Christopher D Nelson, PhD

Affiliations: 
2001-2007 Biochemistry Duke University, Durham, NC 
 2008-2009 Neuroscience Massachusetts Institute of Technology, Cambridge, MA, United States 
 2009-2013 Neuroscience Genentech, San Francisco, CA, United States 
 2014- Diagnostics Roche, Indianapolis, IN, United States 
Area:
GPCRs, arrestin, neuroscience, diagnostics
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Parents

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Robert J. Lefkowitz grad student 2002-2007 Duke
Morgan Sheng post-doc 2008-2013 MIT / Genentech
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Publications

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Nelson CD, Sheng M. (2013) Gpr3 stimulates Aβ production via interactions with APP and β-arrestin2. Plos One. 8: e74680
Nelson CD, Kim MJ, Hsin H, et al. (2013) Phosphorylation of threonine-19 of PSD-95 by GSK-3β is required for PSD-95 mobilization and long-term depression. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 12122-35
Oz G, Vollmers ML, Nelson CD, et al. (2011) In vivo monitoring of recovery from neurodegeneration in conditional transgenic SCA1 mice. Experimental Neurology. 232: 290-8
Chen X, Nelson CD, Li X, et al. (2011) PSD-95 is required to sustain the molecular organization of the postsynaptic density. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 6329-38
Mukhopadhyay S, Wen X, Chih B, et al. (2010) TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia. Genes & Development. 24: 2180-93
Oz G, Nelson CD, Koski DM, et al. (2010) Noninvasive detection of presymptomatic and progressive neurodegeneration in a mouse model of spinocerebellar ataxia type 1. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 3831-8
Iltis I, Koski DM, Eberly LE, et al. (2009) Neurochemical changes in the rat prefrontal cortex following acute phencyclidine treatment: an in vivo localized (1)H MRS study. Nmr in Biomedicine. 22: 737-44
Ozawa K, Whalen EJ, Nelson CD, et al. (2008) S-nitrosylation of beta-arrestin regulates beta-adrenergic receptor trafficking. Molecular Cell. 31: 395-405
Nelson CD, Kovacs JJ, Nobles KN, et al. (2008) Beta-arrestin scaffolding of phosphatidylinositol 4-phosphate 5-kinase Ialpha promotes agonist-stimulated sequestration of the beta2-adrenergic receptor. The Journal of Biological Chemistry. 283: 21093-101
Nelson CD, Perry SJ, Regier DS, et al. (2007) Targeting of diacylglycerol degradation to M1 muscarinic receptors by beta-arrestins. Science (New York, N.Y.). 315: 663-6
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