Nga Bien-Ly, Ph.D. - Publications

Affiliations: 
Neuroscience Genentech, San Francisco, CA, United States 
Area:
Blood-brian barrier

23 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Liao F, Li A, Xiong M, Bien-Ly N, Jiang H, Zhang Y, Finn MB, Hoyle R, Keyser J, Lefton KB, Robinson GO, Serrano JR, Silverman AP, Guo JL, Getz J, et al. Targeting of nonlipidated, aggregated apoE with antibodies inhibits amyloid accumulation. The Journal of Clinical Investigation. PMID 29600961 DOI: 10.1172/JCI96429  1
2015 Zuchero YJ, Chen X, Bien-Ly N, Bumbaca D, Tong RK, Gao X, Zhang S, Hoyte K, Luk W, Huntley MA, Phu L, Tan C, Kallop D, Weimer RM, Lu Y, et al. Discovery of Novel Blood-Brain Barrier Targets to Enhance Brain Uptake of Therapeutic Antibodies. Neuron. PMID 26687840 DOI: 10.1016/j.neuron.2015.11.024  1
2015 Bien-Ly N, Boswell CA, Jeet S, Beach TG, Hoyte K, Luk W, Shihadeh V, Ulufatu S, Foreman O, Lu Y, DeVoss J, van der Brug M, Watts RJ. Lack of Widespread BBB Disruption in Alzheimer's Disease Models: Focus on Therapeutic Antibodies. Neuron. 88: 289-97. PMID 26494278 DOI: 10.1016/j.neuron.2015.09.036  1
2014 Huntley MA, Bien-Ly N, Daneman R, Watts RJ. Dissecting gene expression at the blood-brain barrier. Frontiers in Neuroscience. 8: 355. PMID 25414634 DOI: 10.3389/fnins.2014.00355  1
2014 Bien-Ly N, Watts RJ. The blood-brain barrier's gut check. Science Translational Medicine. 6: 263fs46. PMID 25411469 DOI: 10.1126/scitranslmed.aaa2543  1
2014 Yu YJ, Atwal JK, Zhang Y, Tong RK, Wildsmith KR, Tan C, Bien-Ly N, Hersom M, Maloney JA, Meilandt WJ, Bumbaca D, Gadkar K, Hoyte K, Luk W, Lu Y, et al. Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates. Science Translational Medicine. 6: 261ra154. PMID 25378646 DOI: 10.1126/scitranslmed.3009835  1
2014 Knoferle J, Yoon SY, Walker D, Leung L, Gillespie AK, Tong LM, Bien-Ly N, Huang Y. Apolipoprotein E4 produced in GABAergic interneurons causes learning and memory deficits in mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 14069-78. PMID 25319703 DOI: 10.1523/JNEUROSCI.2281-14.2014  1
2014 Bien-Ly N, Yu YJ, Bumbaca D, Elstrott J, Boswell CA, Zhang Y, Luk W, Lu Y, Dennis MS, Weimer RM, Chung I, Watts RJ. Transferrin receptor (TfR) trafficking determines brain uptake of TfR antibody affinity variants. The Journal of Experimental Medicine. 211: 233-44. PMID 24470444 DOI: 10.1084/jem.20131660  1
2013 Vossel KA, Bien-Ly N, Bernardo A, Rascovsky K, Karydas A, Rabinovici GD, Sidhu M, Huang EJ, Miller BL, Huang Y, Seeley WW. ApoE and TDP-43 neuropathology in two siblings with familial FTLD-motor neuron disease. Neurocase. 19: 295-301. PMID 22512241 DOI: 10.1080/13554794.2012.667124  1
2012 Andrews-Zwilling Y, Gillespie AK, Kravitz AV, Nelson AB, Devidze N, Lo I, Yoon SY, Bien-Ly N, Ring K, Zwilling D, Potter GB, Rubenstein JL, Kreitzer AC, Huang Y. Hilar GABAergic interneuron activity controls spatial learning and memory retrieval. Plos One. 7: e40555. PMID 22792368 DOI: 10.1371/journal.pone.0040555  1
2012 Bien-Ly N, Gillespie AK, Walker D, Yoon SY, Huang Y. Reducing human apolipoprotein E levels attenuates age-dependent Aβ accumulation in mutant human amyloid precursor protein transgenic mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 4803-11. PMID 22492035 DOI: 10.1523/JNEUROSCI.0033-12.2012  1
2011 Bien-Ly N, Andrews-Zwilling Y, Xu Q, Bernardo A, Wang C, Huang Y. C-terminal-truncated apolipoprotein (apo) E4 inefficiently clears amyloid-beta (Abeta) and acts in concert with Abeta to elicit neuronal and behavioral deficits in mice. Proceedings of the National Academy of Sciences of the United States of America. 108: 4236-41. PMID 21368138 DOI: 10.1073/pnas.1018381108  1
