Andrew S. Midzak, Ph.D.
Affiliations: | 2009 | Johns Hopkins University, Baltimore, MD |
Area:
Molecular Biology, Cell BiologyGoogle:
"Andrew Midzak"Parents
Sign in to add mentor| Barry Zirkin | grad student | 2009 | Johns Hopkins | |
| (Mitochondrial regulation of Leydig cell steroid synthesis. Implications for the decline in male testosterone production with advancing age.) | ||||
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Publications
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| Owen DR, Fan J, Campioli E, et al. (2017) TSPO mutations in rats and a human polymorphism impair the rate of steroid synthesis. The Biochemical Journal |
| Midzak A, Papadopoulos V. (2016) Adrenal Mitochondria and Steroidogenesis: From Individual Proteins to Functional Protein Assemblies. Frontiers in Endocrinology. 7: 106 |
| Midzak A, Zirkin B, Papadopoulos V. (2015) Translocator protein: pharmacology and steroidogenesis. Biochemical Society Transactions. 43: 572-8 |
| Fan J, Campioli E, Midzak A, et al. (2015) Conditional steroidogenic cell-targeted deletion of TSPO unveils a crucial role in viability and hormone-dependent steroid formation. Proceedings of the National Academy of Sciences of the United States of America. 112: 7261-6 |
| Midzak A, Denora N, Laquintana V, et al. (2015) 2-Phenylimidazo[1,2-a]pyridine-containing ligands of the 18-kDa translocator protein (TSPO) behave as agonists and antagonists of steroidogenesis in a mouse leydig tumor cell line. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 76: 231-7 |
| Midzak AS, Akula N, Rone MB, et al. (2015) Computational modeling and biological validation of novel non-steroidal ligands for the cholesterol recognition/interaction amino acid consensus (CRAC) motif of the mitochondrial translocator protein (TSPO). Pharmacological Research. 99: 393-403 |
| Papadopoulos V, Aghazadeh Y, Fan J, et al. (2015) Translocator protein-mediated pharmacology of cholesterol transport and steroidogenesis. Molecular and Cellular Endocrinology. 408: 90-8 |
| Rone MB, Midzak AS, Martinez-Arguelles DB, et al. (2014) Steroidogenesis in MA-10 mouse Leydig cells is altered via fatty acid import into the mitochondria. Biology of Reproduction. 91: 96 |
| Midzak A, Papadopoulos V. (2014) Binding domain-driven intracellular trafficking of sterols for synthesis of steroid hormones, bile acids and oxysterols. Traffic (Copenhagen, Denmark). 15: 895-914 |
| Chung JY, Chen H, Midzak A, et al. (2013) Drug ligand-induced activation of translocator protein (TSPO) stimulates steroid production by aged Brown Norway rat leydig cells Endocrinology. 154: 2156-2165 |