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Robert J. Lefkowitz

Affiliations: 
Duke University, Durham, NC 
Area:
G protein-coupled receptors
Website:
http://cardiology.medicine.duke.edu/faculty/details/0096962
Google:
"Robert Lefkowitz"
Bio:

The Nobel Prize in Chemistry 2012 was awarded jointly to Robert J. Lefkowitz and Brian K. Kobilka "for studies of G-protein-coupled receptors."

Mean distance: 13.4 (cluster 11)
 		SNBCP
Cross-listing: Chemistry Tree - Cell Biology Tree

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Parents

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Ira Pastan post-doc 1968-1970 NIH
Jesse Roth post-doc 1968-1970 NIH
Edgar Haber post-doc 1970-1973 Harvard Medical School

Children

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Ronald D. Vale research assistant Duke Medical School (Cell Biology Tree)
Jeffery Benovic grad student Duke
Tom Cahill grad student Duke
Henrik G. Dohlman grad student Duke University / HHMI (Physics Tree)
Anthony Nguyen grad student Duke
Robert W. Walters grad student Duke
Seungkirl Ahn grad student 2002 Duke
Alberuni M. Zamah grad student 2002 Duke
Christopher D Nelson grad student 2002-2007 Duke
Kelly N. Nobles grad student 2010 Duke
Minjung Choi grad student 2012-2018 Duke
Shahab Akhter post-doc Duke
R. Wayne Alexander post-doc Duke
Lee Allen post-doc Duke
Jeffrey Arriza post-doc Duke
Haavard Attramadal post-doc Duke
William G. Barnes post-doc Duke
Jeffrey L. Benovic post-doc Duke (Cell Biology Tree)
Tim Van Biesen post-doc Duke
Nanette H. Bishopric post-doc Duke (Cell Biology Tree)
Jeremy T. Blitzer post-doc Duke (FlyTree)
Mark Bolanowski post-doc Duke
Erin Bressler post-doc Duke
Margaret Briggs-Gowan post-doc Duke
Ernst Burgisser post-doc Duke
Sheng Cai post-doc Duke
Paul G. Campbell post-doc Duke (Literature Tree)
Mei Wang Casey post-doc Duke
Arnab K. Chatterjee post-doc Duke (Chemistry Tree)
Minyong Chen post-doc Duke (Chemistry Tree)
Jing Ruth Chen post-doc Duke
Wei Chen post-doc Duke (Physics Tree)
Yishan Cheng post-doc Duke
Minjung Choi post-doc Duke
Audrey Claing post-doc Duke
William T. Clarke post-doc Duke
Benjamin T. Cocanougher post-doc Duke University / HHMI (Chemistry Tree)
Sheila Collins post-doc Duke
Mei Cong post-doc Duke
Susanna Cotecchia post-doc Duke
Yehia Daaka post-doc Duke University School of Medicine (Chemistry Tree)
Laura Davidson post-doc Duke
Albert S. Davies post-doc Duke (MathTree)
Andre DeLean post-doc Duke
Scott M. DeWire post-doc Duke (Microtree)
Kenneth Dickinson post-doc Duke
Matthew T. Drake post-doc Duke (Chemistry Tree)
Mark Drazner post-doc Duke
David M. Feldman post-doc Duke
Mark Fereshteh post-doc Duke
Michael E. Field post-doc Duke
Zoey Fredericks post-doc Duke
Neil Freedman post-doc Duke
Jennifer Freedman post-doc Duke
Tom Frielle post-doc Duke
Tiffany Garrison post-doc Duke
Diane GetsyPalmer post-doc Duke
Larry Goldstein post-doc Duke (FlyTree)
Thomas Gore post-doc Duke
Emily M. Harris post-doc Duke
William Hausdorff post-doc Duke
Brian Hawes post-doc Duke
James Heinsimer post-doc Duke
Mark Hnatowich post-doc Duke
Brian Jeffrey Hoffman post-doc Duke (Chemistry Tree)
Dan Houtz post-doc Duke
Liaoyuan Hu post-doc Duke
Liyin Huang post-doc Duke
Guido Iaccarino post-doc Duke
Christopher D. Ingersoll post-doc Duke (Biomechanics Tree)
Richard Kent post-doc Duke (Biomechanics Tree)
Khuda Dad Khan post-doc Duke
Klim King post-doc Duke
Michael Kjelsberg post-doc Duke
Andrew Kleist post-doc Duke
Bjoern Klink post-doc Duke
Walter Koch post-doc Duke
Trudy Kohout post-doc Duke
Jeffrey J. Kovacs post-doc Duke
Kathleen Krueger post-doc Duke (SocTree)
Hitoshi Kurose post-doc Duke
Madan Kwatra post-doc Duke
Richard Lebovitz post-doc Duke
L. M. Fredrik Leeb-Lundberg post-doc Duke (Chemistry Tree)
Stephen B. Liggett post-doc Duke (Cell Biology Tree)
Fannie Lin post-doc Duke
Yuan Lin post-doc Duke (Physics Tree)
Mathew Lo post-doc Duke
