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Shu-ou Shan

Affiliations: 
California Institute of Technology, Pasadena, CA 
Area:
Macromolecular machines; protein sorting and localization; molecular recognition and regulation by novel GTPases; protein and nucleic acid structure and function
Website:
http://www.cce.caltech.edu/faculty/shan/index.html
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"Shu-ou Shan"
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SNBCP

Parents

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Daniel Herschlag grad student 2000 Stanford
 (Part I. Energetic analysis of hydrogen bonds in model systems: Implications for enzymatic catalysis. Part II. Probing the role of metal ions in catalysis by the Tetrahymena group I ribozyme.)
Peter Walter post-doc 2005 UCSF

Children

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Tony Z Jia research assistant 2008-2009 Caltech
Xin Zhang grad student Scripps Institute
Peera Jaru-Ampornpan grad student 2011 Caltech
Thang Xuan Nguyen grad student 2013 Caltech
Kuang Shen grad student 2013 Caltech
David Akopian grad student 2014 Caltech
Aileen Renia Ariosa grad student 2014 Caltech
Michael Evan Rome grad student 2014 Caltech
Meera Rao grad student 2016 Caltech
Un Seng Chio grad student 2019 Caltech
Yu-Hsien Hwang Fu grad student 2019 Caltech
Shuai Wang grad student 2013-2019 Caltech (Neurotree)
Ishu Saraogi post-doc Caltech
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Publications

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Cho H, Liu Y, Chung S, et al. (2024) Dynamic stability of Sgt2 enables selective and privileged client handover in a chaperone triad. Nature Communications. 15: 134
Gupta A, Lentzsch AM, Siegel A, et al. (2023) Dodecamer assembly of a metazoan AAA chaperone couples substrate extraction to refolding. Science Advances. 9: eadf5336
Shan SO. (2023) Role of Hsp70 in Post-Translational Protein Targeting: Tail-Anchored Membrane Proteins and Beyond. International Journal of Molecular Sciences. 24
Yang CI, Zhu Z, Jones JJ, et al. (2022) System-wide analyses reveal essential roles of N-terminal protein modification in bacterial membrane integrity. Iscience. 25: 104756
Zhu Z, Wang S, Shan SO. (2022) Ribosome profiling reveals multiple roles of SecA in cotranslational protein export. Nature Communications. 13: 3393
Yang CI, Kim J, Shan SO. (2022) Ribosome-nascent Chain Interaction Regulates N-terminal Protein Modification. Journal of Molecular Biology. 434: 167535
Jomaa A, Gamerdinger M, Hsieh HH, et al. (2022) Mechanism of signal sequence handover from NAC to SRP on ribosomes during ER-protein targeting. Science (New York, N.Y.). 375: 839-844
Hsieh HH, Shan SO. (2021) Fidelity of Cotranslational Protein Targeting to the Endoplasmic Reticulum. International Journal of Molecular Sciences. 23
Chio US, Liu Y, Chung S, et al. (2021) Subunit cooperation in the Get1/2 receptor promotes tail-anchored membrane protein insertion. The Journal of Cell Biology. 220
Ji S, Siegel A, Shan SO, et al. (2021) Chloroplast SRP43 autonomously protects chlorophyll biosynthesis proteins against heat shock. Nature Plants
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