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Shadmehr Demehri, Ph.D. - Publications

Affiliations: 
Biology & Biomedical Sciences (Molecular Cell Biology) Washington University, Saint Louis, St. Louis, MO 
Area:
Notch
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43 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2025 Oka T, Smith SS, Son HG, Lee T, Oliver-Garcia VS, Mortaja M, Trerice KE, Isakoff LS, Conrad DN, Azin M, Raval NS, Tabacchi M, Emdad L, Das SK, Fisher PB, ... ... Demehri S, et al. T helper 2 cell-directed immunotherapy eliminates precancerous skin lesions. The Journal of Clinical Investigation. 135. PMID 39744942 DOI: 10.1172/JCI183274  0.328
2024 Son HG, Ha DT, Xia Y, Li T, Blandin J, Oka T, Azin M, Conrad DN, Zhou C, Zeng Y, Hasegawa T, Strickley JD, Messerschmidt JL, Guennoun R, Erlich TH, ... ... Demehri S, et al. Commensal papillomavirus immunity preserves the homeostasis of highly mutated normal skin. Cancer Cell. PMID 39672169 DOI: 10.1016/j.ccell.2024.11.013  0.323
2022 Cheon SY, Park JH, Ameri AH, Lee RT, Nazarian RM, Demehri S. IL-33/regulatory T cell axis suppresses skin fibrosis. The Journal of Investigative Dermatology. PMID 35341735 DOI: 10.1016/j.jid.2022.03.009  0.337
2020 Messerschmidt JL, Dempsey KE, Dillon KS, Demehri S. Divergent Roles of Epithelium-Derived Alarmins in Notch Signaling Deficient Skin. The Journal of Investigative Dermatology. PMID 32147504 DOI: 10.1016/J.Jid.2020.02.020  0.478
2020 Ameri AH, Foreman RK, Vedak P, Chen S, Miller DM, Demehri S. Hypertrophic Lichen Planus with Histological Features of Squamous Cell Carcinoma Associated with Immune Checkpoint Blockade Therapy. The Oncologist. PMID 32073194 DOI: 10.1634/Theoncologist.2019-0796  0.309
2019 Hasegawa T, Feng Z, Yan Z, Ngo KH, Hosoi J, Demehri S. Reduction in human epidermal Langerhans cells with age is associated with decline in CXCL14-mediated recruitment of CD14 monocytes. The Journal of Investigative Dermatology. PMID 31881212 DOI: 10.1016/J.Jid.2019.11.017  0.43
2019 Strickley JD, Messerschmidt JL, Awad ME, Li T, Hasegawa T, Ha DT, Nabeta HW, Bevins PA, Ngo KH, Asgari MM, Nazarian RM, Neel VA, Jenson AB, Joh J, Demehri S. Immunity to commensal papillomaviruses protects against skin cancer. Nature. PMID 31666702 DOI: 10.1038/S41586-019-1719-9  0.408
2019 Choi BD, Yu X, Castano AP, Bouffard AA, Schmidts A, Larson RC, Bailey SR, Boroughs AC, Frigault MJ, Leick MB, Scarfò I, Cetrulo CL, Demehri S, Nahed BV, Cahill DP, et al. CAR-T cells secreting BiTEs circumvent antigen escape without detectable toxicity. Nature Biotechnology. PMID 31332324 DOI: 10.1038/S41587-019-0192-1  0.323
2019 Ameri AH, Mooradian MJ, Emerick KS, Park JC, Wirth LJ, Asgari MM, Tsao H, Lawrence D, Sullivan RJ, Demehri S. Immunotherapeutic Strategies for Cutaneous Squamous Cell Carcinoma Prevention in Xeroderma Pigmentosum. The British Journal of Dermatology. PMID 31102460 DOI: 10.1111/Bjd.18144  0.405
2019 Rosenberg AR, Tabacchi M, Ngo KH, Wallendorf M, Rosman IS, Cornelius LA, Demehri S. Skin cancer precursor immunotherapy for squamous cell carcinoma prevention. Jci Insight. 4. PMID 30895944 DOI: 10.1172/Jci.Insight.125476  0.335
