
Ajit SK, Ramineni S, Edris W, Hunt RA, Hum WT, Hepler JR, Young KH. RGSZ1 interacts with protein kinase C interacting protein PKCI-1 and modulates mu opioid receptor signaling. Cellular Signalling. 19: 723-30. PMID 17126529 DOI: 10.1016/J.Cellsig.2006.09.008 |
0.382 |
|
| 2007 |
Shu FJ, Ramineni S, Amyot W, Hepler JR. Selective interactions between Gi alpha1 and Gi alpha3 and the GoLoco/GPR domain of RGS14 influence its dynamic subcellular localization. Cellular Signalling. 19: 163-76. PMID 16870394 DOI: 10.1016/J.Cellsig.2006.06.002 |
0.336 |
|
| 2006 |
Neitzel KL, Hepler JR. Cellular mechanisms that determine selective RGS protein regulation of G protein-coupled receptor signaling. Seminars in Cell & Developmental Biology. 17: 383-9. PMID 16647283 DOI: 10.1016/J.Semcdb.2006.03.002 |
0.55 |
|
| 2006 |
Hubbard KB, Hepler JR. Cell signalling diversity of the Gqalpha family of heterotrimeric G proteins. Cellular Signalling. 18: 135-50. PMID 16182515 DOI: 10.1016/J.Cellsig.2005.08.004 |
0.505 |
|
| 2006 |
Roy AA, Baragli A, Bernstein LS, Hepler JR, Hébert TE, Chidiac P. RGS2 interacts with Gs and adenylyl cyclase in living cells. Cellular Signalling. 18: 336-48. PMID 16095880 DOI: 10.1016/J.Cellsig.2005.05.004 |
0.527 |
|
| 2005 |
Hepler JR. R7BP: a surprising new link between G proteins, RGS proteins, and nuclear signaling in the brain. Science's Stke : Signal Transduction Knowledge Environment. 2005: pe38. PMID 16046666 DOI: 10.1126/Stke.2942005Pe38 |
0.517 |
|
| 2005 |
Hague C, Bernstein LS, Ramineni S, Chen Z, Minneman KP, Hepler JR. Selective inhibition of alpha1A-adrenergic receptor signaling by RGS2 association with the receptor third intracellular loop. The Journal of Biological Chemistry. 280: 27289-95. PMID 15917235 DOI: 10.1074/Jbc.M502365200 |
0.509 |
|
| 2005 |
Nicole O, Goldshmidt A, Hamill CE, Sorensen SD, Sastre A, Lyuboslavsky P, Hepler JR, McKeon RJ, Traynelis SF. Activation of protease-activated receptor-1 triggers astrogliosis after brain injury. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 4319-29. PMID 15858058 DOI: 10.1523/Jneurosci.5200-04.2005 |
0.381 |
|
| 2005 |
Hepler JR, Cladman W, Ramineni S, Hollinger S, Chidiac P. Novel activity of RGS14 on Goalpha and Gialpha nucleotide binding and hydrolysis distinct from its RGS domain and GDI activity. Biochemistry. 44: 5495-502. PMID 15807543 DOI: 10.1021/Bi048359D |
0.699 |
|
| 2005 |
Peavy RD, Hubbard KB, Lau A, Fields RB, Xu K, Lee CJ, Lee TT, Gernert K, Murphy TJ, Hepler JR. Differential effects of Gq alpha, G14 alpha, and G15 alpha on vascular smooth muscle cell survival and gene expression profiles. Molecular Pharmacology. 67: 2102-14. PMID 15788742 DOI: 10.1124/Mol.104.007799 |
0.415 |
|
| 2004 |
Junge CE, Lee CJ, Hubbard KB, Zhang Z, Olson JJ, Hepler JR, Brat DJ, Traynelis SF. Protease-activated receptor-1 in human brain: localization and functional expression in astrocytes. Experimental Neurology. 188: 94-103. PMID 15191806 DOI: 10.1016/J.Expneurol.2004.02.018 |
0.38 |
|
| 2004 |
Bernstein LS, Ramineni S, Hague C, Cladman W, Chidiac P, Levey AI, Hepler JR. RGS2 binds directly and selectively to the M1 muscarinic acetylcholine receptor third intracellular loop to modulate Gq/11alpha signaling. The Journal of Biological Chemistry. 279: 21248-56. PMID 14976183 DOI: 10.1074/Jbc.M312407200 |
0.524 |
|
| 2004 |
