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John Raymond Hepler - Publications

Affiliations: 
1996- Pharmacology Emory University School of Medicine, Atlanta, GA, United States 
Area:
G protein signaling, RGS proteins, GPCR
Website:
http://www.pharm.emory.edu/people/primary/hepler-john.html

95 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Gerber KJ, Squires KE, Hepler JR. Correction: 14-3-3γ binds regulator of G protein signaling 14 (RGS14) at distinct sites to inhibit the RGS14:Gα-AlF signaling complex and RGS14 nuclear localization. The Journal of Biological Chemistry. 294: 12262. PMID 31399537 DOI: 10.1074/jbc.AAC119.101131  0.92
2019 Gerber KJ, Dammer EB, Duong DM, Deng Q, Dudek SM, Seyfried NT, Hepler JR. Specific Proteomes of Hippocampal Regions CA2 and CA1 Reveal Proteins Linked to the Unique Physiology of Area CA2. Journal of Proteome Research. PMID 31059263 DOI: 10.1021/acs.jproteome.9b00103  0.92
2018 Gerber KJ, Squires KE, Hepler JR. 14-3-3γ binds RGS14 at distinct sites to inhibit the RGS14:Gαi-AlFsignaling complex and RGS14 nuclear localization. The Journal of Biological Chemistry. PMID 30093406 DOI: 10.1074/jbc.RA118.002816  0.92
2018 Evans PR, Parra-Bueno P, Smirnov MS, Lustberg DJ, Dudek SM, Hepler JR, Yasuda R. RGS14 Restricts Plasticity in Hippocampal CA2 by Limiting Postsynaptic Calcium Signaling. Eneuro. 5. PMID 29911178 DOI: 10.1523/ENEURO.0353-17.2018  0.92
2018 Squires KE, Montañez-Miranda C, Pandya RR, Torres MP, Hepler JR. Genetic Analysis of Rare Human Variants of Regulators of G Protein Signaling Proteins and Their Role in Human Physiology and Disease. Pharmacological Reviews. 70: 446-474. PMID 29871944 DOI: 10.1124/pr.117.015354  0.92
2018 Evans PR, Gerber KJ, Dammer EB, Duong DM, Goswami D, Lustberg DJ, Zou J, Yang JJ, Dudek SM, Griffin PR, Seyfried NT, Hepler JR. Interactome Analysis Reveals Regulator of G Protein Signaling 14 (RGS14) is a Novel Calcium/Calmodulin (Ca2+/CaM) and CaM Kinase II (CaMKII) Binding Partner. Journal of Proteome Research. PMID 29518331 DOI: 10.1021/acs.jproteome.8b00027  0.92
2017 Zou J, Salarian M, Chen Y, Zhuo Y, Brown NE, Hepler JR, Yang J. Direct Visualization of Interaction between Calmodulin and Connexin45. The Biochemical Journal. PMID 28963343 DOI: 10.1042/BCJ20170426  0.48
2017 Branch MR, Hepler JR. Endogenous RGS14 is a cytoplasmic-nuclear shuttling protein that localizes to juxtanuclear membranes and chromatin-rich regions of the nucleus. Plos One. 12: e0184497. PMID 28934222 DOI: 10.1371/journal.pone.0184497  1
2017 Squires KE, Gerber KJ, Pare JF, Branch MR, Smith Y, Hepler JR. Regulator of G protein signaling 14 (RGS14) is expressed pre- and postsynaptically in neurons of hippocampus, basal ganglia, and amygdala of monkey and human brain. Brain Structure & Function. PMID 28776200 DOI: 10.1007/s00429-017-1487-y  1
2016 Brown NE, Lambert NA, Hepler JR. RGS14 regulates the lifetime of Gα-GTP signaling but does not prolong Gβγ signaling following receptor activation in live cells. Pharmacology Research & Perspectives. 4: e00249. PMID 27713821 DOI: 10.1002/prp2.249  0.48
2015 Gerber KJ, Squires KE, Hepler JR. Roles for Regulator of G protein Signaling (RGS) Proteins in Synaptic Signaling and Plasticity. Molecular Pharmacology. PMID 26655302 DOI: 10.1124/mol.115.102210  1
2015 Brown NE, Blumer JB, Hepler JR. Bioluminescence resonance energy transfer to detect protein-protein interactions in live cells. Methods in Molecular Biology (Clifton, N.J.). 1278: 457-65. PMID 25859969 DOI: 10.1007/978-1-4939-2425-7_30  1