2019 Boroughs AC, Larson RC, Choi BD, Bouffard AA, Riley LS, Schiferle E, Kulkarni AS, Cetrulo CL, Ting D, Blazar BR, Demehri S, Maus MV. Chimeric antigen receptor costimulation domains modulate human regulatory T cell function. Jci Insight. 5. PMID 30869654 DOI: 10.1172/Jci.Insight.126194  0.306
2019 Ameri AH, Moradi Tuchayi S, Zaalberg A, Park JH, Ngo KH, Li T, Lopez E, Colonna M, Lee RT, Mino-Kenudson M, Demehri S. IL-33/regulatory T cell axis triggers the development of a tumor-promoting immune environment in chronic inflammation. Proceedings of the National Academy of Sciences of the United States of America. PMID 30696763 DOI: 10.1073/Pnas.1815016116  0.366
2019 Choi BD, Yu X, Castano AP, Bouffard AA, Schmidts A, Larson RC, Bailey SR, Boroughs AC, Frigault MJ, Leick MB, Scarfo I, Cetrulo CL, Demehri S, Nahed BV, Cahill DP, et al. Bispecific T-Cell Engager -Armored Chimeric Antigen Receptor T Cells Overcome Antigen Escape From EGFRvIII-Targeted Therapy For Glioblastoma Neurosurgery. 66. DOI: 10.1093/Neuros/Nyz310_154  0.339
2018 Zaalberg A, Moradi Tuchayi S, Ameri AH, Ngo KH, Cunningham TJ, Eliane JP, Livneh M, Horn TD, Rosman IS, Musiek A, Anadkat MJ, Demehri S. Chronic inflammation promotes skin carcinogenesis in cancer-prone discoid lupus erythematosus. The Journal of Investigative Dermatology. PMID 30030152 DOI: 10.1016/J.Jid.2018.06.185  0.48
2018 Park JC, Wirth LJ, Flaherty K, Lawrence DP, Demehri S, Kraft S, Foreman R, Clark JR, Cohen JV, Kim Y, Boland GM, Frederick DT, Sullivan RJ. Immune checkpoint inhibition (ICI) in advanced cutaneous squamous cell carcinoma (cSCC): Clinical response and correlative biomarker analysis. Journal of Clinical Oncology. 36: 9564-9564. DOI: 10.1200/Jco.2018.36.15_Suppl.9564  0.304
2018 Hasegawa T, Feng R, Zhiyu Y, Hosoi J, Demehri S. 900 Age-associated changes in the human skin immune environment Journal of Investigative Dermatology. 138: S153. DOI: 10.1016/J.Jid.2018.03.912  0.37
2018 Ameri A, Mooradian M, Sullivan R, Demehri S. 417 Immunotherapeutic options for skin cancer prevention in xeroderma pigmentosum Journal of Investigative Dermatology. 138: S71. DOI: 10.1016/J.Jid.2018.03.424  0.396
2017 Blomberg M, He SY, Harwood C, Arron ST, Demehri S, Green A, Asgari MM. Research gaps in the management and prevention of cutaneous squamous cell carcinoma in organ transplant recipients. The British Journal of Dermatology. PMID 29086412 DOI: 10.1111/Bjd.15950  0.327
2017 Kawakubo M, Demehri S, Manstein D. Fractional laser exposure induces neutrophil infiltration (N1 phenotype) into the tumor and stimulates systemic anti-tumor immune response. Plos One. 12: e0184852. PMID 28922374 DOI: 10.1371/Journal.Pone.0184852  0.338
2017 Yesantharao P, Wang W, Ioannidis NM, Demehri S, Whitemore AS, Asgari MM. Cutaneous Squamous Cell Cancer (cSCC) Risk and the Human Leukocyte Antigen (HLA) System. Human Immunology. PMID 28185865 DOI: 10.1016/J.Humimm.2017.02.002  0.32
2016 Cunningham TJ, Tabacchi M, Eliane JP, Tuchayi SM, Manivasagam S, Mirzaalian H, Turkoz A, Kopan R, Schaffer A, Saavedra AP, Wallendorf M, Cornelius LA, Demehri S. Randomized trial of calcipotriol combined with 5-fluorouracil for skin cancer precursor immunotherapy. The Journal of Clinical Investigation. PMID 27869649 DOI: 10.1172/Jci89820  0.613