Hollinger S, Hepler JR. Methods for measuring RGS protein phosphorylation by G protein-regulated kinases. Methods in Molecular Biology (Clifton, N.J.). 237: 205-19. PMID 14501052 DOI: 10.1385/1-59259-430-1:205 |
0.749 |
|
| 2004 |
Bernstein LS, Linder ME, Hepler JR. Analysis of RGS protein palmitoylation. Methods in Molecular Biology (Clifton, N.J.). 237: 195-204. PMID 14501051 DOI: 10.1385/1-59259-430-1:195 |
0.648 |
|
| 2003 |
Sorensen SD, Nicole O, Peavy RD, Montoya LM, Lee CJ, Murphy TJ, Traynelis SF, Hepler JR. Common signaling pathways link activation of murine PAR-1, LPA, and S1P receptors to proliferation of astrocytes. Molecular Pharmacology. 64: 1199-209. PMID 14573770 DOI: 10.1124/Mol.64.5.1199 |
0.432 |
|
| 2003 |
Hepler JR. RGS protein and G protein interactions: a little help from their friends. Molecular Pharmacology. 64: 547-9. PMID 12920189 DOI: 10.1124/Mol.64.3.547 |
0.525 |
|
| 2003 |
Hollinger S, Ramineni S, Hepler JR. Phosphorylation of RGS14 by protein kinase A potentiates its activity toward G alpha i. Biochemistry. 42: 811-9. PMID 12534294 DOI: 10.1021/Bi026664Y |
0.741 |
|
| 2002 |
Hollinger S, Hepler JR. Cellular regulation of RGS proteins: modulators and integrators of G protein signaling. Pharmacological Reviews. 54: 527-59. PMID 12223533 DOI: 10.1124/Pr.54.3.527 |
0.778 |
|
| 2002 |
Chidiac P, Gadd ME, Hepler JR. Measuring RGS protein interactions with Gq alpha. Methods in Enzymology. 344: 686-702. PMID 11771420 DOI: 10.1016/S0076-6879(02)44749-0 |
0.352 |
|
| 2001 |
Hollinger S, Taylor JB, Goldman EH, Hepler JR. RGS14 is a bifunctional regulator of Galphai/o activity that exists in multiple populations in brain. Journal of Neurochemistry. 79: 941-9. PMID 11739605 DOI: 10.1046/J.1471-4159.2001.00629.X |
0.716 |
|
| 2001 |
Cunningham ML, Waldo GL, Hollinger S, Hepler JR, Harden TK. Protein kinase C phosphorylates RGS2 and modulates its capacity for negative regulation of Galpha 11 signaling. The Journal of Biological Chemistry. 276: 5438-44. PMID 11063746 DOI: 10.1074/Jbc.M007699200 |
0.79 |
|
| 2000 |
Rose JJ, Taylor JB, Shi J, Cockett MI, Jones PG, Hepler JR. RGS7 is palmitoylated and exists as biochemically distinct forms. Journal of Neurochemistry. 75: 2103-12. PMID 11032900 DOI: 10.1046/J.1471-4159.2000.0752103.X |
0.442 |
|
| 1999 |
Heximer SP, Srinivasa SP, Bernstein LS, Bernard JL, Linder ME, Hepler JR, Blumer KJ. G protein selectivity is a determinant of RGS2 function. The Journal of Biological Chemistry. 274: 34253-9. PMID 10567399 DOI: 10.1074/Jbc.274.48.34253 |
0.774 |
|
| 1999 |
Hepler JR. Emerging roles for RGS proteins in cell signalling. Trends in Pharmacological Sciences. 20: 376-82. PMID 10462761 DOI: 10.1016/S0165-6147(99)01369-3 |
0.525 |
|
| 1998 |
Saugstad JA, Marino MJ, Folk JA, Hepler JR, Conn PJ. RGS4 inhibits signaling by group I metabotropic glutamate receptors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 905-13. PMID 9437012 DOI: 10.1523/Jneurosci.18-03-00905.1998 |
0.55 |
|
| 1997 |
Heximer SP, Watson N, Linder ME, Blumer KJ, Hepler JR. RGS2/G0S8 is a selective inhibitor of Gqalpha function. Proceedings of the National Academy of Sciences of the United States of America. 94: 14389-93. PMID 9405622 DOI: 10.1073/Pnas.94.26.14389 |
0.772 |
|
| 1997 |
