Raphael Kopan - Publications

Washington University, Saint Louis, St. Louis, MO 

148 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Kobia FM, Preusse K, Dai Q, Weaver N, Hass MR, Chaturvedi P, Stein SJ, Pear WS, Yuan Z, Kovall RA, Kuang Y, Eafergen N, Sprinzak D, Gebelein B, Brunskill EW, ... Kopan R, et al. Notch dimerization and gene dosage are important for normal heart development, intestinal stem cell maintenance, and splenic marginal zone B-cell homeostasis during mite infestation. Plos Biology. 18: e3000850. PMID 33017398 DOI: 10.1371/journal.pbio.3000850  0.48
2020 Mukherjee M, Ratnayake I, Janga M, Fogarty E, Scheidt S, Grassmeyer J, deRiso J, Chandrasekar I, Ahrenkiel P, Kopan R, Surendran K. Notch signaling regulates Akap12 expression and primary cilia length during renal tubule morphogenesis. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 32474964 DOI: 10.1096/fj.201902358RR  0.68
2020 Kuang Y, Golan O, Preusse K, Cain B, Christensen CJ, Salomone J, Campbell I, Okwubido-Williams FV, Hass MR, Yuan Z, Eafergan N, Moberg KH, Kovall RA, Kopan R, Sprinzak D, et al. Enhancer architecture sensitizes cell-specific responses to gene dose via a bind and discard mechanism. Elife. 9. PMID 32297857 DOI: 10.7554/eLife.53659  0.48
2017 Kovall RA, Gebelein B, Sprinzak D, Kopan R. The Canonical Notch Signaling Pathway: Structural and Biochemical Insights into Shape, Sugar, and Force. Developmental Cell. 41: 228-241. PMID 28486129 DOI: 10.1016/j.devcel.2017.04.001  0.48
2016 Cunningham TJ, Tabacchi M, Eliane JP, Tuchayi SM, Manivasagam S, Mirzaalian H, Turkoz A, Kopan R, Schaffer A, Saavedra AP, Wallendorf M, Cornelius LA, Demehri S. Randomized trial of calcipotriol combined with 5-fluorouracil for skin cancer precursor immunotherapy. The Journal of Clinical Investigation. PMID 27869649 DOI: 10.1172/JCI89820  1
2016 Hass MR, Liow HH, Chen X, Sharma A, Inoue YU, Inoue T, Reeb A, Martens A, Fulbright M, Raju S, Stevens M, Boyle S, Park JS, Weirauch MT, Brent MR, ... Kopan R, et al. SpDamID: Marking DNA Bound by Protein Complexes Identifies Notch-Dimer Responsive Enhancers. Molecular Cell. 64: 213. PMID 27716485 DOI: 10.1016/j.molcel.2016.09.035  0.6
2016 Hayashi Y, Nishimune H, Hozumi K, Saga Y, Harada A, Yuzaki M, Iwatsubo T, Kopan R, Tomita T. A novel non-canonical Notch signaling regulates expression of synaptic vesicle proteins in excitatory neurons. Scientific Reports. 6: 23969. PMID 27040987 DOI: 10.1038/srep23969  0.4
2016 Turkoz M, Townsend RR, Kopan R. The Notch intracellular domain has an RBPj-independent role during mouse hair follicular development. The Journal of Investigative Dermatology. PMID 26940862 DOI: 10.1016/j.jid.2016.02.018  0.6
2016 Gama-Norton L, Ferrando E, Ruiz-Herguido C, Liu Z, Guiu J, Islam AB, Lee SU, Yan M, Guidos CJ, López-Bigas N, Maeda T, Espinosa L, Kopan R, Bigas A. Corrigendum: Notch signal strength controls cell fate in the haemogenic endothelium. Nature Communications. 7: 10978. PMID 26939771 DOI: 10.1038/ncomms10978  0.64
2016 Kopan R. The Unaimed Arrow Never Misses Current Topics in Developmental Biology. DOI: 10.1016/bs.ctdb.2015.10.007  1
2015 Gama-Norton L, Ferrando E, Ruiz-Herguido C, Liu Z, Guiu J, Islam AB, Lee SU, Yan M, Guidos CJ, López-Bigas N, Maeda T, Espinosa L, Kopan R, Bigas A. Notch signal strength controls cell fate in the haemogenic endothelium. Nature Communications. 6: 8510. PMID 26465397 DOI: 10.1038/ncomms9510  1
2015 Chen S, Brunskill EW, Potter SS, Dexheimer PJ, Salomonis N, Aronow BJ, Hong CI, Zhang T, Kopan R. Intrinsic Age-Dependent Changes and Cell-Cell Contacts Regulate Nephron Progenitor Lifespan. Developmental Cell. 35: 49-62. PMID 26460946 DOI: 10.1016/j.devcel.2015.09.009  1
2015 Liu Z, Schneider DL, Kornfeld K, Kopan R. Corrigendum: Simple Copy Number Determination with Reference Query Pyrosequencing (RQPS). Cold Spring Harbor Protocols. 2015: pdb.corr090167. PMID 26430946 DOI: 10.1101/pdb.corr090167  0.64
2015 Demitrack ES, Gifford GB, Keeley TM, Carulli AJ, VanDussen KL, Thomas D, Giordano TJ, Liu Z, Kopan R, Samuelson LC. Notch signaling regulates gastric antral LGR5 stem cell function. The Embo Journal. PMID 26271103 DOI: 10.15252/embj.201490583  0.64
2015 Hass MR, Liow HH, Chen X, Sharma A, Inoue YU, Inoue T, Reeb A, Martens A, Fulbright M, Raju S, Stevens M, Boyle S, Park JS, Weirauch MT, Brent MR, ... Kopan R, et al. SpDamID: Marking DNA Bound by Protein Complexes Identifies Notch-Dimer Responsive Enhancers. Molecular Cell. 59: 685-97. PMID 26257285 DOI: 10.1016/j.molcel.2015.07.008  1