2015 Brown NE, Goswami D, Branch MR, Ramineni S, Ortlund EA, Griffin PR, Hepler JR. Integration of G protein α (Gα) signaling by the regulator of G protein signaling 14 (RGS14). The Journal of Biological Chemistry. 290: 9037-49. PMID 25666614 DOI: 10.1074/jbc.M114.634329  1
2015 Evans PR, Dudek SM, Hepler JR. Regulator of G Protein Signaling 14: A Molecular Brake on Synaptic Plasticity Linked to Learning and Memory Progress in Molecular Biology and Translational Science. 133: 169-206. DOI: 10.1016/bs.pmbts.2015.03.006  1
2014 Ghil S, McCoy KL, Hepler JR. Regulator of G protein signaling 2 (RGS2) and RGS4 form distinct G protein-dependent complexes with protease activated-receptor 1 (PAR1) in live cells. Plos One. 9: e95355. PMID 24743392 DOI: 10.1371/journal.pone.0095355  1
2014 Evans PR, Lee SE, Smith Y, Hepler JR. Postnatal developmental expression of regulator of G protein signaling 14 (RGS14) in the mouse brain. The Journal of Comparative Neurology. 522: 186-203. PMID 23817783 DOI: 10.1002/cne.23395  1
2013 Zhao P, Nunn C, Ramineni S, Hepler JR, Chidiac P. The Ras-binding domain region of RGS14 regulates its functional interactions with heterotrimeric G proteins Journal of Cellular Biochemistry. 114: 1414-1423. PMID 23255434 DOI: 10.1002/jcb.24483  1
2013 Vellano CP, Brown NE, Blumer JB, Hepler JR. Assembly and function of the regulator of G protein signaling 14 (RGS14)·H-Ras signaling complex in live cells are regulated by Gαi1 and Gαi-linked G protein-coupled receptors. The Journal of Biological Chemistry. 288: 3620-31. PMID 23250758 DOI: 10.1074/jbc.M112.440057  1
2012 McCoy KL, Gyoneva S, Vellano CP, Smrcka AV, Traynelis SF, Hepler JR. Protease-activated receptor 1 (PAR1) coupling to G(q/11) but not to G(i/o) or G(12/13) is mediated by discrete amino acids within the receptor second intracellular loop. Cellular Signalling. 24: 1351-60. PMID 22306780 DOI: 10.1016/j.cellsig.2012.01.011  1
2011 Vellano CP, Lee SE, Dudek SM, Hepler JR. RGS14 at the interface of hippocampal signaling and synaptic plasticity. Trends in Pharmacological Sciences. 32: 666-74. PMID 21906825 DOI: 10.1016/j.tips.2011.07.005  1
2011 Vellano CP, Maher EM, Hepler JR, Blumer JB. G protein-coupled receptors and resistance to inhibitors of cholinesterase-8A (Ric-8A) both regulate the regulator of g protein signaling 14 RGS14·Gαi1 complex in live cells. The Journal of Biological Chemistry. 286: 38659-69. PMID 21880739 DOI: 10.1074/jbc.M111.274928  1
2011 Vellano CP, Shu FJ, Ramineni S, Yates CK, Tall GG, Hepler JR. Activation of the regulator of G protein signaling 14-Gαi1-GDP signaling complex is regulated by resistance to inhibitors of cholinesterase-8A. Biochemistry. 50: 752-62. PMID 21158412 DOI: 10.1021/bi101910n  1
2010 Lee SE, Simons SB, Heldt SA, Zhao M, Schroeder JP, Vellano CP, Cowan DP, Ramineni S, Yates CK, Feng Y, Smith Y, Sweatt JD, Weinshenker D, Ressler KJ, Dudek SM, Hepler JR, et al. RGS14 is a natural suppressor of both synaptic plasticity in CA2 neurons and hippocampal-based learning and memory. Proceedings of the National Academy of Sciences of the United States of America. 107: 16994-8. PMID 20837545 DOI: 10.1073/pnas.1005362107  1
2010 Jernigan KK, Cselenyi CS, Thorne CA, Hanson AJ, Tahinci E, Hajicek N, Oldham WM, Lee LA, Hamm HE, Hepler JR, Kozasa T, Linder ME, Lee E. Gbetagamma activates GSK3 to promote LRP6-mediated beta-catenin transcriptional activity. Science Signaling. 3: ra37. PMID 20460648 DOI: 10.1126/scisignal.2000647  1