2016 Cunningham T, Tuchayi SM, Tabacchi M, Manivasagam S, Mirzaalian H, Turkoz A, Kopan R, Schaffer A, Wallendorf M, Cornelius L, Demehri S. 222 Topical 5-fluorouracil and calcipotriol combination: A potent immunotherapeutic for actinic keratosis Journal of Investigative Dermatology. 136. DOI: 10.1016/J.Jid.2016.02.251  0.502
2015 Demehri S, Cunningham TJ, Hurst EA, Schaffer A, Sheinbein DM, Yokoyama WM. Abstract A64: Chronic allergic contact dermatitis, A potent tumor promoter of Marjolin's ulcer Cancer Immunology Research. 3. DOI: 10.1158/2326-6074.Tumimm14-A64  0.395
2014 Demehri S, Cunningham TJ, Hurst EA, Schaffer A, Sheinbein DM, Yokoyama WM. Chronic allergic contact dermatitis promotes skin cancer. The Journal of Clinical Investigation. 124: 5037-41. PMID 25295539 DOI: 10.1172/Jci77843  0.422
2014 Demehri S, Yockey LJ, Visness CM, Jaffee KF, Turkoz A, Wood RA, O'Connor GT, Kattan M, Gern JE, Gergen PJ, Holtzman M, Bloomberg G, Kopan R. Circulating TSLP associates with decreased wheezing in non-atopic preschool children: data from the URECA birth cohort. Clinical and Experimental Allergy : Journal of the British Society For Allergy and Clinical Immunology. 44: 851-7. PMID 24397611 DOI: 10.1111/Cea.12270  0.602
2013 Zhao ZQ, Huo FQ, Jeffry J, Hampton L, Demehri S, Kim S, Liu XY, Barry DM, Wan L, Liu ZC, Li H, Turkoz A, Ma K, Cornelius LA, Kopan R, et al. Chronic itch development in sensory neurons requires BRAF signaling pathways. The Journal of Clinical Investigation. 123: 4769-80. PMID 24216512 DOI: 10.1172/Jci70528  0.577
2013 Yockey LJ, Demehri S, Turkoz M, Turkoz A, Ahern PP, Jassim O, Manivasagam S, Kearney JF, Gordon JI, Kopan R. The absence of a microbiota enhances TSLP expression in mice with defective skin barrier but does not affect the severity of their allergic inflammation. The Journal of Investigative Dermatology. 133: 2714-21. PMID 23698100 DOI: 10.1038/Jid.2013.228  0.77
2012 Demehri S, Turkoz A, Manivasagam S, Yockey LJ, Turkoz M, Kopan R. Elevated epidermal thymic stromal lymphopoietin levels establish an antitumor environment in the skin. Cancer Cell. 22: 494-505. PMID 23079659 DOI: 10.1016/J.Ccr.2012.08.017  0.769
2011 Bloomberg G, Demehri S, Visness C, O'Connor G, Kattan M, Wood R, Gern J, Kopan R. Plasma Thymic Stromal Lymphopoietin Concentration is related to Allergen Sensitization in Young Children Journal of Allergy and Clinical Immunology. 127: AB126-AB126. DOI: 10.1016/J.Jaci.2010.12.502  0.48
2010 Dumortier A, Durham AD, Di Piazza M, Vauclair S, Koch U, Ferrand G, Ferrero I, Demehri S, Song LL, Farr AG, Leonard WJ, Kopan R, Miele L, Hohl D, Finke D, et al. Atopic dermatitis-like disease and associated lethal myeloproliferative disorder arise from loss of Notch signaling in the murine skin. Plos One. 5: e9258. PMID 20174635 DOI: 10.1371/Journal.Pone.0009258  0.685
2009 Bazzi H, Demehri S, Potter CS, Barber AG, Awgulewitsch A, Kopan R, Christiano AM. Desmoglein 4 is regulated by transcription factors implicated in hair shaft differentiation. Differentiation; Research in Biological Diversity. 78: 292-300. PMID 19683850 DOI: 10.1016/J.Diff.2009.06.004  0.585
2009 Demehri S, Turkoz A, Kopan R. Epidermal Notch1 loss promotes skin tumorigenesis by impacting the stromal microenvironment. Cancer Cell. 16: 55-66. PMID 19573812 DOI: 10.1016/J.Ccr.2009.05.016  0.651