2015 Liu Z, Brunskill E, Varnum-Finney B, Zhang C, Zhang A, Jay PY, Bernstein I, Morimoto M, Kopan R. The intracellular domains of Notch1 and Notch2 are functionally equivalent during development and carcinogenesis. Development (Cambridge, England). 142: 2452-63. PMID 26062937 DOI: 10.1242/dev.125492  1
2015 Liu Z, Brunskill E, Boyle S, Chen S, Turkoz M, Guo Y, Grant R, Kopan R. Second-generation Notch1 activity-trap mouse line (N1IP::CreHI) provides a more comprehensive map of cells experiencing Notch1 activity. Development (Cambridge, England). 142: 1193-202. PMID 25725069 DOI: 10.1242/dev.119529  1
2014 Ilagan MX, Kopan R. Monitoring Notch activation in cultured mammalian cells: luciferase complementation imaging assays. Methods in Molecular Biology (Clifton, N.J.). 1187: 155-68. PMID 25053488 DOI: 10.1007/978-1-4939-1139-4_12  1
2014 Ilagan MX, Kopan R. Monitoring Notch activation in cultured mammalian cells: transcriptional reporter assays. Methods in Molecular Biology (Clifton, N.J.). 1187: 143-54. PMID 25053487 DOI: 10.1007/978-1-4939-1139-4_11  1
2014 Kopan R, Chen S, Little M. Nephron progenitor cells: shifting the balance of self-renewal and differentiation. Current Topics in Developmental Biology. 107: 293-331. PMID 24439811 DOI: 10.1016/B978-0-12-416022-4.00011-1  1
2014 Demehri S, Yockey LJ, Visness CM, Jaffee KF, Turkoz A, Wood RA, O'Connor GT, Kattan M, Gern JE, Gergen PJ, Holtzman M, Bloomberg G, Kopan R. Circulating TSLP associates with decreased wheezing in non-atopic preschool children: data from the URECA birth cohort. Clinical and Experimental Allergy : Journal of the British Society For Allergy and Clinical Immunology. 44: 851-7. PMID 24397611 DOI: 10.1111/cea.12270  1
2014 Boyle SC, Liu Z, Kopan R. Notch signaling is required for the formation of mesangial cells from a stromal mesenchyme precursor during kidney development. Development (Cambridge, England). 141: 346-54. PMID 24353058 DOI: 10.1242/dev.100271  1
2014 Kopan R, Chen S, Liu Z. Alagille, Notch, and robustness: why duplicating systems does not ensure redundancy. Pediatric Nephrology (Berlin, Germany). 29: 651-7. PMID 24271660 DOI: 10.1007/s00467-013-2661-y  1
2013 Chillakuri CR, Sheppard D, Ilagan MX, Holt LR, Abbott F, Liang S, Kopan R, Handford PA, Lea SM. Structural analysis uncovers lipid-binding properties of Notch ligands. Cell Reports. 5: 861-7. PMID 24239355 DOI: 10.1016/j.celrep.2013.10.029  1
2013 Zhao ZQ, Huo FQ, Jeffry J, Hampton L, Demehri S, Kim S, Liu XY, Barry DM, Wan L, Liu ZC, Li H, Turkoz A, Ma K, Cornelius LA, Kopan R, et al. Chronic itch development in sensory neurons requires BRAF signaling pathways. The Journal of Clinical Investigation. 123: 4769-80. PMID 24216512 DOI: 10.1172/JCI70528  1
2013 Satpathy AT, Briseño CG, Lee JS, Ng D, Manieri NA, Kc W, Wu X, Thomas SR, Lee WL, Turkoz M, McDonald KG, Meredith MM, Song C, Guidos CJ, Newberry RD, ... ... Kopan R, et al. Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens. Nature Immunology. 14: 937-48. PMID 23913046 DOI: 10.1038/ni.2679  0.6
2013 Liu Z, Chen S, Boyle S, Zhu Y, Zhang A, Piwnica-Worms DR, Ilagan MX, Kopan R. The extracellular domain of Notch2 increases its cell-surface abundance and ligand responsiveness during kidney development. Developmental Cell. 25: 585-98. PMID 23806616 DOI: 10.1016/j.devcel.2013.05.022  1
2013 Liu Z, Liu Z, Walters BJ, Owen T, Kopan R, Zuo J. In vivo visualization of Notch1 proteolysis reveals the heterogeneity of Notch1 signaling activity in the mouse cochlea. Plos One. 8: e64903. PMID 23741415 DOI: 10.1371/journal.pone.0064903  1
2013 Yockey LJ, Demehri S, Turkoz M, Turkoz A, Ahern PP, Jassim O, Manivasagam S, Kearney JF, Gordon JI, Kopan R. The absence of a microbiota enhances TSLP expression in mice with defective skin barrier but does not affect the severity of their allergic inflammation. The Journal of Investigative Dermatology. 133: 2714-21. PMID 23698100 DOI: 10.1038/jid.2013.228  1
2013 Groot AJ, Cobzaru C, Weber S, Saftig P, Blobel CP, Kopan R, Vooijs M, Franzke CW. Epidermal ADAM17 is dispensable for notch activation. The Journal of Investigative Dermatology. 133: 2286-8. PMID 23657465 DOI: 10.1038/jid.2013.162  1
2013 Ilagan MX, Kopan R. Selective blockade of transport via SERCA inhibition: the answer for oncogenic forms of Notch? Cancer Cell. 23: 267-9. PMID 23518343 DOI: 10.1016/j.ccr.2013.02.020  1
2012 Morimoto M, Nishinakamura R, Saga Y, Kopan R. Different assemblies of Notch receptors coordinate the distribution of the major bronchial Clara, ciliated and neuroendocrine cells. Development (Cambridge, England). 139: 4365-73. PMID 23132245 DOI: 10.1242/dev.083840  1
2012 Sato C, Turkoz M, Dearborn JT, Wozniak DF, Kopan R, Hass MR. Loss of RBPj in postnatal excitatory neurons does not cause neurodegeneration or memory impairments in aged mice. Plos One. 7: e48180. PMID 23110206 DOI: 10.1371/journal.pone.0048180  1