2010 McCoy KL, Traynelis SF, Hepler JR. PAR1 and PAR2 couple to overlapping and distinct sets of G proteins and linked signaling pathways to differentially regulate cell physiology. Molecular Pharmacology. 77: 1005-15. PMID 20215560 DOI: 10.1124/mol.109.062018  1
2010 Shu FJ, Ramineni S, Hepler JR. RGS14 is a multifunctional scaffold that integrates G protein and Ras/Raf MAPkinase signalling pathways. Cellular Signalling. 22: 366-76. PMID 19878719 DOI: 10.1016/j.cellsig.2009.10.005  1
2009 McCoy KL, Hepler JR. Regulators of G protein signaling proteins as central components of G protein-coupled receptor signaling complexes. Progress in Molecular Biology and Translational Science. 86: 49-74. PMID 20374713 DOI: 10.1016/S1877-1173(09)86003-1  1
2009 Yuan H, Vance KM, Junge CE, Geballe MT, Snyder JP, Hepler JR, Yepes M, Low CM, Traynelis SF. The serine protease plasmin cleaves the amino-terminal domain of the NR2A subunit to relieve zinc inhibition of the N-methyl-D-aspartate receptors. The Journal of Biological Chemistry. 284: 12862-73. PMID 19240037 DOI: 10.1074/jbc.M805123200  1
2008 Mannaioni G, Orr AG, Hamill CE, Yuan H, Pedone KH, McCoy KL, Berlinguer Palmini R, Junge CE, Lee CJ, Yepes M, Hepler JR, Traynelis SF. Plasmin potentiates synaptic N-methyl-D-aspartate receptor function in hippocampal neurons through activation of protease-activated receptor-1. The Journal of Biological Chemistry. 283: 20600-11. PMID 18474593 DOI: 10.1074/jbc.M803015200  1
2007 Gu S, He J, Ho WT, Ramineni S, Thal DM, Natesh R, Tesmer JJ, Hepler JR, Heximer SP. Unique hydrophobic extension of the RGS2 amphipathic helix domain imparts increased plasma membrane binding and function relative to other RGS R4/B subfamily members. The Journal of Biological Chemistry. 282: 33064-75. PMID 17848575 DOI: 10.1074/jbc.M702685200  1
2007 Pedone KH, Hepler JR. The importance of N-terminal polycysteine and polybasic sequences for G14alpha and G16alpha palmitoylation, plasma membrane localization, and signaling function. The Journal of Biological Chemistry. 282: 25199-212. PMID 17620339 DOI: 10.1074/jbc.M610297200  1
2007 Ajit SK, Ramineni S, Edris W, Hunt RA, Hum WT, Hepler JR, Young KH. RGSZ1 interacts with protein kinase C interacting protein PKCI-1 and modulates mu opioid receptor signaling. Cellular Signalling. 19: 723-30. PMID 17126529 DOI: 10.1016/j.cellsig.2006.09.008  1
2007 Shu FJ, Ramineni S, Amyot W, Hepler JR. Selective interactions between Gi alpha1 and Gi alpha3 and the GoLoco/GPR domain of RGS14 influence its dynamic subcellular localization. Cellular Signalling. 19: 163-76. PMID 16870394 DOI: 10.1016/j.cellsig.2006.06.002  1
2006 Neitzel KL, Hepler JR. Cellular mechanisms that determine selective RGS protein regulation of G protein-coupled receptor signaling. Seminars in Cell & Developmental Biology. 17: 383-9. PMID 16647283 DOI: 10.1016/j.semcdb.2006.03.002  1
2006 Hubbard KB, Hepler JR. Cell signalling diversity of the Gqalpha family of heterotrimeric G proteins. Cellular Signalling. 18: 135-50. PMID 16182515 DOI: 10.1016/j.cellsig.2005.08.004  1
2006 Roy AA, Baragli A, Bernstein LS, Hepler JR, Hébert TE, Chidiac P. RGS2 interacts with Gs and adenylyl cyclase in living cells. Cellular Signalling. 18: 336-48. PMID 16095880 DOI: 10.1016/j.cellsig.2005.05.004  1
2005 Hepler JR. R7BP: a surprising new link between G proteins, RGS proteins, and nuclear signaling in the brain. Science's Stke : Signal Transduction Knowledge Environment. 2005: pe38. PMID 16046666 DOI: 10.1126/stke.2942005pe38  1
