Rory Curtis

Affiliations: 
Elixir Pharmaceuticals, Cambridge, MA, United States 
Area:
GAP43, glia, ion channels, regeneration, neurotrophins, GAP-43
Google:
"Rory Curtis"
Bio:

Email: rorycurtis@comcast.net ............ History: PhD, Biochemistry, Imperial College, London, UK;
Post-doc, Regeneron Pharmaceuticals, NY;
Lecturer, Bristol University, Bristol, UK;
Senior Scientist, Millennium Pharmaceuticals, MA;
Senior Director, Elixir Pharmaceuticals, MA;

Mean distance: 14.95 (cluster 11)
 
SNBCP
Cross-listing: Chemistry Tree

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Publications

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Longo KA, Govek EK, Nolan A, et al. (2012) Pharmacologic inhibition of ghrelin receptor signaling is insulin sparing and promotes insulin sensitivity (Journal of Pharmacology and Experimental Therapeutics (2011) 339, (115-124)) Journal of Pharmacology and Experimental Therapeutics. 340: 810
Longo KA, Govek EK, Nolan A, et al. (2011) Pharmacologic inhibition of ghrelin receptor signaling is insulin sparing and promotes insulin sensitivity. The Journal of Pharmacology and Experimental Therapeutics. 339: 115-24
DiStefano PS, Curtis R, Geddes BJ. (2007) Insulin resistance, glycemic control and adiposity: key determinants of healthy lifespan. Current Alzheimer Research. 4: 153-7
Curtis R, O'Connor G, DiStefano PS. (2006) Aging networks in Caenorhabditis elegans: AMP-activated protein kinase (aak-2) links multiple aging and metabolism pathways. Aging Cell. 5: 119-26
Solomon JM, Pasupuleti R, Xu L, et al. (2006) Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage. Molecular and Cellular Biology. 26: 28-38
Napper AD, Hixon J, McDonagh T, et al. (2005) Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1. Journal of Medicinal Chemistry. 48: 8045-54
McDonagh T, Hixon J, DiStefano PS, et al. (2005) Microplate filtration assay for nicotinamide release from NAD using a boronic acid resin. Methods (San Diego, Calif.). 36: 346-50
Curtis R, Geesaman BJ, DiStefano PS. (2005) Ageing and metabolism: drug discovery opportunities. Nature Reviews. Drug Discovery. 4: 569-80
Kaeberlein M, McDonagh T, Heltweg B, et al. (2005) Substrate-specific activation of sirtuins by resveratrol. The Journal of Biological Chemistry. 280: 17038-45
Apfeld J, O'Connor G, McDonagh T, et al. (2004) The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans. Genes & Development. 18: 3004-9
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