2012 Demehri S, Turkoz A, Manivasagam S, Yockey LJ, Turkoz M, Kopan R. Elevated epidermal thymic stromal lymphopoietin levels establish an antitumor environment in the skin. Cancer Cell. 22: 494-505. PMID 23079659 DOI: 10.1016/j.ccr.2012.08.017  1
2012 Kopan R. Notch signaling. Cold Spring Harbor Perspectives in Biology. 4. PMID 23028119 DOI: 10.1101/cshperspect.a011213  1
2012 Barak H, Huh SH, Chen S, Jeanpierre C, Martinovic J, Parisot M, Bole-Feysot C, Nitschké P, Salomon R, Antignac C, Ornitz DM, Kopan R. FGF9 and FGF20 maintain the stemness of nephron progenitors in mice and man. Developmental Cell. 22: 1191-207. PMID 22698282 DOI: 10.1016/j.devcel.2012.04.018  1
2012 Zheng J, Watanabe H, Wines-Samuelson M, Zhao H, Gridley T, Kopan R, Shen J. Conditional deletion of Notch1 and Notch2 genes in excitatory neurons of postnatal forebrain does not cause neurodegeneration or reduction of Notch mRNAs and proteins. The Journal of Biological Chemistry. 287: 20356-68. PMID 22505716 DOI: 10.1074/jbc.M112.349738  1
2012 Tu X, Chen J, Lim J, Karner CM, Lee SY, Heisig J, Wiese C, Surendran K, Kopan R, Gessler M, Long F. Physiological notch signaling maintains bone homeostasis via RBPjk and Hey upstream of NFATc1. Plos Genetics. 8: e1002577. PMID 22457635 DOI: 10.1371/journal.pgen.1002577  1
2012 Zheng J, Watanabe H, Wines-Samuelson M, Zhao H, Gridley T, Kopan R, Shen J. Reply to Gaiano et al.: Expression of notch proteins in pyramidal neurons in vivo Journal of Biological Chemistry. 287: 24596. DOI: 10.1074/jbc.L112.380915  1
2011 Boyle SC, Kim M, Valerius MT, McMahon AP, Kopan R. Notch pathway activation can replace the requirement for Wnt4 and Wnt9b in mesenchymal-to-epithelial transition of nephron stem cells. Development (Cambridge, England). 138: 4245-54. PMID 21852398 DOI: 10.1242/dev.070433  1
2011 Ilagan MX, Lim S, Fulbright M, Piwnica-Worms D, Kopan R. Real-time imaging of notch activation with a luciferase complementation-based reporter. Science Signaling. 4: rs7. PMID 21775282 DOI: 10.1126/scisignal.2001656  1
2011 Surendran K, Kopan R. Chromatin-based mechanisms of renal epithelial differentiation. Journal of the American Society of Nephrology : Jasn. 22: 1208-12. PMID 21700830 DOI: 10.1681/ASN.2010101018  1
2011 Vooijs M, Liu Z, Kopan R. Notch: architect, landscaper, and guardian of the intestine. Gastroenterology. 141: 448-59. PMID 21689653 DOI: 10.1053/j.gastro.2011.06.003  1
2011 Liu Z, Turkoz A, Jackson EN, Corbo JC, Engelbach JA, Garbow JR, Piwnica-Worms DR, Kopan R. Notch1 loss of heterozygosity causes vascular tumors and lethal hemorrhage in mice. The Journal of Clinical Investigation. 121: 800-8. PMID 21266774 DOI: 10.1172/JCI43114  1
2011 Pellegrinet L, Rodilla V, Liu Z, Chen S, Koch U, Espinosa L, Kaestner KH, Kopan R, Lewis J, Radtke F. Dll1- and dll4-mediated notch signaling are required for homeostasis of intestinal stem cells. Gastroenterology. 140: 1230-1240.e1-7. PMID 21238454 DOI: 10.1053/j.gastro.2011.01.005  1
2010 Arnett KL, Hass M, McArthur DG, Ilagan MX, Aster JC, Kopan R, Blacklow SC. Structural and mechanistic insights into cooperative assembly of dimeric Notch transcription complexes. Nature Structural & Molecular Biology. 17: 1312-7. PMID 20972443 DOI: 10.1038/nsmb.1938  1
2010 Liu Z, Schneider DL, Kornfeld K, Kopan R. Simple copy number determination with reference query pyrosequencing (RQPS). Cold Spring Harbor Protocols. 2010: pdb.prot5491. PMID 20810638 DOI: 10.1101/pdb.prot5491  1
2010 Costantini F, Kopan R. Patterning a complex organ: branching morphogenesis and nephron segmentation in kidney development. Developmental Cell. 18: 698-712. PMID 20493806 DOI: 10.1016/j.devcel.2010.04.008  1
2010 Tong Y, Yamaguchi H, Giaime E, Boyle S, Kopan R, Kelleher RJ, Shen J. Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice. Proceedings of the National Academy of Sciences of the United States of America. 107: 9879-84. PMID 20457918 DOI: 10.1073/pnas.1004676107  1
2010 Surendran K, Selassie M, Liapis H, Krigman H, Kopan R. Reduced Notch signaling leads to renal cysts and papillary microadenomas. Journal of the American Society of Nephrology : Jasn. 21: 819-32. PMID 20378824 DOI: 10.1681/ASN.2009090925  1
2010 Dumortier A, Durham AD, Di Piazza M, Vauclair S, Koch U, Ferrand G, Ferrero I, Demehri S, Song LL, Farr AG, Leonard WJ, Kopan R, Miele L, Hohl D, Finke D, et al. Atopic dermatitis-like disease and associated lethal myeloproliferative disorder arise from loss of Notch signaling in the murine skin. Plos One. 5: e9258. PMID 20174635 DOI: 10.1371/journal.pone.0009258  1
