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Nga Bien-Ly, Ph.D.

Affiliations: 
Neuroscience Genentech, Inc., San Francisco, CA, United States 
Area:
Blood-brian barrier
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"Nga Bien-Ly"
Mean distance: 16.79 (cluster 11)
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Ryan Jefferson Watts post-doc Genentech, Inc.

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Publications

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Xiong M, Jiang H, Serrano JR, et al. (2021) APOE immunotherapy reduces cerebral amyloid angiopathy and amyloid plaques while improving cerebrovascular function. Science Translational Medicine. 13
Liao F, Li A, Xiong M, et al. (2018) Targeting of nonlipidated, aggregated apoE with antibodies inhibits amyloid accumulation. The Journal of Clinical Investigation
Rajapaksa KS, Huang T, Sharma N, et al. (2016) Preclinical safety profile of a depleting antibody against CRTh2 for asthma: Well tolerated despite unexpected CRTh2 expression on vascular pericytes in the central nervous system and gastric mucosa. Toxicological Sciences : An Official Journal of the Society of Toxicology
Zuchero YJ, Chen X, Bien-Ly N, et al. (2015) Discovery of Novel Blood-Brain Barrier Targets to Enhance Brain Uptake of Therapeutic Antibodies. Neuron
Bien-Ly N, Boswell CA, Jeet S, et al. (2015) Lack of Widespread BBB Disruption in Alzheimer's Disease Models: Focus on Therapeutic Antibodies. Neuron. 88: 289-97
Huntley MA, Bien-Ly N, Daneman R, et al. (2014) Dissecting gene expression at the blood-brain barrier. Frontiers in Neuroscience. 8: 355
Bien-Ly N, Watts RJ. (2014) The blood-brain barrier's gut check. Science Translational Medicine. 6: 263fs46
Yu YJ, Atwal JK, Zhang Y, et al. (2014) Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates. Science Translational Medicine. 6: 261ra154
Bien-Ly N, Yu YJ, Bumbaca D, et al. (2014) Transferrin receptor (TfR) trafficking determines brain uptake of TfR antibody affinity variants. The Journal of Experimental Medicine. 211: 233-44
Bien-Ly N, Gillespie AK, Walker D, et al. (2012) Reducing human apolipoprotein E levels attenuates age-dependent Aβ accumulation in mutant human amyloid precursor protein transgenic mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 4803-11
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