2005 Hague C, Bernstein LS, Ramineni S, Chen Z, Minneman KP, Hepler JR. Selective inhibition of alpha1A-adrenergic receptor signaling by RGS2 association with the receptor third intracellular loop. The Journal of Biological Chemistry. 280: 27289-95. PMID 15917235 DOI: 10.1074/jbc.M502365200  1
2005 Nicole O, Goldshmidt A, Hamill CE, Sorensen SD, Sastre A, Lyuboslavsky P, Hepler JR, McKeon RJ, Traynelis SF. Activation of protease-activated receptor-1 triggers astrogliosis after brain injury. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 4319-29. PMID 15858058 DOI: 10.1523/JNEUROSCI.5200-04.2005  1
2005 Hepler JR, Cladman W, Ramineni S, Hollinger S, Chidiac P. Novel activity of RGS14 on Goalpha and Gialpha nucleotide binding and hydrolysis distinct from its RGS domain and GDI activity. Biochemistry. 44: 5495-502. PMID 15807543 DOI: 10.1021/bi048359d  1
2005 Peavy RD, Hubbard KB, Lau A, Fields RB, Xu K, Lee CJ, Lee TT, Gernert K, Murphy TJ, Hepler JR. Differential effects of Gq alpha, G14 alpha, and G15 alpha on vascular smooth muscle cell survival and gene expression profiles. Molecular Pharmacology. 67: 2102-14. PMID 15788742 DOI: 10.1124/mol.104.007799  1
2004 Junge CE, Lee CJ, Hubbard KB, Zhang Z, Olson JJ, Hepler JR, Brat DJ, Traynelis SF. Protease-activated receptor-1 in human brain: localization and functional expression in astrocytes. Experimental Neurology. 188: 94-103. PMID 15191806 DOI: 10.1016/j.expneurol.2004.02.018  1
2004 Bernstein LS, Ramineni S, Hague C, Cladman W, Chidiac P, Levey AI, Hepler JR. RGS2 binds directly and selectively to the M1 muscarinic acetylcholine receptor third intracellular loop to modulate Gq/11alpha signaling. The Journal of Biological Chemistry. 279: 21248-56. PMID 14976183 DOI: 10.1074/jbc.M312407200  1
2004 Hollinger S, Hepler JR. Methods for measuring RGS protein phosphorylation by G protein-regulated kinases. Methods in Molecular Biology (Clifton, N.J.). 237: 205-19. PMID 14501052  1
2004 Bernstein LS, Linder ME, Hepler JR. Analysis of RGS protein palmitoylation. Methods in Molecular Biology (Clifton, N.J.). 237: 195-204. PMID 14501051  1
2003 Sorensen SD, Nicole O, Peavy RD, Montoya LM, Lee CJ, Murphy TJ, Traynelis SF, Hepler JR. Common signaling pathways link activation of murine PAR-1, LPA, and S1P receptors to proliferation of astrocytes. Molecular Pharmacology. 64: 1199-209. PMID 14573770 DOI: 10.1124/mol.64.5.1199  1
2003 Hepler JR. RGS protein and G protein interactions: a little help from their friends. Molecular Pharmacology. 64: 547-9. PMID 12920189 DOI: 10.1124/mol.64.3.547  1
2003 Hollinger S, Ramineni S, Hepler JR. Phosphorylation of RGS14 by protein kinase A potentiates its activity toward G alpha i. Biochemistry. 42: 811-9. PMID 12534294 DOI: 10.1021/bi026664y  1
2002 Hollinger S, Hepler JR. Cellular regulation of RGS proteins: modulators and integrators of G protein signaling. Pharmacological Reviews. 54: 527-59. PMID 12223533 DOI: 10.1124/pr.54.3.527  1
2002 Chidiac P, Gadd ME, Hepler JR. Measuring RGS protein interactions with Gq alpha. Methods in Enzymology. 344: 686-702. PMID 11771420 DOI: 10.1016/S0076-6879(02)44749-0  1
2001 Hollinger S, Taylor JB, Goldman EH, Hepler JR. RGS14 is a bifunctional regulator of Galphai/o activity that exists in multiple populations in brain. Journal of Neurochemistry. 79: 941-9. PMID 11739605 DOI: 10.1046/j.1471-4159.2001.00629.x  1
2001 Cunningham ML, Waldo GL, Hollinger S, Hepler JR, Harden TK. Protein kinase C phosphorylates RGS2 and modulates its capacity for negative regulation of Galpha 11 signaling. The Journal of Biological Chemistry. 276: 5438-44. PMID 11063746 DOI: 10.1074/jbc.M007699200  1