Jon Lomasney post-doc Duke
Wulfing Lorenz post-doc Duke
Louis Luttrell post-doc Duke (Cell Biology Tree)
Sandy Macrae post-doc Duke
Negin P. Martin post-doc Duke (Chemistry Tree)
Ali Masoudi post-doc Duke (Physics Tree)
Ali Masoudi post-doc Duke Medical School
Hiroyaki Matsui post-doc Duke
Stuart Maudsley post-doc Duke
Federico Mayor post-doc Duke
Patsy McDonald post-doc Duke
Thomas Michel post-doc Duke
John Mickey post-doc Duke
Carmelo Milano post-doc Duke
William E. Miller post-doc Duke
Debra Mullikin-Kilpatrick post-doc Duke
Hiroyasu Nakata post-doc Duke
Ponnal Nambi post-doc Duke
Canan Nebigil post-doc Duke
Chris Nelson post-doc Duke
Brian F. O'Dowd post-doc Duke
Lina M. Obeid post-doc Duke (MathTree)
James Onorato post-doc Duke
Martin Opperman post-doc Duke
Natalia Pakharukova post-doc Duke
Biswaranjan Pani post-doc Duke
Gang Pei post-doc Duke
Karsten Peppel post-doc Duke
Steve Perry post-doc Duke (Chemistry Tree)
Kristen J. Pierce post-doc Duke (ID Tree)
Linda J. Pike post-doc Duke (Chemistry Tree)
Julie Pitcher post-doc Duke
Steve Plonk post-doc Duke
Tom Povsic post-doc Duke
Nadeem Rahman post-doc Duke
Michael Raisch post-doc Duke
Keshava Rajagopal post-doc Duke (Cell Biology Tree)
Sudar Rajagopal post-doc Duke
John C. Raymond post-doc Duke (Physics Tree)
John W. Regan post-doc Duke
Rosana Reis post-doc Duke
Eric Reiter post-doc Duke
Xiu-Rong Ren post-doc Duke
Greg Della Rocca post-doc Duke
Neil Roth post-doc Duke
Greg Sabo post-doc Duke
Philippe Samama post-doc Duke
Mika Scheinin post-doc Duke
Douglas Schocken post-doc Duke
Debra A. Schwinn post-doc Duke
Sudha K. Shenoy post-doc Duke
Robert Shorr post-doc Duke
Arun K. Shukla post-doc Duke
Robert F. Spurney post-doc Duke
Dean Staus post-doc Duke
Gary L. Stiles post-doc Duke
Robert Stoffel post-doc Duke
Carl Stone post-doc Duke
Ryan Strachan post-doc Duke
Cathy Strader post-doc Duke
Ruth Strasser post-doc Duke
Daniel Stroik post-doc Duke
Berta Strulovici post-doc Duke
Jinpeng Sun post-doc Duke
Robert L. Tate post-doc Duke (Microtree)
Blossom Tewelde post-doc Duke
Michael Tharp post-doc Duke
Alex Thomsen post-doc Duke
Akira Tohgo post-doc Duke
Kazushige Touhara post-doc Duke
Bie Shung Tsai post-doc Duke
Vivek Upadhyay post-doc Duke
Johnathan Violin post-doc Duke
Huijun Wei post-doc Duke (Chemistry Tree)
Michael Wessels post-doc Duke
Erin J. Whalen post-doc Duke
Jarl Wikberg post-doc Duke
R. Sanders Williams post-doc Duke
Lewis T. Williams post-doc Duke
Laura M. Wingler post-doc Duke (Chemistry Tree)
Dennis Scott Witherow post-doc Duke (Cell Biology Tree)
Kevin Xiao post-doc Duke
Helen Yao post-doc Duke
Takaaki Yoshimasa post-doc Duke
Musa Zamah post-doc Duke
Yunxiang Zang post-doc Duke
Dave Zidar post-doc Duke
Marc Caron post-doc 1973-1976 Duke
Lee Limbird post-doc 1973-1978 Duke
Warren J. Strittmatter post-doc 1978-1978 Duke
Richard A. Cerione post-doc 1982-1985 Duke University / HHMI (Chemistry Tree)
David R. Sibley post-doc 1983-1987 Duke
Brian K. Kobilka post-doc 1984-1989 Duke
Michel Bouvier post-doc 1985-1989 Université de Montréal
James Inglese post-doc 1989-1994 Duke
Richard T Premont post-doc 1992-1997 Duke University School of Medicine (Chemistry Tree)
Randy A. Hall post-doc 1996-1999 Duke
Guido Iaccarino post-doc 1996-1999 Duke University / HHMI
David S Feldman post-doc 1997-2000 Duke University / HHMI
Sudarshan Rajagopal post-doc 2008-2011 Duke University School of Medicine (Chemistry Tree)
Makoto R. Hara post-doc 2006-2012 Duke
Alem Kahsai research scientist Duke (Chemistry Tree)
Jihee Kim research scientist Duke
Lindsay Rein research scientist Duke
Paul J Shim research scientist
Jim Wisler research scientist Duke
Martin J. Lohse research scientist 1988-1990 Duke University / HHMI
Jennifer J. Linderman research scientist 1996-1997 Duke
Michael E Rockman research scientist 2009-2010 Duke (Chemistry Tree)
Kurt D. Newman division chief Duke (Pediatric Surgery Tree)