2010 Andrews-Zwilling Y, Bien-Ly N, Xu Q, Li G, Bernardo A, Yoon SY, Zwilling D, Yan TX, Chen L, Huang Y. Apolipoprotein E4 causes age- and Tau-dependent impairment of GABAergic interneurons, leading to learning and memory deficits in mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 13707-17. PMID 20943911 DOI: 10.1523/JNEUROSCI.4040-10.2010  1
2009 Li G, Bien-Ly N, Andrews-Zwilling Y, Xu Q, Bernardo A, Ring K, Halabisky B, Deng C, Mahley RW, Huang Y. GABAergic interneuron dysfunction impairs hippocampal neurogenesis in adult apolipoprotein E4 knockin mice. Cell Stem Cell. 5: 634-45. PMID 19951691 DOI: 10.1016/j.stem.2009.10.015  1
2007 Palop JJ, Chin J, Roberson ED, Wang J, Thwin MT, Bien-Ly N, Yoo J, Ho KO, Yu GQ, Kreitzer A, Finkbeiner S, Noebels JL, Mucke L. Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease. Neuron. 55: 697-711. PMID 17785178 DOI: 10.1016/j.neuron.2007.07.025  1
2007 Cheng IH, Scearce-Levie K, Legleiter J, Palop JJ, Gerstein H, Bien-Ly N, Puoliväli J, Lesné S, Ashe KH, Muchowski PJ, Mucke L. Accelerating amyloid-beta fibrillization reduces oligomer levels and functional deficits in Alzheimer disease mouse models. The Journal of Biological Chemistry. 282: 23818-28. PMID 17548355 DOI: 10.1074/jbc.M701078200  1
2007 Chin J, Massaro CM, Palop JJ, Thwin MT, Yu GQ, Bien-Ly N, Bender A, Mucke L. Reelin depletion in the entorhinal cortex of human amyloid precursor protein transgenic mice and humans with Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 2727-33. PMID 17360894 DOI: 10.1523/JNEUROSCI.3758-06.2007  1
2006 Esposito L, Raber J, Kekonius L, Yan F, Yu GQ, Bien-Ly N, Puoliväli J, Scearce-Levie K, Masliah E, Mucke L. Reduction in mitochondrial superoxide dismutase modulates Alzheimer's disease-like pathology and accelerates the onset of behavioral changes in human amyloid precursor protein transgenic mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 5167-79. PMID 16687508 DOI: 10.1523/JNEUROSCI.0482-06.2006  1
2005 Chin J, Palop JJ, Puoliväli J, Massaro C, Bien-Ly N, Gerstein H, Scearce-Levie K, Masliah E, Mucke L. Fyn kinase induces synaptic and cognitive impairments in a transgenic mouse model of Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 9694-703. PMID 16237174 DOI: 10.1523/JNEUROSCI.2980-05.2005  1
2005 Palop JJ, Chin J, Bien-Ly N, Massaro C, Yeung BZ, Yu GQ, Mucke L. Vulnerability of dentate granule cells to disruption of arc expression in human amyloid precursor protein transgenic mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 9686-93. PMID 16237173 DOI: 10.1523/JNEUROSCI.2829-05.2005  1
2005 Hezi-Yamit A, Wong PW, Bien-Ly N, Komuves LG, Prasad KS, Phillips DR, Sinha U. Synergistic induction of tissue factor by coagulation factor Xa and TNF: evidence for involvement of negative regulatory signaling cascades. Proceedings of the National Academy of Sciences of the United States of America. 102: 12077-82. PMID 16105945 DOI: 10.1073/pnas.0504526102  1
2004 Cheng IH, Palop JJ, Esposito LA, Bien-Ly N, Yan F, Mucke L. Aggressive amyloidosis in mice expressing human amyloid peptides with the Arctic mutation. Nature Medicine. 10: 1190-2. PMID 15502844 DOI: 10.1038/nm1123  1
2004 Kuhn M, Ng CK, Su YH, Kilić A, Mitko D, Bien-Ly N, Kömüves LG, Yang RB. Identification of an orphan guanylate cyclase receptor selectively expressed in mouse testis. The Biochemical Journal. 379: 385-93. PMID 14713286 DOI: 10.1042/BJ20031624  1
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