2000 Rose JJ, Taylor JB, Shi J, Cockett MI, Jones PG, Hepler JR. RGS7 is palmitoylated and exists as biochemically distinct forms. Journal of Neurochemistry. 75: 2103-12. PMID 11032900 DOI: 10.1046/j.1471-4159.2000.0752103.x  1
1999 Heximer SP, Srinivasa SP, Bernstein LS, Bernard JL, Linder ME, Hepler JR, Blumer KJ. G protein selectivity is a determinant of RGS2 function. The Journal of Biological Chemistry. 274: 34253-9. PMID 10567399 DOI: 10.1074/jbc.274.48.34253  1
1999 Hepler JR. Emerging roles for RGS proteins in cell signalling. Trends in Pharmacological Sciences. 20: 376-82. PMID 10462761 DOI: 10.1016/S0165-6147(99)01369-3  1
1998 Saugstad JA, Marino MJ, Folk JA, Hepler JR, Conn PJ. RGS4 inhibits signaling by group I metabotropic glutamate receptors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 905-13. PMID 9437012  1
1997 Heximer SP, Watson N, Linder ME, Blumer KJ, Hepler JR. RGS2/G0S8 is a selective inhibitor of Gqalpha function. Proceedings of the National Academy of Sciences of the United States of America. 94: 14389-93. PMID 9405622 DOI: 10.1073/pnas.94.26.14389  1
1997 Huang C, Hepler JR, Chen LT, Gilman AG, Anderson RG, Mumby SM. Organization of G proteins and adenylyl cyclase at the plasma membrane. Molecular Biology of the Cell. 8: 2365-78. PMID 9398661  1
1997 Huang C, Hepler JR, Gilman AG, Mumby SM. Attenuation of Gi- and Gq-mediated signaling by expression of RGS4 or GAIP in mammalian cells. Proceedings of the National Academy of Sciences of the United States of America. 94: 6159-63. PMID 9177187 DOI: 10.1073/pnas.94.12.6159  1
1997 Hepler JR, Berman DM, Gilman AG, Kozasa T. RGS4 and GAIP are GTPase-activating proteins for Gq alpha and block activation of phospholipase C beta by gamma-thio-GTP-Gq alpha. Proceedings of the National Academy of Sciences of the United States of America. 94: 428-32. PMID 9012799 DOI: 10.1073/pnas.94.2.428  1
1997 Huang C, Hepler JR, Caiman AG, Mumby SM. Attenuation of Gi- and Gq-mediated signaling by expression of RGS4 or GAIP in mammalian cells Faseb Journal. 11: A1326.  1
1996 Hepler JR, Biddlecome GH, Kleuss C, Camp LA, Hofmann SL, Ross EM, Gilman AG. Functional importance of the amino terminus of Gq alpha. The Journal of Biological Chemistry. 271: 496-504. PMID 8550609  1
1994 Taussig R, Tang WJ, Hepler JR, Gilman AG. Distinct patterns of bidirectional regulation of mammalian adenylyl cyclases. The Journal of Biological Chemistry. 269: 6093-100. PMID 8119955  1
1994 Hepler JR, Kozasa T, Gilman AG. Purification of recombinant Gq alpha, G11 alpha, and G16 alpha from Sf9 cells. Methods in Enzymology. 237: 191-212. PMID 7934997 DOI: 10.1016/S0076-6879(94)37063-X  1
1993 Linder ME, Middleton P, Hepler JR, Taussig R, Gilman AG, Mumby SM. Lipid modifications of G proteins: alpha subunits are palmitoylated. Proceedings of the National Academy of Sciences of the United States of America. 90: 3675-9. PMID 8475115  1
1993 Kozasa T, Hepler JR, Smrcka AV, Simon MI, Rhee SG, Sternweis PC, Gilman AG. Purification and characterization of recombinant G16 alpha from Sf9 cells: activation of purified phospholipase C isozymes by G-protein alpha subunits. Proceedings of the National Academy of Sciences of the United States of America. 90: 9176-80. PMID 8415674  1
1993 Hepler JR, Kozasa T, Smrcka AV, Simon MI, Rhee SG, Sternweis PC, Gilman AG. Purification from Sf9 cells and characterization of recombinant Gq alpha and G11 alpha. Activation of purified phospholipase C isozymes by G alpha subunits. The Journal of Biological Chemistry. 268: 14367-75. PMID 8314796  1