2010 Zhao G, Liu Z, Ilagan MX, Kopan R. Gamma-secretase composed of PS1/Pen2/Aph1a can cleave notch and amyloid precursor protein in the absence of nicastrin. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 1648-56. PMID 20130175 DOI: 10.1523/JNEUROSCI.3826-09.2010  1
2010 Morimoto M, Liu Z, Cheng HT, Winters N, Bader D, Kopan R. Canonical Notch signaling in the developing lung is required for determination of arterial smooth muscle cells and selection of Clara versus ciliated cell fate. Journal of Cell Science. 123: 213-24. PMID 20048339 DOI: 10.1242/jcs.058669  1
2010 Roe CM, Fitzpatrick AL, Xiong C, Sieh W, Kuller L, Miller JP, Williams MM, Kopan R, Behrens MI, Morris JC. Cancer linked to Alzheimer disease but not vascular dementia. Neurology. 74: 106-12. PMID 20032288 DOI: 10.1212/WNL.0b013e3181c91873  1
2010 Johnson SE, Ilagan MX, Kopan R, Barrick D. Thermodynamic analysis of the CSL x Notch interaction: distribution of binding energy of the Notch RAM region to the CSL beta-trefoil domain and the mode of competition with the viral transactivator EBNA2. The Journal of Biological Chemistry. 285: 6681-92. PMID 20028974 DOI: 10.1074/jbc.M109.019968  1
2010 Surendran K, Boyle S, Barak H, Kim M, Stomberski C, McCright B, Kopan R. The contribution of Notch1 to nephron segmentation in the developing kidney is revealed in a sensitized Notch2 background and can be augmented by reducing Mint dosage. Developmental Biology. 337: 386-95. PMID 19914235 DOI: 10.1016/j.ydbio.2009.11.017  1
2010 Van Tetering G, Van Diest P, Verlaan I, Van Der Wall E, Kopan R, Vooijs M. Metalloprotease ADAM10 is required for Notch1 site 2 cleavage (Journal of Biological Chemistry (2009), 284 (31018-31027)) Journal of Biological Chemistry. 285: 11754. DOI: 10.1074/jbc.A109.006775  1
2009 Riesenberg AN, Liu Z, Kopan R, Brown NL. Rbpj cell autonomous regulation of retinal ganglion cell and cone photoreceptor fates in the mouse retina. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 12865-77. PMID 19828801 DOI: 10.1523/JNEUROSCI.3382-09.2009  1
2009 Liu Z, Obenauf AC, Speicher MR, Kopan R. Rapid identification of homologous recombinants and determination of gene copy number with reference/query pyrosequencing (RQPS). Genome Research. 19: 2081-9. PMID 19797679 DOI: 10.1101/gr.093856.109  1
2009 van Tetering G, van Diest P, Verlaan I, van der Wall E, Kopan R, Vooijs M. Metalloprotease ADAM10 is required for Notch1 site 2 cleavage. The Journal of Biological Chemistry. 284: 31018-27. PMID 19726682 DOI: 10.1074/jbc.M109.006775  1
2009 Cras-Méneur C, Li L, Kopan R, Permutt MA. Presenilins, Notch dose control the fate of pancreatic endocrine progenitors during a narrow developmental window. Genes & Development. 23: 2088-101. PMID 19723764 DOI: 10.1101/gad.1800209  1
2009 Bazzi H, Demehri S, Potter CS, Barber AG, Awgulewitsch A, Kopan R, Christiano AM. Desmoglein 4 is regulated by transcription factors implicated in hair shaft differentiation. Differentiation; Research in Biological Diversity. 78: 292-300. PMID 19683850 DOI: 10.1016/j.diff.2009.06.004  1
2009 Demehri S, Turkoz A, Kopan R. Epidermal Notch1 loss promotes skin tumorigenesis by impacting the stromal microenvironment. Cancer Cell. 16: 55-66. PMID 19573812 DOI: 10.1016/j.ccr.2009.05.016  1
2009 Demehri S, Morimoto M, Holtzman MJ, Kopan R. Skin-derived TSLP triggers progression from epidermal-barrier defects to asthma. Plos Biology. 7: e1000067. PMID 19557146 DOI: 10.1371/journal.pbio.1000067  1
2009 Kopan R, Ilagan MX. The canonical Notch signaling pathway: unfolding the activation mechanism. Cell. 137: 216-33. PMID 19379690 DOI: 10.1016/j.cell.2009.03.045  1
2009 Demehri S, Kopan R. Notch signaling in bulge stem cells is not required for selection of hair follicle fate. Development (Cambridge, England). 136: 891-6. PMID 19211676 DOI: 10.1242/dev.030700  1
2009 Cai J, Lee J, Kopan R, Ma L. Genetic interplays between Msx2 and Foxn1 are required for Notch1 expression and hair shaft differentiation. Developmental Biology. 326: 420-30. PMID 19103190 DOI: 10.1016/j.ydbio.2008.11.021  1
2009 Hass MR, Sato C, Kopan R, Zhao G. Presenilin: RIP and beyond. Seminars in Cell & Developmental Biology. 20: 201-10. PMID 19073272 DOI: 10.1016/j.semcdb.2008.11.014  1
2009 Morimoto M, Kopan R. rtTA toxicity limits the usefulness of the SP-C-rtTA transgenic mouse. Developmental Biology. 325: 171-8. PMID 19013447 DOI: 10.1016/j.ydbio.2008.10.013  1
2008 Ong CT, Sedy JR, Murphy KM, Kopan R. Notch and presenilin regulate cellular expansion and cytokine secretion but cannot instruct Th1/Th2 fate acquisition. Plos One. 3: e2823. PMID 18665263 DOI: 10.1371/journal.pone.0002823  1
