Enfu Hui, Ph.D.
Affiliations: | 2010-2016 | Cellular and Molecular Pharmacology | University of California, San Francisco, San Francisco, CA |
| 2016- | Cell and Developmental Biology | University of California, San Diego, La Jolla, CA |
Area:
T cell signalingWebsite:
https://biology.ucsd.edu/research/faculty/enfuhuiGoogle:
"Enfu Hui"Bio:
https://www.huilab-ucsd.org/
https://orcid.org/0000-0001-7876-2783
https://www.researchgate.net/profile/Enfu-Hui
https://scholar.google.com/citations?user=Yf2eFEwAAAAJ&hl=en
Parents
Sign in to add mentor| Edwin R. Chapman | grad student | 2003-2010 | UW Madison (Neurotree) | |
| (Nano-mechanics and functional consequences of synaptotagmin·membrane interactions.) | ||||
| Ronald D. Vale | post-doc | UCSF | ||
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Publications
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| Banta KL, Xu X, Chitre AS, et al. (2022) Mechanistic convergence of the TIGIT and PD-1 inhibitory pathways necessitates co-blockade to optimize anti-tumor CD8 T cell responses. Immunity. 55: 512-526.e9 |
| Xu X, Masubuchi T, Cai Q, et al. (2021) Molecular features underlying differential SHP1/SHP2 binding of immune checkpoint receptors. Elife. 10 |
| Wu W, Zhou Q, Masubuchi T, et al. (2020) Multiple Signaling Roles of CD3ε and Its Application in CAR-T Cell Therapy. Cell |
| Xu X, Hou B, Fulzele A, et al. (2020) PD-1 and BTLA regulate T cell signaling differentially and only partially through SHP1 and SHP2. The Journal of Cell Biology. 219 |
| Zhao Y, Lee CK, Lin CH, et al. (2019) PD-L1:CD80 Cis-Heterodimer Triggers the Co-stimulatory Receptor CD28 While Repressing the Inhibitory PD-1 and CTLA-4 Pathways. Immunity |
| Sasmal DK, Feng W, Roy S, et al. (2019) TCR-pMHC bond conformation controls TCR ligand discrimination. Cellular & Molecular Immunology |
| Hui E. (2019) Understanding T cell signaling using membrane reconstitution. Immunological Reviews. 291: 44-56 |
| Zhao Y, Harrison DL, Song Y, et al. (2018) Antigen-Presenting Cell-Intrinsic PD-1 Neutralizes PD-L1 in cis to Attenuate PD-1 Signaling in T Cells. Cell Reports. 24: 379-390.e6 |
| Carbone CB, Kern N, Fernandes RA, et al. (2017) In vitro reconstitution of T cell receptor-mediated segregation of the CD45 phosphatase. Proceedings of the National Academy of Sciences of the United States of America |
| Hui E, Cheung J, Zhu J, et al. (2017) T cell costimulatory receptor CD28 is a primary target for PD-1-mediated inhibition. Science (New York, N.Y.) |