Huang C, Hepler JR, Chen LT, Gilman AG, Anderson RG, Mumby SM. Organization of G proteins and adenylyl cyclase at the plasma membrane. Molecular Biology of the Cell. 8: 2365-78. PMID 9398661 DOI: 10.1091/Mbc.8.12.2365 |
0.63 |
|
| 1997 |
Huang C, Hepler JR, Gilman AG, Mumby SM. Attenuation of Gi- and Gq-mediated signaling by expression of RGS4 or GAIP in mammalian cells. Proceedings of the National Academy of Sciences of the United States of America. 94: 6159-63. PMID 9177187 DOI: 10.1073/Pnas.94.12.6159 |
0.71 |
|
| 1997 |
Hepler JR, Berman DM, Gilman AG, Kozasa T. RGS4 and GAIP are GTPase-activating proteins for Gq alpha and block activation of phospholipase C beta by gamma-thio-GTP-Gq alpha. Proceedings of the National Academy of Sciences of the United States of America. 94: 428-32. PMID 9012799 DOI: 10.1073/Pnas.94.2.428 |
0.668 |
|
| 1996 |
Hepler JR, Biddlecome GH, Kleuss C, Camp LA, Hofmann SL, Ross EM, Gilman AG. Functional importance of the amino terminus of Gq alpha. The Journal of Biological Chemistry. 271: 496-504. PMID 8550609 DOI: 10.1074/Jbc.271.1.496 |
0.703 |
|
| 1994 |
Taussig R, Tang WJ, Hepler JR, Gilman AG. Distinct patterns of bidirectional regulation of mammalian adenylyl cyclases. The Journal of Biological Chemistry. 269: 6093-100. PMID 8119955 |
0.556 |
|
| 1994 |
Hepler JR, Kozasa T, Gilman AG. Purification of recombinant Gq alpha, G11 alpha, and G16 alpha from Sf9 cells. Methods in Enzymology. 237: 191-212. PMID 7934997 DOI: 10.1016/S0076-6879(94)37063-X |
0.585 |
|
| 1993 |
Linder ME, Middleton P, Hepler JR, Taussig R, Gilman AG, Mumby SM. Lipid modifications of G proteins: alpha subunits are palmitoylated. Proceedings of the National Academy of Sciences of the United States of America. 90: 3675-9. PMID 8475115 DOI: 10.1073/Pnas.90.8.3675 |
0.68 |
|
| 1993 |
Kozasa T, Hepler JR, Smrcka AV, Simon MI, Rhee SG, Sternweis PC, Gilman AG. Purification and characterization of recombinant G16 alpha from Sf9 cells: activation of purified phospholipase C isozymes by G-protein alpha subunits. Proceedings of the National Academy of Sciences of the United States of America. 90: 9176-80. PMID 8415674 DOI: 10.1073/Pnas.90.19.9176 |
0.727 |
|
| 1993 |
Hepler JR, Kozasa T, Smrcka AV, Simon MI, Rhee SG, Sternweis PC, Gilman AG. Purification from Sf9 cells and characterization of recombinant Gq alpha and G11 alpha. Activation of purified phospholipase C isozymes by G alpha subunits. The Journal of Biological Chemistry. 268: 14367-75. PMID 8314796 |
0.508 |
|
| 1993 |
Lee SB, Shin SH, Hepler JR, Gilman AG, Rhee SG. Activation of phospholipase C-beta 2 mutants by G protein alpha q and beta gamma subunits. The Journal of Biological Chemistry. 268: 25952-7. PMID 8245028 |
0.49 |
|
| 1992 |
Hepler JR, Gilman AG. G proteins. Trends in Biochemical Sciences. 17: 383-7. PMID 1455506 DOI: 10.1016/0968-0004(92)90005-T |
0.656 |
|
| 1991 |
Smrcka AV, Hepler JR, Brown KO, Sternweis PC. Regulation of polyphosphoinositide-specific phospholipase C activity by purified Gq. Science (New York, N.Y.). 251: 804-7. PMID 1846707 DOI: 10.1126/Science.1846707 |
0.728 |
|
| 1990 |
Morris AJ, Waldo GL, Boyer JL, Hepler JR, Downes CP, Harden TK. Regulation of phospholipase C. Society of General Physiologists Series. 45: 61-75. PMID 2116041 |
0.425 |
|
| 1990 |