2008 Demehri S, Liu Z, Lee J, Lin MH, Crosby SD, Roberts CJ, Grigsby PW, Miner JH, Farr AG, Kopan R. Notch-deficient skin induces a lethal systemic B-lymphoproliferative disorder by secreting TSLP, a sentinel for epidermal integrity. Plos Biology. 6: e123. PMID 18507503 DOI: 10.1371/journal.pbio.0060123  1
2008 Hilton MJ, Tu X, Wu X, Bai S, Zhao H, Kobayashi T, Kronenberg HM, Teitelbaum SL, Ross FP, Kopan R, Long F. Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation. Nature Medicine. 14: 306-14. PMID 18297083 DOI: 10.1038/nm1716  1
2008 Bai S, Kopan R, Zou W, Hilton MJ, Ong CT, Long F, Ross FP, Teitelbaum SL. NOTCH1 regulates osteoclastogenesis directly in osteoclast precursors and indirectly via osteoblast lineage cells. The Journal of Biological Chemistry. 283: 6509-18. PMID 18156632 DOI: 10.1074/jbc.M707000200  1
2008 Lee J, Wu W, Kopan R. Murine vibrissae cultured in serum-free medium reinitiate anagen. The Journal of Investigative Dermatology. 128: 482-5. PMID 17687387 DOI: 10.1038/sj.jid.5701024  1
2008 Demehri S, Liu Z, Lee J, Lin MH, Crosby SD, Roberts CJ, Grigsby PW, Miner JH, Farr AG, Kopan R. Correction: Notch-deficient skin induces a lethal systemic B-lymphoproliferative disorder by secreting TSLP, a sentinel for epidermal integrity (PLoS Biology (2008) 6,5 (e123) DOI: 10.1371/journal.pbio.0060123) Plos Biology. 6: 1599. DOI: 10.1371/journal.pbio.0060169  1
2007 Khandelwal A, Chandu D, Roe CM, Kopan R, Quatrano RS. Moonlighting activity of presenilin in plants is independent of gamma-secretase and evolutionarily conserved. Proceedings of the National Academy of Sciences of the United States of America. 104: 13337-42. PMID 17684101 DOI: 10.1073/pnas.0702038104  1
2007 Lee J, Basak JM, Demehri S, Kopan R. Bi-compartmental communication contributes to the opposite proliferative behavior of Notch1-deficient hair follicle and epidermal keratinocytes. Development (Cambridge, England). 134: 2795-806. PMID 17611229 DOI: 10.1242/dev.02868  1
2007 Kopan R, Cheng HT, Surendran K. Molecular insights into segmentation along the proximal-distal axis of the nephron. Journal of the American Society of Nephrology : Jasn. 18: 2014-20. PMID 17568016 DOI: 10.1681/ASN.2007040453  1
2007 Ilagan MX, Kopan R. SnapShot: notch signaling pathway. Cell. 128: 1246. PMID 17382890 DOI: 10.1016/j.cell.2007.03.011  1
2007 Cheng HT, Kim M, Valerius MT, Surendran K, Schuster-Gossler K, Gossler A, McMahon AP, Kopan R. Notch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephron. Development (Cambridge, England). 134: 801-11. PMID 17229764 DOI: 10.1242/dev.02773  1
2007 Vooijs M, Ong CT, Hadland B, Huppert S, Liu Z, Korving J, van den Born M, Stappenbeck T, Wu Y, Clevers H, Kopan R. Mapping the consequence of Notch1 proteolysis in vivo with NIP-CRE. Development (Cambridge, England). 134: 535-44. PMID 17215306 DOI: 10.1242/dev.02733  1
2007 Lubman OY, Ilagan MX, Kopan R, Barrick D. Quantitative dissection of the Notch:CSL interaction: insights into the Notch-mediated transcriptional switch. Journal of Molecular Biology. 365: 577-89. PMID 17070841 DOI: 10.1016/j.jmb.2006.09.071  1
2007 Kopan R. Alzheimer research forum discussion: Gain or loss of function - Time to shake up assumptions on γ-secretase in Alzheimer disease? Commentary Journal of Alzheimer's Disease. 11: 409.  1
2006 Weinmaster G, Kopan R. A garden of Notch-ly delights. Development (Cambridge, England). 133: 3277-82. PMID 16908627 DOI: 10.1242/dev.02515  1
2006 Keller PC, Tomita T, Hayashi I, Chandu D, Weber JD, Cistola DP, Kopan R. A faster migrating variant masquerades as NICD when performing in vitro gamma-secretase assays with bacterially expressed Notch substrates. Biochemistry. 45: 5351-8. PMID 16618124 DOI: 10.1021/bi052228a  1
2006 Ogura T, Mio K, Hayashi I, Miyashita H, Fukuda R, Kopan R, Kodama T, Hamakubo T, Iwatsubo T, Iwastubo T, Tomita T, Sato C. Three-dimensional structure of the gamma-secretase complex. Biochemical and Biophysical Research Communications. 343: 525-34. PMID 16546128 DOI: 10.1016/j.bbrc.2006.02.158  1
2006 Barrick D, Kopan R. The Notch transcription activation complex makes its move. Cell. 124: 883-5. PMID 16530033 DOI: 10.1016/j.cell.2006.02.028  1
2006 Yang X, Tomita T, Wines-Samuelson M, Beglopoulos V, Tansey MG, Kopan R, Shen J. Notch1 signaling influences v2 interneuron and motor neuron development in the spinal cord. Developmental Neuroscience. 28: 102-17. PMID 16508308 DOI: 10.1159/000090757  1
2006 Ong CT, Cheng HT, Chang LW, Ohtsuka T, Kageyama R, Stormo GD, Kopan R. Target selectivity of vertebrate notch proteins. Collaboration between discrete domains and CSL-binding site architecture determines activation probability. The Journal of Biological Chemistry. 281: 5106-19. PMID 16365048 DOI: 10.1074/jbc.M506108200  1