1993 Lee SB, Shin SH, Hepler JR, Gilman AG, Rhee SG. Activation of phospholipase C-beta 2 mutants by G protein alpha q and beta gamma subunits. The Journal of Biological Chemistry. 268: 25952-7. PMID 8245028  1
1992 Hepler JR, Gilman AG. G proteins. Trends in Biochemical Sciences. 17: 383-7. PMID 1455506 DOI: 10.1016/0968-0004(92)90005-T  1
1991 Smrcka AV, Hepler JR, Brown KO, Sternweis PC. Regulation of polyphosphoinositide-specific phospholipase C activity by purified Gq. Science (New York, N.Y.). 251: 804-7. PMID 1846707  1
1990 Morris AJ, Waldo GL, Boyer JL, Hepler JR, Downes CP, Harden TK. Regulation of phospholipase C. Society of General Physiologists Series. 45: 61-75. PMID 2116041  1
1990 Huckle WR, Hepler JR, Rhee SG, Harden TK, Earp HS. Protein kinase C inhibits epidermal growth factor-dependent tyrosine phosphorylation of phospholipase C gamma and activation of phosphoinositide hydrolysis. Endocrinology. 127: 1697-705. PMID 1698145 DOI: 10.1210/endo-127-4-1697  1
1990 Hepler JR, Jeffs RA, Huckle WR, Outlaw HE, Rhee SG, Earp HS, Harden TK. Evidence that the epidermal growth factor receptor and non-tyrosine kinase hormone receptors stimulate phosphoinositide hydrolysis by independent pathways. The Biochemical Journal. 270: 337-44. PMID 1698055  1
1989 Roe MW, Hepler JR, Harden TK, Herman B. Platelet-derived growth factor and angiotensin II cause increases in cytosolic free calcium by different mechanisms in vascular smooth muscle cells. Journal of Cellular Physiology. 139: 100-8. PMID 2708448 DOI: 10.1002/jcp.1041390115  1
1989 Boyer JL, Hepler JR, Harden TK. Hormone and growth factor receptor-mediated regulation of phospholipase C activity. Trends in Pharmacological Sciences. 10: 360-4. PMID 2557690 DOI: 10.1016/0165-6147(89)90008-4  1
1988 Hepler JR, Toomim CS, McCarthy KD, Conti F, Battaglia G, Rustioni A, Petrusz P. Characterization of antisera to glutamate and aspartate. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 36: 13-22. PMID 2891743  1
1988 Earp HS, Hepler JR, Petch LA, Miller A, Berry AR, Harris J, Raymond VW, McCune BK, Lee LW, Grisham JW. Epidermal growth factor (EGF) and hormones stimulate phosphoinositide hydrolysis and increase EGF receptor protein synthesis and mRNA levels in rat liver epithelial cells. Evidence for protein kinase C-dependent and -independent pathways. The Journal of Biological Chemistry. 263: 13868-74. PMID 2843541  1
1988 Hepler JR, Earp HS, Harden TK. Long-term phorbol ester treatment down-regulates protein kinase C and sensitizes the phosphoinositide signaling pathway to hormone and growth factor stimulation. Evidence for a role of protein kinase C in agonist-induced desensitization. The Journal of Biological Chemistry. 263: 7610-9. PMID 2836390  1
1988 Zagari M, Hepler JR, Harris C, Herman B. Inhibition of early platelet-derived growth factor responses in BALB/c-3T3 cells by interferon. Biochemical and Biophysical Research Communications. 150: 1207-12. PMID 2449206 DOI: 10.1016/0006-291X(88)90757-7  1
1987 Lee TF, Rezvani AH, Hepler JR, Myers RD. Neurotensin releases norepinephrine differentially from perfused hypothalamus of sated and fasted rat. The American Journal of Physiology. 252: E102-9. PMID 3544861  1
1987 Hepler JR, Nakahata N, Lovenberg TW, DiGuiseppi J, Herman B, Earp HS, Harden TK. Epidermal growth factor stimulates the rapid accumulation of inositol (1,4,5)-trisphosphate and a rise in cytosolic calcium mobilized from intracellular stores in A431 cells. The Journal of Biological Chemistry. 262: 2951-6. PMID 3102480  1