Huckle WR, Hepler JR, Rhee SG, Harden TK, Earp HS. Protein kinase C inhibits epidermal growth factor-dependent tyrosine phosphorylation of phospholipase C gamma and activation of phosphoinositide hydrolysis. Endocrinology. 127: 1697-705. PMID 1698145 DOI: 10.1210/Endo-127-4-1697 |
0.571 |
|
| 1990 |
Hepler JR, Jeffs RA, Huckle WR, Outlaw HE, Rhee SG, Earp HS, Harden TK. Evidence that the epidermal growth factor receptor and non-tyrosine kinase hormone receptors stimulate phosphoinositide hydrolysis by independent pathways. The Biochemical Journal. 270: 337-44. PMID 1698055 DOI: 10.1042/Bj2700337 |
0.553 |
|
| 1989 |
Roe MW, Hepler JR, Harden TK, Herman B. Platelet-derived growth factor and angiotensin II cause increases in cytosolic free calcium by different mechanisms in vascular smooth muscle cells. Journal of Cellular Physiology. 139: 100-8. PMID 2708448 DOI: 10.1002/Jcp.1041390115 |
0.548 |
|
| 1989 |
Boyer JL, Hepler JR, Harden TK. Hormone and growth factor receptor-mediated regulation of phospholipase C activity. Trends in Pharmacological Sciences. 10: 360-4. PMID 2557690 DOI: 10.1016/0165-6147(89)90008-4 |
0.6 |
|
| 1988 |
Hepler JR, Earp HS, Harden TK. Long-term phorbol ester treatment down-regulates protein kinase C and sensitizes the phosphoinositide signaling pathway to hormone and growth factor stimulation. Evidence for a role of protein kinase C in agonist-induced desensitization. The Journal of Biological Chemistry. 263: 7610-9. PMID 2836390 |
0.515 |
|
| 1987 |
Hepler JR, Nakahata N, Lovenberg TW, DiGuiseppi J, Herman B, Earp HS, Harden TK. Epidermal growth factor stimulates the rapid accumulation of inositol (1,4,5)-trisphosphate and a rise in cytosolic calcium mobilized from intracellular stores in A431 cells. The Journal of Biological Chemistry. 262: 2951-6. PMID 3102480 |
0.478 |
|
| 1987 |
Hepler JR, Hughes AR, Harden TK. Evidence that muscarinic cholinergic receptors selectively interact with either the cyclic AMP or the inositol phosphate second-messenger response systems. The Biochemical Journal. 247: 793-6. PMID 2827638 DOI: 10.1042/Bj2470793 |
0.561 |
|
| 1987 |
Pallotta BS, Hepler JR, Oglesby SA, Harden TK. A comparison of calcium-activated potassium channel currents in cell-attached and excised patches. The Journal of General Physiology. 89: 985-97. PMID 2440980 DOI: 10.1085/Jgp.89.6.985 |
0.539 |
|
| 1986 |
Hepler JR, Harden TK. Guanine nucleotide-dependent pertussis-toxin-insensitive stimulation of inositol phosphate formation by carbachol in a membrane preparation from human astrocytoma cells. The Biochemical Journal. 239: 141-6. PMID 3800973 DOI: 10.1042/Bj2390141 |
0.574 |
|
| 1986 |
Nakahata N, Martin MW, Hughes AR, Hepler JR, Harden TK. H1-histamine receptors on human astrocytoma cells. Molecular Pharmacology. 29: 188-95. PMID 2419744 |
0.502 |
|
| 1985 |
Evans T, Hepler JR, Masters SB, Brown JH, Harden TK. Guanine nucleotide regulation of agonist binding to muscarinic cholinergic receptors. Relation to efficacy of agonists for stimulation of phosphoinositide breakdown and Ca2+ mobilization. The Biochemical Journal. 232: 751-7. PMID 3004418 |
0.512 |
|
| 1985 |
Harden TK, Evans T, Hepler JR, Hughes AR, Martin MW, Meeker RB, Smith MM, Tanner LI. Regulation of cyclic AMP metabolism by muscarinic cholinergic receptors. Advances in Cyclic Nucleotide and Protein Phosphorylation Research. 19: 207-20. PMID 2988297 |
0.534 |
|
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