2006 Chandu D, Huppert SS, Kopan R. Analysis of transmembrane domain mutants is consistent with sequential cleavage of Notch by gamma-secretase. Journal of Neurochemistry. 96: 228-35. PMID 16300632 DOI: 10.1111/j.1471-4159.2005.03547.x  1
2006 Ogura T, Mio K, Hayashi I, Miyashita H, Fukuda R, Kopan R, Kodama T, Hamakubo T, Iwatsubo T, Tomita T, Sato C. Corrigendum to "Three-dimensional structure of the γ-secretase complex" [Biochem. Biophys. Res. Commun. 343 (2006) 525-534] (DOI:10.1016/j.bbrc.2006.02.158) Biochemical and Biophysical Research Communications. 345: 543. DOI: 10.1016/j.bbrc.2006.04.025  1
2005 Cheng HT, Kopan R. The role of Notch signaling in specification of podocyte and proximal tubules within the developing mouse kidney. Kidney International. 68: 1951-2. PMID 16221173 DOI: 10.1111/j.1523-1755.2005.00627.x  1
2005 Pan Y, Liu Z, Shen J, Kopan R. Notch1 and 2 cooperate in limb ectoderm to receive an early Jagged2 signal regulating interdigital apoptosis. Developmental Biology. 286: 472-82. PMID 16169548 DOI: 10.1016/j.ydbio.2005.08.037  1
2005 Kiernan AE, Cordes R, Kopan R, Gossler A, Gridley T. The Notch ligands DLL1 and JAG2 act synergistically to regulate hair cell development in the mammalian inner ear. Development (Cambridge, England). 132: 4353-62. PMID 16141228 DOI: 10.1242/dev.02002  1
2005 Huppert SS, Ilagan MX, De Strooper B, Kopan R. Analysis of Notch function in presomitic mesoderm suggests a gamma-secretase-independent role for presenilins in somite differentiation. Developmental Cell. 8: 677-88. PMID 15866159 DOI: 10.1016/j.devcel.2005.02.019  1
2005 Lubman OY, Kopan R, Waksman G, Korolev S. The crystal structure of a partial mouse Notch-1 ankyrin domain: repeats 4 through 7 preserve an ankyrin fold. Protein Science : a Publication of the Protein Society. 14: 1274-81. PMID 15802643 DOI: 10.1110/ps.041184105  1
2004 Pan Y, Lin MH, Tian X, Cheng HT, Gridley T, Shen J, Kopan R. gamma-secretase functions through Notch signaling to maintain skin appendages but is not required for their patterning or initial morphogenesis. Developmental Cell. 7: 731-43. PMID 15525534 DOI: 10.1016/j.devcel.2004.09.014  1
2004 Vooijs M, Schroeter EH, Pan Y, Blandford M, Kopan R. Ectodomain shedding and intramembrane cleavage of mammalian Notch proteins is not regulated through oligomerization. The Journal of Biological Chemistry. 279: 50864-73. PMID 15448134 DOI: 10.1074/jbc.M409430200  1
2004 Nichols AM, Pan Y, Herreman A, Hadland BK, De Strooper B, Kopan R, Huppert SS. Notch pathway is dispensable for adipocyte specification. Genesis (New York, N.Y. : 2000). 40: 40-4. PMID 15354292 DOI: 10.1002/gene.20061  1
2004 Wolfe MS, Kopan R. Intramembrane proteolysis: theme and variations. Science (New York, N.Y.). 305: 1119-23. PMID 15326347 DOI: 10.1126/science.1096187  1
2004 Koo EH, Kopan R. Potential role of presenilin-regulated signaling pathways in sporadic neurodegeneration. Nature Medicine. 10: S26-33. PMID 15272268 DOI: 10.1038/nm1065  1
2004 Hadland BK, Huppert SS, Kanungo J, Xue Y, Jiang R, Gridley T, Conlon RA, Cheng AM, Kopan R, Longmore GD. A requirement for Notch1 distinguishes 2 phases of definitive hematopoiesis during development. Blood. 104: 3097-105. PMID 15251982 DOI: 10.1182/blood-2004-03-1224  1
2004 Kopan R, Ilagan MX. Gamma-secretase: proteasome of the membrane? Nature Reviews. Molecular Cell Biology. 5: 499-504. PMID 15173829 DOI: 10.1038/nrm1406  1
2004 Yang X, Klein R, Tian X, Cheng HT, Kopan R, Shen J. Notch activation induces apoptosis in neural progenitor cells through a p53-dependent pathway. Developmental Biology. 269: 81-94. PMID 15081359 DOI: 10.1016/j.ydbio.2004.01.014  1
2004 Lubman OY, Korolev SV, Kopan R. Anchoring notch genetics and biochemistry; structural analysis of the ankyrin domain sheds light on existing data. Molecular Cell. 13: 619-26. PMID 15023333 DOI: 10.1016/S1097-2765(04)00120-0  1
2003 Lin MH, Kopan R. Long-range, nonautonomous effects of activated Notch1 on tissue homeostasis in the nail. Developmental Biology. 263: 343-59. PMID 14597207 DOI: 10.1016/j.ydbio.2003.07.007  1
2003 Hu QD, Ang BT, Karsak M, Hu WP, Cui XY, Duka T, Takeda Y, Chia W, Sankar N, Ng YK, Ling EA, Maciag T, Small D, Trifonova R, Kopan R, et al. F3/contactin acts as a functional ligand for Notch during oligodendrocyte maturation. Cell. 115: 163-75. PMID 14567914 DOI: 10.1016/S0092-8674(03)00810-9  1