Collaborators

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Abraham White collaborator 1975-1981 Duke (Chemistry Tree)
Bruno Giros collaborator 1992-1994 Duke University Medical Center
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Publications

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Pakharukova N, Thomas BN, Bansia H, et al. (2024) Beta-arrestin 1 mediated Src activation via Src SH3 domain revealed by cryo-electron microscopy. Biorxiv : the Preprint Server For Biology
Liu S, Anderson PJ, Rajagopal S, et al. (2024) G Protein-Coupled Receptors: A Century of Research and Discovery. Circulation Research. 135: 174-197
Casiraghi M, Wang H, Brennan P, et al. (2024) Molecular insights into G protein specificity and biased agonism at the β -adrenergic receptor. Biorxiv : the Preprint Server For Biology
Rockman HA, Lefkowitz RJ. (2024) G protein-coupled receptors: from radioligand binding to cellular signaling. The Journal of Clinical Investigation. 134
Lefkowitz RJ, Rockman HA, Shim PJ, et al. (2023) How carvedilol does not activate β-adrenoceptors. Nature Communications. 14: 7866
Kahsai AW, Shah KS, Shim PJ, et al. (2023) Signal transduction at GPCRs: Allosteric activation of the ERK MAPK by β-arrestin. Proceedings of the National Academy of Sciences of the United States of America. 120: e2303794120
Ahn S, Maarsingh H, Walker JK, et al. (2023) Allosteric modulator potentiates β2AR agonist-promoted bronchoprotection in asthma models. The Journal of Clinical Investigation
Li A, Liu S, Huang R, et al. (2023) Loss of biased signaling at a G protein-coupled receptor in overexpressed systems. Plos One. 18: e0283477
Asher WB, Terry DS, Gregorio GGA, et al. (2022) GPCR-mediated β-arrestin activation deconvoluted with single-molecule precision. Cell
Utz PJ, Jain MK, Cheung VG, et al. (2022) Translating science to medicine: The case for physician-scientists. Science Translational Medicine. 14: eabg7852
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