Robert Drolet, PhD

Affiliations: 
Merck, Semoy, Centre-Val de Loire, France 
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"Robert Drolet"
Mean distance: 17.21 (cluster 32)
 
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Publications

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Cosden M, Jinn S, Yao L, et al. (2021) A novel glucosylceramide synthase inhibitor attenuates alpha synuclein pathology and lysosomal dysfunction in preclinical models of synucleinopathy. Neurobiology of Disease. 105507
Polinski NK, Martinez TN, Gorodinsky A, et al. (2021) Decreased glucocerebrosidase activity and substrate accumulation of glycosphingolipids in a novel GBA1 D409V knock-in mouse model. Plos One. 16: e0252325
Rocha EM, De Miranda BR, Castro S, et al. (2019) LRRK2 inhibition prevents endolysosomal deficits seen in human Parkinson's disease. Neurobiology of Disease. 104626
Jinn S, Blauwendraat C, Toolan D, et al. (2019) Functionalization of the TMEM175 p.M393T Variant as a risk factor for Parkinson Disease. Human Molecular Genetics
Scott JD, DeMong DE, Greshock TJ, et al. (2017) Discovery of a 3-(4-Pyrimidinyl) Indazole (MLi-2), an Orally Available and Selective Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitor that Reduces Brain Kinase Activity. Journal of Medicinal Chemistry
Jinn S, Drolet RE, Cramer PE, et al. (2017) TMEM175 deficiency impairs lysosomal and mitochondrial function and increases α-synuclein aggregation. Proceedings of the National Academy of Sciences of the United States of America
Greshock TJ, Sanders JM, Drolet RE, et al. (2016) Potent, selective and orally bioavailable leucine-rich repeat kinase 2 (LRRK2) inhibitors. Bioorganic & Medicinal Chemistry Letters
Usenovic M, Niroomand S, Drolet RE, et al. (2015) Internalized Tau Oligomers Cause Neurodegeneration by Inducing Accumulation of Pathogenic Tau in Human Neurons Derived from Induced Pluripotent Stem Cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 14234-50
Légaré F, Stacey D, Brière N, et al. (2014) An interprofessional approach to shared decision making: an exploratory case study with family caregivers of one IP home care team. Bmc Geriatrics. 14: 83
Farrell KF, Krishnamachari S, Villanueva E, et al. (2014) Non-motor parkinsonian pathology in aging A53T α-synuclein mice is associated with progressive synucleinopathy and altered enzymatic function. Journal of Neurochemistry. 128: 536-46
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