2003 Schroeter EH, Ilagan MX, Brunkan AL, Hecimovic S, Li YM, Xu M, Lewis HD, Saxena MT, De Strooper B, Coonrod A, Tomita T, Iwatsubo T, Moore CL, Goate A, Wolfe MS, ... ... Kopan R, et al. A presenilin dimer at the core of the gamma-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis. Proceedings of the National Academy of Sciences of the United States of America. 100: 13075-80. PMID 14566063 DOI: 10.1073/pnas.1735338100  1
2003 Cheng HT, Miner JH, Lin M, Tansey MG, Roth K, Kopan R. Gamma-secretase activity is dispensable for mesenchyme-to-epithelium transition but required for podocyte and proximal tubule formation in developing mouse kidney. Development (Cambridge, England). 130: 5031-42. PMID 12952904 DOI: 10.1242/dev.00697  1
2003 Selkoe D, Kopan R. Notch and Presenilin: regulated intramembrane proteolysis links development and degeneration. Annual Review of Neuroscience. 26: 565-97. PMID 12730322 DOI: 10.1146/annurev.neuro.26.041002.131334  1
2002 Michelson A, Kopan R. Differentiation and gene regulation: toward a holistic understanding of animal development: intercellular communication and transcriptional regulation are two sides of the same coin. Current Opinion in Genetics & Development. 12: 499-502. PMID 12200153 DOI: 10.1016/S0959-437X(02)00332-5  1
2002 Kopan R. Notch: a membrane-bound transcription factor. Journal of Cell Science. 115: 1095-7. PMID 11884509  1
2002 Kopan R, Goate A. Aph-2/Nicastrin: an essential component of gamma-secretase and regulator of Notch signaling and Presenilin localization. Neuron. 33: 321-4. PMID 11832221 DOI: 10.1016/S0896-6273(02)00585-8  1
2002 Kopan R, Lee J, Lin MH, Syder AJ, Kesterson J, Crutchfield N, Li CR, Wu W, Books J, Gordon JI. Genetic mosaic analysis indicates that the bulb region of coat hair follicles contains a resident population of several active multipotent epithelial lineage progenitors. Developmental Biology. 242: 44-57. PMID 11795939 DOI: 10.1006/dbio.2001.0516  1
2001 Huppert S, Kopan R. Regulated intramembrane proteolysis takes another twist. Developmental Cell. 1: 590-2. PMID 11709178 DOI: 10.1016/S1534-5807(01)00081-8  1
2001 Saxena MT, Schroeter EH, Mumm JS, Kopan R. Murine notch homologs (N1-4) undergo presenilin-dependent proteolysis. The Journal of Biological Chemistry. 276: 40268-73. PMID 11518718 DOI: 10.1074/jbc.M107234200  1
2001 Tomita T, Watabiki T, Takikawa R, Morohashi Y, Takasugi N, Kopan R, De Strooper B, Iwatsubo T. The first proline of PALP motif at the C terminus of presenilins is obligatory for stabilization, complex formation, and gamma-secretase activities of presenilins. The Journal of Biological Chemistry. 276: 33273-81. PMID 11432849 DOI: 10.1074/jbc.M011152200  1
2001 Hadland BK, Manley NR, Su D, Longmore GD, Moore CL, Wolfe MS, Schroeter EH, Kopan R. Gamma -secretase inhibitors repress thymocyte development. Proceedings of the National Academy of Sciences of the United States of America. 98: 7487-91. PMID 11416218 DOI: 10.1073/pnas.131202798  1
2000 Mumm JS, Kopan R. Notch signaling: from the outside in. Developmental Biology. 228: 151-65. PMID 11112321 DOI: 10.1006/dbio.2000.9960  1
2000 Kopan R, Goate A. A common enzyme connects notch signaling and Alzheimer's disease. Genes & Development. 14: 2799-806. PMID 11090127 DOI: 10.1101/gad.836900  1
2000 Mumm JS, Schroeter EH, Saxena MT, Griesemer A, Tian X, Pan DJ, Ray WJ, Kopan R. A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1. Molecular Cell. 5: 197-206. PMID 10882062  1
2000 Huppert SS, Le A, Schroeter EH, Mumm JS, Saxena MT, Milner LA, Kopan R. Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1. Nature. 405: 966-70. PMID 10879540 DOI: 10.1038/35016111  1
2000 Lin MH, Leimeister C, Gessler M, Kopan R. Activation of the Notch pathway in the hair cortex leads to aberrant differentiation of the adjacent hair-shaft layers. Development (Cambridge, England). 127: 2421-32. PMID 10804183  1
1999 Kopan R. All good things must come to an end: how is Notch signaling turned off? Science's Stke : Signal Transduction Knowledge Environment. 1999: PE1. PMID 11865186 DOI: 10.1126/stke.1999.9.pe1  1
1999 Ray WJ, Yao M, Mumm J, Schroeter EH, Saftig P, Wolfe M, Selkoe DJ, Kopan R, Goate AM. Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch. The Journal of Biological Chemistry. 274: 36801-7. PMID 10593990 DOI: 10.1074/jbc.274.51.36801  1
1999 Steiner H, Duff K, Capell A, Romig H, Grim MG, Lincoln S, Hardy J, Yu X, Picciano M, Fechteler K, Citron M, Kopan R, Pesold B, Keck S, Baader M, et al. A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling. The Journal of Biological Chemistry. 274: 28669-73. PMID 10497236 DOI: 10.1074/jbc.274.40.28669  1
1999 De Strooper B, Annaert W, Cupers P, Saftig P, Craessaerts K, Mumm JS, Schroeter EH, Schrijvers V, Wolfe MS, Ray WJ, Goate A, Kopan R. A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain. Nature. 398: 518-22. PMID 10206645 DOI: 10.1038/19083  1
