Panos Zanos, Ph.D.
Affiliations: | 2014-2021 | Psychiatry | University of Maryland School of Medicine, Baltimore, MD, United States |
2021- | Psychology | University of Cyprus, Nicosia, Nicosia, Cyprus |
Area:
opioid addiction, ketamine, rodent models, rapid-acting antidepressants, substance use disordersWebsite:
https://zanoslab.com/Google:
"Panos Zanos"Bio:
Dr. Zanos is a prominent figure in brain disease research, focusing on innovative therapies for major depressive disorders and related conditions. His groundbreaking work, particularly on the use of ketamine metabolites as rapid-acting antidepressants, has shown promise in transforming depression treatment. Notably, his discoveries have led to a phase I clinical trial with positive outcomes, paving the way for a phase II trial. Despite being an early career researcher, Dr. Zanos has achieved remarkable accomplishments, securing significant grant funding and publishing over 60 peer-reviewed articles in prestigious journals. His research has gained global recognition, with collaborations and partnerships with influential figures in addiction and depression research. Additionally, Dr. Zanos is involved in a groundbreaking clinical trial on ketamine's efficacy in preventing opioid relapse, marking a milestone in Cyprus. Beyond ketamine research, he has contributed to neuropharmacology, exploring oxytocin's role in drug addiction and investigating receptor interactions, genetic vulnerabilities, and sleep disorders in mental health conditions.
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Parents
Sign in to add mentorAlexis Bailey | grad student | 2010-2013 | University of Surrey (United Kingdom) |
Ian Kitchen | grad student | 2010-2013 | University of Surrey |
Raphaelle Winsky-Sommerer | grad student | 2010-2013 | University of Surrey (United Kingdom) |
Todd D. Gould | post-doc | 2013- | University of Maryland Medical School |
Children
Sign in to add traineeMorfeas Koumas | research assistant | 2023- | University of Cyprus |
Tellos Fatta | research assistant | 2024- | University of Cyprus |
Despina Melanthiou | grad student | 2023- | University of Cyprus |
Stylianos Valiantis | grad student | 2023- | University of Cyprus |
Derrick Phillips | grad student | 2020-2021 | University of Idaho |
Andria Michael | post-doc | 2022- | University of Cyprus |
Anna Onisiforou | post-doc | 2022- | University of Cyprus |
Markos Apostolakis | post-doc | 2023- | University of Cyprus |
Eleftheria Charalambous | post-doc | 2023- | University of Cyprus |
Andrea Georgiou | post-doc | 2023- | University of Cyprus |
Mary Haddad | post-doc | 2024- | University of Cyprus |
Elmar Mammadov | post-doc | 2019-2021 | University of Maryland Baltimore, School of Medicine |
Collaborators
Sign in to add collaboratorPolymnia Georgiou | collaborator | 2012- | University of Wisconsin, Milwaukee |
Publications
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Christodoulou CC, Onisiforou A, Zanos P, et al. (2023) Unraveling the transcriptomic signatures of Parkinson's disease and major depression using single-cell and bulk data. Frontiers in Aging Neuroscience. 15: 1273855 |
Onisiforou A, Georgiou P, Zanos P. (2023) Role of group II metabotropic glutamate receptors in ketamine's antidepressant actions. Pharmacology, Biochemistry, and Behavior. 223: 173531 |
Zanos P, Brown KA, Georgiou P, et al. (2023) NMDA RECEPTOR ACTIVATION-DEPENDENT ANTIDEPRESSANT-RELEVANT BEHAVIORAL AND SYNAPTIC ACTIONS OF KETAMINE. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience |
Brown KA, Zanos P, Powels CF, et al. (2022) Ketamine preservative benzethonium chloride potentiates hippocampal synaptic transmission and binds neurotransmitter receptors and transporters. Neuropharmacology. 225: 109403 |
Georgiou P, Zanos P, Mou TM, et al. (2022) Experimenters' sex modulates mouse behaviors and neural responses to ketamine via corticotropin releasing factor. Nature Neuroscience |
Bonaventura J, Gomez JL, Carlton ML, et al. (2022) Target deconvolution studies of (2R,6R)-hydroxynorketamine: an elusive search. Molecular Psychiatry |
Moaddel R, Zanos P, Farmer CA, et al. (2022) Comparative metabolomic analysis in plasma and cerebrospinal fluid of humans and in plasma and brain of mice following antidepressant-dose ketamine administration. Translational Psychiatry. 12: 179 |
Highland JN, Morris PJ, Konrath KM, et al. (2022) Hydroxynorketamine Pharmacokinetics and Antidepressant Behavioral Effects of (26)- and (5)-Methyl-(26)-hydroxynorketamines. Acs Chemical Neuroscience. 13: 510-523 |
Troppoli TA, Zanos P, Georgiou P, et al. (2021) Negative Allosteric Modulation of Gamma-Aminobutyric Acid A Receptors at α5 Subunit-Containing Benzodiazepine Sites Reverses Stress-Induced Anhedonia and Weakened Synaptic Function in Mice. Biological Psychiatry |
Highland JN, Farmer CA, Zanos P, et al. (2021) Sex-dependent metabolism of ketamine and ()-hydroxynorketamine in mice and humans. Journal of Psychopharmacology (Oxford, England). 2698811211064922 |