Robert Drolet, PhD

Affiliations: 
Merck, Semoy, Centre-Val de Loire, France 
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"Robert Drolet"
Mean distance: 17.21 (cluster 32)
 
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Publications

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Cosden M, Jinn S, Yao L, et al. (2021) A novel glucosylceramide synthase inhibitor attenuates alpha synuclein pathology and lysosomal dysfunction in preclinical models of synucleinopathy. Neurobiology of Disease. 105507
Polinski NK, Martinez TN, Gorodinsky A, et al. (2021) Decreased glucocerebrosidase activity and substrate accumulation of glycosphingolipids in a novel GBA1 D409V knock-in mouse model. Plos One. 16: e0252325
Rocha EM, De Miranda BR, Castro S, et al. (2019) LRRK2 inhibition prevents endolysosomal deficits seen in human Parkinson's disease. Neurobiology of Disease. 104626
Jinn S, Blauwendraat C, Toolan D, et al. (2019) Functionalization of the TMEM175 p.M393T Variant as a risk factor for Parkinson Disease. Human Molecular Genetics
Jinn S, Drolet RE, Cramer PE, et al. (2017) TMEM175 deficiency impairs lysosomal and mitochondrial function and increases α-synuclein aggregation. Proceedings of the National Academy of Sciences of the United States of America
Farrell KF, Krishnamachari S, Villanueva E, et al. (2014) Non-motor parkinsonian pathology in aging A53T α-synuclein mice is associated with progressive synucleinopathy and altered enzymatic function. Journal of Neurochemistry. 128: 536-46
Greenamyre JT, Cannon JR, Drolet R, et al. (2010) Lessons from the rotenone model of Parkinson's disease. Trends in Pharmacological Sciences. 31: 141-2; author reply
Drolet RE, Cannon JR, Montero L, et al. (2009) Chronic rotenone exposure reproduces Parkinson's disease gastrointestinal neuropathology. Neurobiology of Disease. 36: 96-102
Cannon JR, Tapias V, Na HM, et al. (2009) A highly reproducible rotenone model of Parkinson's disease. Neurobiology of Disease. 34: 279-90
Drolet RE, Cannon JR, Montero LM, et al. (2009) T1782 Rotenone Recapitulates Parkinson's Disease-Related Gastrointestinal Motility Deficits and Alpha-Synuclein Pathology in the Enteric Nervous System Gastroenterology. 136: A-578-A-579
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