1999 Wittenberger T, Steinbach OC, Authaler A, Kopan R, Rupp RA. MyoD stimulates delta-1 transcription and triggers notch signaling in the Xenopus gastrula. The Embo Journal. 18: 1915-22. PMID 10202155 DOI: 10.1093/emboj/18.7.1915  1
1999 Ray WJ, Yao M, Nowotny P, Mumm J, Zhang W, Wu JY, Kopan R, Goate AM. Evidence for a physical interaction between presenilin and Notch. Proceedings of the National Academy of Sciences of the United States of America. 96: 3263-8. PMID 10077672 DOI: 10.1073/pnas.96.6.3263  1
1998 Schroeter EH, Kisslinger JA, Kopan R. Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain. Nature. 393: 382-6. PMID 9620803 DOI: 10.1038/30756  1
1997 Kopan R, Cagan R. Notch on the cutting edge. Trends in Genetics : Tig. 13: 465-7. PMID 9433133  1
1996 Kopan R, Turner DL. The Notch pathway: democracy and aristocracy in the selection of cell fate. Current Opinion in Neurobiology. 6: 594-601. PMID 8937822 DOI: 10.1016/S0959-4388(96)80090-0  1
1996 Milner LA, Bigas A, Kopan R, Brashem-Stein C, Bernstein ID, Martin DI. Inhibition of granulocytic differentiation by mNotch1. Proceedings of the National Academy of Sciences of the United States of America. 93: 13014-9. PMID 8917536 DOI: 10.1073/pnas.93.23.13014  1
1996 Kopan R, Schroeter EH, Weintraub H, Nye JS. Signal transduction by activated mNotch: importance of proteolytic processing and its regulation by the extracellular domain. Proceedings of the National Academy of Sciences of the United States of America. 93: 1683-8. PMID 8643690 DOI: 10.1073/pnas.93.4.1683  1
1995 Nye JS, Kopan R. Developmental signaling. Vertebrate ligands for Notch. Current Biology : Cb. 5: 966-9. PMID 8542284 DOI: 10.1016/S0960-9822(95)00189-8  1
1995 Jarriault S, Brou C, Logeat F, Schroeter EH, Kopan R, Israel A. Signalling downstream of activated mammalian Notch. Nature. 377: 355-8. PMID 7566092 DOI: 10.1038/377355a0  1
1994 Nye JS, Kopan R, Axel R. An activated Notch suppresses neurogenesis and myogenesis but not gliogenesis in mammalian cells. Development (Cambridge, England). 120: 2421-30. PMID 7956822  1
1994 Kopan R, Nye JS, Weintraub H. The intracellular domain of mouse Notch: a constitutively activated repressor of myogenesis directed at the basic helix-loop-helix region of MyoD. Development (Cambridge, England). 120: 2385-96. PMID 7956819  1
1994 Milner LA, Kopan R, Martin DI, Bernstein ID. A human homologue of the Drosophila developmental gene, Notch, is expressed in CD34+ hematopoietic precursors. Blood. 83: 2057-62. PMID 7512837  1
1993 Kopan R, Weintraub H. Mouse notch: expression in hair follicles correlates with cell fate determination. The Journal of Cell Biology. 121: 631-41. PMID 8486742  1
1989 Coulombe PA, Kopan R, Fuchs E. Expression of keratin K14 in the epidermis and hair follicle: insights into complex programs of differentiation. The Journal of Cell Biology. 109: 2295-312. PMID 2478566 DOI: 10.1083/jcb.109.5.2295  1
1989 Kopan R, Fuchs E. The use of retinoic acid to probe the relation between hyperproliferation-associated keratins and cell proliferation in normal and malignant epidermal cells. The Journal of Cell Biology. 109: 295-307. PMID 2473080 DOI: 10.1083/JCB.109.1.295  1
1989 Kopan R, Fuchs E. A new look into an old problem: keratins as tools to investigate determination, morphogenesis, and differentiation in skin. Genes & Development. 3: 1-15. PMID 2468556 DOI: 10.1101/GAD.3.1.1  1
1988 McCance DJ, Kopan R, Fuchs E, Laimins LA. Human papillomavirus type 16 alters human epithelial cell differentiation in vitro. Proceedings of the National Academy of Sciences of the United States of America. 85: 7169-73. PMID 2459699  1
1988 Stoler A, Kopan R, Duvic M, Fuchs E. Use of monospecific antisera and cRNA probes to localize the major changes in keratin expression during normal and abnormal epidermal differentiation. The Journal of Cell Biology. 107: 427-46. PMID 2458356 DOI: 10.1083/JCB.107.2.427  1
1987 Liebowitz D, Kopan R, Fuchs E, Sample J, Kieff E. An Epstein-Barr virus transforming protein associates with vimentin in lymphocytes. Molecular and Cellular Biology. 7: 2299-308. PMID 3039344 DOI: 10.1128/MCB.7.7.2299  1
1987 Kopan R, Traska G, Fuchs E. Retinoids as important regulators of terminal differentiation: examining keratin expression in individual epidermal cells at various stages of keratinization. The Journal of Cell Biology. 105: 427-40. PMID 2440897  1
1985 Kopan R, Kurn N, Ovadia M. Synthesis and possible role of proteoglycans during Volvox development. Cell Differentiation. 16: 119-32. PMID 3891100 DOI: 10.1016/0045-6039(85)90525-1  1
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