1987 Hepler JR, Hughes AR, Harden TK. Evidence that muscarinic cholinergic receptors selectively interact with either the cyclic AMP or the inositol phosphate second-messenger response systems. The Biochemical Journal. 247: 793-6. PMID 2827638  1
1987 Pallotta BS, Hepler JR, Oglesby SA, Harden TK. A comparison of calcium-activated potassium channel currents in cell-attached and excised patches. The Journal of General Physiology. 89: 985-97. PMID 2440980  1
1986 Hepler JR, Harden TK. Guanine nucleotide-dependent pertussis-toxin-insensitive stimulation of inositol phosphate formation by carbachol in a membrane preparation from human astrocytoma cells. The Biochemical Journal. 239: 141-6. PMID 3800973  1
1986 Myers RD, Swartzwelder HS, Peinado JM, Lee TF, Hepler JR, Denbow DM, Ferrer JM. CCK and other peptides modulate hypothalamic norepinephrine release in the rat: dependence on hunger or satiety. Brain Research Bulletin. 17: 583-97. PMID 3536002 DOI: 10.1016/0361-9230(86)90229-7  1
1986 Nakahata N, Martin MW, Hughes AR, Hepler JR, Harden TK. H1-histamine receptors on human astrocytoma cells. Molecular Pharmacology. 29: 188-95. PMID 2419744  0.28
1985 Evans T, Hepler JR, Masters SB, Brown JH, Harden TK. Guanine nucleotide regulation of agonist binding to muscarinic cholinergic receptors. Relation to efficacy of agonists for stimulation of phosphoinositide breakdown and Ca2+ mobilization. The Biochemical Journal. 232: 751-7. PMID 3004418  1
1985 Harden TK, Evans T, Hepler JR, Hughes AR, Martin MW, Meeker RB, Smith MM, Tanner LI. Regulation of cyclic AMP metabolism by muscarinic cholinergic receptors. Advances in Cyclic Nucleotide and Protein Phosphorylation Research. 19: 207-20. PMID 2988297  1
1984 Myers RD, Hepler JR, Schwartzwelder HS, Noto T, Denbow DM. Changes in Ca2+ ion activity within unrestrained rat's hippocampus perfused with alcohol or acetaldehyde. Neuroscience. 13: 355-65. PMID 6514184 DOI: 10.1016/0306-4522(84)90235-5  1
1984 Noto T, Hepler JR, Myers RD. Profile of amino acid synthesis in rat hippocampus during push-pull perfusion of ethanol or morphine. Neuroscience. 13: 367-76. PMID 6151146 DOI: 10.1016/0306-4522(84)90236-7  1
1983 Myers RD, Hepler JR, Holahan W. Action of anorexigenic peptide injected into the brain: dissociation of effect on body weight and feeding in the rat. Peptides. 4: 85-8. PMID 6866812 DOI: 10.1016/0196-9781(83)90171-7  1
1983 Hepler JR, Myers RD. New multi-cannula pedestal device for micro-injection of drugs into brain tissue or cerebral ventricle. Pharmacology, Biochemistry, and Behavior. 18: 791-5. PMID 6856651 DOI: 10.1016/0091-3057(83)90024-2  1
1983 Myers RD, Hepler JR. Glass-plastic push-pull cannula system for regional perfusion of sites in the brain. Journal of Neuroscience Methods. 9: 163-71. PMID 6316040 DOI: 10.1016/0165-0270(83)90129-2  1
1983 Lee TF, Hepler JR, Myers RD. Evaluation of neurotensin's thermolytic action by ICV infusion with receptor antagonists and a Ca++ chelator. Pharmacology, Biochemistry, and Behavior. 19: 477-81. PMID 6195677 DOI: 10.1016/0091-3057(83)90123-5  1
1982 Swartzwelder HS, Hepler J, Holahan W, King SE, Leverenz HA, Miller PA, Myers RD. Imparied maze performance in the rat caused by trimethyltin treatment: problem-solving deficits and perseveration. Neurobehavioral Toxicology and Teratology. 4: 169-76. PMID 7201086  1
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