2009 Demehri S, Morimoto M, Holtzman MJ, Kopan R. Skin-derived TSLP triggers progression from epidermal-barrier defects to asthma. Plos Biology. 7: e1000067. PMID 19557146 DOI: 10.1371/Journal.Pbio.1000067  0.628
2009 Demehri S, Kopan R. Notch signaling in bulge stem cells is not required for selection of hair follicle fate. Development (Cambridge, England). 136: 891-6. PMID 19211676 DOI: 10.1242/Dev.030700  0.573
2009 Pazolli E, Luo X, Brehm S, Carbery K, Chung JJ, Prior JL, Doherty J, Demehri S, Salavaggione L, Piwnica-Worms D, Stewart SA. Senescent stromal-derived osteopontin promotes preneoplastic cell growth. Cancer Research. 69: 1230-9. PMID 19155301 DOI: 10.1158/0008-5472.Can-08-2970  0.332
2008 Demehri S, Liu Z, Lee J, Lin MH, Crosby SD, Roberts CJ, Grigsby PW, Miner JH, Farr AG, Kopan R. Notch-deficient skin induces a lethal systemic B-lymphoproliferative disorder by secreting TSLP, a sentinel for epidermal integrity. Plos Biology. 6: e123. PMID 18507503 DOI: 10.1371/Journal.Pbio.0060123  0.777
2008 Demehri S, Liu Z, Lee J, Lin MH, Crosby SD, Roberts CJ, Grigsby PW, Miner JH, Farr AG, Kopan R. Correction: Notch-deficient skin induces a lethal systemic B-lymphoproliferative disorder by secreting TSLP, a sentinel for epidermal integrity (PLoS Biology (2008) 6,5 (e123) DOI: 10.1371/journal.pbio.0060123) Plos Biology. 6: 1599. DOI: 10.1371/journal.pbio.0060169  0.765
2008 Demehri S, Liu Z, Lee J, Lin M, Crosby S, Roberts C, Grigsby P, Miner J, Farr A, Kopan R. O4-03-06: Notch or gamma-secretase-deficient skin creates an environment inducing a lethal systemic B-lymphoproliferative disorder by overproducing TSLP, a sentinel for epidermal integrity Alzheimer's & Dementia. 4: T190-T190. DOI: 10.1016/J.Jalz.2008.05.523  0.756
2007 Lee J, Basak JM, Demehri S, Kopan R. Bi-compartmental communication contributes to the opposite proliferative behavior of Notch1-deficient hair follicle and epidermal keratinocytes. Development (Cambridge, England). 134: 2795-806. PMID 17611229 DOI: 10.1242/Dev.02868  0.743
2006 Demehri S, Corbin A, Loriaux M, Druker BJ, Deininger MW. Establishment of a murine model of aggressive systemic mastocytosis/mast cell leukemia. Experimental Hematology. 34: 284-8. PMID 16543062 DOI: 10.1016/J.Exphem.2005.11.015  0.344
2005 Corbin AS, Demehri S, Griswold IJ, Wang Y, Metcalf CA, Sundaramoorthi R, Shakespeare WC, Snodgrass J, Wardwell S, Dalgarno D, Iuliucci J, Sawyer TK, Heinrich MC, Druker BJ, Deininger MW. In vitro and in vivo activity of ATP-based kinase inhibitors AP23464 and AP23848 against activation-loop mutants of Kit. Blood. 106: 227-34. PMID 15746079 DOI: 10.1182/Blood-2004-12-4771  0.311
2004 Corbin AS, Demehri S, Griswold IJ, Metcalf CA, Shakespeare WC, Snodgrass J, Wardwell S, Dalgarno DC, Iuliucci J, Sawyer TK, Druker BJ, Deininger MW. In Vitro and In Vivo Activity of the Src/Abl Kinase Inhibitor AP23464 and Analogs Against Activation Loop Mutants of KIT. Blood. 104: 793-793. DOI: 10.1182/Blood.V104.11.793.793  0.303
2004 Demehri S, Corbin AS, Loriaux M, Druker BJ, Deininger MW. Murine Model of Aggressive Systemic Mastocytosis: A Disease Caused by Oncogenic Kit. Blood. 104: 2426-2426. DOI: 10.1182/Blood.V104.11.2426.2426  0.332
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