Rebecca Lock, Ph.D.
Affiliations: | 2012 | Biomedical Sciences | University of California, San Francisco, San Francisco, CA |
Area:
Cell Biology, OncologyGoogle:
"Rebecca Lock"Mean distance: 42746.4
Parents
Sign in to add mentor| Gerard Evan | grad student | 2012 | UCSF | |
| (Novel functions for autophagy during Ras transformation.) | ||||
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Publications
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| Perurena N, Lock R, Davis RA, et al. (2023) USP9X mediates an acute adaptive response to MAPK suppression in pancreatic cancer but creates multiple actionable therapeutic vulnerabilities. Cell Reports. Medicine. 101007 |
| Tian T, Lofftus S, Pan Y, et al. (2020) IL1α antagonizes IL1β and promotes adaptive immune rejection of malignant tumors. Cancer Immunology Research |
| Lock R, Ingraham R, Maertens O, et al. (2017) Abstract A18: Targeting the MNK kinases for the treatment of NF1-mutant cancers Clinical Cancer Research. 23 |
| Lock R, Ingraham R, Maertens O, et al. (2016) Cotargeting MNK and MEK kinases induces the regression of NF1-mutant cancers. The Journal of Clinical Investigation |
| Lock R, Cichowski K. (2015) Loss of negative regulators amplifies RAS signaling. Nature Genetics. 47: 426-7 |
| Lock R, Kenific CM, Leidal AM, et al. (2014) Autophagy-dependent production of secreted factors facilitates oncogenic RAS-driven invasion. Cancer Discovery. 4: 466-79 |
| Chen N, Eritja N, Lock R, et al. (2013) Autophagy restricts proliferation driven by oncogenic phosphatidylinositol 3-kinase in three-dimensional culture Oncogene. 32: 2543-2554 |
| Lock R, Debnath J. (2011) Ras, autophagy and glycolysis. Cell Cycle (Georgetown, Tex.). 10: 1516-7 |
| Lock R, Roy S, Kenific CM, et al. (2011) Autophagy facilitates glycolysis during Ras-mediated oncogenic transformation. Molecular Biology of the Cell. 22: 165-78 |
| Lock R, Debnath J. (2008) Extracellular matrix regulation of autophagy. Current Opinion in Cell Biology. 20: 583-8 |